Neuroscience Applied最新文献

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Testing the usefulness of a quality system in preclinical research 测试质量体系在临床前研究中的实用性

Neuroscience Applied

Pub Date : 2024-11-13 DOI: 10.1016/j.nsa.2024.105395

René Bernard , Björn Gerlach , Magali Haas , Malcolm Macleod , Heidrun Potschka , Andrew S.C. Rice , Thomas Steckler , Vootele Voikar , Kimberley E. Wever

引用次数: 0

Telomere length and mitochondrial DNA copy number in association with trauma-focused psychotherapy efficacy 端粒长度和线粒体DNA拷贝数与创伤心理治疗疗效的关系

Neuroscience Applied

Pub Date : 2024-10-23 DOI: 10.1016/j.nsa.2024.104095

Alessandra Minelli , Anna Meloni , Marco Bortolomasi , Claudia Pisanu , Elisa Zampieri , Donatella Congiu , Beatrice Lana , Mirko Manchia , Mattia Meattini , Pasquale Paribello

Early life adversities (ELA) have been linked to a greater risk for major depressive disorder (MDD) and treatment-resistant depression (TRD). The molecular mechanisms underlying the link between ELA and MDD and/or TRD are yet unknown. It has been suggested that ELA induces an allostatic burden, which in turn promotes oxidative stress and an inflammatory response that are further intensified by the influence of maladaptive coping behaviour. In this study we explored the role of two markers of cellular aging and oxidative stress (leukocyte telomere length (LTL) and mitochondrial DNA copy number (mtDNAcn)) in TRD and in response to trauma-focused psychotherapies. The study comprised 30 TRD patients receiving trauma-focused psychotherapies and 65 healthy controls. LTL and mtDNAcn were measured at baseline and four weeks after the end of the psychotherapy sessions. Response was defined based on reduction in the Montgomery-Åsberg Depression Rating Scale (MADRS). In the case control analysis, the logistic regression model showed that mtDNAcn but not LTL was a significant predictor of diagnosis (chi-square 92.108, p = 7.72e-20; contribution of mtDNAcn, B = −9-297, p = 0.00009). In the TRD sample, LTL and mtDNAcn were inversely correlated with MADRS score at baseline (LTL, Pearson's r = −0.478, p = 0.008; mtDNAcn, Pearson's r = −0.656, p = 0.00008), but there was no difference in either LTL or mtDNAcn between responders and non-responders. In conclusion, our findings support an involvement of cellular aging in TRD, and suggest that LTL and mtDNAcn are not predictors or mediators of response to trauma-focused psychotherapies.

早期生活逆境（ELA）与罹患重度抑郁症（MDD）和耐药性抑郁症（TRD）的更大风险有关。ELA与MDD和/或TRD之间的分子机制尚不清楚。有研究认为，ELA 会诱发异质负荷，进而促进氧化应激和炎症反应，而适应不良的应对行为又会进一步加剧这种反应。在这项研究中，我们探讨了细胞衰老和氧化应激的两个标志物（白细胞端粒长度（LTL）和线粒体DNA拷贝数（mtDNAcn））在TRD中的作用以及对以创伤为重点的心理疗法的反应。研究对象包括30名接受创伤心理治疗的TRD患者和65名健康对照者。LTL和mtDNAcn分别在基线和心理治疗疗程结束后四周进行测量。根据蒙哥马利-阿斯伯格抑郁评定量表（MADRS）的降低程度来定义反应。在病例对照分析中，逻辑回归模型显示，mtDNAcn而非LTL是诊断的重要预测因素（秩方92.108，p = 7.72e-20；mtDNAcn的贡献，B = -9-297，p = 0.00009）。在TRD样本中，LTL和mtDNAcn与基线时的MADRS评分成反比（LTL，Pearson's r = -0.478，p = 0.008；mtDNAcn，Pearson's r = -0.656，p = 0.00008），但LTL或mtDNAcn在应答者和非应答者之间没有差异。总之，我们的研究结果支持细胞老化参与了TRD，并表明LTL和mtDNAcn不是创伤心理治疗反应的预测因子或中介因子。

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引用次数: 0

Safety pharmacology of acute psilocybin administration in healthy participants 对健康参与者急性服用迷幻药的安全药理学研究

Neuroscience Applied

Pub Date : 2024-03-01 DOI: 10.1016/j.nsa.2024.104060

I. Straumann, F. Holze, Anna M. Becker, L. Ley, Nepomuk Halter, M.E. Liechti

引用次数: 0

Longitudinal development of resting-state functional connectivity in adolescents with and without internalizing disorders 有内化障碍和无内化障碍青少年静息态功能连接的纵向发展

Neuroscience Applied

Pub Date : 2024-01-01 DOI: 10.1016/j.nsa.2024.104090

Eline F. Roelofs , Janna Marie Bas-Hoogendam , Anderson M. Winkler , Nic J.A. van der Wee , Robert R.J. M. Vermeiren

Longitudinal studies using resting-state functional magnetic resonance imaging (rs-fMRI) focused on adolescent internalizing psychopathology are scarce and have mostly investigated standardized treatment effects on functional connectivity (FC) of the full amygdala. The role of amygdala subregions and large resting-state networks had yet to be elucidated, and treatment is in practice often personalized. Here, longitudinal FC development of amygdala subregions and whole-brain networks are investigated in a clinically representative sample.

Treatment-naïve adolescents with clinical depression and comorbid anxiety who started care-as-usual (n = 23; INT) and healthy controls (n = 24; HC) participated in rs-fMRI scans and questionnaires at baseline (before treatment) and after three months. Changes between and within groups over time in FC of the laterobasal amygdala (LBA), centromedial amygdala (CMA) and whole-brain networks derived from independent component analysis (ICA) were investigated.

Groups differed significantly in FC development of the right LBA to the postcentral gyrus and the left LBA to the frontal pole. Within INT, FC to the frontal pole and postcentral gyrus changed over time while changes in FC of the right LBA were also linked to symptom change. No significant interactions were observed when considering FC from CMA bilateral seeds or within ICA-derived networks.

Results in this cohort suggest divergent longitudinal development of FC from bilateral LBA subregions in adolescents with internalizing disorders compared to healthy peers, possibly reflecting nonspecific treatment effects. Moreover, associations were found with symptom change. These results highlight the importance of differentiation of amygdala subregions in neuroimaging research in adolescents.

使用静息态功能磁共振成像（rs-fMRI）对青少年内化心理病理学进行的纵向研究很少，而且大多是调查标准化治疗对整个杏仁核功能连接（FC）的影响。杏仁核亚区和大型静息态网络的作用尚待阐明，而治疗实际上往往是个性化的。在此，我们以临床代表性样本为研究对象，对杏仁核亚区和全脑网络的纵向FC发展进行了研究。患有临床抑郁症和合并焦虑症、开始接受常规治疗的未经治疗的青少年（n = 23；INT）和健康对照组（n = 24；HC）在基线（治疗前）和三个月后参加了rs-fMRI扫描和问卷调查。研究人员调查了基底后叶杏仁核（LBA）、中央内侧杏仁核（CMA）和独立成分分析（ICA）得出的全脑网络的 FC 随时间推移在组间和组内的变化情况。在INT内，额极和中央后回的FC随时间变化，而右侧LBA的FC变化也与症状变化有关。该队列的研究结果表明，与健康同龄人相比，内化障碍青少年双侧LBA亚区的FC纵向发展存在差异，这可能反映了非特异性治疗效果。此外，研究还发现了与症状变化的关联。这些结果凸显了在青少年神经影像研究中区分杏仁核亚区的重要性。

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引用次数: 0

Cerebral blood flow in treatment resistant schizophrenia and during clozapine treatment 耐药性精神分裂症和氯氮平治疗期间的脑血流量

Neuroscience Applied

Pub Date : 2024-01-01 DOI: 10.1016/j.nsa.2024.103949

J. Sun , F. Zelaya , K.V. Sendt , G. Mcqueen , A. Gillespie , O. Howes , G. Barker , J. Maccabe , A. Egerton

引用次数: 0

ADHD treatment landscape: Conventional, alternative, and their self-rated effectiveness 多动症治疗现状：传统疗法、替代疗法及其自评疗效

Neuroscience Applied

Pub Date : 2024-01-01 DOI: 10.1016/j.nsa.2024.103959

E. Haijen , P. Hurks , K. Kuypers

引用次数: 0

Effect of four antidepressant treatments on human dentate gyrus: a multisite longitudinal MRI study 四种抗抑郁治疗对人类齿状回的影响：多部位纵向磁共振成像研究

Neuroscience Applied

Pub Date : 2024-01-01 DOI: 10.1016/j.nsa.2024.103945

A. Takamiya , J. Hirano , K. Kamiya , R. Ueda , M. Tajima , Y. Kobayashi , N. Katayama , B. Yamagata , T. Kishimoto , T. Suwa , J. Miyata , T. Noda , T. Murai , K. Nakagome , M. Mimura

引用次数: 0

Lipoproteome dysregulation precedes conversion to psychosis in ultra-high-risk subjects 脂蛋白组失调先于超高风险受试者转为精神病

Neuroscience Applied

Pub Date : 2024-01-01 DOI: 10.1016/j.nsa.2024.103948

M.T. Avella , G. Bertho , O. Kébir , C. Caradeuc , M.O. Krebs , N. Giraud , B. Chaumette , A. Frajerman

引用次数: 0

The impact of methylation patterns and epigenetic aging in lithium response 甲基化模式和表观遗传老化对锂反应的影响

Neuroscience Applied

Pub Date : 2024-01-01 DOI: 10.1016/j.nsa.2024.104032

M. Zafrilla López , M. Acosta-Díez , A. Giménez-Palomo , P.A. Saiz , C. Barrot-Feixat , E. Jiménez , S. Papiol , V. Ruiz , P. Gavín , M.P. García-Portilla , L. González-Blanco , J. Bobes , T.G. Schulze , E. Vieta , A. Benabarre , M. Mitjans , B. Arias

引用次数: 0

Unveiling the role of gut microbiota in shaping food addiction-like behaviour in mice 揭示肠道微生物群在塑造小鼠食物成瘾行为中的作用

Neuroscience Applied

Pub Date : 2024-01-01 DOI: 10.1016/j.nsa.2024.103983

S. Samulenaite , A. Burokas , E. Martín-García , R. Maldonado

引用次数: 0

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