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Sensitivity and specificity of DSM-5 diagnostic criteria for autism spectrum disorder in a child and adolescent sample 儿童和青少年自闭症谱系障碍的DSM-5诊断标准的敏感性和特异性
Pub Date : 2021-10-01 DOI: 10.1016/j.rpsmen.2019.10.005
Ana Blázquez Hinojosa , Luisa Lázaro Garcia , Olga Puig Navarro , Eva Varela Bondelle , Rosa Calvo Escalona

Background

Controversy exists regarding the DSM-5 criteria for autism spectrum disorders (ASD). Given the mixed results that have been reported, our main aim was to determine DSM-5 sensitivity and specificity in a child and adolescent Spanish sample. As secondary goals, we assessed the diagnostic stability of DSM-IV-TR in DSM-5, and clinical differences between children diagnosed with an ASD or a social (pragmatic) communication disorder (SPCD).

Methods

This study was carried out in 2017, reviewing the medical records of patients evaluated in our service. Items from a parent report measure of ASD symptoms (Autism Diagnostic Interview-Revised) were matched to DSM-5 criteria and used to assess the sensitivity and specificity of the DSM-5 criteria and current DSM-IV criteria when compared with clinical diagnoses.

Results

DSM-5 sensitivity ranged from .69 to 1.00, and was higher in females. By age, the DSM-5 and DSM-IV-TR criteria showed similar sensitivity. In the case of intellectual quotient, DSM-5 criteria sensitivity was lower for those in the “low-functioning” category. DSM-5 specificity ranged from .64 to .73, while DSM-5 specificity was similar for all phenotypic subgroups. With respect to stability, 83.3% of autism disorder cases retained a diagnosis of ASD using the DSM-5 criteria. With regard to differences between ASD and SPCD, we found that patients diagnosed with ASD received more pharmacological treatment than those diagnosed with SPCD.

Conclusions

Further research is required to confirm our results. Studies focusing on the SPCD phenotype will be necessary to determine outcome differences with ASD and the most effective diagnostic and therapeutic tools.

关于自闭症谱系障碍(ASD)的DSM-5标准存在争议。鉴于已报道的混合结果,我们的主要目的是确定DSM-5在儿童和青少年西班牙样本中的敏感性和特异性。作为次要目标,我们评估了DSM-IV-TR在DSM-5中的诊断稳定性,以及诊断为ASD或社会(实用)沟通障碍(SPCD)的儿童之间的临床差异。方法本研究于2017年开展,回顾我院所评估患者的病历。来自ASD症状的家长报告测量项目(自闭症诊断访谈-修订版)与DSM-5标准相匹配,并用于评估DSM-5标准和现行DSM-IV标准与临床诊断相比的敏感性和特异性。结果dsm -5的敏感性在0.69 ~ 1.00之间,女性较高。按年龄划分,DSM-5和DSM-IV-TR标准的敏感性相似。在智商的情况下,DSM-5标准对“低功能”类别的人的敏感度较低。DSM-5的特异性范围从0.64到0.73,而DSM-5的特异性在所有表型亚组中相似。在稳定性方面,83.3%的自闭症病例保留了使用DSM-5标准诊断的ASD。关于ASD和SPCD之间的差异,我们发现ASD患者比SPCD患者接受更多的药物治疗。结论需要进一步的研究来证实我们的结果。研究集中在SPCD表型将是必要的,以确定与ASD的结果差异和最有效的诊断和治疗工具。
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引用次数: 0
Lithium toxicity: The SILENT threat 锂中毒:无声的威胁
Pub Date : 2021-10-01 DOI: 10.1016/j.rpsmen.2021.11.001
Álvaro Martínez-Martín , Álvaro Sánchez-Larsen , Carolina Sánchez-Mora , Rocío Sáez-Povedano , Tomás Segura
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引用次数: 1
Depression in late life: Linking the immunometabolic dysregulation with clinical features 晚年抑郁:免疫代谢失调与临床特征的联系
Pub Date : 2021-10-01 DOI: 10.1016/j.rpsmen.2021.06.001
Alejandro de la Torre-Luque , Jose Luis Ayuso-Mateos
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引用次数: 0
Real clinical setting intravenous ketamine use for treatment resistant depression: 12 month follow-up after initial response 真实临床背景静脉注射氯胺酮治疗难治性抑郁症:初步反应后12个月随访
Pub Date : 2021-10-01 DOI: 10.1016/j.rpsmen.2021.11.004
Nora Olazabal , Sonia Bustamante , M. Aranzazu Madrazo , Luis Osa , Ana M. O’Neill of Tyrone , Ana Catalán , Miguel Angel González-Torres
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引用次数: 0
Psychiatric patients are more vulnerable to the Spanish euthanasia law? 精神病患者更容易受到西班牙安乐死法的影响?
Pub Date : 2021-10-01 DOI: 10.1016/j.rpsmen.2021.01.001
Adrián Alacreu-Crespo , Lucas Giner , Philippe Courtet
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引用次数: 0
Obsessive–compulsive symptoms in anxiety and depressive disorders: Influence of recent and/or traumatic life events 焦虑和抑郁障碍中的强迫症状:近期和/或创伤性生活事件的影响
Pub Date : 2021-10-01 DOI: 10.1016/j.rpsmen.2020.12.002
Arantxa Orozco , Narcís Cardoner , Cristina F. Aragón , Salvador Ruiz-Murugarren , María Vicens , Miguel Ángel Álvarez-Mon , Guillermo Lahera

Introduction

A high prevalence of obsessive–compulsive symptoms (OCSs) in anxiety-depressive disorders ranging from 30 to 67% has been described.

Objective

This study aims to assess the presence and persistence of OCSs in an outpatient sample of subjects with anxiety and depressive disorders, as well as its relationship with recent life events (RLEs) and/or traumatic experiences (TEs).

Method

We conducted a prospective, observational, analytical study of 200 subjects with DSM-5 diagnoses of anxiety and/or depression. Participants were included by consecutive sampling and were evaluated at baseline and after 6–12 months (mean 8.5 months) of follow-up. The severity of the symptoms was assessed through the Hamilton Anxiety Scale (HARS) and Hamilton Scale for the evaluation of depression (HRSD-17), and comorbidity was assessed through the International Neuropsychiatric Interview (MINI). The Revised Inventory of Obsessions and Compulsions (OCI-R), the Recent Vital Changes Questionnaire (CVSV), and the Diagnostic Scale for Post-Traumatic Stress (PDS) were also administered.

Results

54% of the sample presented OCSs, and 30.5% presented one or more TEs throughout life. At the baseline visit, the presence of OCSs was associated with the severity of depressive symptoms (p = 0.028), the presence of TEs (p < 0.01), symptoms of post-traumatic stress disorder (p < 0.01) and the number of RLEs (p < 0.01). Response rate at follow-up was 38%, and persistence of OCSs was found in 60.5% of patients, independent of depressive or anxious symptoms, but was associated with the number of RLEs (p < 0.01).

Conclusion

The presence of OCSs in patients with anxiety and depressive disorders is frequent and persistent. Anxious-depressive patients with a history of TEs and RLEs had higher OCS levels. These findings highlight the importance of early detection and the use of therapeutic strategies focused on resilience to stress and trauma.

据报道,焦虑抑郁障碍中强迫症(OCSs)的患病率很高,从30%到67%不等。目的本研究旨在评估门诊焦虑症和抑郁症患者OCSs的存在和持续性,以及其与近期生活事件(RLEs)和/或创伤经历(TEs)的关系。方法对200名DSM-5诊断为焦虑和/或抑郁的受试者进行前瞻性、观察性、分析性研究。参与者通过连续抽样纳入,并在基线和6-12个月(平均8.5个月)随访后进行评估。通过汉密尔顿焦虑量表(HARS)和汉密尔顿抑郁评估量表(HRSD-17)评估症状严重程度,通过国际神经精神病学访谈(MINI)评估合并症。同时进行强迫强迫修正量表(OCI-R)、近期生命变化问卷(CVSV)和创伤后应激诊断量表(PDS)。结果54%的患者出现过OCSs, 30.5%的患者一生中出现过一次或多次TEs。基线访视时,OCSs的存在与抑郁症状的严重程度相关(p = 0.028), TEs的存在与抑郁症状的严重程度相关(p <0.01),创伤后应激障碍症状(p <0.01)和RLEs数量(p <0.01)。随访有效率为38%,60.5%的患者持续存在OCSs,与抑郁或焦虑症状无关,但与RLEs次数有关(p <0.01)。结论焦虑抑郁障碍患者出现OCSs的频率和持续性较高。有TEs和RLEs病史的焦虑抑郁患者OCS水平较高。这些发现强调了早期发现和使用治疗策略的重要性,重点是对压力和创伤的恢复能力。
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引用次数: 0
Screening for anxiety and depression in Primary Care: Utility of 2 brief scales adapted to the ICD-11-PC 初级保健中焦虑和抑郁的筛查:适用于ICD-11-PC的2个简短量表的应用
Pub Date : 2021-10-01 DOI: 10.1016/j.rpsmen.2019.12.004
Celso Iglesias García , Pilar López García , José Luis Ayuso Mateos , José Ángel García , Julio Bobes

Introduction

The World Health Organization has developed a new classification of mental disorders in Primary Health Care (PHC), the ICD-11-PHC, in which there are changes in the diagnostic criteria of anxiety and depression disorder. In addition, 2 screening instruments have been developed for the detection of anxious and depressive symptoms according to the criteria of the new classification.

Objectives

To evaluate the capacity of the Spanish version of the 2 brief scales Dep5 and Anx5 to identify cases of depression and anxiety in PHC in Spain.

Method

A cross-sectional study conducted by 37 PHC physicians who selected 284 patients with suspected emotional distress. This sample was administered the screening scales (Anx5 and Dep5) and a diagnostic instrument (Clinical Interview Schedule-Revised) contemplating the new ICD-11 criteria as used as gold standard.

Results

The Anx5, using a cut-off point of 3, showed a sensitivity of 0.75 and specificity of 0.53. Using a cut-off point of 4, the Dep5 showed a sensitivity of 0.48 and a specificity of 0.8. The 2 scales together, with a cut-off point of 3 for each, classified correctly 73,57% as cases or non-cases. The diagnosis most frequently observed was anxious depression.

Conclusions

The screening scales for anxious and depressive symptoms (Anx5 and Dep5) are simple and easy-to-use instruments for assessing anxious and depressive symptoms in PHC. The reliability and validity data of each of the scales separately are limited but the figures improve when they are used together.

世界卫生组织制定了一项新的初级卫生保健(PHC)精神障碍分类,即ICD-11-PHC,其中对焦虑和抑郁症的诊断标准进行了修改。此外,根据新分类标准,开发了2种检测焦虑和抑郁症状的筛查工具。目的评价西班牙语版Dep5和Anx5简易量表对西班牙PHC患者抑郁和焦虑的识别能力。方法37名初级保健医生选取284例疑似情绪困扰患者进行横断面研究。对该样本进行筛查量表(Anx5和Dep5)和诊断工具(临床访谈计划-修订),考虑将新的ICD-11标准作为金标准。结果Anx5的灵敏度为0.75,特异性为0.53,截断点为3。采用截断点4,Dep5的敏感性为0.48,特异性为0.8。这两个量表加在一起,每个分界点为3,正确地将73,57%分类为病例或非病例。最常见的诊断是焦虑性抑郁。结论焦虑抑郁症状筛查量表(Anx5和Dep5)是评估PHC患者焦虑抑郁症状的简单易行的工具。每个量表单独使用的信度和效度数据都是有限的,但它们一起使用时,数据得到了改善。
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引用次数: 2
Waiting for Godot or the use of biomarkers in clinical practice 等待戈多或生物标志物在临床实践中的应用
Pub Date : 2021-07-01 DOI: 10.1016/j.rpsmen.2021.07.003
Emilio Fernández-Egea
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引用次数: 0
Predictive value of prolactin in first episode psychosis at ten years follow-up 催乳素对首发精神病10年随访的预测价值
Pub Date : 2021-07-01 DOI: 10.1016/j.rpsmen.2020.10.002
Manuel Delgado-Alvarado , Javier Vázquez-Bourgon , Rosa Ayesa-Arriola , Victor Ortiz-García de la Foz , Jacqueline Mayoral-van Son , Javier Labad , Benedicto Crespo-Facorro
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引用次数: 0
Four-subtest short-form of the WAIS-IV for assessment of patients diagnosed with schizophrenia 用于评估被诊断为精神分裂症的患者的WAIS-IV的四亚测试简写
Pub Date : 2021-07-01 DOI: 10.1016/j.rpsmen.2019.12.003
Carmen Dasí , Inmaculada Fuentes-Durá , Juan C. Ruiz , Marisa Navarro

Introduction

The present study aimed to obtain a short form of the Spanish version of the WAIS-IV for patients diagnosed with schizophrenia that requires about half an hour to be administered. The reduced test can be very useful in clinical and research settings when an estimation of the intelligence quotient (IQ) is required to decide about intervention programs or to describe the sample.

Materials and methods

A sample of 143 patients participated in the study, 91 out of them were the test group, and the other 52 were used for a cross-validation analysis. To increase the content validity, the decision was made to create a short form composed of a subtest of each of the four cognitive domains that the scale measures.

Results

Several analyses showed that the best combination was composed of the Information, Block Design, Arithmetic, and Symbol Search subtests. Nine different criteria were calculated to evaluate the quality of the short form.

Conclusions

The data showed very good results for the criteria: correlations, difference of means, and cross-validation. The results were satisfactory for: category agreement, band of error, clinical accuracy, and reliability.

本研究旨在获得一种简短的西班牙语版本的WAIS-IV,用于诊断为精神分裂症的患者,需要大约半小时的时间来给药。在临床和研究环境中,当需要对智商(IQ)的估计来决定干预方案或描述样本时,简化测试非常有用。材料与方法本研究共纳入143例患者,其中试验组91例,其余52例进行交叉验证分析。为了提高内容的效度,我们决定创建一个简短的表格,由量表测量的四个认知领域中的每个领域的子测试组成。结果分析表明,信息测试、块设计测试、算术测试和符号搜索测试的组合效果最好。计算了九种不同的标准来评估短文的质量。结论数据在相关性、均数差异、交叉验证等标准上均取得了较好的结果。结果令人满意:分类一致性,误差范围,临床准确性和可靠性。
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引用次数: 0
期刊
Revista de Psiquiatría y Salud Mental (English Edition)
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