iLABMED最新文献

Since the first reported case of monkeypox in the UK in May 2022, there has been an upward trend in monkeypox cases and a global outbreak. However, reports of severe cases are relatively limited. In this study, we report a case of severe monkeypox in a patient with HIV. The patient presented with skin lesions that started on his face and around the penis and persisted for several months. Throughout the course of the disease, he received systematic symptomatic supportive treatment, topical remedies, and special care for the rash. He also underwent cidofovir antiviral therapy and smallpox-vaccinated healthy population-derived plasma therapy in succession, with the condition ultimately showing improvement after plasma treatment. After more than 3 months of hospitalization, he fully recovered. To the best of our knowledge, this is the first reported use of smallpox-vaccinated healthy population-derived plasma in the treatment of severe monkeypox cases.

Mpox (formerly Monkeypox) is a zoonotic infection caused by Monkeypox virus (MPXV). Since 2022, Mpox epidemics have occurred in many non-endemic countries and regions, leading the World Health Organization to declare a public health emergency of international concern. With the persistent transmission and evolution of MPXV, symptoms of Mpox have become milder, with some infections being asymptomatic. In addition, MPXV has become more contagious. Therefore, rapid and accurate diagnosis and screening of MPXV is vital to prevent and control MPXV epidemics. Here, we review and summarize the technical details, application scenarios, and the advantages and disadvantages of MPXV-specific diagnostic methods.

Since the new iLABMED was founded in June 2023, it has published three issues with 21 articles (till Dec 2023). As a journal majored in laboratory medicine, iLABMED also has to face many opportunities and challenges of laboratory medicine. This editorial summarized the main opportunities and challenges faced by iLABMED. The future prospects of laboratory medicine, which must be highlighted by iLABMED were also discussed based on a brief review of the current advances in laboratory medicine. iLABMED will continue to provide a useful platform for general-interested, insightful, and informative articles with high quality.

Cancer immunotherapy has emerged as the fourth most prevalent approach to tumor treatment, alongside surgery, radiotherapy, and chemotherapy. After several decades of development, chimeric antigen receptor T (CAR-T) cell therapy, a promising branch of adoptive T-cell therapy, has demonstrated superior efficacy and safety in comparison to other cell therapies in the treatment of cancer. At present, CAR-T cells are predominantly used to treat hematological malignancies, although their application in solid tumors is being readily investigated. Although numerous studies have examined the biomarkers associated with the safety of CAR-T cell therapy, few have evaluated predictors of CAR-T cell therapeutic efficacy. Thus, the primary objective of this review article was to provide a comprehensive overview of the factors predicting the efficacy of CAR-T cell therapy, with a particular focus on biomarkers and their detection methods.

Mycoplasma pneumoniae (M. pneumoniae) is a cell wall-less respiratory pathogen causing community-acquired pneumonia and extrapulmonary manifestations. It is transmitted through close contact and shows periodic regional outbreaks. The coronavirus disease (COVID-19) pandemic interfered with the global spread of M. pneumoniae. A large-scale post-COVID outbreak is currently ongoing in China. To help physicians better understand and manage this epidemic, we provide this review summarizing current knowledge on the pathogenesis, epidemic characteristics, macrolide resistance, diagnostic methods, and clinical treatment strategies for this pathogen.

Skin biopsy is an important, efficient, and safe procedure for diagnosing infectious dermatopathy, including mpox. An optimal approach of laboratory diagnosis of mpox should include obtaining a skin punch biopsy from pertinent lesions for pathologic evaluation in addition to conventional swab or scrap for molecular testing.

Pathogenic Escherichia coli is of great concern in the clinical setting. But few reports have demonstrated the variation in disease course. We present a severe case of multiple organ dysfunction syndrome caused by E. coli infection. Pathogens isolated from blood and urine samples harboured many virulence factors. Whole-genome sequencing and conventional analyses showed that the isolates experienced beneficial variations, both genetically and phenotypically, during the disease course. These findings showed that E. coli can cause systemic symptoms and informed us of the importance of assessing the reasons for such variations in pathogens occurring in vivo.