Revista de Psiquiatría y Salud Mental (English Edition)最新文献

英文中文

Is intensive home-treatment a real alternative to classical hospitalization for managing acute psychiatric processes? Insights from clinical practice 强化家庭治疗是治疗急性精神疾病的传统住院治疗的真正替代方案吗?临床实践感悟

Revista de Psiquiatría y Salud Mental (English Edition)

Pub Date : 2022-07-01 DOI: 10.1016/j.rpsmen.2022.09.009

Ana Martín-Blanco , Laura Calvo-Saiz , Jacopo Baccarin , Alba González-Fernández , Alejandro Keymer-Gausset , Sara Vieira-Costa , Núria Ribas-Fitó , Carles Garcia-Ribera

引用次数: 0

The effect of occupation on the incidence of vascular dementia: A 12-year follow-up cohort study 职业对血管性痴呆发病率的影响:一项12年随访队列研究

Revista de Psiquiatría y Salud Mental (English Edition)

Pub Date : 2022-07-01 DOI: 10.1016/j.rpsmen.2022.09.007

Ana Cristina Gracia-Rebled , Raúl Lopez-Anton , Concepción Tomás , Elena Lobo , Guillermo Marcos , Antonio Lobo , Javier Santabárbara

Introduction

Vascular dementia (DV) is the second cause of dementia with 15.8-20% of cases. Previous studies of the effect of occupation in DV do not show conclusive results, therefore, the objective was to analyze if the type of occupation can vary the risk of developing DV in those older than 55 years.

Material and methods

In the ZARADEMP project, a community sample of 4,803 individuals were followed longitudinally in four waves. The occupation was classified following the National Classification of Occupations (CNO-11) and the International Standard Classification of Occupations (ISCO-08). Different standardized instruments were used: the medical and psychiatric histories (History and Aetiology Schedule) and other risk factors (Mini-Mental Status Examination, Geriatric Mental State-AGECAT). For this study, we calculated incidence rates, incidence rate ratios and hazard ratios in multivariate Cox regression models, stratified by gender. For this study, we included 3,883 participants.

Results

In women, the risk of DV was doubled in Blue-collar workers, with a moderate effect (Cohen’s d = 0.54) and multiplying by 2.7 in Homeworks respect to White Collar with a moderate effect (Cohen's d = 0.77), although they did not reach statistical significance. We did not observe the effect of occupation on the risk of DV in men.

Conclusions

We have found a moderate but non-significant effect between occupation and DV risk in women. We found no effect of occupation on the risk of VD in males while other clinical factors (age, diabetes or body mass index) presented a clearer effect than the occupation.

血管性痴呆(DV)是痴呆的第二大原因，占15.8-20%。先前关于职业对家庭暴力的影响的研究没有得出结论性的结果，因此，本研究的目的是分析职业类型是否会改变55岁以上家庭暴力的发生风险。材料和方法在ZARADEMP项目中，对4803人的社区样本进行了四波纵向跟踪。该职业按照国家职业分类(CNO-11)和国际标准职业分类(ISCO-08)进行分类。使用不同的标准化工具:医疗和精神病史(病史和病因表)和其他危险因素(迷你精神状态检查，老年精神状态agecat)。在本研究中，我们计算了按性别分层的多变量Cox回归模型中的发病率、发病率比和风险比。在这项研究中，我们纳入了3883名参与者。结果在女性中，蓝领工人患家庭暴力的风险是中等影响的两倍(Cohen’s d = 0.54)，而在家庭作业方面，白领工人患家庭暴力的风险是中等影响的2.7倍(Cohen’s d = 0.77)，尽管两者没有达到统计学意义。我们没有观察到职业对男性家庭暴力风险的影响。结论我们发现职业与女性家庭暴力风险之间存在中等但不显著的影响。我们发现职业对男性患VD的风险没有影响，而其他临床因素(年龄、糖尿病或体重指数)的影响比职业更明显。

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引用次数: 0

ECT: A decision to decrease risks during COVID-19 pandemic 等:决定在COVID-19大流行期间降低风险

Revista de Psiquiatría y Salud Mental (English Edition)

Pub Date : 2022-04-01 DOI: 10.1016/j.rpsmen.2021.04.002

Miguel Martinez-Roig, Jose Alfonso Arilla-Aguilella, Maria Carmen Bono-Ariño, Raquel Rolando-Urbizu, Argia Arriola-Segura

引用次数: 0

Another Godot who is still not coming: More on biomarkers for depression 另一个尚未到来的戈多:更多关于抑郁症的生物标志物

Revista de Psiquiatría y Salud Mental (English Edition)

Pub Date : 2022-04-01 DOI: 10.1016/j.rpsmen.2022.07.005

Milena Čukić , Danka Savić

引用次数: 0

Increase in urgent care for patients with an eating disorder during the COVID-19 pandemic in a Spanish province 西班牙某省在COVID-19大流行期间增加了对饮食失调患者的紧急护理

Revista de Psiquiatría y Salud Mental (English Edition)

Pub Date : 2022-04-01 DOI: 10.1016/j.rpsmen.2022.07.002

María Irigoyen-Otiñano , Ana González-Pinto , Vicent Llorca-Bofí , Marina Adrados-Pérez , Laura Arenas-Pijoan , Giovanni Torterolo , Marta Sánchez-Cazalilla , Esther Buil , Eugènia Nicolau-Subires , Carla Albert-Porcar , Lucía Ibarra-Pertusa , Margarita Puigdevall-Ruestes

Introduction

The COVID-19 pandemic has had a great impact on people's mental health. Patients with eating disorders (ED) are also highly sensitive to the pandemic situation due to their physical and mental health. The objective of this study is to evaluate the impact that the COVID-19 pandemic may have had on the reasons for the urgent care of patients with an eating disorder, comparing the reasons for care with those from a previous period.

Method

We compared the visits to the emergency room and their characteristics before and after the pandemic of patients with an eating disorder in the province of Lleida. Information regarding sociodemographic status, reason for consultation, diagnosis, characteristics of suicidal behaviour, and other data were obtained from the electronic medical records.

Results

Within the total emergency attendances, eating disorders increased from 1.7% in the pre-pandemic period to 3.1% during the pandemic (p = 0.030). Regarding the reason for consultation, a change in the pattern is observed, decreasing consultations for anxious decompensation (p < 0.001) and increasing suicidal behaviour (p = 0.016) and behavioural disorder (p = 0.022).

Conclusions

In our study we ascertained an increase in urgent care given to patients with an eating disorder during the two states of alarm, while consultations for anxiety symptoms decreased notably. However, care for suicidal behaviour increased, especially in women with comorbidity of personality disorders and who were unemployed.

2019冠状病毒病大流行对人们的心理健康产生了巨大影响。饮食失调患者由于身心健康，对疫情也高度敏感。本研究的目的是评估COVID-19大流行可能对饮食失调患者紧急护理的原因产生的影响，并将护理原因与前一时期的原因进行比较。方法比较利莱达省饮食失调患者大流行前后急诊室就诊情况及特点。从电子病历中获得了有关社会人口状况、咨询原因、诊断、自杀行为特征和其他数据的信息。结果在急诊总就诊人数中，饮食失调从大流行前的1.7%上升到大流行期间的3.1% (p = 0.030)。关于咨询的原因，观察到模式的变化，减少咨询焦虑失代偿(p <0.001)，自杀行为(p = 0.016)和行为障碍(p = 0.022)的增加。结论:在我们的研究中，我们确定了在两种警报状态下对饮食失调患者的紧急护理增加，而对焦虑症状的咨询明显减少。然而，对自杀行为的护理增加了，特别是在患有人格障碍和失业的妇女中。

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引用次数: 1

COVID-19 mortality and its relationship with internet searches on mental health during the first year of pandemic COVID-19死亡率及其与大流行第一年互联网心理健康搜索的关系

Revista de Psiquiatría y Salud Mental (English Edition)

Pub Date : 2022-04-01 DOI: 10.1016/j.rpsmen.2022.06.002

Juan Antonio Becerra-García, Teresa Sánchez-Gutiérrez, Sara Barbeito Resa, Ana Calvo Calvo

引用次数: 1

Improving the effectiveness of electroconvulsive therapy through the determination of anaesthetic depth. Preliminary results 通过麻醉深度的确定提高电休克治疗的有效性。初步结果

Revista de Psiquiatría y Salud Mental (English Edition)

Pub Date : 2022-04-01 DOI: 10.1016/j.rpsmen.2021.07.004

Òscar Alcoverro-Fortuny , Ferran Viñas Usan , Carmen Elena Sanabria , José Emilio Rojo Rodes

引用次数: 0

Ketamine triggers rapid antidepressant effects by modulating synaptic plasticity in a new depressive-like mouse model based on astrocyte glutamate transporter GLT-1 knockdown in infralimbic cortex 在一种基于边缘下皮层星形胶质细胞谷氨酸转运体GLT-1敲低的新抑郁样小鼠模型中，氯胺酮通过调节突触可塑性触发快速抗抑郁作用

Revista de Psiquiatría y Salud Mental (English Edition)

Pub Date : 2022-04-01 DOI: 10.1016/j.rpsmen.2022.06.008

M. Neus Fullana , Verónica Paz , Francesc Artigas , Analia Bortolozzi

Objective

Recently, we reported on a new MDD-like mouse model based on a regionally selective knockdown of astroglial glutamate transporters, GLAST/GLT-1, in infralimbic cortex (IL) which evokes widespread changes in mouse brain associated with the typical alterations found in MDD patients. To further characterize this new MDD-like mouse model, here we examine some transcriptional elements of glutamatergic/GABAergic neurotransmission and neuroplasticity in forebrain regions in the GLT-1 knockdown mice. Furthermore, we assess the acute ketamine effects on these transcriptional processes.

Material and methods

We used a small interfering RNA (siRNA) pool targeting GLT-1 mRNA to disrupt the GLT-1 transcription in mouse IL. Histological assays were performed to examine postsynaptic density protein-95 (PSD95), neuritin (NRN), glutamine acid descarboxilase-65 (GAD65), and GLT-1 mRNA expression in IL and hippocampus.

Results

Knockdown of GLT-1 in mouse IL leads to decreased expression of PSD95 and NRN neuroplasticity mRNAs in IL and hippocampus, which was reversed by an acute dose of ketamine antidepressant. Likewise, a single dose of ketamine also increased the mRNA levels of GAD65 and GLT-1 in IL of GLT-1 knockdown mice, reaching the basal values of control mice.

Conclusions

The glutamatergic neuronal hyperactivity and deficits in the GABA system resulting from siRNA-induced astroglial glutamate transporter knockdown in IL can compromise the integrity/plasticity of neurocircuits affected in MDD. Suitable depressive-like animal models to address the neurobiological changes in MDD are an unmet need and the development of the GLAST/GLT-1 knockdown mouse model may represent a better option to understand the rapid-acting antidepressant effects of ketamine.

最近，我们报道了一种新的MDD样小鼠模型，该模型基于边缘下皮层(IL)星形胶质谷氨酸转运体GLAST/GLT-1的区域选择性敲除，该模型引起了小鼠大脑中与MDD患者中发现的典型改变相关的广泛变化。为了进一步表征这种新的mdd样小鼠模型，我们研究了GLT-1敲除小鼠前脑区域谷氨酸能/ gaba能神经传递和神经可塑性的一些转录因子。此外，我们评估了氯胺酮对这些转录过程的急性影响。材料和方法采用靶向GLT-1 mRNA的小干扰RNA (siRNA)池破坏小鼠IL中GLT-1的转录。采用组织学方法检测突触后密度蛋白-95 (PSD95)、神经素(NRN)、谷氨酰胺脱羧酶-65 (GAD65)以及IL和海马中GLT-1 mRNA的表达。结果小鼠IL中GLT-1表达下调可导致IL和海马中PSD95和NRN神经可塑性mrna表达降低，急性剂量氯胺酮抗抑郁药可逆转这一趋势。同样，单剂量氯胺酮也使GLT-1敲低小鼠IL中GAD65和GLT-1 mRNA水平升高，达到对照小鼠的基础水平。结论sirna诱导IL中星形胶质细胞谷氨酸转运蛋白敲低导致的谷氨酸能神经元过度活跃和GABA系统缺陷可损害MDD中受影响的神经回路的完整性/可塑性。合适的抑郁样动物模型来解决重度抑郁症的神经生物学变化是一个未被满足的需求，GLAST/GLT-1敲低小鼠模型的开发可能是了解氯胺酮速效抗抑郁作用的更好选择。

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引用次数: 0

The KDM6B mutation: Phenotype and clinical characteristics—Report of a case KDM6B突变:表型和临床特征- 1例报告

Revista de Psiquiatría y Salud Mental (English Edition)

Pub Date : 2022-04-01 DOI: 10.1016/j.rpsmen.2022.06.005

Inmaculada Insa Pineda , Cristina Luz Gómez González

Introduction

Alterations in the genes of lysine methylation as Lysine-specific demethylase 6B (KDM6B) have been associated with multiple neurodevelopmental disorders. Until now, there are few cases in the literature attributed to KDM6B mutations. This gap may be due to the fact that the exome sequencing technique is still being implemented in routine clinical practice.

Material and methods

A case is presented with its clinical and phenotypic characteristics. The sequence exome analysis was done with the Nimblegen SeqCap EZ MedExome capture kit + mtDNA 47Mb. The psychopathological approach from mental health was carried out through individual and family interviews, the Conner's questionnaires, ADHD rating scale, as well as the psychometry.

Results

A frameshift variant in the KDM6B gene related to neurodevelopmental disorders with facial and body dysmorphia was obtained. The case was oriented as a neurodevelopmental disorder secondary to a genetic alteration and a comorbid Attention Deficit Hyperactivity Disorder (ADHD).

Conclusions

The clinical peculiarities shared by patients identified with the KDM6B mutation, raises the need to recognize it as a particular entity. The possibility of applying the exome sequencing technique to patients with syndromic phenotype and developmental impairment may clarify its etiopathogenesis. It is highly probable that the complexity of these cases requires an approach by a multidisciplinary team that includes genetics, neurology and psychiatry, among other specialties. The coordinated approach is essential to have a comprehensive vision of the case.

赖氨酸甲基化基因作为赖氨酸特异性去甲基化酶6B (KDM6B)的改变与多种神经发育障碍有关。到目前为止，文献中很少有病例归因于KDM6B突变。这种差距可能是由于外显子组测序技术仍在常规临床实践中实施。材料与方法报告1例患者的临床和表型特征。序列外显子组分析使用Nimblegen SeqCap EZ MedExome捕获试剂盒+ mtDNA 47Mb进行。心理健康的精神病理学方法通过个人和家庭访谈、Conner's问卷、ADHD评定量表以及心理测量法进行。结果获得了一个与面部和身体畸形相关的神经发育障碍KDM6B基因移码变异。该病例被定位为继发于遗传改变的神经发育障碍和共病的注意缺陷多动障碍(ADHD)。结论KDM6B突变患者的临床特征表明，有必要将其视为一种特殊的实体。将外显子组测序技术应用于综合征表型和发育障碍患者的可能性可能阐明其发病机制。这些病例的复杂性很可能需要一个多学科团队的方法，包括遗传学、神经病学和精神病学，以及其他专业。协调一致的方法对于全面了解情况至关重要。

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引用次数: 1

Precuneus and insular hypoactivation during cognitive processing in first-episode psychosis: Systematic review and meta-analysis of fMRI studies 首发精神病认知加工过程中的楔前叶和岛叶失活:功能磁共振成像研究的系统回顾和荟萃分析

Revista de Psiquiatría y Salud Mental (English Edition)

Pub Date : 2022-04-01 DOI: 10.1016/j.rpsmen.2022.06.004

Pau Soldevila-Matías , Anton Albajes-Eizagirre , Joaquim Radua , Gracián García-Martí , José M. Rubio , Diana Tordesillas-Gutierrez , Inmaculada Fuentes-Durá , Aleix Solanes , Lydia Fortea , Dominic Oliver , Julio Sanjuán

Introduction

The neural correlates of the cognitive dysfunction in first-episode psychosis (FEP) are still unclear. The present review and meta-analysis provide an update of the location of the abnormalities in the fMRI-measured brain response to cognitive processes in individuals with FEP.

Methods

Systematic review and voxel-based meta-analysis of cross-sectional fMRI studies comparing neural responses to cognitive tasks between individuals with FEP and healthy controls (HC) according to PRISMA guidelines.

Results

Twenty-six studies were included, comprising 598 individuals with FEP and 567 HC. Individual studies reported statistically significant hypoactivation in the dorsolateral prefrontal cortex (6 studies), frontal lobe (8 studies), cingulate (6 studies) and insula (5 studies). The meta-analysis showed statistically significant hypoactivation in the left anterior insula, precuneus and bilateral striatum.

Conclusions

While the studies tend to highlight frontal hypoactivation during cognitive tasks in FEP, our meta-analytic results show that the left precuneus and insula primarily display aberrant activation in FEP that may be associated with salience attribution to external stimuli and related to deficits in perception and regulation.

首发精神病(FEP)中认知功能障碍的神经相关机制尚不清楚。本综述和荟萃分析提供了fmri测量的FEP患者大脑对认知过程反应异常位置的最新信息。方法系统回顾和基于体素的横断面fMRI研究，比较FEP患者和健康对照(HC)根据PRISMA指南对认知任务的神经反应。结果共纳入26项研究，其中FEP患者598例，HC患者567例。个别研究报告了背外侧前额叶皮层(6项研究)、额叶(8项研究)、扣带(6项研究)和脑岛(5项研究)的活性降低具有统计学意义。荟萃分析显示，左前叶岛、楔前叶和双侧纹状体的活性降低具有统计学意义。虽然研究倾向于强调FEP认知任务中额叶失活，但我们的meta分析结果显示，左侧楔前叶和脑岛在FEP中主要表现出异常激活，这可能与外部刺激的显著性归因有关，并与感知和调节缺陷有关。

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