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Assays for human cytokines and their interpretation 人类细胞因子的测定及其解释
Clinical Immunology Newsletter
Pub Date : 1998-07-01 DOI: 10.1016/S0197-1859(00)89179-7
PhD Theresa L. Whiteside

Assays for cytokines have become a part of a laboratory repertoire at many institutions. As the knowledge of cytokine biology and their role in human disease accumulates, cytokine assessment is likely to become even more extensive. It is essential that this assessment be performed expertly, preferably in clinical laboratories with established QC and QA programs, and interpreted accurately. The correct interpretation of results is a key to defining and validating clinical usefulness of cytokine assays. More than a single assay may be necessary to confirm the involvement of a cytokine in a disease. Cytokines mediate interactions between various cells and they are also involved in signaling within the cell. The wide choice of cytokine assays available today offers possibilities for evaluating diverse aspects of the cytokine biology. Monitoring strategies for biotherapy trials as well as cytokine profiling in disease are likely to represent major efforts of clinical immunology laboratories in the immediate future.

细胞因子的测定已成为许多机构实验室曲目的一部分。随着对细胞因子生物学及其在人类疾病中的作用的了解的积累，细胞因子的评估可能会变得更加广泛。必须熟练地进行评估，最好是在具有已建立的QC和QA程序的临床实验室中进行，并准确地解释。对结果的正确解释是确定和验证细胞因子测定的临床用途的关键。要确认某种细胞因子在某种疾病中的作用，可能需要不止一种检测方法。细胞因子介导各种细胞之间的相互作用，也参与细胞内的信号传导。细胞因子测定的广泛选择今天提供了评估细胞因子生物学的不同方面的可能性。在不久的将来，生物治疗试验的监测策略以及疾病中的细胞因子谱可能是临床免疫学实验室的主要工作。
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引用次数: 1
Abstracts from the eleventh annual meeting of the association of medical laboratory immunologists (AMLI) 医学实验室免疫学家协会(AMLI)第十一届年会摘要
Clinical Immunology Newsletter
Pub Date : 1998-07-01 DOI: 10.1016/S0197-1859(00)89181-5
M.R.G. O'Gorman
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引用次数: 0
Reference standards and quality performance considerations for measurements of cytokines and soluble markers of immune activation 细胞因子和免疫活化可溶性标记物测量的参考标准和质量性能考虑
Clinical Immunology Newsletter
Pub Date : 1998-07-01 DOI: 10.1016/S0197-1859(00)89178-5
MD John L. Fahey , Najib Aziz , Pari Nishanian
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引用次数: 0
The use of amplification technology in the detection and quantitation of viruses 扩增技术在病毒检测和定量中的应用
Clinical Immunology Newsletter
Pub Date : 1998-06-01 DOI: 10.1016/S0197-1859(00)89176-1
Chris Cunneen, Kevin J. Reagan, Joerg Laudemann, Barry Shuman, Neil Stollar, Cy Cabradilla
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引用次数: 0
U-Small nuclear ribonucleoprotein (RNP)-reactive autoantibodies: Diagnostic testing and clinical interpretation 小核核糖核蛋白(RNP)反应性自身抗体:诊断测试和临床解释
Clinical Immunology Newsletter
Pub Date : 1998-06-01 DOI: 10.1016/S0197-1859(00)89175-X
Margaret-Mary Holyst, Robert W. Hoffman
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引用次数: 13
The use of cleavase® fragment length polymorphism (CFLP®) and invader technologies in the detection of human pathogens and drug resistance 利用裂解酶片段长度多态性(CFLP®)和入侵技术检测人类病原体和耐药性
Clinical Immunology Newsletter
Pub Date : 1998-06-01 DOI: 10.1016/S0197-1859(00)89177-3
Laura Heisler, Mary Ann Brow, Monika de Arruda, Bruce Neri, Lance Fors
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引用次数: 0
CD27 in clinical (neuro-)immunology CD27在临床(神经)免疫学中的作用
Clinical Immunology Newsletter
Pub Date : 1998-04-01 DOI: 10.1016/S0197-1859(00)89171-2
MD, PhD R.Q. Hintzen

CD27 is an interesting lymphocyte specific member of the still growing TNF-R family, a group of molecules that are involved in the regulation of differentiation, activation and survival of lymphocytes. Some of these molecules have already been shown to play essential roles in autoimmunity and lymphoproliferation. The exact biological role of CD27 remains to be resolved, but it can be anticipated that it modulates antigen specific immune responses and that it is mainly functional in lymphoid tissue such as germinal centers. Study of the expression of CD27 and its ligand CD70 on lymphocytes can provide insight in different immunopathological conditions. Finally, measurement of sCD27 concentrations in body fluids can, on one hand, be used as a marker for immune activation in vivo and, on the other hand, serve as tumor marker for certain lymphoid malignancies.

CD27是仍在生长的TNF-R家族中一个有趣的淋巴细胞特异性成员，TNF-R家族是一组参与淋巴细胞分化、激活和存活调节的分子。其中一些分子已被证明在自身免疫和淋巴细胞增殖中发挥重要作用。CD27的确切生物学作用仍有待解决，但可以预期的是，它调节抗原特异性免疫反应，并主要在淋巴组织如生发中心发挥作用。研究CD27及其配体CD70在淋巴细胞上的表达，可以为不同免疫病理条件下的病理变化提供依据。最后，体液中sCD27浓度的测定一方面可以作为体内免疫激活的标志物，另一方面也可以作为某些淋巴恶性肿瘤的肿瘤标志物。
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引用次数: 1
Update in clinical trials and immunological monitoring in multiple sclerosis 多发性硬化症临床试验和免疫监测的最新进展
Clinical Immunology Newsletter
Pub Date : 1998-04-01 DOI: 10.1016/S0197-1859(00)89173-6
MD Anthony T. Reder
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引用次数: 0
Transplantation immunology (unit 23) undergraduate teaching project American gastroenterological association 移植免疫学(第23单元)本科教学项目
Clinical Immunology Newsletter
Pub Date : 1998-04-01 DOI: 10.1016/S0197-1859(00)89174-8
MD Estella M. Alonso
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引用次数: 0
Human leukocyte differentiation antigens of the sixth international workshop: What can we expect to see in the clinic? 第六届人白细胞分化抗原国际研讨会:我们可以期待在临床中看到什么?
Clinical Immunology Newsletter
Pub Date : 1998-04-01 DOI: 10.1016/S0197-1859(00)89172-4
Nicole Johnson, Susan B. Wormsley
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引用次数: 1
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