首页 > 最新文献

Journal of Medicine, Surgery, and Public Health最新文献

英文 中文
Behavioral and psychosocial correlates of hope among youth 青少年希望的行为和社会心理相关因素
Pub Date : 2024-03-16 DOI: 10.1016/j.glmedi.2024.100088
Shervin Assari , Babak Najand , Izadrad Najand , Stephen Grace

Introduction

Hope plays a crucial role in the well-being of youth, impacting various aspects of their lives. However, less is known about the role of hope in pre-adolescents. This study aims to explore the psychosocial and behavioral correlates of hope in 9–10-year-old pre-youth transitioning into adolescence.

Methods

Using data from the Adolescent Brain Cognitive Development (ABCD) study, 4631 youth entered our study. The investigation follows these individuals for up to 36 months, specifically observing the initiation of marijuana and tobacco use. The methods employed include bivariate correlations.

Results

Baseline high hope offered protection against marijuana and tobacco use over the following 36 months. Elevated levels of hope could be seen in pre-youth with higher family income and those experienced lower levels of stressful life events and financial difficulties. High hope was also linked to lower behavioral problems, improved emotional function, lower impulsivity, lower sensation seeking, and higher cognitive function. Notably, hope was not correlated with parental education, neighborhood income, family conflict, blood pressure, body mass index, grade point average, prosocial behaviors, or puberty.

Conclusion

In conclusion, the findings suggest a close interplay between hope and various dimensions of resilience including lower tobacco and marijuana use. Higher levels of hope, influenced by factors such as family income and life events, may be a mechanism that connects hope to enhanced emotional and cognitive functioning and acts as a protective factor against early initiation of substance use. These findings underscore the potential utility of fostering hope as a strategy to promote positive development and reduce tobacco and marijuana use.

导言希望在青少年的幸福生活中扮演着至关重要的角色,影响着他们生活的方方面面。然而,人们对青少年前期希望的作用却知之甚少。本研究旨在探究 9-10 岁即将步入青春期的学龄前青少年的社会心理和行为与希望的相关性。调查对这些人进行了长达 36 个月的跟踪,特别观察了他们开始吸食大麻和烟草的情况。研究采用的方法包括双变量相关分析。结果在随后的 36 个月中,基线希望水平高的人可以避免使用大麻和烟草。家庭收入较高、经历的生活压力事件和经济困难较少的青少年的希望水平较高。高希望也与较低的行为问题、情绪功能改善、较低的冲动性、较低的感觉寻求和较高的认知功能有关。值得注意的是,希望与父母教育程度、邻里收入、家庭冲突、血压、体重指数、平均成绩、亲社会行为或青春期并无关联。受家庭收入和生活事件等因素的影响,较高水平的希望可能是一种将希望与增强情绪和认知功能联系起来的机制,也是防止过早开始使用药物的保护因素。这些发现强调了培养希望作为促进积极发展、减少烟草和大麻使用的一种策略的潜在效用。
{"title":"Behavioral and psychosocial correlates of hope among youth","authors":"Shervin Assari ,&nbsp;Babak Najand ,&nbsp;Izadrad Najand ,&nbsp;Stephen Grace","doi":"10.1016/j.glmedi.2024.100088","DOIUrl":"https://doi.org/10.1016/j.glmedi.2024.100088","url":null,"abstract":"<div><h3>Introduction</h3><p>Hope plays a crucial role in the well-being of youth, impacting various aspects of their lives. However, less is known about the role of hope in pre-adolescents. This study aims to explore the psychosocial and behavioral correlates of hope in 9–10-year-old pre-youth transitioning into adolescence.</p></div><div><h3>Methods</h3><p>Using data from the Adolescent Brain Cognitive Development (ABCD) study, 4631 youth entered our study. The investigation follows these individuals for up to 36 months, specifically observing the initiation of marijuana and tobacco use. The methods employed include bivariate correlations.</p></div><div><h3>Results</h3><p>Baseline high hope offered protection against marijuana and tobacco use over the following 36 months. Elevated levels of hope could be seen in pre-youth with higher family income and those experienced lower levels of stressful life events and financial difficulties. High hope was also linked to lower behavioral problems, improved emotional function, lower impulsivity, lower sensation seeking, and higher cognitive function. Notably, hope was not correlated with parental education, neighborhood income, family conflict, blood pressure, body mass index, grade point average, prosocial behaviors, or puberty.</p></div><div><h3>Conclusion</h3><p>In conclusion, the findings suggest a close interplay between hope and various dimensions of resilience including lower tobacco and marijuana use. Higher levels of hope, influenced by factors such as family income and life events, may be a mechanism that connects hope to enhanced emotional and cognitive functioning and acts as a protective factor against early initiation of substance use. These findings underscore the potential utility of fostering hope as a strategy to promote positive development and reduce tobacco and marijuana use.</p></div>","PeriodicalId":100804,"journal":{"name":"Journal of Medicine, Surgery, and Public Health","volume":"2 ","pages":"Article 100088"},"PeriodicalIF":0.0,"publicationDate":"2024-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949916X24000410/pdfft?md5=678fdb5254d927f00ddaa9f2e3127972&pid=1-s2.0-S2949916X24000410-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140138432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The link between residential stability and youth substance use: Role of stressful life events and behavioral problems 居住稳定性与青少年药物使用之间的联系:生活压力事件和行为问题的作用
Pub Date : 2024-03-13 DOI: 10.1016/j.glmedi.2024.100084
Shervin Assari , Babak Najand , Hossein Zare

Introduction

Residential stability is increasingly recognized as a significant factor influencing youth positive development. While the existing body of research provides valuable insights, gaps remain regarding the determinants of residential stability and how its outcomes may vary by gender and race. This study aims to investigate the relationship between residential stability, substance use, and behavioral issues among children aged 9–10 years, with a focus on the mediating role of trauma exposure.

Methods

This research utilizes data from the Adolescent Brain Cognitive Development (ABCD) study, a longitudinal project initiated in 2016 with a sample of 11,849 participants. It explores the links between residential stability, socioeconomic factors, stress, and emotional and behavioral outcomes using the Child Behavior Checklist (CBCL). Structural equation modeling was employed to analyze the data.

Results findings

indicate that higher household income, living in a household with married parents, and residing in areas with greater household incomes correlate with residential stability. In turn, residential stability is linked to lower levels of life stress and reduced substance use in the future. Furthermore, the impact of residential stability on substance uses and CBCL scores was entirely mediated by trauma exposure.

Conclusions

The findings advocate for the implementation of economic, social, and public policies aimed at fostering stable living environments for children and families to mitigate the emotional and behavioral challenges future generations may face. Enhancing socioeconomic status and supporting structures that promote married family living arrangements emerge as effective strategies to improve residential stability and the well-being of young people in the United States.

导言:人们日益认识到,居住稳定性是影响青少年积极发展的一个重要因素。虽然现有的研究提供了宝贵的见解,但在居住稳定性的决定因素及其结果如何因性别和种族而异方面仍存在差距。本研究旨在调查 9-10 岁儿童的居住稳定性、药物使用和行为问题之间的关系,重点关注创伤暴露的中介作用。方法本研究利用了青少年大脑认知发展(ABCD)研究的数据,该研究是 2016 年启动的一个纵向项目,有 11,849 名参与者参与。研究使用儿童行为检查表(CBCL)探讨了居住稳定性、社会经济因素、压力以及情绪和行为结果之间的联系。结果表明,家庭收入越高、生活在父母已婚的家庭中以及居住在家庭收入较高的地区与居住稳定性相关。反过来,居住稳定性又与较低的生活压力水平和未来减少药物使用有关。此外,居住稳定性对药物使用和 CBCL 分数的影响完全受创伤暴露的中介作用。结论:研究结果提倡实施旨在为儿童和家庭营造稳定生活环境的经济、社会和公共政策,以减轻后代可能面临的情感和行为挑战。提高社会经济地位和支持促进已婚家庭生活安排的结构,是改善美国青少年居住稳定性和福祉的有效策略。
{"title":"The link between residential stability and youth substance use: Role of stressful life events and behavioral problems","authors":"Shervin Assari ,&nbsp;Babak Najand ,&nbsp;Hossein Zare","doi":"10.1016/j.glmedi.2024.100084","DOIUrl":"https://doi.org/10.1016/j.glmedi.2024.100084","url":null,"abstract":"<div><h3>Introduction</h3><p>Residential stability is increasingly recognized as a significant factor influencing youth positive development. While the existing body of research provides valuable insights, gaps remain regarding the determinants of residential stability and how its outcomes may vary by gender and race. This study aims to investigate the relationship between residential stability, substance use, and behavioral issues among children aged 9–10 years, with a focus on the mediating role of trauma exposure.</p></div><div><h3>Methods</h3><p>This research utilizes data from the Adolescent Brain Cognitive Development (ABCD) study, a longitudinal project initiated in 2016 with a sample of 11,849 participants. It explores the links between residential stability, socioeconomic factors, stress, and emotional and behavioral outcomes using the Child Behavior Checklist (CBCL). Structural equation modeling was employed to analyze the data.</p></div><div><h3>Results findings</h3><p>indicate that higher household income, living in a household with married parents, and residing in areas with greater household incomes correlate with residential stability. In turn, residential stability is linked to lower levels of life stress and reduced substance use in the future. Furthermore, the impact of residential stability on substance uses and CBCL scores was entirely mediated by trauma exposure.</p></div><div><h3>Conclusions</h3><p>The findings advocate for the implementation of economic, social, and public policies aimed at fostering stable living environments for children and families to mitigate the emotional and behavioral challenges future generations may face. Enhancing socioeconomic status and supporting structures that promote married family living arrangements emerge as effective strategies to improve residential stability and the well-being of young people in the United States.</p></div>","PeriodicalId":100804,"journal":{"name":"Journal of Medicine, Surgery, and Public Health","volume":"2 ","pages":"Article 100084"},"PeriodicalIF":0.0,"publicationDate":"2024-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949916X24000379/pdfft?md5=e4cd833cfc452a872f7ae6c6f840f67f&pid=1-s2.0-S2949916X24000379-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140122926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Burn-out among practitioners managing abdominal surgical emergencies in Senegal 塞内加尔腹部外科急诊医师的职业倦怠问题
Pub Date : 2024-03-12 DOI: 10.1016/j.glmedi.2024.100087
Abdourahmane Ndong , Lebem Togtoga , Mamadou Saidou Bah , Pape Djibril Ndoye , Jean Augustin Diegane Tine , Ibrahima Konaté , Khadim Niang

Introduction

Surgery represents a distinct medical specialization that necessitates direct interaction with patients and the ability to manage complications. Burn-out is defined as a syndrome arising from persistent workplace stress that has not been effectively addressed. The objective of this work was to assess the prevalence and factors associated with burn-out among practitioners managing abdominal surgical emergencies in Senegal. A descriptive and analytical cross-sectional study was conducted; the study included healthcare professionals (general practitioners, general surgeons, anesthesiologists, nurses) involved in the management of surgical emergencies across all hospitals in Senegal. A standardized assessment of perceived stress was conducted using the Maslach Burnout Inventory (MBI) in three domains: emotional exhaustion, depersonalization, and personal accomplishment. A multiple linear regression model was used to estimate the determinants of burn-out on the three subscales. A total of 186 observations were included in the study, for a response rate of 90.7%. The majority of participants were from the capital region of Dakar (44. 6%). There were 46 women (24. 7%) and 140 men (75. 3%). The mean age was 34 years 9 ±6.7 years, with a range of 24–59 years. The majority of participants were married (71%), followed by single individuals (26. 3%), divorced (2. 2%), and widowed (0. 5%). The majority of participants were physicians (80. 6%), followed by nurses (19. 4%). The most common medical specializations were general surgery (58.7%), anesthesia and resuscitation (22. 7%), and general medicine (18. 7%). Additionally, 46% of participants were in training (residency program). The predominant motivations included passion for the profession (75.3%), patient satisfaction (69. 9%), stimulating challenges (21%), and salary considerations (11. 8%). The overall prevalence of high burn-out (at least in one dimension) was 46.2%. A multiple linear regression model showed that the risk factors contributing to high burn-out were divorce status, being in training, and being motivated by stimulating challenges, salary considerations or passion for the profession. The protective factors were a positive perception of one's salary, a favorable physical work environment, and high-quality training. This study revealed an alarming prevalence of burn-out among surgical teams dealing with abdominal emergencies in Senegal. These findings call for immediate action to ensure the well-being of surgical teams and, by extension, the quality of healthcare delivery.

引言 外科是一门独特的医学专业,需要与病人直接交流,并有能力处理并发症。职业倦怠被定义为一种因工作场所持续压力而导致的综合症,但却没有得到有效解决。这项研究旨在评估塞内加尔腹部外科急诊从业人员倦怠感的发生率和相关因素。研究对象包括塞内加尔所有医院中参与外科急症管理的医护人员(全科医生、普通外科医生、麻醉师和护士)。采用马斯拉赫职业倦怠量表(Maslach Burnout Inventory,MBI)从情绪衰竭、人格解体和个人成就感三个方面对感知到的压力进行了标准化评估。采用多元线性回归模型估算了三个分量表中职业倦怠的决定因素。本研究共纳入 186 名观察对象,回复率为 90.7%。大多数参与者来自达喀尔首都地区(44.6%)。其中女性 46 人(24.7%),男性 140 人(75.3%)。平均年龄为 34 岁(9 ± 6.7),介于 24-59 岁之间。大多数参与者已婚(71%),其次是单身(26.3%)、离异(2.2%)和丧偶(0.5%)。大多数参与者是医生(80.6%),其次是护士(19.4%)。最常见的医学专业是普通外科(58.7%)、麻醉和复苏(22.7%)以及普通内科(18.7%)。此外,46%的参与者正在接受培训(住院医师培训计划)。主要动机包括对专业的热情(75.3%)、患者满意度(69.9%)、激励挑战(21%)和薪酬考虑(11.8%)。高度职业倦怠(至少在一个方面)的总体发生率为 46.2%。多元线性回归模型显示,导致高度职业倦怠的风险因素是离婚状态、正在接受培训、受到激励性挑战的激励、薪酬因素或对职业的热情。而保护因素则是对个人薪酬的积极看法、良好的物质工作环境以及高质量的培训。这项研究显示,在塞内加尔,处理腹部急症的外科团队中普遍存在着令人担忧的职业倦怠现象。这些发现要求我们立即采取行动,确保外科团队的健康,进而提高医疗服务的质量。
{"title":"Burn-out among practitioners managing abdominal surgical emergencies in Senegal","authors":"Abdourahmane Ndong ,&nbsp;Lebem Togtoga ,&nbsp;Mamadou Saidou Bah ,&nbsp;Pape Djibril Ndoye ,&nbsp;Jean Augustin Diegane Tine ,&nbsp;Ibrahima Konaté ,&nbsp;Khadim Niang","doi":"10.1016/j.glmedi.2024.100087","DOIUrl":"https://doi.org/10.1016/j.glmedi.2024.100087","url":null,"abstract":"<div><h3>Introduction</h3><p>Surgery represents a distinct medical specialization that necessitates direct interaction with patients and the ability to manage complications. Burn-out is defined as a syndrome arising from persistent workplace stress that has not been effectively addressed. The objective of this work was to assess the prevalence and factors associated with burn-out among practitioners managing abdominal surgical emergencies in Senegal. A descriptive and analytical cross-sectional study was conducted; the study included healthcare professionals (general practitioners, general surgeons, anesthesiologists, nurses) involved in the management of surgical emergencies across all hospitals in Senegal. A standardized assessment of perceived stress was conducted using the Maslach Burnout Inventory (MBI) in three domains: emotional exhaustion, depersonalization, and personal accomplishment. A multiple linear regression model was used to estimate the determinants of burn-out on the three subscales. A total of 186 observations were included in the study, for a response rate of 90.7%. The majority of participants were from the capital region of Dakar (44. 6%). There were 46 women (24. 7%) and 140 men (75. 3%). The mean age was 34 years 9 ±6.7 years, with a range of 24–59 years. The majority of participants were married (71%), followed by single individuals (26. 3%), divorced (2. 2%), and widowed (0. 5%). The majority of participants were physicians (80. 6%), followed by nurses (19. 4%). The most common medical specializations were general surgery (58.7%), anesthesia and resuscitation (22. 7%), and general medicine (18. 7%). Additionally, 46% of participants were in training (residency program). The predominant motivations included passion for the profession (75.3%), patient satisfaction (69. 9%), stimulating challenges (21%), and salary considerations (11. 8%). The overall prevalence of high burn-out (at least in one dimension) was 46.2%. A multiple linear regression model showed that the risk factors contributing to high burn-out were divorce status, being in training, and being motivated by stimulating challenges, salary considerations or passion for the profession. The protective factors were a positive perception of one's salary, a favorable physical work environment, and high-quality training. This study revealed an alarming prevalence of burn-out among surgical teams dealing with abdominal emergencies in Senegal. These findings call for immediate action to ensure the well-being of surgical teams and, by extension, the quality of healthcare delivery.</p></div>","PeriodicalId":100804,"journal":{"name":"Journal of Medicine, Surgery, and Public Health","volume":"2 ","pages":"Article 100087"},"PeriodicalIF":0.0,"publicationDate":"2024-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949916X24000409/pdfft?md5=7b33aec927390670a315d742c5ab7dbb&pid=1-s2.0-S2949916X24000409-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140134478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
PANDAS coexisting with gastrointestinal and cerebellar manifestation PANDAS 并发胃肠道和小脑症状
Pub Date : 2024-03-11 DOI: 10.1016/j.glmedi.2024.100086
Aftab Ahmed , Fatima Bint Sajid , Zaib Un Nisa Mughal , Wajeeha Binte Sajid , Abdul Haseeb

This case report highlights a rare condition known as PANDAS (Pediatrics Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections), which is characterized by sudden-onset neuropsychiatric symptoms following a streptococcal infection. The report also describes the unusual occurrence of cerebellitis, an uncommon neurological manifestation involving inflammation of the cerebellum, along with symptoms of vomiting and cerebellitis in a 9-year-old patient. The patient exhibited sudden onset of obsessive-compulsive symptoms, tics, stomach pain, and signs of intestinal blockage, which led to cerebellar dysfunction upon neurological examination. Laboratory tests confirmed a recent streptococcal infection, suggesting a diagnosis of PANDAS, while imaging studies revealed inflammation in the cerebellum and intestinal obstruction. This case presents a challenge to our understanding of the pathophysiological processes underlying PANDAS and its relationship with gastrointestinal and cerebellar symptoms. The treatment plan included immunomodulatory therapy, antibiotics, and surgical intervention for the intestinal obstruction, which led to a gradual improvement in symptoms. The report underscores the importance of considering atypical manifestations of PANDAS and adopting a multidisciplinary approach for precise diagnosis and effective management in complex situations.

本病例报告重点介绍了一种称为 PANDAS(链球菌感染相关的儿科自身免疫性神经精神障碍)的罕见疾病,其特点是链球菌感染后突然出现神经精神症状。报告还描述了一名 9 岁患者小脑炎的不寻常发生,这是一种涉及小脑炎症的不常见神经系统表现,同时伴有呕吐和小脑炎症状。患者突然出现强迫症状、抽搐、胃痛和肠梗阻症状,经神经系统检查发现小脑功能障碍。实验室检查证实该患儿近期曾感染链球菌,建议诊断为 PANDAS,而影像学检查则显示小脑存在炎症和肠梗阻。该病例对我们理解 PANDAS 的病理生理过程及其与胃肠道和小脑症状的关系提出了挑战。治疗方案包括免疫调节疗法、抗生素和针对肠梗阻的手术治疗,从而使症状逐渐得到改善。该报告强调了考虑 PANDAS 的非典型表现以及在复杂情况下采用多学科方法进行精确诊断和有效管理的重要性。
{"title":"PANDAS coexisting with gastrointestinal and cerebellar manifestation","authors":"Aftab Ahmed ,&nbsp;Fatima Bint Sajid ,&nbsp;Zaib Un Nisa Mughal ,&nbsp;Wajeeha Binte Sajid ,&nbsp;Abdul Haseeb","doi":"10.1016/j.glmedi.2024.100086","DOIUrl":"https://doi.org/10.1016/j.glmedi.2024.100086","url":null,"abstract":"<div><p>This case report highlights a rare condition known as PANDAS (Pediatrics Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections), which is characterized by sudden-onset neuropsychiatric symptoms following a streptococcal infection. The report also describes the unusual occurrence of cerebellitis, an uncommon neurological manifestation involving inflammation of the cerebellum, along with symptoms of vomiting and cerebellitis in a 9-year-old patient. The patient exhibited sudden onset of obsessive-compulsive symptoms, tics, stomach pain, and signs of intestinal blockage, which led to cerebellar dysfunction upon neurological examination. Laboratory tests confirmed a recent streptococcal infection, suggesting a diagnosis of PANDAS, while imaging studies revealed inflammation in the cerebellum and intestinal obstruction. This case presents a challenge to our understanding of the pathophysiological processes underlying PANDAS and its relationship with gastrointestinal and cerebellar symptoms. The treatment plan included immunomodulatory therapy, antibiotics, and surgical intervention for the intestinal obstruction, which led to a gradual improvement in symptoms. The report underscores the importance of considering atypical manifestations of PANDAS and adopting a multidisciplinary approach for precise diagnosis and effective management in complex situations.</p></div>","PeriodicalId":100804,"journal":{"name":"Journal of Medicine, Surgery, and Public Health","volume":"2 ","pages":"Article 100086"},"PeriodicalIF":0.0,"publicationDate":"2024-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949916X24000392/pdfft?md5=7d5e660a7d19d7fe33e71aea05ff13bb&pid=1-s2.0-S2949916X24000392-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140134479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lifecourse correlates of self-rated health and associations with subsequent mortality: findings from the Hertfordshire Cohort Study 自评健康的终生相关性及其与后续死亡率的关系:赫特福德郡队列研究的结果
Pub Date : 2024-03-11 DOI: 10.1016/j.glmedi.2024.100085
Roshan Rambukwella , Leo D. Westbury , Cyrus Cooper , Nicholas C. Harvey , Elaine M. Dennison

Background

Poor self-rated health (SRH) has been shown to predict adverse health outcomes among older people, however these associations have traditionally only been considered at one point in the lifecourse, usually midlife or later. Here we examined lifecourse correlates of SRH in early, mid and later life, relating these to subsequent risk of mortality in a community-dwelling cohort.

Methods

2989 men and women from the Hertfordshire Cohort Study (HCS) were included in this study. The HCS was initially retrospective and linked contemporary health outcome data to early life data available from health ledgers but investigations from baseline (1998–2004, aged 59–73) onwards have been prospective. At baseline, participants completed an initial clinic visit, which included questionnaire assessment of SRH, reported as 'excellent', 'very good', 'good', 'fair', or 'poor'. Socioeconomic, lifestyle, mental health and demographic information was also collected. Deaths were recorded from baseline to 31/12/2018. Baseline characteristics in relation to SRH were examined using sex-stratified ordinal logistic regression; these factors were examined in relation to mortality using sex-stratified Cox regression. Statistically significant exposures were then included in sex-stratified mutually-adjusted models.

Results

In mutually-adjusted analysis, numerous contemporaneous correlates of poorer SRH in the seventh decade were identified and included obesity, lower physical activity, greater comorbidity and higher levels of depression among men and women. For example, odds ratios for being in a lower category of SRH were as follows: obese (BMI≥30) vs underweight/healthy (BMI<25) (men 1.60 (1.21, 2.11), women 1.65 (1.25, 2.17)) and per additional system medicated (men 1.62 (1.47, 1.77), women 1.53 (1.41, 1.66)). By contrast, factors earlier in the lifecourse (early growth, age left full-time education) were not associated with SRH in late adulthood. 36% of men and 26% of women died during follow-up. Hazard ratios (95% CI) for mortality per lower category of SRH were 1.22 (1.10,1.36) among men and 1.17 (1.01,1.35) among women after adjustment for age, BMI, smoking, physical activity, diet quality, education, home ownership status, comorbidity level and depression levels, suggesting residual confounding by other unrecorded factors that are related to SRH.

Conclusions

Poorer SRH in the seventh decade was a risk factor for mortality. Importantly modifiable adverse health behaviours in the seventh decade, such as low physical activity, were associated with poorer SRH and later mortality after adjustment for socioeconomic factors and comorbidity level. By contrast early growth and education were not related to later SRH. These data suggest that attention to lifestyle in late midlife may be associated with better SRH and subsequent health outcomes, highlighting the value of interven

背景事实证明,自我评定健康状况(SRH)较差可预测老年人的不良健康后果,但传统上只考虑生命过程中的某一点,通常是中年或晚年。在此,我们研究了生命历程中早年、中年和晚年自我健康状况的相关性,并将这些相关性与社区居住队列中的后续死亡风险联系起来。方法 本研究纳入了赫特福德郡队列研究(HCS)中的 2989 名男性和女性。赫特福德郡队列研究最初是回顾性的,将当代健康结果数据与健康分类账中的早期生活数据联系起来,但从基线(1998-2004 年,59-73 岁)开始的调查是前瞻性的。在基线阶段,参与者完成首次门诊,其中包括性健康和生殖健康问卷评估,评估结果分为 "优秀"、"非常好"、"好"、"一般 "或 "差"。此外,还收集了社会经济、生活方式、心理健康和人口统计信息。死亡记录从基线到 2018 年 12 月 31 日。采用性别分层序数逻辑回归法研究了与性健康和生殖健康有关的基线特征;采用性别分层 Cox 回归法研究了这些因素与死亡率的关系。结果在相互调整分析中,确定了第七个十年中SRH较差的许多同期相关因素,包括肥胖、体力活动较少、合并症较多以及男性和女性抑郁程度较高。例如,处于 SRH 较低类别的几率比如下:肥胖(BMI≥30)与体重不足/健康(BMI<25)(男性为 1.60(1.21,2.11),女性为 1.65(1.25,2.17))和每个额外系统用药(男性为 1.62(1.47,1.77),女性为 1.53(1.41,1.66))。相比之下,生命历程早期的因素(早期发育、离开全日制教育的年龄)与成年后期的性健康和生殖健康无关。在随访期间,36% 的男性和 26% 的女性死亡。在对年龄、体重指数、吸烟、体力活动、饮食质量、教育程度、房屋所有权状况、合并症水平和抑郁水平进行调整后,SRH每降低一个等级,男性死亡率的危险比(95% CI)为1.22(1.10,1.36),女性死亡率的危险比为1.17(1.01,1.35)。重要的是,在对社会经济因素和合并症水平进行调整后,第七个十年中可改变的不良健康行为(如体力活动少)与较差的性健康和生殖健康状况及以后的死亡率相关。相比之下,早期发育和教育与以后的性健康和生殖健康无关。这些数据表明,在中年晚期关注生活方式可能与更好的性健康和生殖健康以及随后的健康结果有关,这突出了在生命过程的这一阶段进行干预的价值。
{"title":"Lifecourse correlates of self-rated health and associations with subsequent mortality: findings from the Hertfordshire Cohort Study","authors":"Roshan Rambukwella ,&nbsp;Leo D. Westbury ,&nbsp;Cyrus Cooper ,&nbsp;Nicholas C. Harvey ,&nbsp;Elaine M. Dennison","doi":"10.1016/j.glmedi.2024.100085","DOIUrl":"https://doi.org/10.1016/j.glmedi.2024.100085","url":null,"abstract":"<div><h3>Background</h3><p>Poor self-rated health (SRH) has been shown to predict adverse health outcomes among older people, however these associations have traditionally only been considered at one point in the lifecourse, usually midlife or later. Here we examined lifecourse correlates of SRH in early, mid and later life, relating these to subsequent risk of mortality in a community-dwelling cohort.</p></div><div><h3>Methods</h3><p>2989 men and women from the Hertfordshire Cohort Study (HCS) were included in this study. The HCS was initially retrospective and linked contemporary health outcome data to early life data available from health ledgers but investigations from baseline (1998–2004, aged 59–73) onwards have been prospective. At baseline, participants completed an initial clinic visit, which included questionnaire assessment of SRH, reported as 'excellent', 'very good', 'good', 'fair', or 'poor'. Socioeconomic, lifestyle, mental health and demographic information was also collected. Deaths were recorded from baseline to 31/12/2018. Baseline characteristics in relation to SRH were examined using sex-stratified ordinal logistic regression; these factors were examined in relation to mortality using sex-stratified Cox regression. Statistically significant exposures were then included in sex-stratified mutually-adjusted models.</p></div><div><h3>Results</h3><p>In mutually-adjusted analysis, numerous contemporaneous correlates of poorer SRH in the seventh decade were identified and included obesity, lower physical activity, greater comorbidity and higher levels of depression among men and women. For example, odds ratios for being in a lower category of SRH were as follows: obese (BMI≥30) vs underweight/healthy (BMI&lt;25) (men 1.60 (1.21, 2.11), women 1.65 (1.25, 2.17)) and per additional system medicated (men 1.62 (1.47, 1.77), women 1.53 (1.41, 1.66)). By contrast, factors earlier in the lifecourse (early growth, age left full-time education) were not associated with SRH in late adulthood. 36% of men and 26% of women died during follow-up. Hazard ratios (95% CI) for mortality per lower category of SRH were 1.22 (1.10,1.36) among men and 1.17 (1.01,1.35) among women after adjustment for age, BMI, smoking, physical activity, diet quality, education, home ownership status, comorbidity level and depression levels, suggesting residual confounding by other unrecorded factors that are related to SRH.</p></div><div><h3>Conclusions</h3><p>Poorer SRH in the seventh decade was a risk factor for mortality. Importantly modifiable adverse health behaviours in the seventh decade, such as low physical activity, were associated with poorer SRH and later mortality after adjustment for socioeconomic factors and comorbidity level. By contrast early growth and education were not related to later SRH. These data suggest that attention to lifestyle in late midlife may be associated with better SRH and subsequent health outcomes, highlighting the value of interven","PeriodicalId":100804,"journal":{"name":"Journal of Medicine, Surgery, and Public Health","volume":"2 ","pages":"Article 100085"},"PeriodicalIF":0.0,"publicationDate":"2024-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949916X24000380/pdfft?md5=1982fcf2e137e239a5cb51cfad66ae44&pid=1-s2.0-S2949916X24000380-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140138431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unilateral gestational gigantomastia in the third trimester 怀孕三个月时的单侧妊娠巨大乳房症
Pub Date : 2024-03-10 DOI: 10.1016/j.glmedi.2024.100083
Ahmet Necati Sanli

Gestational gigantomastia is a sudden and rapidly developing unilateral or bilateral excessive breast enlargement during pregnancy. In this case report, we aimed to present a 27-year-old female patient who presented with the complaint of unilateral breast enlargement while she was 7 months pregnant in her second pregnancy and diagnosed with gestational gigantomastia, with clinical and treatment features. Since it is very rare, it may cause difficulties for clinicians in differential diagnosis. Although clinical and examination features suggest malignant or inflammatory processes, it is easy to exclude with radiological imaging methods. Medical or surgical treatment methods should be applied before delivery, as they may cause both psychological and physical deterioration, breast pain, or life-threatening complications such as ulceration-hematoma in the breast for the patient. Malignant and inflammatory processes should be ruled out in the case of rapidly developing breast enlargement during pregnancy, and medical or surgical treatment options should be performed based on the patient's preferences and the gestational week.

妊娠巨乳症是指在妊娠期间突然发生的、迅速发展的单侧或双侧乳房过度增大。在本病例报告中,我们旨在介绍一位 27 岁的女性患者,她在第二次怀孕 7 个月时主诉单侧乳房增大,被诊断为妊娠巨乳症,并介绍了临床和治疗特点。由于该病非常罕见,可能会给临床医生的鉴别诊断带来困难。虽然临床和检查特征提示有恶性或炎症过程,但通过放射成像方法很容易排除。应在分娩前采用内科或外科治疗方法,因为这些方法可能会导致患者的心理和身体状况恶化、乳房疼痛或危及生命的并发症,如乳房溃疡-血肿。如果妊娠期乳腺增生发展迅速,应排除恶性和炎症过程,并根据患者的喜好和孕周选择药物或手术治疗方案。
{"title":"Unilateral gestational gigantomastia in the third trimester","authors":"Ahmet Necati Sanli","doi":"10.1016/j.glmedi.2024.100083","DOIUrl":"https://doi.org/10.1016/j.glmedi.2024.100083","url":null,"abstract":"<div><p>Gestational gigantomastia is a sudden and rapidly developing unilateral or bilateral excessive breast enlargement during pregnancy. In this case report, we aimed to present a 27-year-old female patient who presented with the complaint of unilateral breast enlargement while she was 7 months pregnant in her second pregnancy and diagnosed with gestational gigantomastia, with clinical and treatment features. Since it is very rare, it may cause difficulties for clinicians in differential diagnosis. Although clinical and examination features suggest malignant or inflammatory processes, it is easy to exclude with radiological imaging methods. Medical or surgical treatment methods should be applied before delivery, as they may cause both psychological and physical deterioration, breast pain, or life-threatening complications such as ulceration-hematoma in the breast for the patient. Malignant and inflammatory processes should be ruled out in the case of rapidly developing breast enlargement during pregnancy, and medical or surgical treatment options should be performed based on the patient's preferences and the gestational week.</p></div>","PeriodicalId":100804,"journal":{"name":"Journal of Medicine, Surgery, and Public Health","volume":"2 ","pages":"Article 100083"},"PeriodicalIF":0.0,"publicationDate":"2024-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949916X24000367/pdfft?md5=33ad4c17d5ae729861e6737ff2130607&pid=1-s2.0-S2949916X24000367-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140122927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A puzzling case: A unique presentation of massive heterotopic ossification on the Spleen’s outer surface 一个令人费解的病例脾脏外表面大量异位骨化的独特表现
Pub Date : 2024-03-02 DOI: 10.1016/j.glmedi.2024.100080
Jayeshkumar Kanani, Mohammed Iliyas Sheikh

Heterotopic ossification (HO) is defined as the development of lamellar bone growth in non-osseous tissues, such as muscles and tendons around major joints such as hip, elbow, knee, and shoulder. This article explores a unique case of heterotopic ossification (HO) on the outer surface of the spleen, presenting a rare and atypical manifestation of lamellar bone growth. The patient was a 50-year-old male who died under unclear circumstances and requested a medico-legal autopsy. Surprisingly, autopsy examination revealed a substantial, massive bone-like structure firmly attached to the spleen. Further histopathological examination revealed gamma gandy bodies, fibrosis, chronic venous congestion, and medial calcific sclerosis in the blood vessels of the spleen. The cut section of the bony structure showed areas of congestion, heterotopic ossification, and patchy calcification. The absence of a history of trauma adds complexity to the case, as ossification typically manifests in skeletal tissues. These findings underscore the rarity of HO in this anatomical location and emphasize the need for further research to unravel its causes, implications, and potential therapeutic interventions. This unique presentation highlights the importance of understanding heterotopic ossification intricacies, exploring organ-specific functions, and recognizing the role of autopsies in understanding unusual medical phenomena.

异位骨化(HO)是指非骨性组织(如髋、肘、膝和肩等主要关节周围的肌肉和肌腱)中的片状骨生长。本文探讨了一例独特的脾脏外表面异位骨化(HO)病例,这是片状骨增生的一种罕见和非典型表现。患者为一名 50 岁男性,死因不明,要求进行医学解剖。令人惊讶的是,尸检发现脾脏上牢牢地附着着一个巨大的骨样结构。进一步的组织病理学检查显示,脾脏血管中存在伽马甘蒂体、纤维化、慢性静脉充血和内侧钙化硬化。骨骼结构的切片显示有充血、异位骨化和斑点状钙化的区域。由于骨化通常表现在骨骼组织中,因此没有外伤史增加了病例的复杂性。这些发现凸显了HO在这一解剖位置的罕见性,并强调了进一步研究的必要性,以揭示其病因、影响和潜在的治疗干预措施。这一独特的报告强调了了解异位骨化的复杂性、探索器官特异性功能以及认识尸体解剖在理解不寻常医学现象中的作用的重要性。
{"title":"A puzzling case: A unique presentation of massive heterotopic ossification on the Spleen’s outer surface","authors":"Jayeshkumar Kanani,&nbsp;Mohammed Iliyas Sheikh","doi":"10.1016/j.glmedi.2024.100080","DOIUrl":"https://doi.org/10.1016/j.glmedi.2024.100080","url":null,"abstract":"<div><p>Heterotopic ossification (HO) is defined as the development of lamellar bone growth in non-osseous tissues, such as muscles and tendons around major joints such as hip, elbow, knee, and shoulder. This article explores a unique case of heterotopic ossification (HO) on the outer surface of the spleen, presenting a rare and atypical manifestation of lamellar bone growth. The patient was a 50-year-old male who died under unclear circumstances and requested a medico-legal autopsy. Surprisingly, autopsy examination revealed a substantial, massive bone-like structure firmly attached to the spleen. Further histopathological examination revealed gamma gandy bodies, fibrosis, chronic venous congestion, and medial calcific sclerosis in the blood vessels of the spleen. The cut section of the bony structure showed areas of congestion, heterotopic ossification, and patchy calcification. The absence of a history of trauma adds complexity to the case, as ossification typically manifests in skeletal tissues. These findings underscore the rarity of HO in this anatomical location and emphasize the need for further research to unravel its causes, implications, and potential therapeutic interventions. This unique presentation highlights the importance of understanding heterotopic ossification intricacies, exploring organ-specific functions, and recognizing the role of autopsies in understanding unusual medical phenomena.</p></div>","PeriodicalId":100804,"journal":{"name":"Journal of Medicine, Surgery, and Public Health","volume":"2 ","pages":"Article 100080"},"PeriodicalIF":0.0,"publicationDate":"2024-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949916X24000331/pdfft?md5=a8dcca17ff166416941e0d75c4832d5f&pid=1-s2.0-S2949916X24000331-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140031011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ketorolac vs. Fentanyl: A retrospective chart review of analgesia in the prehospital environment 酮咯酸与芬太尼:院前环境镇痛的回顾性病历审查
Pub Date : 2024-03-02 DOI: 10.1016/j.glmedi.2024.100082
Kane Darling , Brandon Wilkinson , Cheyenne Wong , Angela MacFarlane , Camille Brummett , Isain Zapata

Background

With growing concerns on the worsening opioid epidemic and provider hesitation for opioid use, opioid-sparing treatment regimens are being introduced such as ketorolac administration. The primary aims of this study are to compare the safety and efficacy of ketorolac to fentanyl in the prehospital setting and to determine ketorolac's potential as a practical alternative analgesic.

Methods

A retrospective chart review of patient encounters obtained from a prehospital emergency medical services agency in New Mexico was conducted to evaluate the safety and efficacy of ketorolac vs. fentanyl in the prehospital setting. Primary outcomes assessed were the reported medication complications, initial pain, last pain, and pain reduction on a Numerical Rating Scale. Data was evaluated using unadjusted and adjusted (age, gender, and weight of the patient) models.

Results

A total of 4102 records were evaluated (3182 fentanyl cases vs. 920 ketorolac cases). No significant differences in initial, last pain or pain reduction were seen in unadjusted models and for age, gender, or weight adjusted models. However, adjusted models displayed a difference in the number of complications that occurred while all cases of medication complications occurred within the fentanyl group (64 occurrences, P<0.0001). Among the complications seen, nausea and hypoxia are the most frequent with 40.6 and 29.7% of occurrences respectively).

Conclusion

Findings suggest that ketorolac is both effective and safe in the prehospital environment when compared to fentanyl. These findings encourage prehospital agencies to adopt opioid-sparing treatment protocols to encourage increased treatment of pain without potentiating the current opioid epidemic.

背景随着人们对阿片类药物疫情日益恶化的担忧以及医疗服务提供者对阿片类药物使用的犹豫不决,人们开始采用克罗拉克等阿片类药物替代治疗方案。本研究的主要目的是比较酮咯酸与芬太尼在院前环境中的安全性和疗效,并确定酮咯酸作为一种实用替代镇痛药的潜力。方法 对从新墨西哥州一家院前急救医疗服务机构获得的患者就诊情况进行回顾性病历审查,以评估酮咯酸与芬太尼在院前环境中的安全性和疗效。评估的主要结果是报告的用药并发症、最初疼痛、最后疼痛以及数字评分量表上的疼痛减轻程度。采用未调整和调整(患者年龄、性别和体重)模型对数据进行了评估。结果 共评估了 4102 条记录(芬太尼病例 3182 对酮咯酸病例 920)。在未经调整的模型以及年龄、性别或体重调整模型中,初始疼痛、最后疼痛或疼痛减轻程度均无明显差异。然而,调整后的模型显示出并发症发生数量的差异,而所有药物并发症病例均发生在芬太尼组(64 例,P<0.0001)。结论研究结果表明,与芬太尼相比,酮咯酸在院前环境中既有效又安全。这些研究结果鼓励院前机构采用节省阿片类药物的治疗方案,以鼓励在不加剧当前阿片类药物流行的情况下增加对疼痛的治疗。
{"title":"Ketorolac vs. Fentanyl: A retrospective chart review of analgesia in the prehospital environment","authors":"Kane Darling ,&nbsp;Brandon Wilkinson ,&nbsp;Cheyenne Wong ,&nbsp;Angela MacFarlane ,&nbsp;Camille Brummett ,&nbsp;Isain Zapata","doi":"10.1016/j.glmedi.2024.100082","DOIUrl":"https://doi.org/10.1016/j.glmedi.2024.100082","url":null,"abstract":"<div><h3>Background</h3><p>With growing concerns on the worsening opioid epidemic and provider hesitation for opioid use, opioid-sparing treatment regimens are being introduced such as ketorolac administration. The primary aims of this study are to compare the safety and efficacy of ketorolac to fentanyl in the prehospital setting and to determine ketorolac's potential as a practical alternative analgesic.</p></div><div><h3>Methods</h3><p>A retrospective chart review of patient encounters obtained from a prehospital emergency medical services agency in New Mexico was conducted to evaluate the safety and efficacy of ketorolac vs. fentanyl in the prehospital setting. Primary outcomes assessed were the reported medication complications, initial pain, last pain, and pain reduction on a Numerical Rating Scale. Data was evaluated using unadjusted and adjusted (age, gender, and weight of the patient) models.</p></div><div><h3>Results</h3><p>A total of 4102 records were evaluated (3182 fentanyl cases vs. 920 ketorolac cases). No significant differences in initial, last pain or pain reduction were seen in unadjusted models and for age, gender, or weight adjusted models. However, adjusted models displayed a difference in the number of complications that occurred while all cases of medication complications occurred within the fentanyl group (64 occurrences, P&lt;0.0001). Among the complications seen, nausea and hypoxia are the most frequent with 40.6 and 29.7% of occurrences respectively).</p></div><div><h3>Conclusion</h3><p>Findings suggest that ketorolac is both effective and safe in the prehospital environment when compared to fentanyl. These findings encourage prehospital agencies to adopt opioid-sparing treatment protocols to encourage increased treatment of pain without potentiating the current opioid epidemic.</p></div>","PeriodicalId":100804,"journal":{"name":"Journal of Medicine, Surgery, and Public Health","volume":"2 ","pages":"Article 100082"},"PeriodicalIF":0.0,"publicationDate":"2024-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949916X24000355/pdfft?md5=2f325625a9381393806432e639e38e1f&pid=1-s2.0-S2949916X24000355-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140042198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Antimicrobial resistance: Impacts, challenges, and future prospects 抗菌药耐药性:影响、挑战和未来前景
Pub Date : 2024-03-02 DOI: 10.1016/j.glmedi.2024.100081
Sirwan Khalid Ahmed , Safin Hussein , Karzan Qurbani , Radhwan Hussein Ibrahim , Abdulmalik Fareeq , Kochr Ali Mahmood , Mona Gamal Mohamed

Antimicrobial resistance (AMR) is a critical global health issue driven by antibiotic misuse and overuse in various sectors, leading to the emergence of resistant microorganisms. The history of AMR dates back to the discovery of penicillin, with the rise of multidrug-resistant pathogens posing significant challenges to healthcare systems worldwide. The misuse of antibiotics in human and animal health, as well as in agriculture, contributes to the spread of resistance genes, creating a "Silent Pandemic" that could surpass other causes of mortality by 2050. AMR affects both humans and animals, with resistant pathogens posing challenges in treating infections. Various mechanisms, such as enzymatic modification and biofilm formation, enable microbes to withstand the effects of antibiotics. The lack of effective antibiotics threatens routine medical procedures and could lead to millions of deaths annually if left unchecked. The economic impact of AMR is substantial, with projected losses in the trillions of dollars and significant financial burdens on healthcare systems and agriculture. Artificial intelligence is being explored as a tool to combat AMR by improving diagnostics and treatment strategies, although challenges such as data quality and algorithmic biases exist. To address AMR effectively, a One Health approach that considers human, animal, and environmental factors is crucial. This includes enhancing surveillance systems, promoting stewardship programs, and investing in research and development for new antimicrobial options. Public awareness, education, and international collaboration are essential for combating AMR and preserving the efficacy of antibiotics for future generations.

抗菌药耐药性(AMR)是一个严重的全球健康问题,其原因是各行各业滥用和过度使用抗生素,导致耐药微生物的出现。AMR 的历史可以追溯到青霉素的发现,随着耐多药病原体的增多,AMR 给全球医疗保健系统带来了重大挑战。抗生素在人类和动物健康以及农业中的滥用助长了抗药性基因的传播,造成了一种 "无声的大流行",到 2050 年可能会超过其他致死原因。AMR 对人类和动物都有影响,抗药性病原体给治疗感染带来了挑战。酶修饰和生物膜形成等各种机制使微生物能够抵御抗生素的作用。缺乏有效的抗生素威胁着常规医疗程序,如果任其发展,每年可能导致数百万人死亡。AMR 对经济的影响是巨大的,预计将造成数万亿美元的损失,并给医疗保健系统和农业带来沉重的经济负担。尽管存在数据质量和算法偏差等挑战,但人们正在探索将人工智能作为一种工具,通过改进诊断和治疗策略来应对 AMR。要有效解决 AMR 问题,必须采取综合考虑人类、动物和环境因素的 "一体健康 "方法。这包括加强监测系统、推广管理计划以及投资研发新的抗菌药物。公众意识、教育和国际合作对于抗击 AMR 和为子孙后代保护抗生素的有效性至关重要。
{"title":"Antimicrobial resistance: Impacts, challenges, and future prospects","authors":"Sirwan Khalid Ahmed ,&nbsp;Safin Hussein ,&nbsp;Karzan Qurbani ,&nbsp;Radhwan Hussein Ibrahim ,&nbsp;Abdulmalik Fareeq ,&nbsp;Kochr Ali Mahmood ,&nbsp;Mona Gamal Mohamed","doi":"10.1016/j.glmedi.2024.100081","DOIUrl":"https://doi.org/10.1016/j.glmedi.2024.100081","url":null,"abstract":"<div><p>Antimicrobial resistance (AMR) is a critical global health issue driven by antibiotic misuse and overuse in various sectors, leading to the emergence of resistant microorganisms. The history of AMR dates back to the discovery of penicillin, with the rise of multidrug-resistant pathogens posing significant challenges to healthcare systems worldwide. The misuse of antibiotics in human and animal health, as well as in agriculture, contributes to the spread of resistance genes, creating a \"Silent Pandemic\" that could surpass other causes of mortality by 2050. AMR affects both humans and animals, with resistant pathogens posing challenges in treating infections. Various mechanisms, such as enzymatic modification and biofilm formation, enable microbes to withstand the effects of antibiotics. The lack of effective antibiotics threatens routine medical procedures and could lead to millions of deaths annually if left unchecked. The economic impact of AMR is substantial, with projected losses in the trillions of dollars and significant financial burdens on healthcare systems and agriculture. Artificial intelligence is being explored as a tool to combat AMR by improving diagnostics and treatment strategies, although challenges such as data quality and algorithmic biases exist. To address AMR effectively, a One Health approach that considers human, animal, and environmental factors is crucial. This includes enhancing surveillance systems, promoting stewardship programs, and investing in research and development for new antimicrobial options. Public awareness, education, and international collaboration are essential for combating AMR and preserving the efficacy of antibiotics for future generations.</p></div>","PeriodicalId":100804,"journal":{"name":"Journal of Medicine, Surgery, and Public Health","volume":"2 ","pages":"Article 100081"},"PeriodicalIF":0.0,"publicationDate":"2024-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949916X24000343/pdfft?md5=01f37ccfb21954681f5e6615fda255bf&pid=1-s2.0-S2949916X24000343-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140063111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Compartment syndrome as a complication of transradial access 经桡动脉入路并发腔室综合征
Pub Date : 2024-02-29 DOI: 10.1016/j.glmedi.2024.100079
Jessica Schmerler , Sarah Rapaport , Alexandra M. Dunham , Sophia Strike , E. Gene Deune , Dawn LaPorte

Compartment syndrome (CS) is an orthopaedic emergency that can result in vascular and neurologic compromise and necrosis due to increased pressure in an anatomic compartment, commonly the lower leg or forearm. The purpose of this case series study was to demonstrate that CS is a rare but serious complication for which physicians should have a low threshold for suspicion after transradial access procedures. We present a series of five patients who underwent fasciotomy for upper extremity CS in the setting of recent transradial access at a large, busy, tertiary academic center from 1/1/2015–12/31/2022. Cases were identified retrospectively from departmental case logs and data were collected by manual chart review. Patient demographics and comorbidities, as well as details of transradial access procedures and anticoagulation use were recorded. The outcome variables collected included time from access removal to hand surgery consult, symptoms present at the time of the consult, procedural details, and postoperative outcomes. Of the five cases presented, three underwent transradial access for percutaneous coronary intervention (PCI) and two for invasive blood pressure monitoring. Four of the five patients received systemic anticoagulation prior to or during transradial access, and the fifth received anticoagulation after the procedure. All five patients presented with large forearm hematomas at the time of initial consult, and three of the five were found at the time of fasciotomies to have radial artery lacerations. Two patients had subsequent surgeries after the primary fasciotomy, and one patient had residual neurologic symptoms. The results point to several key takeaways regarding CS in the setting of transradial access, including association with receipt of systemic anticoagulation, presence of forearm hematomas as potential markers for radial artery laceration, and multiple arterial lacerations as potential risk factors for worse post-fasciotomy outcomes. To our knowledge, this is the largest case series describing this specific, devasting complication of transradial access. Hand surgeons should be aware of this rare etiology of compartment syndrome so that they may more quickly recognize and respond to this potential complication.

Level of evidence

IV.

腔室综合征(CS)是一种骨科急症,可因解剖腔室(通常是小腿或前臂)内压力增高而导致血管和神经受损及坏死。本病例系列研究的目的是证明 CS 是一种罕见但严重的并发症,医生在经桡动脉入路手术后应降低怀疑阈值。我们介绍了自 2015 年 1 月 1 日至 2022 年 12 月 31 日期间,在一家大型、繁忙的三级学术中心,因近期经桡动脉入路而接受筋膜切开术治疗上肢 CS 的五名患者的系列病例。病例从科室病例日志中进行回顾性识别,并通过人工病历审查收集数据。记录了患者的人口统计学特征和合并症,以及经桡动脉入路手术和抗凝治疗的详细情况。所收集的结果变量包括从通道移除到手外科会诊的时间、会诊时出现的症状、手术细节和术后结果。在报告的五例患者中,三例接受了经桡动脉入路,用于经皮冠状动脉介入治疗(PCI),两例用于有创血压监测。五名患者中有四名在经桡动脉入路之前或过程中接受了全身抗凝治疗,第五名患者在术后接受了抗凝治疗。五名患者在初诊时均出现前臂大面积血肿,其中三人在筋膜切开术时被发现有桡动脉撕裂伤。两名患者在初次筋膜切开术后进行了后续手术,一名患者有残留神经症状。研究结果指出了经桡动脉入路 CS 的几个关键要点,包括与接受全身抗凝治疗有关、前臂血肿的存在是桡动脉裂伤的潜在标志、多处动脉裂伤是筋膜切开术后预后较差的潜在风险因素。据我们所知,这是描述经桡动脉入路术中这种特殊的、毁灭性并发症的最大系列病例。手外科医生应该了解这种罕见的腔室综合征病因,以便更快地识别和应对这种潜在的并发症。
{"title":"Compartment syndrome as a complication of transradial access","authors":"Jessica Schmerler ,&nbsp;Sarah Rapaport ,&nbsp;Alexandra M. Dunham ,&nbsp;Sophia Strike ,&nbsp;E. Gene Deune ,&nbsp;Dawn LaPorte","doi":"10.1016/j.glmedi.2024.100079","DOIUrl":"https://doi.org/10.1016/j.glmedi.2024.100079","url":null,"abstract":"<div><p>Compartment syndrome (CS) is an orthopaedic emergency that can result in vascular and neurologic compromise and necrosis due to increased pressure in an anatomic compartment, commonly the lower leg or forearm. The purpose of this case series study was to demonstrate that CS is a rare but serious complication for which physicians should have a low threshold for suspicion after transradial access procedures. We present a series of five patients who underwent fasciotomy for upper extremity CS in the setting of recent transradial access at a large, busy, tertiary academic center from 1/1/2015–12/31/2022. Cases were identified retrospectively from departmental case logs and data were collected by manual chart review. Patient demographics and comorbidities, as well as details of transradial access procedures and anticoagulation use were recorded. The outcome variables collected included time from access removal to hand surgery consult, symptoms present at the time of the consult, procedural details, and postoperative outcomes. Of the five cases presented, three underwent transradial access for percutaneous coronary intervention (PCI) and two for invasive blood pressure monitoring. Four of the five patients received systemic anticoagulation prior to or during transradial access, and the fifth received anticoagulation after the procedure. All five patients presented with large forearm hematomas at the time of initial consult, and three of the five were found at the time of fasciotomies to have radial artery lacerations. Two patients had subsequent surgeries after the primary fasciotomy, and one patient had residual neurologic symptoms. The results point to several key takeaways regarding CS in the setting of transradial access, including association with receipt of systemic anticoagulation, presence of forearm hematomas as potential markers for radial artery laceration, and multiple arterial lacerations as potential risk factors for worse post-fasciotomy outcomes. To our knowledge, this is the largest case series describing this specific, devasting complication of transradial access. Hand surgeons should be aware of this rare etiology of compartment syndrome so that they may more quickly recognize and respond to this potential complication.</p></div><div><h3>Level of evidence</h3><p>IV.</p></div>","PeriodicalId":100804,"journal":{"name":"Journal of Medicine, Surgery, and Public Health","volume":"2 ","pages":"Article 100079"},"PeriodicalIF":0.0,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949916X2400032X/pdfft?md5=2e76e243b16215bf1b8e31c09018c622&pid=1-s2.0-S2949916X2400032X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140000066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Journal of Medicine, Surgery, and Public Health
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1