Neuroscience Applied最新文献

英文中文

Exploring the molecular basis of treatment-resistant depression: Discoveries from a rat model and psilocybin therapy 探索耐药性抑郁症的分子基础：大鼠模型和迷幻药疗法的发现

Neuroscience Applied

Pub Date : 2024-01-01 DOI: 10.1016/j.nsa.2024.104020

A. Korlatowicz , K. Latocha , P. Pabian , R. Bugno , A. Hogendorf , T. Kovács , A.J. Bojarski , Z. Varga , A. Faron-Górecka

引用次数: 0

Graphene nanoparticles: An innovative approach to preventing α-synuclein aggregations in diverse neuron types 石墨烯纳米粒子：防止α-突触核蛋白在不同类型神经元中聚集的创新方法

Neuroscience Applied

Pub Date : 2024-01-01 DOI: 10.1016/j.nsa.2024.104034

A. Alwani , K. Maziarz , M. Figiel , M. Kujawska , P. Chmielarz

引用次数: 0

Social dysfunction is associated with altered facial emotion neural processing across diverse neuropsychiatric disorders 社交功能障碍与各种神经精神疾病的面部情绪神经处理改变有关

Neuroscience Applied

Pub Date : 2024-01-01 DOI: 10.1016/j.nsa.2024.103977

S. Braak , G. Bakker , T. Su , Y. Pijnenburg , A.V. Campos , A. De la Torre-Luque , A. Beckenstrom , A. Malik , G.R. Dawson , H. Marston , J. Alvarez-Linera , J.L. Ayuso-Mateos , C. Arango , M.J. Van Tol , N. Van der Wee , M.J. Kas , M. Aghajani , B.W.J.H. Penninx

引用次数: 0

Anxiolytic-like and activating effect of a novel mRNA m6A methylation activator in the rat 一种新型 mRNA m6A 甲基化激活剂对大鼠的抗焦虑和激活作用

Neuroscience Applied

Pub Date : 2024-01-01 DOI: 10.1016/j.nsa.2024.103978

I. Teino , M. Kanarik , K. Liiver , M. Školnaja , T. Org , K. Laugus , R. Shimmo , M. Karelson , M. Saarma , J. Harro

引用次数: 0

Characterizing the effects of psychedelics and polydrug abuse on the blood-brain barrier properties 描述迷幻剂和多种药物滥用对血脑屏障特性的影响

Neuroscience Applied

Pub Date : 2024-01-01 DOI: 10.1016/j.nsa.2024.104021

R. Alarcão , V. Neves , A.M. Sebastião

引用次数: 0

Role of histone deacetylases in neuroplasticity impairments and inflammation in major depression 组蛋白去乙酰化酶在重度抑郁症的神经可塑性损伤和炎症中的作用

Neuroscience Applied

Pub Date : 2024-01-01 DOI: 10.1016/j.nsa.2024.104081

A. Garayo-Larrea , A. Azqueta , R.M. Tordera

This paper critically reviews the interesting and extensive knowledge regarding the role of some HDACs in major depression. MD is associated with neuroplasticity failure and inflammatory events, in which, several histone deacetylase (HDACs) enzymes play a key role. Specifically, increased expression of specific HDACs are linked to depressive-like behaviour, repress the expression of the brain derived neurotrophic factor (BDNF), and induce a pro-inflammatory response. Conversely, other HDACs exert an antidepressant action, promote dendritic growth and protect neurons or immune cells from inflammatory events. The right balance between both types is needed to respond correctly to the different physiological/pathological stimuli. However, aberrant expressions or activities of specific HDACs could be associated with MD. Further studies should identify the mechanism by which MD regulates specific HDAC subtypes both in post-mortem brain tissue and in peripheral immune cells.

本文对有关某些 HDACs 在重度抑郁症中的作用的有趣而广泛的知识进行了评论。重度抑郁症与神经可塑性衰竭和炎症事件有关，其中，几种组蛋白去乙酰化酶（HDACs）发挥着关键作用。具体来说，特定 HDACs 的表达增加与抑郁样行为有关，会抑制脑源性神经营养因子（BDNF）的表达，并诱发促炎反应。相反，其他 HDACs 则具有抗抑郁作用，促进树突生长，保护神经元或免疫细胞免受炎症事件的影响。要正确应对不同的生理/病理刺激，就必须在这两种类型之间取得适当的平衡。然而，特定 HDACs 的异常表达或活性可能与 MD 有关。进一步的研究应确定 MD 在死后脑组织和外周免疫细胞中调节特定 HDAC 亚型的机制。

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引用次数: 0

Social isolation during adolescence causes increased generalised anxiety-like behaviour in male rats and increased sociability in male and female rats 青春期的社会隔离会导致雄性大鼠的广泛焦虑行为增加，并提高雄性和雌性大鼠的交际能力

Neuroscience Applied

Pub Date : 2024-01-01 DOI: 10.1016/j.nsa.2024.104068

Marina Manojlović , Filip Milosavljević , Andrea Atanasov , Bojan Batinić , Pavle Sitarica , Vesna Pešić , Marin M. Jukić

As one of the main characteristics of adolescence is the increased desire for social interaction and formation of meaningful relationships, it represents a particularly vulnerable period for social stressors. Moreover, social isolation during adolescence can significantly alter brain function and increase the likelihood of anxiety disorders in early adulthood. The aim of this retrospective meta-analysis and prospective behavioural experiment was to investigate whether chronic isolation stress during adolescence causes generalised and social anxiety-like behaviour in rodents. The meta-analysis of previously published data showed that social isolation during adolescence leads to an increase in generalised anxiety-like behaviour exclusively in male isolated rodents and has ambiguous effect on social anxiety-like behaviour. In the subsequent prospective experiment, Sprague-Dawley rats of both sexes were subjected to six weeks of social isolation and their behaviour was investigated in the open field, elevated plus maze, and three-chamber test. Consistent with the retrospective literature analysis, social isolation in adolescence increased generalised anxiety-like behaviour exclusively in males, as indicated by a decrease in time spent in the centre of the open field and open arms of the elevated plus maze, compared to controls. Both male and female isolated rats showed an increase in sociability in the three-chamber test, as indicated by the increase in the preference ratio for social versus neutral stimuli, compared to controls. Altogether, social isolation leads to an increase in generalised anxiety-like behaviour exclusively in males and to increased sociability in both males and females.

青春期的主要特征之一是对社会交往和建立有意义的人际关系的渴望日益强烈，因此这个时期特别容易受到社会压力的影响。此外，青春期的社会隔离会显著改变大脑功能，增加成年早期患焦虑症的可能性。这项回顾性荟萃分析和前瞻性行为实验旨在研究青春期的长期隔离压力是否会导致啮齿类动物出现类似社交焦虑的广泛行为。对以前发表的数据进行的荟萃分析表明，青春期的社会隔离只会导致雄性被隔离啮齿动物的广泛性焦虑样行为增加，而对社会焦虑样行为的影响则不明确。在随后的前瞻性实验中，Sprague-Dawley雌雄大鼠均接受了为期六周的社会隔离，并在开放场地、高架加迷宫和三室试验中对它们的行为进行了调查。与回顾性文献分析一致的是，与对照组相比，雄性大鼠在开阔地中心和高架迷宫开阔臂所花费的时间减少，这表明青春期的社会隔离会增加其广泛的焦虑行为。与对照组相比，雄性和雌性被隔离大鼠在三室试验中的社会性都有所增强，这表现在对社会性刺激和中性刺激的偏好比率增加。总之，社会隔离只会导致雄性大鼠的广泛焦虑行为增加，而雄性和雌性大鼠的交际能力都会增加。

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引用次数: 0

BehavioUral profiling predicts vulnerability and resilience to stress exposure 行为特征分析可预测面对压力时的脆弱性和复原力

Neuroscience Applied

Pub Date : 2024-01-01 DOI: 10.1016/j.nsa.2024.104016

F. Marsili , G. Matte Bon , A. Viglione , C. Delli Colli , S. Poggini , I. Branchi

引用次数: 0

Positive allosteric modulation of α5 GABAA receptors effects on binge eating and hyperactivity in two-hit model 在两击模型中，α5 GABAA 受体的正异构调节对暴食和多动的影响

Neuroscience Applied

Pub Date : 2024-01-01 DOI: 10.1016/j.nsa.2024.104018

K. Mirković , J. Aranđelović , J. Kojić , B. Batinić , B. Divović Matović , M. Savić

引用次数: 0

Impact of maternal microbiome disruption on early-life brain barriers: insights from caesarean-section offspring 母体微生物群紊乱对生命早期大脑屏障的影响：剖腹产后代的启示

Neuroscience Applied

Pub Date : 2024-01-01 DOI: 10.1016/j.nsa.2024.104039

V. Turpin , A. Cergneux , L. Morales , J. Morael , H. Blair , A. Ratsika , J. Shearer , C. Tessier , E. Cintado , J.F. Cryan , M.R. Aburto

引用次数: 0

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