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Pattern recognition for flow cytometric data analysis: A brief review 流式细胞术数据分析的模式识别:简要回顾
Clinical Immunology Newsletter
Pub Date : 1998-03-01 DOI: 10.1016/S0197-1859(00)89169-4
Ph.D. Gary C. Salzman
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引用次数: 0
Quantitative cytology and histology by laser scanning cytometry 激光扫描细胞术定量细胞学和组织学
Clinical Immunology Newsletter
Pub Date : 1998-03-01 DOI: 10.1016/S0197-1859(00)89168-2
Ph.D., P.M.I.A.C. James B. Hendricks , M.D., M.I.A.C. Eva M. Wojcik
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引用次数: 5
Analysis of the T cell receptor (TCR) V beta repertoire in HIV disease HIV疾病中T细胞受体(TCR) V β库的分析
Clinical Immunology Newsletter
Pub Date : 1998-03-01 DOI: 10.1016/S0197-1859(00)89170-0
PhD J. Philip McCoy Jr.
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引用次数: 0
The cellular physiology of apoptosis mapped by multilaser flow cytometry 多激光流式细胞术研究细胞凋亡的生理机制
Clinical Immunology Newsletter
Pub Date : 1998-01-01 DOI: 10.1016/S0197-1859(00)89164-5
M.D. David W. Hedley
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引用次数: 0
Anti-neutrophil cytoplasmic antibody (ANCA) target antigens, disease associations, and laboratory testing 抗中性粒细胞胞浆抗体(ANCA)靶抗原、疾病关联和实验室检测
Clinical Immunology Newsletter
Pub Date : 1998-01-01 DOI: 10.1016/S0197-1859(00)89166-9
Hitendra S. Jethwa , Ronald J. Falk , J. Charles Jennette
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引用次数: 0
Novel autoimmune targets and crossreactivity in myasthenia gravis 重症肌无力的新自身免疫靶点和交叉反应性
Clinical Immunology Newsletter
Pub Date : 1998-01-01 DOI: 10.1016/S0197-1859(00)89167-0
Mark A. Agius, Robert H. Fairclough

The identification of the AChR as the antigenic target in the autoimmune disease MG stemmed from advances in understanding of the structure of the neuromuscular junction. The improved understanding of the structure of the synapse is being associated, concomitantly, with improved understanding of the antigenic targets of autoimmune disease of the neuromuscular junction. Intramolecular and inter-molecular spreading of antigenic targets appears to occur at the synapse and may explain the development of antibodies against cytoskeletal proteins in patients whose initial immune attack is directed against the AChR. Immune responses directed exclusively against these cytoskeletal proteins however may explain the phenomenon of seronegative myasthenia gravis. Molecular mimickry with crossreactive immune responses may explain the development of anti-AChR, anti-titin and anti-ryanodine receptor antibodies in patients with thymoma and MG. The chemical reactivity of proteins at the synapse may also render them susceptible to immune attack as a consequence of altered structure.

在自身免疫性疾病MG中，AChR作为抗原靶点的鉴定源于对神经肌肉连接结构的理解的进步。对突触结构的进一步了解与对神经肌肉交界处自身免疫性疾病的抗原靶点的进一步了解是相关的。抗原靶点的分子内和分子间扩散似乎发生在突触上，这可能解释了最初免疫攻击针对AChR的患者中针对细胞骨架蛋白的抗体的发展。然而，针对这些细胞骨架蛋白的免疫反应可能解释了血清阴性重症肌无力的现象。分子模拟与交叉反应性免疫反应可能解释胸腺瘤和MG患者中抗achr、抗titin和抗ryanodine受体抗体的发展。突触上蛋白质的化学反应性也可能使它们由于结构改变而容易受到免疫攻击。
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引用次数: 0
Complement receptor type 2 (CR2/CD21) as a central link between innate and acquired immunity 补体受体2型(CR2/CD21)作为先天免疫和获得性免疫之间的中心联系
Clinical Immunology Newsletter
Pub Date : 1998-01-01 DOI: 10.1016/S0197-1859(00)89165-7
M.D. V. Michael Holers

The complement system is activated by many molecules, including several important proteins of the innate immune system, that results in the covalent linkage of C3 activation fragments to Ag and/or Ab. Receptors for C3 activation fragments, especially CD21, play central roles in linking the B lymphocyte adaptive immune system to the complement system. CD21 deficient mice demonstrate pronounced immune defects. These defects are apparent because CD21 plays an important role in the activation of B lymphocytes, FDC, and likely T lymphocytes in vivo. Manipulation of CD21 activities by either blocking the binding of ligands to CD21, or targeting Ags to this receptor in vaccination strategies, are currently being explored as options to regulate several human immune responses. The regulation of immune responses through these and other strategies will likely further define the pivotal role CD21 plays in connecting innate to acquired immunity.

补体系统被许多分子激活，包括先天免疫系统的几种重要蛋白质，导致C3激活片段与Ag和/或Ab的共价连锁。C3激活片段的受体，特别是CD21，在连接B淋巴细胞适应性免疫系统和补体系统中起着核心作用。CD21缺陷小鼠表现出明显的免疫缺陷。这些缺陷是明显的，因为CD21在体内B淋巴细胞、FDC和可能的T淋巴细胞的激活中起重要作用。通过阻断配体与CD21的结合或在疫苗接种策略中将Ags靶向到该受体来操纵CD21的活性，目前正在探索作为调节几种人类免疫反应的选择。通过这些和其他策略调节免疫反应可能会进一步确定CD21在连接先天免疫和获得性免疫方面所起的关键作用。
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引用次数: 1
Modulation of complement-mediated tissue injury by IVIG 补体介导的组织损伤的IVIG调节
Clinical Immunology Newsletter
Pub Date : 1997-12-01 DOI: 10.1016/S0197-1859(00)80024-2
M.D. Michael M. Frank
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引用次数: 0
Complement inhibitors as therapeutic agents 补体抑制剂作为治疗剂
Clinical Immunology Newsletter
Pub Date : 1997-12-01 DOI: 10.1016/S0197-1859(00)80025-4
M. Kathryn Liszewski, V. Bala Subramanian, John P. Atkinson

This report has described several currently evolving strategies and therapeutic agents designed to inhibit the complement system. Many others can be envisioned. Analagous to the utility of therapeutic agents that inhibit the coagulation cascade, it can be anticipated that complement inhibitors will find an important niche in our armamentarium of drugs to reduce undesirable inflammatory reactions

本报告描述了几种目前发展的策略和治疗药物，旨在抑制补体系统。还可以设想许多其他的例子。与抑制凝血级联的治疗药物类似，可以预见，补体抑制剂将在我们的药物宝库中找到一个重要的利基，以减少不良的炎症反应
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引用次数: 4
Modulation of complement activation in the management of disease processes 在疾病过程管理中补体激活的调节
Clinical Immunology Newsletter
Pub Date : 1997-12-01 DOI: 10.1016/S0197-1859(00)80023-0
M.D. Barry Lee Myones (Associate Professor)
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引用次数: 0
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