Engineering Microbiology最新文献

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Isolation, biosynthesis, and biological activity of rubromycins derived from actinomycetes 放线菌源红霉素的分离、生物合成及生物活性研究

Engineering Microbiology

Pub Date : 2022-09-01 DOI: 10.1016/j.engmic.2022.100039

Ping Lin , Xue Li , Yuchen Xin , Hongying Li , Gang Li , Hongxiang Lou

Natural occurring aromatic polyketides from actinomycetes indicate a structurally and functionally diverse family of polycyclic polyphenols. Some of them are consequently suggested as lead structures for drug development. Among them, rubromycins are derived from a single C26 polyketide chain and exhibit an unusual bisbenzannulated [5,6]-spiroketal system that connects a highly oxygenated naphthazarin motif to an isocoumarin unit. This type of biosynthetically elusive polycyclic polyketides has shown promising pharmacological activities, including antimicrobial, anticancer, and enzyme inhibition activity. The unique structures, intriguing biosynthesis, and marked bioactivities of rubromycins have drawn considerable attention from several chemists and biologists. This review covers the isolation, characterization, biosynthesis, and biological studies of these structurally diverse and complex rubromycins.

放线菌中天然存在的芳香聚酮表明多环多酚是一个结构和功能多样的家族。因此，其中一些被认为是药物开发的先导结构。其中，红霉素来源于单一的C26聚酮链，并表现出一种不同寻常的双苄环化[5,6]-螺酮系统，该系统将高度氧化的萘氮杂基序连接到异香豆素单元。这种类型的生物合成难以捉摸的多环聚酮已显示出有前景的药理活性，包括抗菌、抗癌和酶抑制活性。红霉素独特的结构、有趣的生物合成和显著的生物活性引起了一些化学家和生物学家的极大关注。这篇综述涵盖了这些结构多样和复杂的红霉素的分离、表征、生物合成和生物学研究。

引用次数: 0

Cascade-Cas3 facilitates high-accuracy genome engineering in Pseudomonas using phage-encoded homologous recombination Cascade-Cas3利用噬菌体编码的同源重组促进假单胞菌的高精度基因组工程

Engineering Microbiology

Pub Date : 2022-08-01 DOI: 10.1016/j.engmic.2022.100046

Wentao Zheng, Yandong Xia, Xue Wang, Shiqing Gao, Diao Zhou, Jun Fu, Ruijuan Li, Jia Yin

引用次数: 3

Lysine acetylation decreases enzyme activity and protein level of Escherichia coli lactate dehydrogenase 赖氨酸乙酰化降低了大肠杆菌乳酸脱氢酶活性和蛋白质水平

Engineering Microbiology

Pub Date : 2022-08-01 DOI: 10.1016/j.engmic.2022.100045

Min Liu, Meitong Huo, Likun Guo, Yingxin Fu, M. Xian, Q. Qi, Wei Liu, Guang Zhao

引用次数: 0

Copper-radical oxidases: A diverse group of biocatalysts with distinct properties and a broad range of biotechnological applications 铜自由基氧化酶:一组不同的生物催化剂具有不同的性质和广泛的生物技术应用

Engineering Microbiology

Pub Date : 2022-07-01 DOI: 10.1016/j.engmic.2022.100037

K. Koschorreck, Saadet Alpdağtaş, V. Urlacher

引用次数: 3

Discovery and analysis of a new class of triterpenes derived from hexaprenyl pyrophosphate 一类新的由焦磷酸六戊烯基衍生的三萜化合物的发现和分析

Engineering Microbiology

Pub Date : 2022-07-01 DOI: 10.1016/j.engmic.2022.100035

Dan Hu

引用次数: 1

Metabolic engineering using acetate as a promising building block for the production of bio-based chemicals 代谢工程利用醋酸酯作为生产生物基化学品的有前途的基石

Engineering Microbiology

Pub Date : 2022-07-01 DOI: 10.1016/j.engmic.2022.100036

Guiping Gong, Bo Wu, Linpei Liu, Jianting Li, Qi-li Zhu, Mingxiong He, Guoquan Hu

引用次数: 12

Isolation, Biosynthesis, and Biological Activity of Rubromycins Derived from Actinomycetes 放线菌源红霉素的分离、生物合成及生物活性研究

Engineering Microbiology

Pub Date : 2022-07-01 DOI: 10.1016/j.engmic.2022.100039

Pingzhou Lin, Xue Li, Yu Xin, Hong-Ying Li, Gang Li, H. Lou

引用次数: 0

The Type IX Secretion System: Insights into Its Function and Connection to Glycosylation in Cytophaga hutchinsonii 哈氏细胞吞噬体IX型分泌系统的功能及其与糖基化的关系

Engineering Microbiology

Pub Date : 2022-07-01 DOI: 10.1016/j.engmic.2022.100038

Wenxia Song, Xueke Zhuang, Yahong Tan, Q. Qi, Xuemei Lu

引用次数: 0

Engineering for life in toxicity: Key to industrializing microbial synthesis of high energy density fuels 毒性生命工程：高能量密度燃料微生物合成工业化的关键

Engineering Microbiology

Pub Date : 2022-06-01 DOI: 10.1016/j.engmic.2022.100013

Lijuan Liu , Wenzhi Bao , Xiao Men , Haibo Zhang

With the growing demand for air transportation combined with global concerns about environmental issues and the instability and lack of renewability of the oil market, microbial production of high energy density fuels for jets (bio-jet fuels) has received more attention in recent years. Bio-jet fuels can be derived from both isoprenoids and fatty acids, and, additionally, aromatic hydrocarbons derived from expanded shikimate pathways are also candidates for jet fuels. Compared to fatty acid derivatives, most of isoprenoids and aromatic hydrocarbons used for jet fuels have higher density energies. However, they are also highly toxic to host microbes. The cytotoxicity induced during the synthesis of isoprenoid or shikimate pathway-derived biofuels remains one of the major obstacles for industrial production even though synthetic and systems biology approaches have reconstructed and optimized metabolic pathways for production of these bio-jet fuels. Here, we review recent developments in the production of known and potential jet fuels by microorganisms, with a focus on alleviating cytotoxicity caused by the final products, intermediates, and metabolic pathways.

近年来，随着航空运输需求的增长，加上全球对环境问题的担忧，以及石油市场的不稳定和缺乏可再生性，微生物生产用于喷气式飞机的高能量密度燃料（生物喷气燃料）受到了更多关注。生物喷气燃料可以从类异戊二烯和脂肪酸中提取，此外，从扩展的莽草酸途径中提取的芳烃也是喷气燃料的候选者。与脂肪酸衍生物相比，大多数用于喷气燃料的类异戊二烯和芳烃具有更高的密度能量。然而，它们对宿主微生物也具有高度毒性。尽管合成和系统生物学方法已经重建和优化了生产这些生物喷气燃料的代谢途径，但类异戊二烯或莽草酸途径衍生的生物燃料的合成过程中诱导的细胞毒性仍然是工业生产的主要障碍之一。在这里，我们回顾了微生物生产已知和潜在喷气燃料的最新进展，重点是减轻最终产物、中间体和代谢途径引起的细胞毒性。

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引用次数: 0

Peptaibols: diversity, bioactivity, and biosynthesis 肽:多样性，生物活性和生物合成

Engineering Microbiology

Pub Date : 2022-06-01 DOI: 10.1016/j.engmic.2022.100026

Xuewen Hou, Ruonan Sun, Yanyan Feng, Runfang Zhang, T. Zhu, Qian Che, Guojian Zhang, Dehai Li

引用次数: 9

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