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In time: misuse and overuse of amino acid formulas in cow milk allergy 及时:牛奶中氨基酸配方的误用和过度使用引起过敏
Pub Date : 2015-12-01 DOI: 10.1016/j.rppede.2015.09.001
Jon A. Vanderhoof
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引用次数: 0
Changes in physical fitness and nutritional status of schoolchildren in a period of 30 years (1980–2010) 1980-2010年30年间小学生体质和营养状况的变化
Pub Date : 2015-12-01 DOI: 10.1016/j.rppede.2015.03.001
Gerson Luis de Moraes Ferrari , Victor Keihan Rodrigues Matsudo , Mauro Fisberg

Objective

To analyze and compare the changes in physical fitness according to the nutritional status and gender of schoolchildren during a period of 30 years (1980–2010).

Methods

Four cross-sectional evaluations were performed every 10 years in a period of 30 years from 1978 to 1980 (baseline), 1988–1990 (10 years), 1998–2000 (20 years) and 2008–2010 (30 years). The sample consisted of 1291 schoolchildren (188 in baseline, 307 in 10 years; 375 in 20 years; 421 in 30 years) of 10 and 11 years old. The variables assessed were: body weight (kg), height (cm), upper limb strength (ULS; kg), lower limb strength (LLS; cm), agility (seconds) and velocity (seconds). Schoolchildren were classified as normal weight and overweight according to World Health Organization reference of body mass index for age and gender. Comparisons among periods applied ANOVA followed by Bonferroni test, with a significance level set at of p<0.01. Variation between baseline and 30 years was assessed by the percentage delta. Seven different percentile values were presented for each variable.

Results

In eutrophic boys and girls, mean values of ULS (−16.7%; −3.2%), agility (−1.5%; −1.6%) decreased significantly after 30 years (p<0.001). In the overweight boys and girls, only the average ULS (−15.5%; −12.5%) decreased significantly over time (p<0.001). After 30 years, the ULS percentile changed in boys.

Conclusions

The decline in physical fitness was greater in schoolchildren with normal weight than in those with overweight.

目的分析比较1980-2010年30年间小学生营养状况和性别对体质变化的影响。方法在1978 - 1980年(基线)、1988-1990年(10年)、1998-2000年(20年)和2008-2010年(30年)的30年间,每10年进行4次横断面评价。样本包括1291名学童(基线188人,10年307人;20年375人;421岁(30岁),10岁和11岁。评估的变量为:体重(kg)、身高(cm)、上肢力量(ULS);kg),下肢力量(LLS;敏捷性(秒)和速度(秒)。根据世界卫生组织参照年龄和性别的体重指数,将学童分为正常体重和超重。期间间比较采用方差分析,然后进行Bonferroni检验,显著性水平设为p<0.01。基线和30年之间的变化通过百分比增量来评估。每个变量有7个不同的百分位数。结果富营养化男孩和女孩的ULS平均值(- 16.7%;−3.2%),敏捷性(−1.5%;−1.6%)在30年后显著下降(p<0.001)。在超重的男孩和女孩中,只有平均ULS (- 15.5%;−12.5%)随着时间的推移显著下降(p<0.001)。30年后,男孩的ULS百分比发生了变化。结论体重正常学童体质下降幅度大于超重学童。
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引用次数: 0
Speech and language disorders in children from public schools in Belo Horizonte 贝洛奥里藏特公立学校儿童的语言障碍
Pub Date : 2015-12-01 DOI: 10.1016/j.rppede.2015.08.008
Alessandra Terra Vasconcelos Rabelo, Fernanda Rodrigues Campos, Clarice Passos Friche, Bárbara Suelen Vasconcelos da Silva, Amélia Augusta de Lima Friche, Claudia Regina Lindgren Alves, Lúcia Maria Horta de Figueiredo Goulart

Objective

To investigate the prevalence of oral language, orofacial motor skill and auditory processing disorders in children aged 4–10 years and verify their association with age and gender.

Methods

Cross-sectional study with stratified, random sample consisting of 539 students. The evaluation consisted of three protocols: orofacial motor skill protocol, adapted from the Myofunctional Evaluation Guidelines; the Child Language Test ABFW – Phonology; and a simplified auditory processing evaluation. Descriptive and associative statistical analyses were performed using Epi Info software, release 6.04. Chi-square test was applied to compare proportion of events and analysis of variance was used to compare mean values. Significance was set at p≤0.05.

Results

Of the studied subjects, 50.1% had at least one of the assessed disorders; of those, 33.6% had oral language disorder, 17.1% had orofacial motor skill impairment, and 27.3% had auditory processing disorder. There were significant associations between auditory processing skills’ impairment, oral language impairment and age, suggesting a decrease in the number of disorders with increasing age. Similarly, the variable “one or more speech, language and hearing disorders” was also associated with age.

Conclusions

The prevalence of speech, language and hearing disorders in children was high, indicating the need for research and public health efforts to cope with this problem.

目的了解4 ~ 10岁儿童口头语言、口面运动技能和听觉加工障碍的患病率,并验证其与年龄和性别的关系。方法横断面分层随机抽样539名学生。评估包括三个方案:口面部运动技能方案,改编自肌功能评估指南;儿童语言测试ABFW -音系学以及一个简化的听觉处理评价。采用Epi Info软件6.04版进行描述性和关联性统计分析。事件比例比较采用卡方检验,均值比较采用方差分析。p≤0.05为显著性。研究对象中,50.1%至少有一种评估障碍;其中,33.6%患有口头语言障碍,17.1%患有口面部运动技能障碍,27.3%患有听觉加工障碍。听觉处理技能障碍、口头语言障碍与年龄之间存在显著关联,表明障碍的数量随着年龄的增长而减少。同样,变量“一种或多种言语、语言和听力障碍”也与年龄有关。结论儿童言语、语言和听力障碍的患病率较高,表明需要研究和公共卫生努力来应对这一问题。
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引用次数: 0
Early introduction of food to prevent food allergy. The LEAP study (Learning Early about Peanut) 尽早引入食物,防止食物过敏。LEAP研究(尽早了解花生)
Pub Date : 2015-12-01 DOI: 10.1016/j.rppede.2015.08.015
Nelson Rosário Filho
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引用次数: 0
Beta 2-adrenergic receptor gene association with overweight and asthma in children and adolescents and its relationship with physical fitness - 2-肾上腺素能受体基因与儿童和青少年超重和哮喘的关系及其与身体健康的关系
Pub Date : 2015-12-01 DOI: 10.1016/j.rppede.2015.08.006
Neiva Leite, Leilane Lazarotto, Gerusa Eisfeld Milano, Ana Claudia Kapp Titski, Cássio Leandro Mühe Consentino, Fernanda de Mattos, Fabiana Antunes de Andrade, Lupe Furtado-Alle

Objective

To investigate the association of Arg16Gly and Gln27Glu polymorphisms of β2-adrenergic receptor gene (ADRB2) with the occurrence of asthma and overweight and the gene's influence on anthropometric, clinic, biochemical and physical fitness variables in children and adolescents.

Methods

Subjects were evaluated for allelic frequencies of the β2-adrenergic receptor gene, height, weight, body mass index (BMI), BMI Z-score, waist circumference (WC), pubertal stage, resting heart rate (HRres), blood pressure (BP), total cholesterol (TC), glucose, insulin, high density lipoprotein (HDL-C), low density lipoprotein (LDL-C), triglyceride (TG), Homeostasis Metabolic Assessment (HOMA2-IR), Quantitative Insulin Sensitivity Check Index (QUICKI) and maximal oxygen uptake (VO2max). The participants were divided in four groups: overweight asthmatic (n=39), overweight non-asthmatic (n=115), normal weight asthmatic (n=12), and normal weight non-asthmatic (n=40).

Results

Regarding the Gln27Glu polymorphism, higher total cholesterol was observed in usual genotype individuals than in genetic variant carriers (p=0.04). No evidence was found that the evaluated polymorphisms are influencing the physical fitness. The Arg16 allele was found more frequently among the normal weight asthmatic group when compared to the normal weight non-asthmatic group (p=0.02), and the Glu27 allele was more frequently found in the overweight asthmatics group when compared to the normal weight non-asthmatic group (p=0.03).

Conclusions

The association of Arg16 allele with the occurrence of asthma and of the Glu27 allele with overweight asthmatic adolescents evidenced the contribution of the β2-adrenergic receptor gene to the development of obesity and asthma.

目的探讨儿童青少年β2-肾上腺素能受体基因(ADRB2) Arg16Gly和Gln27Glu多态性与哮喘和超重发生的关系及其对人体测量、临床、生化和体质指标的影响。方法测定受试者的β2-肾上腺素能受体基因等位基因频率、身高、体重、体重指数(BMI)、BMI z评分、腰围(WC)、青春期阶段、静息心率(HRres)、血压(BP)、总胆固醇(TC)、葡萄糖、胰岛素、高密度脂蛋白(HDL-C)、低密度脂蛋白(LDL-C)、甘油三酯(TG)、稳态代谢评估(HOMA2-IR)、胰岛素敏感性定量检查指数(QUICKI)和最大摄氧量(VO2max)。参与者被分为四组:超重哮喘患者(n=39)、超重非哮喘患者(n=115)、正常体重哮喘患者(n=12)和正常体重非哮喘患者(n=40)。结果在Gln27Glu多态性方面,普通基因型个体的总胆固醇高于变异基因携带者(p=0.04)。没有证据表明所评估的多态性影响身体健康。Arg16等位基因在正常体重哮喘组的出现频率高于正常体重非哮喘组(p=0.02), Glu27等位基因在超重哮喘组的出现频率高于正常体重非哮喘组(p=0.03)。结论Arg16等位基因与哮喘的发生有关,Glu27等位基因与超重哮喘青少年的发生有关,证明β2-肾上腺素能受体基因与肥胖和哮喘的发生有关。
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引用次数: 0
Prevalence of excessive screen time and associated factors in adolescents 青少年屏幕时间过长及其相关因素的流行程度
Pub Date : 2015-12-01 DOI: 10.1016/j.rppede.2015.08.014
Joana Marcela Sales de Lucena , Luanna Alexandra Cheng , Thaísa Leite Mafaldo Cavalcante , Vanessa Araújo da Silva , José Cazuza de Farias Júnior

Objective

To determine the prevalence of excessive screen time and to analyze associated factors among adolescents.

Methods

This was a cross-sectional school-based epidemiological study with 2874 high school adolescents with age 14–19 years (57.8% female) from public and private schools in the city of João Pessoa, PB, Northeast Brazil. Excessive screen time was defined as watching television and playing video games or using the computer for more than 2 h/day. The associated factors analyzed were: sociodemographic (gender, age, economic class, and skin color), physical activity and nutritional status of adolescents.

Results

The prevalence of excessive screen time was 79.5% (95%CI 78.1–81.1) and it was higher in males (84.3%) compared to females (76.1%; p<0.001). In multivariate analysis, adolescent males, those aged 14-15 year old and the highest economic class had higher chances of exposure to excessive screen time. The level of physical activity and nutritional status of adolescents were not associated with excessive screen time.

Conclusions

The prevalence of excessive screen time was high and varied according to sociodemographic characteristics of adolescents. It is necessary to develop interventions to reduce the excessive screen time among adolescents, particularly in subgroups with higher exposure.

目的了解青少年屏幕时间过长情况,并分析相关因素。方法对巴西东北部约奥佩索阿市公立和私立学校2874名14-19岁的高中青少年(57.8%为女性)进行基于学校的横断面流行病学研究。过度使用屏幕时间被定义为每天看电视、玩视频游戏或使用电脑超过2小时。相关因素分析为:社会人口统计学(性别、年龄、经济阶层和肤色)、青少年的身体活动和营养状况。结果屏幕时间过长的患病率为79.5% (95%CI 78.1-81.1),男性(84.3%)高于女性(76.1%;术中,0.001)。在多变量分析中,青少年男性、14-15岁的青少年和经济水平最高的阶层更有可能接触过多的屏幕时间。青少年的身体活动水平和营养状况与屏幕时间过长无关。结论青少年屏幕时间过长患病率较高,且因其社会人口学特征而异。有必要制定干预措施,以减少青少年,特别是接触较多的亚组中过多的屏幕时间。
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引用次数: 17
Family presence during pediatric invasive procedures and resuscitation 儿科侵入性手术和复苏中的家庭存在
Pub Date : 2015-12-01 DOI: 10.1016/j.rppede.2015.08.001
Amélia Gorete Reis
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引用次数: 0
Safety of human papillomavirus 6, 11, 16 and 18 (recombinant): systematic review and meta-analysis 人乳头瘤病毒6,11,16和18(重组)的安全性:系统评价和荟萃分析
Pub Date : 2015-12-01 DOI: 10.1016/j.rppede.2015.08.017
Pedro Luiz Spinelli Coelho , Gustavo Lacerda da Silva Calestini , Fernando Salgueiro Alvo , Jefferson Michel de Moura Freitas , Paula Marcela Vilela Castro , Tulio Konstantyner

Objective

To identify and quantify the adverse effects associated with the recombinant human papillomavirus (types 6, 11, 16 and 18) vaccine in adolescents.

Data source

Systematic review of randomized clinical trials from PubMed, SciELO and Lilacs databases. Articles investigating the safety of the vaccine in subjects under 18 years and comparing the recombinant human papillomavirus types 6, 11, 16 and 18 vaccine with a control group were included. Meta-analyses were performed for the outcomes of pain, erythema, swelling and fever, using clinical trials with maximum Jadad score.

Data synthesis

Fourteen studies were included. The most common adverse effects related to the human papillomavirus vaccine were effects with no severity (pain, erythema, edema, and fever). Five studies were used for the meta-analyses: pain–risk difference (RD)=11% (p<0.001); edema–RD=8% (p<0.001); erythema–RD=5% (p<0.001); fever–RD=2% (p<0.003).

Conclusions

The recombinant human papillomavirus types 6, 11, 16 and 18 vaccine was safe and well tolerated. The main adverse effects related to vaccination were pain, erythema, edema and fever. The low frequency of severe adverse effects encourages the administration of the vaccine in the population at risk.

目的鉴定和量化重组人乳头瘤病毒(6型、11型、16型和18型)疫苗在青少年中的不良反应。数据来源对PubMed、SciELO和Lilacs数据库中随机临床试验的系统评价。研究了该疫苗在18岁以下人群中的安全性,并将重组人乳头瘤病毒6、11、16和18型疫苗与对照组进行了比较。采用Jadad评分最高的临床试验,对疼痛、红斑、肿胀和发热的结果进行meta分析。数据综合纳入14项研究。与人乳头瘤病毒疫苗相关的最常见不良反应是无严重程度的不良反应(疼痛、红斑、水肿和发烧)。5项研究用于荟萃分析:疼痛风险差异(RD)=11% (p<0.001);edema-RD = 8%(术中,0.001);erythema-RD = 5%(术中,0.001);fever-RD = 2%(术中,0.003)。结论重组人乳头瘤病毒6、11、16、18型疫苗安全、耐受性良好。与接种疫苗有关的主要不良反应是疼痛、红斑、水肿和发热。严重不良反应的低频率鼓励在高危人群中接种疫苗。
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引用次数: 0
Clinical evolution and nutritional status in asthmatic children and adolescents enrolled in Primary Health Care 在初级卫生保健登记的哮喘儿童和青少年的临床演变和营养状况
Pub Date : 2015-12-01 DOI: 10.1016/j.rppede.2015.08.007
Rosinha Yoko Matsubayaci Morishita, Maria Wany Louzada Strufaldi, Rosana Fiorini Puccini

Objective

To evaluate the clinical evolution and the association between nutritional status and severity of asthma in children and adolescents enrolled in Primary Health Care.

Methods

A retrospective cohort study of 219 asthmatic patients (3–17 years old) enrolled in Primary Care Services (PCSs) in Embu das Artes (SP), from 2007 to 2011. Secondary data: gender, age, diagnosis of asthma severity, other atopic diseases, family history of atopy, and body mass index. To evaluate the clinical outcome of asthma, data were collected on number of asthma exacerbations, number of emergency room consultations and doses of inhaled corticosteroids at follow-up visits in the 6th and 12th months. The statistical analysis included chi-square and Kappa agreement index, with 5% set as the significance level.

Results

50.5% of patients started wheezing before the age of 2 years, 99.5% had allergic rhinitis and 65.2% had a positive family history of atopy. Regarding severity, intermittent asthma was more frequent (51.6%) and, in relation to nutritional status, 65.8% of patients had normal weight. There was no association between nutritional status and asthma severity (p=0.409). After 1 year of follow-up, 25.2% of patients showed reduction in exacerbations and emergency room consultations, and 16.2% reduced the amount of inhaled corticosteroids.

Conclusions

The monitoring of asthmatic patients in Primary Care Services showed improvement in clinical outcome, with a decreased number of exacerbations, emergency room consultations and doses of inhaled corticosteroids. No association between nutritional status and asthma severity was observed in this study.

目的评价在初级卫生保健机构登记的儿童和青少年哮喘的临床演变及营养状况与哮喘严重程度的关系。方法回顾性队列研究2007 - 2011年在Embu das Artes (SP)初级保健服务(PCSs)就诊的219例哮喘患者(3-17岁)。次要资料:性别、年龄、哮喘严重程度诊断、其他特应性疾病、特应性家族史和体重指数。为了评估哮喘的临床结果,收集了6个月和12个月随访期间哮喘发作次数、急诊室就诊次数和吸入皮质类固醇剂量的数据。结果50.5%的患者在2岁前出现喘息,99.5%的患者有变应性鼻炎,65.2%的患者有特应性家族史。就严重程度而言,间歇性哮喘更为常见(51.6%),而就营养状况而言,65.8%的患者体重正常。营养状况与哮喘严重程度无相关性(p=0.409)。经过1年的随访,25.2%的患者病情恶化和急诊室就诊减少,16.2%的患者吸入皮质类固醇的量减少。结论在初级保健服务中对哮喘患者进行监测,临床结果有所改善,病情加重次数、急诊室就诊次数和吸入皮质类固醇剂量均有所减少。本研究未观察到营养状况与哮喘严重程度之间的关联。
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引用次数: 0
Prevalence and factors associated with the co-occurrence of health risk behaviors in adolescents 青少年健康危险行为的患病率及相关因素
Pub Date : 2015-12-01 DOI: 10.1016/j.rppede.2015.08.011
Anísio Luiz da Silva Brito , Carla Meneses Hardman , Mauro Virgílio Gomes de Barros

Objective

To analyze the prevalence and factors associated with the co-occurrence of health risk behaviors in adolescents.

Methods

A cross-sectional study was performed with a sample of high school students from state public schools in Pernambuco, Brazil (n=4207, 14–19 years old). Data were obtained using a questionnaire. The co-occurrence of health risk behaviors was established based on the sum of five behavioral risk factors (low physical activity, sedentary behavior, low consumption of fruits/vegetables, alcohol consumption and tobacco use). The independent variables were gender, age group, time of day attending school, school size, maternal education, occupational status, skin color, geographic region and place of residence. Data were analyzed by ordinal logistic regression with proportional odds model.

Results

Approximately 10% of adolescents were not exposed to health risk behaviors, while 58.5% reported being exposed to at least two health risk behaviors simultaneously. There was a higher likelihood of co-occurrence of health risk behaviors among adolescents in the older age group, with intermediate maternal education (9–11 years of schooling), and who reported living in the driest (semi-arid) region of the state of Pernambuco. Adolescents who reported having a job and living in rural areas had a lower likelihood of co-occurrence of risk behaviors.

Conclusions

The findings suggest a high prevalence of co-occurrence of health risk behaviors in this group of adolescents, with a higher chance in five subgroups (older age, intermediate maternal education, the ones that reported not working, those living in urban areas and in the driest region of the state).

目的分析青少年健康危险行为的发生率及相关因素。方法以巴西伯南布哥州公立学校高中生为样本(n=4207, 14-19岁)进行横断面研究。通过问卷调查获得数据。健康风险行为的共发生是基于五种行为风险因素(低体力活动、久坐行为、低水果/蔬菜消费、饮酒和吸烟)的总和。自变量为性别、年龄组、上学时间、学校规模、母亲教育程度、职业状况、肤色、地理区域和居住地。采用比例odds模型进行有序logistic回归分析。结果约10%的青少年未暴露于健康危险行为,58.5%的青少年同时暴露于至少两种健康危险行为。在年龄较大、母亲受教育程度中等(9-11年学校教育)、报告生活在伯南布哥州最干旱(半干旱)地区的青少年中,健康风险行为同时发生的可能性更高。报告有工作并生活在农村地区的青少年同时发生危险行为的可能性较低。结论:研究结果表明,在这一青少年群体中,健康风险行为的发生率很高,其中五个亚组(年龄较大、母亲受教育程度中等、报告没有工作、生活在城市地区和该州最干旱地区的青少年)的发生率更高。
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引用次数: 0
期刊
Revista Paulista de Pediatria (English Edition)
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