首页 > 最新文献

Neuroscience Applied最新文献

英文 中文
Incidence and predictors of problem gambling in first-episode psychosis: a prospective multicenter cohort study 问题赌博在首发精神病中的发病率和预测因素:一项前瞻性多中心队列研究
Pub Date : 2026-01-01 Epub Date: 2026-01-02 DOI: 10.1016/j.nsa.2025.105545
O. Corbeil , M. Huot-Lavoie , L. Béchard , S. Brodeur , A. Abdel-Baki , C. Jacques , M. Solmi , D. Talbot , M. Dorval , I. Giroux , M.A. Roy , M.F. Demers
{"title":"Incidence and predictors of problem gambling in first-episode psychosis: a prospective multicenter cohort study","authors":"O. Corbeil , M. Huot-Lavoie , L. Béchard , S. Brodeur , A. Abdel-Baki , C. Jacques , M. Solmi , D. Talbot , M. Dorval , I. Giroux , M.A. Roy , M.F. Demers","doi":"10.1016/j.nsa.2025.105545","DOIUrl":"10.1016/j.nsa.2025.105545","url":null,"abstract":"","PeriodicalId":100952,"journal":{"name":"Neuroscience Applied","volume":"5 ","pages":"Article 105545"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145868989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A dual-lever operant approach to ethanol and cocaine co-administration 双杠杆操作方法乙醇和可卡因的共同管理
Pub Date : 2026-01-01 Epub Date: 2026-01-02 DOI: 10.1016/j.nsa.2025.105543
G.V.L. Costa , L. Teodoro , P. Palombo , B.T. Rodolpho , V. Nascimento-Rocha , J. Castelani , C. Estevam , C.J. Farias , R.M. Leão , F.C. Cruz
{"title":"A dual-lever operant approach to ethanol and cocaine co-administration","authors":"G.V.L. Costa , L. Teodoro , P. Palombo , B.T. Rodolpho , V. Nascimento-Rocha , J. Castelani , C. Estevam , C.J. Farias , R.M. Leão , F.C. Cruz","doi":"10.1016/j.nsa.2025.105543","DOIUrl":"10.1016/j.nsa.2025.105543","url":null,"abstract":"","PeriodicalId":100952,"journal":{"name":"Neuroscience Applied","volume":"5 ","pages":"Article 105543"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145868976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Risk and protective factors for anxiety, depression, and PTSS symptoms following the october 7th attacks in israel 以色列10月7日袭击后焦虑、抑郁和创伤后应激障碍症状的风险和保护因素
Pub Date : 2026-01-01 Epub Date: 2026-01-02 DOI: 10.1016/j.nsa.2025.105562
Y. Stukalin , N. Eliyahu , O. Ashkenazi , T. Tarkay , O. Elkana
{"title":"Risk and protective factors for anxiety, depression, and PTSS symptoms following the october 7th attacks in israel","authors":"Y. Stukalin , N. Eliyahu , O. Ashkenazi , T. Tarkay , O. Elkana","doi":"10.1016/j.nsa.2025.105562","DOIUrl":"10.1016/j.nsa.2025.105562","url":null,"abstract":"","PeriodicalId":100952,"journal":{"name":"Neuroscience Applied","volume":"5 ","pages":"Article 105562"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145869177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sleep, Steps, and Screens: Between- and within-person effects of digital markers of daily life behaviors on smartphone-based assessments of cognitive functioning in depression 睡眠,步骤和屏幕:日常生活行为的数字标记对基于智能手机的抑郁症认知功能评估的人与人之间和内部影响。
Pub Date : 2026-01-01 Epub Date: 2026-02-14 DOI: 10.1016/j.nsa.2026.106985
Marcos Ross-Adelman , George Aalbers , Faith Matcham , Daniel Leightley , Carolin Oetzmann , Ewan Carr , Sara Siddi , Josep M. Haro , Peter Annas , Maria Dalby , Vaibhav A. Narayan , Matthew Hotopf , Inez Myin-Germeys , Femke Lamers , Brenda W.J.H. Penninx , RADAR-CNS consortium
Cognitive impairment represents a core feature of major depressive disorder (MDD), often persisting after mood symptoms remit and not addressed by usual antidepressant treatments. Despite its relevance, cognition is typically assessed with infrequent tests in clinical settings, overlooking its contextual nature. Smartphones and wearables enable ecologically valid, repeated measurements of cognition and daily life behaviors that may impact it. We examined whether sleep duration, step count, and smartphone screen time are associated with cognitive functioning in MDD.
We conducted secondary analyses of RADAR-MDD, a multicenter study following individuals with recurrent MDD. Cognitive functioning – self-reported and performance-based – was assessed with the THINC-it® app. Sleep duration and step count were measured with Fitbit devices, and screen time with the RADAR-Base app. Cognitive assessments (outcomes) were linked to behavioral measures (predictors) from the day of and the day preceding each assessment. Two-level multilevel models estimated between-person (differences in participant means) and within-person (deviations from participant means) effects. The sample included 502 participants, further subdivided by behavior–cognitive outcome pair.
For performance-based cognitive assessments, positive associations at the between-person level were found for step count (β = 0.104, SE = 0.031, p < 0.001) and screen time (β = 0.075, SE = 0.036, p = 0.038), and sleep duration showed a quadratic negative effect (β = −0.080, SE = 0.018, p < 0.001). No within-person effects were detected. For self-reported cognitive functioning, step count showed positive associations both between (β = 0.161, SE = 0.037, p < 0.001) and within persons (β = 0.027, SE = 0.010, p = 0.005), while screen time was negatively associated within persons (β = −0.033, SE = 0.011, p = 0.002).
Our findings illustrate that smartphones and wearables can collect meaningful daily life data of MDD patients that can be used to support cognitive health. Step count emerges as a promising behavioral target as it is simple to track and is correlated with better cognitive outcomes.
认知障碍是重度抑郁障碍(MDD)的核心特征,通常在情绪症状缓解后持续存在,并且通常的抗抑郁治疗无法解决。尽管与认知相关,但在临床环境中,认知通常是通过不频繁的测试来评估的,而忽略了其上下文性质。智能手机和可穿戴设备可以对可能影响认知的认知和日常生活行为进行生态有效的重复测量。我们研究了睡眠时间、步数和智能手机屏幕时间是否与重度抑郁症的认知功能有关。我们对RADAR-MDD进行了二次分析,这是一项针对复发性MDD患者的多中心研究。认知功能(自我报告和基于表现)通过THINC-it®应用程序进行评估。睡眠时间和步数通过Fitbit设备测量,屏幕时间通过RADAR-Base应用程序测量。认知评估(结果)与每次评估当天和前一天的行为测量(预测因子)相关联。两级多水平模型估计了人与人之间(参与者均值的差异)和人与人之间(参与者均值的偏差)的影响。样本包括502名参与者,进一步细分为行为-认知结果对。在基于表现的认知评估中,步数在个人水平上呈正相关(β = 0.104, SE = 0.031, p
{"title":"Sleep, Steps, and Screens: Between- and within-person effects of digital markers of daily life behaviors on smartphone-based assessments of cognitive functioning in depression","authors":"Marcos Ross-Adelman ,&nbsp;George Aalbers ,&nbsp;Faith Matcham ,&nbsp;Daniel Leightley ,&nbsp;Carolin Oetzmann ,&nbsp;Ewan Carr ,&nbsp;Sara Siddi ,&nbsp;Josep M. Haro ,&nbsp;Peter Annas ,&nbsp;Maria Dalby ,&nbsp;Vaibhav A. Narayan ,&nbsp;Matthew Hotopf ,&nbsp;Inez Myin-Germeys ,&nbsp;Femke Lamers ,&nbsp;Brenda W.J.H. Penninx ,&nbsp;RADAR-CNS consortium","doi":"10.1016/j.nsa.2026.106985","DOIUrl":"10.1016/j.nsa.2026.106985","url":null,"abstract":"<div><div>Cognitive impairment represents a core feature of major depressive disorder (MDD), often persisting after mood symptoms remit and not addressed by usual antidepressant treatments. Despite its relevance, cognition is typically assessed with infrequent tests in clinical settings, overlooking its contextual nature. Smartphones and wearables enable ecologically valid, repeated measurements of cognition and daily life behaviors that may impact it. We examined whether sleep duration, step count, and smartphone screen time are associated with cognitive functioning in MDD.</div><div>We conducted secondary analyses of RADAR-MDD, a multicenter study following individuals with recurrent MDD. Cognitive functioning – self-reported and performance-based – was assessed with the THINC-it® app. Sleep duration and step count were measured with Fitbit devices, and screen time with the RADAR-Base app. Cognitive assessments (outcomes) were linked to behavioral measures (predictors) from the day of and the day preceding each assessment. Two-level multilevel models estimated between-person (differences in participant means) and within-person (deviations from participant means) effects. The sample included 502 participants, further subdivided by behavior–cognitive outcome pair.</div><div>For performance-based cognitive assessments, positive associations at the between-person level were found for step count (β = 0.104, SE = 0.031, p &lt; 0.001) and screen time (β = 0.075, SE = 0.036, p = 0.038), and sleep duration showed a quadratic negative effect (β = −0.080, SE = 0.018, p &lt; 0.001). No within-person effects were detected. For self-reported cognitive functioning, step count showed positive associations both between (β = 0.161, SE = 0.037, p &lt; 0.001) and within persons (β = 0.027, SE = 0.010, p = 0.005), while screen time was negatively associated within persons (β = −0.033, SE = 0.011, p = 0.002).</div><div>Our findings illustrate that smartphones and wearables can collect meaningful daily life data of MDD patients that can be used to support cognitive health. Step count emerges as a promising behavioral target as it is simple to track and is correlated with better cognitive outcomes.</div></div>","PeriodicalId":100952,"journal":{"name":"Neuroscience Applied","volume":"5 ","pages":"Article 106985"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147328986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Old enough to be a model? On the role of maturity in stem cell-based models for neuropsychiatric disorders 到当模特的年龄了吗?基于干细胞的神经精神疾病模型成熟度的作用
Pub Date : 2026-01-01 Epub Date: 2026-01-22 DOI: 10.1016/j.nsa.2026.106982
Bingqing He , Erik Smedler
Mental disorders profoundly influence cognition, emotion, and self-perception, and collectively represent a major cause of global disability. Their onset spans distinct developmental periods, from early childhood in neurodevelopmental conditions such as autism spectrum disorder, through adolescence in eating and obsessive-compulsive disorders, to early adulthood in bipolar disorder and schizophrenia. Twin and family studies have established that these disorders are substantially heritable, and large-scale genomic analyses have identified numerous common and rare risk variants. Yet, the biological mechanisms through which genetic and environmental factors converge to shape disease trajectories remain elusive. Patient-derived induced pluripotent stem cells (iPSCs) have emerged as a promising tool for investigating disease-relevant mechanisms in human neurons and neural circuits. However, most iPSC-derived neural cells and organoids resemble embryonic/fetal-stage brain tissue in both molecular and functional characteristics, raising questions about their relevance for disorders that manifest later in life. In this narrative review, we discuss how developmental timing, both in disease onset and in cellular models, shapes the interpretation of iPSC-based findings. We outline how differences in neuronal maturity may constrain or enable mechanistic insight, summarize emerging methods for accelerating or extending neuronal aging in vitro, and consider how leveraging developmental immaturity might illuminate early pathogenic processes underlying mental disorders.
精神障碍深刻地影响认知、情感和自我感知,并共同构成全球残疾的主要原因。它们的发病跨越了不同的发育时期,从儿童早期的自闭症谱系障碍等神经发育疾病,到青少年时期的饮食和强迫症,再到成年早期的双相情感障碍和精神分裂症。双胞胎和家族研究已经确定,这些疾病基本上是遗传的,大规模的基因组分析已经确定了许多常见和罕见的风险变异。然而,遗传和环境因素汇聚形成疾病轨迹的生物学机制仍然难以捉摸。患者来源的诱导多能干细胞(iPSCs)已成为研究人类神经元和神经回路中疾病相关机制的一种有前途的工具。然而,大多数ipsc衍生的神经细胞和类器官在分子和功能特征上与胚胎/胎儿期脑组织相似,这就提出了它们与生命后期出现的疾病是否相关的问题。在这篇叙述性综述中,我们讨论了疾病发病和细胞模型中的发育时间如何影响ipsc研究结果的解释。我们概述了神经元成熟度的差异如何限制或使机制洞察成为可能,总结了体外加速或延长神经元衰老的新方法,并考虑了如何利用发育不成熟来阐明精神障碍的早期致病过程。
{"title":"Old enough to be a model? On the role of maturity in stem cell-based models for neuropsychiatric disorders","authors":"Bingqing He ,&nbsp;Erik Smedler","doi":"10.1016/j.nsa.2026.106982","DOIUrl":"10.1016/j.nsa.2026.106982","url":null,"abstract":"<div><div>Mental disorders profoundly influence cognition, emotion, and self-perception, and collectively represent a major cause of global disability. Their onset spans distinct developmental periods, from early childhood in neurodevelopmental conditions such as autism spectrum disorder, through adolescence in eating and obsessive-compulsive disorders, to early adulthood in bipolar disorder and schizophrenia. Twin and family studies have established that these disorders are substantially heritable, and large-scale genomic analyses have identified numerous common and rare risk variants. Yet, the biological mechanisms through which genetic and environmental factors converge to shape disease trajectories remain elusive. Patient-derived induced pluripotent stem cells (iPSCs) have emerged as a promising tool for investigating disease-relevant mechanisms in human neurons and neural circuits. However, most iPSC-derived neural cells and organoids resemble embryonic/fetal-stage brain tissue in both molecular and functional characteristics, raising questions about their relevance for disorders that manifest later in life. In this narrative review, we discuss how developmental timing, both in disease onset and in cellular models, shapes the interpretation of iPSC-based findings. We outline how differences in neuronal maturity may constrain or enable mechanistic insight, summarize emerging methods for accelerating or extending neuronal aging <em>in vitro</em>, and consider how leveraging developmental immaturity might illuminate early pathogenic processes underlying mental disorders.</div></div>","PeriodicalId":100952,"journal":{"name":"Neuroscience Applied","volume":"5 ","pages":"Article 106982"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146077727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Psychostimulant and addictive effects of α-PiHP and MDPiHP, two novel second-generation synthetic cathinones 第二代新合成卡西酮α-PiHP和MDPiHP的精神兴奋和成瘾作用
Pub Date : 2026-01-01 Epub Date: 2026-01-02 DOI: 10.1016/j.nsa.2025.105536
M.D. Pazos , X. Berzosa , J. Camarasa , D. Pubill , E. Escubedo , N. Nadal-Gratacós , R. López-Arnau
{"title":"Psychostimulant and addictive effects of α-PiHP and MDPiHP, two novel second-generation synthetic cathinones","authors":"M.D. Pazos ,&nbsp;X. Berzosa ,&nbsp;J. Camarasa ,&nbsp;D. Pubill ,&nbsp;E. Escubedo ,&nbsp;N. Nadal-Gratacós ,&nbsp;R. López-Arnau","doi":"10.1016/j.nsa.2025.105536","DOIUrl":"10.1016/j.nsa.2025.105536","url":null,"abstract":"","PeriodicalId":100952,"journal":{"name":"Neuroscience Applied","volume":"5 ","pages":"Article 105536"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145872521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploring the potential role of metabolic equivalents of physical activity in ADHD patients with and without substance use disorder 探索身体活动的代谢当量在伴有或不伴有物质使用障碍的ADHD患者中的潜在作用
Pub Date : 2026-01-01 Epub Date: 2026-01-02 DOI: 10.1016/j.nsa.2025.105533
P. Bauco , R.M. Fatica , F. Tassi , M. Servasi , L. Orsolini , U. Volpe
{"title":"Exploring the potential role of metabolic equivalents of physical activity in ADHD patients with and without substance use disorder","authors":"P. Bauco ,&nbsp;R.M. Fatica ,&nbsp;F. Tassi ,&nbsp;M. Servasi ,&nbsp;L. Orsolini ,&nbsp;U. Volpe","doi":"10.1016/j.nsa.2025.105533","DOIUrl":"10.1016/j.nsa.2025.105533","url":null,"abstract":"","PeriodicalId":100952,"journal":{"name":"Neuroscience Applied","volume":"5 ","pages":"Article 105533"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145872528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prenatal and early postnatal immune activation and supplementation with lactiplantibacillus plantarum modify adult mouse behavioural response to lipopolysaccharide immunostimulation 产前和产后早期免疫激活和补充植物乳杆菌可改变成年小鼠对脂多糖免疫刺激的行为反应
Pub Date : 2026-01-01 Epub Date: 2026-01-02 DOI: 10.1016/j.nsa.2025.105557
A. Ottomana , A. Racca , M.A. Marconi , N. Battista , A. Corsetti , N. Ciano Albanese , G. Calamandrei , L. Ricceri
{"title":"Prenatal and early postnatal immune activation and supplementation with lactiplantibacillus plantarum modify adult mouse behavioural response to lipopolysaccharide immunostimulation","authors":"A. Ottomana ,&nbsp;A. Racca ,&nbsp;M.A. Marconi ,&nbsp;N. Battista ,&nbsp;A. Corsetti ,&nbsp;N. Ciano Albanese ,&nbsp;G. Calamandrei ,&nbsp;L. Ricceri","doi":"10.1016/j.nsa.2025.105557","DOIUrl":"10.1016/j.nsa.2025.105557","url":null,"abstract":"","PeriodicalId":100952,"journal":{"name":"Neuroscience Applied","volume":"5 ","pages":"Article 105557"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145868852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Accelerated biological aging in bipolar disorder as determined by artificial intelligence-based electrocardiographic assessment 基于人工智能的心电图评估确定双相情感障碍的加速生物衰老
Pub Date : 2026-01-01 Epub Date: 2026-01-02 DOI: 10.1016/j.nsa.2025.105588
A. Miola , B.J. Medina-Inojosa , A.B. Cuellar-Barboza , M.L. Prieto , R.J. Morgan , B.J. Coombes , M. Veldic , A. Ozerdem , B. Singh , M. Gardea-Reséndez , M. Ercis , L. Suarez Pardo , F. Romo-Nava , S.L. McElroy , J.M. Biernacka , J.R. Medina-Inojosa , K.M. Lara–Breitinger , M.A. Frye , F. Lopez-Jimenez
{"title":"Accelerated biological aging in bipolar disorder as determined by artificial intelligence-based electrocardiographic assessment","authors":"A. Miola ,&nbsp;B.J. Medina-Inojosa ,&nbsp;A.B. Cuellar-Barboza ,&nbsp;M.L. Prieto ,&nbsp;R.J. Morgan ,&nbsp;B.J. Coombes ,&nbsp;M. Veldic ,&nbsp;A. Ozerdem ,&nbsp;B. Singh ,&nbsp;M. Gardea-Reséndez ,&nbsp;M. Ercis ,&nbsp;L. Suarez Pardo ,&nbsp;F. Romo-Nava ,&nbsp;S.L. McElroy ,&nbsp;J.M. Biernacka ,&nbsp;J.R. Medina-Inojosa ,&nbsp;K.M. Lara–Breitinger ,&nbsp;M.A. Frye ,&nbsp;F. Lopez-Jimenez","doi":"10.1016/j.nsa.2025.105588","DOIUrl":"10.1016/j.nsa.2025.105588","url":null,"abstract":"","PeriodicalId":100952,"journal":{"name":"Neuroscience Applied","volume":"5 ","pages":"Article 105588"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145868885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Promoting brain health across the lifespan: Socioeconomic burden, global recommendations, and the Spanish national plan 促进整个生命周期的大脑健康:社会经济负担、全球建议和西班牙国家计划
Pub Date : 2026-01-01 Epub Date: 2025-12-17 DOI: 10.1016/j.nsa.2025.106879
Verónica Robles , Meritxell Valentí , Mar Mendibe , Álvaro Hidalgo , Fernanda Albamonte , Esther Berrocoso , Monica Lara , Rosa Calvo , Cristina López , Ojas Deshpande , Helena Palma-Gudiel , Guillermo Benito , Marina Díaz Marsa , Mara Parellada , Mara Dierssen , Spanish Brain Council
Neurological and mental health disorders substantially reduce life expectancy and represent a major public health and socioeconomic burden in Europe, accounting for a significant proportion of disability and productivity loss. In Spain, conditions affecting brain health are among the most costly chronic diseases, representing nearly 8 % of the national gross domestic product. In response to this growing challenge, and in line with the World Health Organization's definition of brain health as a life-course concept encompassing cognitive, emotional, behavioral, and motor functioning, several European countries have developed national brain plans under the coordination and advocacy of the European Brain Council.
This white paper presents the Spanish Brain Plan, a national, policy-oriented framework designed to promote brain health across the lifespan through prevention, early detection, evidence-based treatment, integrated care, and research coordination. The document aims to (i) synthesize current evidence on the burden of brain disorders in Spain, (ii) identify structural gaps in research, care, and data infrastructures, and (iii) propose strategic priorities aligned with European and international brain health initiatives. The Spanish Brain Plan is situated within the broader landscape of existing European national brain plans, enabling cross-country comparison and shared learning. The manuscript was developed through expert consultation within the Spanish Brain Council, complemented by a review of current scientific literature, policy documents, and international frameworks. By articulating a coordinated, science-based strategy, this white paper seeks to support policymakers, clinicians, researchers, and patient stakeholders in advancing brain health as a national and European public health priority.
神经和精神疾病大大缩短了预期寿命,是欧洲公共卫生和社会经济的主要负担,在残疾和生产力损失中占很大比例。在西班牙,影响大脑健康的疾病是最昂贵的慢性病之一,占全国国内生产总值的近8%。为了应对这一日益严峻的挑战,并根据世界卫生组织将大脑健康定义为一个涵盖认知、情感、行为和运动功能的生命过程概念,一些欧洲国家在欧洲大脑理事会的协调和倡导下制定了国家大脑计划。本白皮书介绍了西班牙大脑计划,这是一个国家政策导向的框架,旨在通过预防、早期发现、循证治疗、综合护理和研究协调,促进整个生命周期的大脑健康。该文件旨在(i)综合目前关于西班牙脑部疾病负担的证据,(ii)确定研究、护理和数据基础设施方面的结构性差距,以及(iii)提出与欧洲和国际脑健康倡议相一致的战略优先事项。西班牙大脑计划位于现有欧洲国家大脑计划的更广阔的范围内,使跨国比较和共享学习成为可能。该手稿是通过西班牙大脑委员会的专家咨询制定的,并辅以对当前科学文献、政策文件和国际框架的审查。通过阐明协调一致的、以科学为基础的战略,本白皮书旨在支持政策制定者、临床医生、研究人员和患者利益相关者将大脑健康作为国家和欧洲公共卫生的优先事项来推进。
{"title":"Promoting brain health across the lifespan: Socioeconomic burden, global recommendations, and the Spanish national plan","authors":"Verónica Robles ,&nbsp;Meritxell Valentí ,&nbsp;Mar Mendibe ,&nbsp;Álvaro Hidalgo ,&nbsp;Fernanda Albamonte ,&nbsp;Esther Berrocoso ,&nbsp;Monica Lara ,&nbsp;Rosa Calvo ,&nbsp;Cristina López ,&nbsp;Ojas Deshpande ,&nbsp;Helena Palma-Gudiel ,&nbsp;Guillermo Benito ,&nbsp;Marina Díaz Marsa ,&nbsp;Mara Parellada ,&nbsp;Mara Dierssen ,&nbsp;Spanish Brain Council","doi":"10.1016/j.nsa.2025.106879","DOIUrl":"10.1016/j.nsa.2025.106879","url":null,"abstract":"<div><div>Neurological and mental health disorders substantially reduce life expectancy and represent a major public health and socioeconomic burden in Europe, accounting for a significant proportion of disability and productivity loss. In Spain, conditions affecting brain health are among the most costly chronic diseases, representing nearly 8 % of the national gross domestic product. In response to this growing challenge, and in line with the World Health Organization's definition of brain health as a life-course concept encompassing cognitive, emotional, behavioral, and motor functioning, several European countries have developed national brain plans under the coordination and advocacy of the European Brain Council.</div><div>This <strong>white paper</strong> presents the <strong>Spanish Brain Plan</strong>, a national, policy-oriented framework designed to promote brain health across the lifespan through prevention, early detection, evidence-based treatment, integrated care, and research coordination. The document aims to (i) synthesize current evidence on the burden of brain disorders in Spain, (ii) identify structural gaps in research, care, and data infrastructures, and (iii) propose strategic priorities aligned with European and international brain health initiatives. The Spanish Brain Plan is situated within the broader landscape of existing European national brain plans, enabling cross-country comparison and shared learning. The manuscript was developed through expert consultation within the Spanish Brain Council, complemented by a review of current scientific literature, policy documents, and international frameworks. By articulating a coordinated, science-based strategy, this white paper seeks to support policymakers, clinicians, researchers, and patient stakeholders in advancing brain health as a national and European public health priority.</div></div>","PeriodicalId":100952,"journal":{"name":"Neuroscience Applied","volume":"5 ","pages":"Article 106879"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145925521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Neuroscience Applied
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1