Pub Date : 2025-02-14DOI: 10.1016/j.glmedi.2025.100185
Taylor W. Young , Geoffrey Zhang , Linwood R. Haith Jr.
Dercum’s disease, alternatively known as adiposis dolorosa, is a rare condition characterized by multiple lipomas causing palpable skin defects associated with pain and tenderness. The prevalence and etiology of this disease remain unknown despite its debilitating impact on affected individuals. Current literature describes individuals with Dercum’s disease to be predominantly older, obese females. This report details a unique case involving a 29-year-old male who, between 2022 and 2024, underwent surgical excision of over 80 lipomas on five separate occasions. Prior to surgery, the nodules were assessed in an outpatient setting to determine their location, confirm skin changes, and evaluate their debilitating effects on the patient’s quality of life, thereby justifying the surgical approach. Histology proved all the lesions to be benign lipomas. Subsequent to the initial lipoma excisions, new lesions recurred on the torso and extremities. Differential diagnoses were considered such as neurofibromatosis, multiple familial lipomatosis, Madelung disease, Bannayan-Zonana syndrome, and Cowden syndrome were ruled out by family history, location of lesions, and histology. Although Dercum’s disease has been recognized since the late 1800s, advances in understanding and treating the condition have been limited. This case aims to shed light on the experience of a young patient with multiple recrudescent lipomas necessitating surgery.
{"title":"Dercum's disease: A unique case of recrudescent lipomas necessitating surgery","authors":"Taylor W. Young , Geoffrey Zhang , Linwood R. Haith Jr.","doi":"10.1016/j.glmedi.2025.100185","DOIUrl":"10.1016/j.glmedi.2025.100185","url":null,"abstract":"<div><div>Dercum’s disease, alternatively known as adiposis dolorosa, is a rare condition characterized by multiple lipomas causing palpable skin defects associated with pain and tenderness. The prevalence and etiology of this disease remain unknown despite its debilitating impact on affected individuals. Current literature describes individuals with Dercum’s disease to be predominantly older, obese females. This report details a unique case involving a 29-year-old male who, between 2022 and 2024, underwent surgical excision of over 80 lipomas on five separate occasions. Prior to surgery, the nodules were assessed in an outpatient setting to determine their location, confirm skin changes, and evaluate their debilitating effects on the patient’s quality of life, thereby justifying the surgical approach. Histology proved all the lesions to be benign lipomas. Subsequent to the initial lipoma excisions, new lesions recurred on the torso and extremities. Differential diagnoses were considered such as neurofibromatosis, multiple familial lipomatosis, Madelung disease, Bannayan-Zonana syndrome, and Cowden syndrome were ruled out by family history, location of lesions, and histology. Although Dercum’s disease has been recognized since the late 1800s, advances in understanding and treating the condition have been limited. This case aims to shed light on the experience of a young patient with multiple recrudescent lipomas necessitating surgery.</div></div>","PeriodicalId":100804,"journal":{"name":"Journal of Medicine, Surgery, and Public Health","volume":"5 ","pages":"Article 100185"},"PeriodicalIF":0.0,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143428233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Acute lymphoblastic leukemia (ALL) is the most prevalent form of hematological cancer in children. In Bangladesh, the number of acute leukemia among children has been increasing each year and the genome studies regarding single nucleotide polymorphisms (SNP) in different genes related to lymphocyte development have not been explored yet. Therefore, the study aimed to examine the association between a specific SNP (rs10821936) in the ARID5B gene and the risk of childhood ALL in Bangladeshi children. The identification of the children's demographic and clinical characteristics as well as real-time PCR-based allelic discrimination method was employed to identify the genotypes of 194 ALL cases and 209 controls, respectively. Both the age difference and serum creatinine level between the control and patient groups were insignificant. In comparison to individuals who were healthy, both the blood ALT and LDH levels of the male and female child ALL participants were considerably high. However, compared to control groups, the serum calcium level in child ALL patients was considerably low. Serum ALT and LDH had a significant positive relationship while both had a negative correlation with serum calcium. The investigation revealed that the minor allele C was the risk allele for the SNP (rs10821936) and it has been linked to a higher incidence of ALL in Bangladeshi children [Odds ratio (OR) = 1.35; 95 % Confidence Interval (CI) = 1.02–1.79; P-value = 0.0380]. Thus, the findings of this study could help to understand the background of genetic predisposition and risk assessment of childhood ALL.
{"title":"Genetic polymorphisms in the chromatin modifier gene ARID5B in modulating the risk of pediatric acute lymphoblastic leukemia in Bangladesh","authors":"Farhana Jahan , Sajib Chakraborty , Mahrima Parvin , ATM Atikur Rahman , Zakir Hossain Howlader , Md. Ismail Hosen","doi":"10.1016/j.glmedi.2025.100184","DOIUrl":"10.1016/j.glmedi.2025.100184","url":null,"abstract":"<div><div>Acute lymphoblastic leukemia (ALL) is the most prevalent form of hematological cancer in children. In Bangladesh, the number of acute leukemia among children has been increasing each year and the genome studies regarding single nucleotide polymorphisms (SNP) in different genes related to lymphocyte development have not been explored yet. Therefore, the study aimed to examine the association between a specific SNP (rs10821936) in the <em>ARID5B</em> gene and the risk of childhood ALL in Bangladeshi children. The identification of the children's demographic and clinical characteristics as well as real-time PCR-based allelic discrimination method was employed to identify the genotypes of 194 ALL cases and 209 controls, respectively. Both the age difference and serum creatinine level between the control and patient groups were insignificant. In comparison to individuals who were healthy, both the blood ALT and LDH levels of the male and female child ALL participants were considerably high. However, compared to control groups, the serum calcium level in child ALL patients was considerably low. Serum ALT and LDH had a significant positive relationship while both had a negative correlation with serum calcium. The investigation revealed that the minor allele C was the risk allele for the SNP (rs10821936) and it has been linked to a higher incidence of ALL in Bangladeshi children [Odds ratio (OR) = 1.35; 95 % Confidence Interval (CI) = 1.02–1.79; <em>P</em>-value = 0.0380]. Thus, the findings of this study could help to understand the background of genetic predisposition and risk assessment of childhood ALL.</div></div>","PeriodicalId":100804,"journal":{"name":"Journal of Medicine, Surgery, and Public Health","volume":"5 ","pages":"Article 100184"},"PeriodicalIF":0.0,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143438239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-27DOI: 10.1016/j.glmedi.2025.100183
Corey H. Basch, Helen Yousaf, Grace C. Hillyer
The proliferation of online pharmaceutical sales necessitates a deeper understanding of how medications such as the diabetes treatment Ozempic® are presented and marketed on Google Shopping, a major aggregator of e-commerce merchants. We analyzed the representation and characteristics of Ozempic® listings, which were provided as regular and sponsored product results, with options to filter by medication form (liquid, tablet, capsule, wipes), specific pain relief applications (e.g., migraine, arthritis), free shipping offers, and price ranges. Additional filters included selection by store, however no sorting or filtering criteria were applied to maintain neutrality in the initial data capture. The 57 results were vetted for duplication, relevance, and English language usage. The final sample analyzed included 19 unique URLs. Results indicated that pricing ranged between $65 for proprietary compounded semaglutides and other weight loss products and $1399.99 for Ozempic®. Nearly half of the vendors offered introductory discounts, while others offered payment plans; 21.1 % mentioned a money-back guarantee but insurance coverage received little attention. Nearly half of the websites (42.1 %) were sponsored by telemedicine platforms, 26 % by patient/weight loss services, and 21.1 % of these were pharmacies. To access these medications, 15 vendors (78.9 %) required a prescription and of these13/15 (86.7 %) could be provided through the vendor’s company physician after completing an online questionnaire. The majority of programs (94.7 %) were accessible remotely with no direct personal interaction with the company physician or supplier. Nearly 80 % of the websites mentioned the pros of the weight loss product they promoted compared to 68.4 % that mentioned any cons. Around one-third of the sites (36.8 %) made product safety claims and 10.5 % mentioned “testing” without any specific details, while just over one-half referenced the FDA (57.9 %) or cited research to support credibility (52.6 %). The reliance on online pharmacies for GLP-1 agonists highlights the need for safeguards to ensure consumer health and safety.
{"title":"Online purchasing options for GLP-1 agonists: Accessibility, marketing practices, and consumer safety concerns","authors":"Corey H. Basch, Helen Yousaf, Grace C. Hillyer","doi":"10.1016/j.glmedi.2025.100183","DOIUrl":"10.1016/j.glmedi.2025.100183","url":null,"abstract":"<div><div>The proliferation of online pharmaceutical sales necessitates a deeper understanding of how medications such as the diabetes treatment Ozempic® are presented and marketed on Google Shopping, a major aggregator of e-commerce merchants. We analyzed the representation and characteristics of Ozempic® listings, which were provided as regular and sponsored product results, with options to filter by medication form (liquid, tablet, capsule, wipes), specific pain relief applications (e.g., migraine, arthritis), free shipping offers, and price ranges. Additional filters included selection by store, however no sorting or filtering criteria were applied to maintain neutrality in the initial data capture. The 57 results were vetted for duplication, relevance, and English language usage. The final sample analyzed included 19 unique URLs. Results indicated that pricing ranged between $65 for proprietary compounded semaglutides and other weight loss products and $1399.99 for Ozempic®. Nearly half of the vendors offered introductory discounts, while others offered payment plans; 21.1 % mentioned a money-back guarantee but insurance coverage received little attention. Nearly half of the websites (42.1 %) were sponsored by telemedicine platforms, 26 % by patient/weight loss services, and 21.1 % of these were pharmacies. To access these medications, 15 vendors (78.9 %) required a prescription and of these13/15 (86.7 %) could be provided through the vendor’s company physician after completing an online questionnaire. The majority of programs (94.7 %) were accessible remotely with no direct personal interaction with the company physician or supplier. Nearly 80 % of the websites mentioned the pros of the weight loss product they promoted compared to 68.4 % that mentioned any cons. Around one-third of the sites (36.8 %) made product safety claims and 10.5 % mentioned “testing” without any specific details, while just over one-half referenced the FDA (57.9 %) or cited research to support credibility (52.6 %). The reliance on online pharmacies for GLP-1 agonists highlights the need for safeguards to ensure consumer health and safety.</div></div>","PeriodicalId":100804,"journal":{"name":"Journal of Medicine, Surgery, and Public Health","volume":"5 ","pages":"Article 100183"},"PeriodicalIF":0.0,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143092785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-24DOI: 10.1016/j.glmedi.2025.100182
Ogochukwu Juliet Ezeigwe , Samuel Tundealao , Ogochukwu Ruth Abasilim , Olajumoke Ope Oladoyin , Manali Desai , Devesh Malgave , Lekan Ajijola , Xianglin L. Du
Introduction
Effective patient-physician communication is essential for the uptake of preventive services. This study examined the association between patient-physician communication index and being up-to-date with cervical cancer screening.
Methods
The analysis used self-reported data from the Health Information National Trends Survey (HINTS) 5, Cycle 4 (2020), and Cycle 6 (2022). The outcome variable was “Up-to-date with cervical cancer Screening.” Logistic regression and Cronbach’s Alpha were used to measure the association and internal consistency between communication items.
Results
A total of 3207 women aged 25–65 were included in the analysis, 2415 (77.5 %) were up-to-date with screenings, with 50.9 % having a patient-physician communication index of 17 or higher. In model 0, participants with a patient-physician communication index of ≥ 17 had 1.57 times higher odds (95 % CI: 1.23–2.00) of being up-to-date with their screening. In model 1, the individual communication items were not significantly associated with screening. In model 2, a patient-physician communication index of 17 or higher was associated with screening (aOR:1.62, 95 % CI: 1.20–2.19). Having health insurance (aOR:1.87, 95 % CI: 1.11–3.17) was significantly associated with screening. Non-Hispanic Blacks (aOR:1.77, 95 % CI: 1.10–2.85) and Hispanics (aOR:1.64, 95 % CI: 1.02–2.64) had higher odds of screening than non-Hispanic Whites.
Conclusion
This study found a significant relationship between a high patient-physician communication index and cervical cancer screening. The study findings highlight the critical role of effective patient-physician communication in improving adherence to cervical screening recommendations across the U.S.
{"title":"Impact of patient-physician communication on cervical cancer screening among women aged 25–65","authors":"Ogochukwu Juliet Ezeigwe , Samuel Tundealao , Ogochukwu Ruth Abasilim , Olajumoke Ope Oladoyin , Manali Desai , Devesh Malgave , Lekan Ajijola , Xianglin L. Du","doi":"10.1016/j.glmedi.2025.100182","DOIUrl":"10.1016/j.glmedi.2025.100182","url":null,"abstract":"<div><h3>Introduction</h3><div>Effective patient-physician communication is essential for the uptake of preventive services. This study examined the association between patient-physician communication index and being up-to-date with cervical cancer screening.</div></div><div><h3>Methods</h3><div>The analysis used self-reported data from the Health Information National Trends Survey (HINTS) 5, Cycle 4 (2020), and Cycle 6 (2022). The outcome variable was “Up-to-date with cervical cancer Screening.” Logistic regression and Cronbach’s Alpha were used to measure the association and internal consistency between communication items.</div></div><div><h3>Results</h3><div>A total of 3207 women aged 25–65 were included in the analysis, 2415 (77.5 %) were up-to-date with screenings, with 50.9 % having a patient-physician communication index of 17 or higher. In model 0, participants with a patient-physician communication index of ≥ 17 had 1.57 times higher odds (95 % CI: 1.23–2.00) of being up-to-date with their screening. In model 1, the individual communication items were not significantly associated with screening. In model 2, a patient-physician communication index of 17 or higher was associated with screening (aOR:1.62, 95 % CI: 1.20–2.19). Having health insurance (aOR:1.87, 95 % CI: 1.11–3.17) was significantly associated with screening. Non-Hispanic Blacks (aOR:1.77, 95 % CI: 1.10–2.85) and Hispanics (aOR:1.64, 95 % CI: 1.02–2.64) had higher odds of screening than non-Hispanic Whites.</div></div><div><h3>Conclusion</h3><div>This study found a significant relationship between a high patient-physician communication index and cervical cancer screening. The study findings highlight the critical role of effective patient-physician communication in improving adherence to cervical screening recommendations across the U.S.</div></div>","PeriodicalId":100804,"journal":{"name":"Journal of Medicine, Surgery, and Public Health","volume":"5 ","pages":"Article 100182"},"PeriodicalIF":0.0,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143092768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-22DOI: 10.1016/j.glmedi.2025.100179
Gabriel Oke
Africa is grappling with a severe healthcare workforce shortage, with only 1.55 health workers per 1000 people, far below the WHO’s recommended threshold of 4.45. This deficit is exacerbated by the migration of healthcare professionals to developed countries. This study conducts a comprehensive review to identify practical solutions to mitigate healthcare workforce migration in Africa. A targeted literature review methodology was employed, utilizing databases such as PubMed, Google Scholar, Cochrane Library, Scopus, Ovid, and WHO repositories from 2014 to 2024. Supplementary searches were performed using Google, incorporating grey literature, reports from governmental and international organizations, and media articles. A total of 45 sources were included, consisting of 36 peer-reviewed articles and 15 pieces of grey literature, including blogs, news articles, and reports. The review identified 13 key solutions from peer-reviewed sources and 11 additional solutions from grey literature, which were analyzed and categorized into thematic areas. Key solutions highlighted by the review include enhancing professional training and career development opportunities, offering financial incentives, improving working conditions, and fostering international collaboration. Specific strategies include addressing wage disparities, providing mentorship, creating competitive postgraduate training programs, and improving workplace environments. These factors are critical to retaining healthcare professionals within African countries and ensuring their sustained engagement in the local healthcare systems. Results indicate that while salary increases were frequently suggested, a multifaceted approach is essential for addressing healthcare migration. Improvements in working conditions, career development, and the establishment of robust mentorship programs were emphasized as more sustainable solutions. In particular, the study highlighted the importance of comprehensive strategies that go beyond financial incentives, as merely increasing salaries may not adequately address the structural issues driving migration. The findings suggest that combating healthcare migration in Africa requires coordinated efforts across multiple sectors, including government, health administration, and international organizations. A holistic approach, focusing on strengthening local healthcare systems, improving professional opportunities, and creating supportive working environments, is crucial for mitigating brain drain and improving healthcare delivery on the continent. The review underscores the need for sustained policy interventions, with a focus on both retention and attraction of healthcare professionals within Africa.
{"title":"Interdisciplinary cross-sectoral strategies to mitigate health workforce migration in Africa","authors":"Gabriel Oke","doi":"10.1016/j.glmedi.2025.100179","DOIUrl":"10.1016/j.glmedi.2025.100179","url":null,"abstract":"<div><div>Africa is grappling with a severe healthcare workforce shortage, with only 1.55 health workers per 1000 people, far below the WHO’s recommended threshold of 4.45. This deficit is exacerbated by the migration of healthcare professionals to developed countries. This study conducts a comprehensive review to identify practical solutions to mitigate healthcare workforce migration in Africa. A targeted literature review methodology was employed, utilizing databases such as PubMed, Google Scholar, Cochrane Library, Scopus, Ovid, and WHO repositories from 2014 to 2024. Supplementary searches were performed using Google, incorporating grey literature, reports from governmental and international organizations, and media articles. A total of 45 sources were included, consisting of 36 peer-reviewed articles and 15 pieces of grey literature, including blogs, news articles, and reports. The review identified 13 key solutions from peer-reviewed sources and 11 additional solutions from grey literature, which were analyzed and categorized into thematic areas. Key solutions highlighted by the review include enhancing professional training and career development opportunities, offering financial incentives, improving working conditions, and fostering international collaboration. Specific strategies include addressing wage disparities, providing mentorship, creating competitive postgraduate training programs, and improving workplace environments. These factors are critical to retaining healthcare professionals within African countries and ensuring their sustained engagement in the local healthcare systems. Results indicate that while salary increases were frequently suggested, a multifaceted approach is essential for addressing healthcare migration. Improvements in working conditions, career development, and the establishment of robust mentorship programs were emphasized as more sustainable solutions. In particular, the study highlighted the importance of comprehensive strategies that go beyond financial incentives, as merely increasing salaries may not adequately address the structural issues driving migration. The findings suggest that combating healthcare migration in Africa requires coordinated efforts across multiple sectors, including government, health administration, and international organizations. A holistic approach, focusing on strengthening local healthcare systems, improving professional opportunities, and creating supportive working environments, is crucial for mitigating brain drain and improving healthcare delivery on the continent. The review underscores the need for sustained policy interventions, with a focus on both retention and attraction of healthcare professionals within Africa.</div></div>","PeriodicalId":100804,"journal":{"name":"Journal of Medicine, Surgery, and Public Health","volume":"5 ","pages":"Article 100179"},"PeriodicalIF":0.0,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143092765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-17DOI: 10.1016/j.glmedi.2025.100181
Imad Talahma , Yazan Abudeyak , Mahmoud N. Khadra , Hamza A. Abdul-Hafez , Yousef S. Abuzneid
This case report describes a 58-year-old male who presented with severe headache two months after head trauma, with imaging confirming a left-sided chronic subdural hematoma (cSDH). He underwent Burr hole craniotomy for hematoma evacuation, followed by skull reconstruction using a titanium mesh implant. Postoperative recovery was smooth, with no neurological symptoms or complications, and follow-up imaging showed no residual hematoma. Titanium mesh allowed for effective skull reconstruction, eliminating risks of cosmetic deformities like scalp depression and potentially reducing infection and other post-surgical complications. Our findings highlight titanium mesh as a valuable option in neurosurgery for cSDH, providing both functional and cosmetic benefits. While complications with titanium implants have been noted in some cases, our patient’s recovery was uneventful. This case highlights titanium mesh’s use and supports further exploration of materials to enhance outcomes in surgical management of cSDH.
{"title":"Skull reconstruction with titanium mesh following burr hole craniotomy for chronic subdural hematoma","authors":"Imad Talahma , Yazan Abudeyak , Mahmoud N. Khadra , Hamza A. Abdul-Hafez , Yousef S. Abuzneid","doi":"10.1016/j.glmedi.2025.100181","DOIUrl":"10.1016/j.glmedi.2025.100181","url":null,"abstract":"<div><div>This case report describes a 58-year-old male who presented with severe headache two months after head trauma, with imaging confirming a left-sided chronic subdural hematoma (cSDH). He underwent Burr hole craniotomy for hematoma evacuation, followed by skull reconstruction using a titanium mesh implant. Postoperative recovery was smooth, with no neurological symptoms or complications, and follow-up imaging showed no residual hematoma. Titanium mesh allowed for effective skull reconstruction, eliminating risks of cosmetic deformities like scalp depression and potentially reducing infection and other post-surgical complications. Our findings highlight titanium mesh as a valuable option in neurosurgery for cSDH, providing both functional and cosmetic benefits. While complications with titanium implants have been noted in some cases, our patient’s recovery was uneventful. This case highlights titanium mesh’s use and supports further exploration of materials to enhance outcomes in surgical management of cSDH.</div></div>","PeriodicalId":100804,"journal":{"name":"Journal of Medicine, Surgery, and Public Health","volume":"5 ","pages":"Article 100181"},"PeriodicalIF":0.0,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143092770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-17DOI: 10.1016/j.glmedi.2025.100177
Gabriella Szörényiné Ványi , Annamária Szigeti , János G. Pitter , Zita Battyáni , Imre Repa
Early detection and early treatment are key to melanoma survival. To organise prevention programs, we need to know the detailed datas of melanoma. Our objective was to assess and understand the epidemiological data of melanoma patients treated at our institution. We investigate whether the available database is suitable for more detailed epidemiological and morphological data analysis; and whether the results can contribute to the design of programs for melanoma prevention and detection. In our study, we retrospectively analyzed data from 636 melanoma patients treated at the Moritz Kaposi General Hospital, based on a unique clinical oncology patient pathway management system (Onkonetwork) database. We analyzed the distribution by sex and age, the subtype of melanoma, localization, tumor thickness, stage, risks, and detection mode. Our results showed that most melanoma cases occurred in women under 40 years and in men aged 60–79 years. There was an increase in the incidence of thin melanomas and a relatively stable incidence of thick melanomas. The study confirmed that the Onkonetwork system serves as a valuable database to support the identification of prevention sites where improvements in early detection, prevention and early treatment of melanoma are needed, tailored to the specific geographical location.
{"title":"The importance of an oncology database in planning melanoma prevention programs","authors":"Gabriella Szörényiné Ványi , Annamária Szigeti , János G. Pitter , Zita Battyáni , Imre Repa","doi":"10.1016/j.glmedi.2025.100177","DOIUrl":"10.1016/j.glmedi.2025.100177","url":null,"abstract":"<div><div>Early detection and early treatment are key to melanoma survival. To organise prevention programs, we need to know the detailed datas of melanoma. Our objective was to assess and understand the epidemiological data of melanoma patients treated at our institution. We investigate whether the available database is suitable for more detailed epidemiological and morphological data analysis; and whether the results can contribute to the design of programs for melanoma prevention and detection. In our study, we retrospectively analyzed data from 636 melanoma patients treated at the Moritz Kaposi General Hospital, based on a unique clinical oncology patient pathway management system (Onkonetwork) database. We analyzed the distribution by sex and age, the subtype of melanoma, localization, tumor thickness, stage, risks, and detection mode. Our results showed that most melanoma cases occurred in women under 40 years and in men aged 60–79 years. There was an increase in the incidence of thin melanomas and a relatively stable incidence of thick melanomas. The study confirmed that the Onkonetwork system serves as a valuable database to support the identification of prevention sites where improvements in early detection, prevention and early treatment of melanoma are needed, tailored to the specific geographical location.</div></div>","PeriodicalId":100804,"journal":{"name":"Journal of Medicine, Surgery, and Public Health","volume":"5 ","pages":"Article 100177"},"PeriodicalIF":0.0,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143092767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Female smoking in Bangladesh is a growing public health concern, though the overall prevalence remains lower compared to men. Cultural norms and social stigma surrounding women’s smoking habits have traditionally kept the rates relatively low. However, the influence of urbanization, changing lifestyles, and increased access to tobacco products may be contributing to a rise in female smoking rates. A comprehensive search across multiple databases identified 25 studies for the meta-analysis. The I² statistic and Q-tests were used to assess heterogeneity. A random-effects model and subgroup analyses were conducted. Egger's test and funnel plots were utilized to evaluate potential publication bias. Meta-regression analysis was performed. Sensitivity analysis was conducted to assess the robustness of the meta-analysis. All analyses were performed using STATA 17. The results showed that women's pooled smoking prevalence was 5.50 % (95 % CI: 3.19–7.81) based on 25 selected studies (n = 71,824). The pooled prevalence was 4.90 % (95 % CI: 1.18–8.62) from 2001–2008, dropped to 3.11 % (95 % CI: 1.09–5.12) in 2009–2016, and then rose to 6.28 % (95 % CI: 1.67–10.89) in 2017–2024. Among age groups, the prevalence stood at 6.39 % for those aged ≥ 15 and slightly decreased to 5.36 % for those ≥ 18. For students, the pooled prevalence was 7.61 %. Public health interventions should emphasize smoking cessation programs, with a particular focus on implementing prevention strategies targeted at younger women. Community outreach and awareness efforts will further promote smoking reduction across all age groups.
{"title":"Smoking among females in Bangladesh: A systematic review and meta-analysis","authors":"Tonmoy Alam Shuvo , Kabir Hossain , Sorif Hossain , Asma-Ul-Hosna , Dipu Rani Dey","doi":"10.1016/j.glmedi.2025.100180","DOIUrl":"10.1016/j.glmedi.2025.100180","url":null,"abstract":"<div><div>Female smoking in Bangladesh is a growing public health concern, though the overall prevalence remains lower compared to men. Cultural norms and social stigma surrounding women’s smoking habits have traditionally kept the rates relatively low. However, the influence of urbanization, changing lifestyles, and increased access to tobacco products may be contributing to a rise in female smoking rates. A comprehensive search across multiple databases identified 25 studies for the meta-analysis. The I² statistic and Q-tests were used to assess heterogeneity. A random-effects model and subgroup analyses were conducted. Egger's test and funnel plots were utilized to evaluate potential publication bias. Meta-regression analysis was performed. Sensitivity analysis was conducted to assess the robustness of the meta-analysis. All analyses were performed using STATA 17. The results showed that women's pooled smoking prevalence was 5.50 % (95 % CI: 3.19–7.81) based on 25 selected studies (n = 71,824). The pooled prevalence was 4.90 % (95 % CI: 1.18–8.62) from 2001–2008, dropped to 3.11 % (95 % CI: 1.09–5.12) in 2009–2016, and then rose to 6.28 % (95 % CI: 1.67–10.89) in 2017–2024. Among age groups, the prevalence stood at 6.39 % for those aged ≥ 15 and slightly decreased to 5.36 % for those ≥ 18. For students, the pooled prevalence was 7.61 %. Public health interventions should emphasize smoking cessation programs, with a particular focus on implementing prevention strategies targeted at younger women. Community outreach and awareness efforts will further promote smoking reduction across all age groups.</div></div>","PeriodicalId":100804,"journal":{"name":"Journal of Medicine, Surgery, and Public Health","volume":"5 ","pages":"Article 100180"},"PeriodicalIF":0.0,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143092787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-14DOI: 10.1016/j.glmedi.2025.100178
Daniel Felipe Fernandes Paiva, Andressa de Oliveira Rocha, Ana Julia Puppin de Campos Toledo, Liana Andrade Veríssimo Araujo, Marcelo de Castro Meneghin
By 2015, an estimated 570 million people will be affected by diabetes mellitus (DM), positioning it as one of the most prevalent global diseases and reaffirming the urgent need for effective control measures. DM ranks among the leading causes of mortality worldwide, with its impact particularly severe in elderly populations and low- and middle-income countries. It is closely linked to the progression of comorbidities and systemic complications, including vascular, cardiac, renal, neurological, and ophthalmic problems, with a projected global financial burden of $673 billion annually over the coming decades. An underexplored yet significant approach to DM management is its relationship with oral health, which includes conditions such as exacerbated xerostomia, periodontitis, fungal infections, and an increased risk of cancer. The link between oral health and glycemic control is particularly evident in patients with periodontitis, who exhibit elevated inflammatory mediators that complicate diabetes management. Furthermore, inadequate oral hygiene habits worsen periodontal disease and are recognized as risk factors for DM. This association also contributes to increased pain, tooth loss, and diminished quality of life, further accelerating the development of comorbidities such as retinopathy and nephropathy. Promoting proper oral hygiene, particularly toothbrushing, as a preventive measure for periodontitis could play a pivotal role in controlling and preventing DM. Understanding the impact of these simple yet effective measures on the epidemiology of DM is essential. This communication highlights the importance of fostering public health policies and integrating dentists into multidisciplinary healthcare teams to improve systemic health outcomes and reduce long-term healthcare costs.
{"title":"Can toothbrushing frequency impact the risk of diabetes mellitus?","authors":"Daniel Felipe Fernandes Paiva, Andressa de Oliveira Rocha, Ana Julia Puppin de Campos Toledo, Liana Andrade Veríssimo Araujo, Marcelo de Castro Meneghin","doi":"10.1016/j.glmedi.2025.100178","DOIUrl":"10.1016/j.glmedi.2025.100178","url":null,"abstract":"<div><div>By 2015, an estimated 570 million people will be affected by diabetes mellitus (DM), positioning it as one of the most prevalent global diseases and reaffirming the urgent need for effective control measures. DM ranks among the leading causes of mortality worldwide, with its impact particularly severe in elderly populations and low- and middle-income countries. It is closely linked to the progression of comorbidities and systemic complications, including vascular, cardiac, renal, neurological, and ophthalmic problems, with a projected global financial burden of $673 billion annually over the coming decades. An underexplored yet significant approach to DM management is its relationship with oral health, which includes conditions such as exacerbated xerostomia, periodontitis, fungal infections, and an increased risk of cancer. The link between oral health and glycemic control is particularly evident in patients with periodontitis, who exhibit elevated inflammatory mediators that complicate diabetes management. Furthermore, inadequate oral hygiene habits worsen periodontal disease and are recognized as risk factors for DM. This association also contributes to increased pain, tooth loss, and diminished quality of life, further accelerating the development of comorbidities such as retinopathy and nephropathy. Promoting proper oral hygiene, particularly toothbrushing, as a preventive measure for periodontitis could play a pivotal role in controlling and preventing DM. Understanding the impact of these simple yet effective measures on the epidemiology of DM is essential. This communication highlights the importance of fostering public health policies and integrating dentists into multidisciplinary healthcare teams to improve systemic health outcomes and reduce long-term healthcare costs.</div></div>","PeriodicalId":100804,"journal":{"name":"Journal of Medicine, Surgery, and Public Health","volume":"5 ","pages":"Article 100178"},"PeriodicalIF":0.0,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143092784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-03DOI: 10.1016/j.glmedi.2024.100176
Muzamil Akhtar , Danish Ali Ashraf , Muhammad Umar Liaqat , Mohammad Saad Ullah , Mehmood Akhtar , Muhammad Salman Nadeem , Shehar Bano
Despite being a critical area of concern, mortality trends for postoperative respiratory disorders in the United States remain underexplored. This study analyzes nationwide trends and regional disparities in deaths related to these disorders using CDC WONDER mortality data from 1999 to 2020, categorized under ICD-10 code J95. Age-adjusted mortality rates (AAMR) per 100,000 were calculated, and trends were analyzed across demographics, regions, urbanization levels, places of death, and states. Annual percentage change (APC) and average annual percentage change (AAPC) with 95 % confidence intervals (CI) were computed using Joinpoint regression. From 1999–2020, 45,828 deaths related to postoperative respiratory disorders were recorded, with AAMR declining from 1.06 in 1999–0.33 in 2020 (AAPC: −5.55 %; 95 % CI: −5.96 to −4.98). Males had higher AAMR (0.8) than females (0.5). Non-Hispanic (NH) Blacks reported the highest AAMR (0.75), followed by NH Whites (0.63), Hispanics (0.45), and NH Asians (0.37). Nonmetropolitan areas had higher AAMR (0.75) compared to small (0.68) and medium metropolitan areas (0.64). Regionally, the Midwest had the highest AAMR (0.67). State-level disparities were notable, ranging from 0.26 in Massachusetts to 0.98 in New Mexico. Despite a significant decline in mortality, likely driven by advancements in management and technology, persistent disparities highlight the urgent need for targeted interventions to address underlying inequities in healthcare access and outcomes.
{"title":"Mortality trends related to postoperative respiratory disorders in the United States, 1999–2020","authors":"Muzamil Akhtar , Danish Ali Ashraf , Muhammad Umar Liaqat , Mohammad Saad Ullah , Mehmood Akhtar , Muhammad Salman Nadeem , Shehar Bano","doi":"10.1016/j.glmedi.2024.100176","DOIUrl":"10.1016/j.glmedi.2024.100176","url":null,"abstract":"<div><div>Despite being a critical area of concern, mortality trends for postoperative respiratory disorders in the United States remain underexplored. This study analyzes nationwide trends and regional disparities in deaths related to these disorders using CDC WONDER mortality data from 1999 to 2020, categorized under ICD-10 code J95. Age-adjusted mortality rates (AAMR) per 100,000 were calculated, and trends were analyzed across demographics, regions, urbanization levels, places of death, and states. Annual percentage change (APC) and average annual percentage change (AAPC) with 95 % confidence intervals (CI) were computed using Joinpoint regression. From 1999–2020, 45,828 deaths related to postoperative respiratory disorders were recorded, with AAMR declining from 1.06 in 1999–0.33 in 2020 (AAPC: −5.55 %; 95 % CI: −5.96 to −4.98). Males had higher AAMR (0.8) than females (0.5). Non-Hispanic (NH) Blacks reported the highest AAMR (0.75), followed by NH Whites (0.63), Hispanics (0.45), and NH Asians (0.37). Nonmetropolitan areas had higher AAMR (0.75) compared to small (0.68) and medium metropolitan areas (0.64). Regionally, the Midwest had the highest AAMR (0.67). State-level disparities were notable, ranging from 0.26 in Massachusetts to 0.98 in New Mexico. Despite a significant decline in mortality, likely driven by advancements in management and technology, persistent disparities highlight the urgent need for targeted interventions to address underlying inequities in healthcare access and outcomes.</div></div>","PeriodicalId":100804,"journal":{"name":"Journal of Medicine, Surgery, and Public Health","volume":"5 ","pages":"Article 100176"},"PeriodicalIF":0.0,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143092764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
扫码关注我们
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号