Pub Date : 2025-01-18DOI: 10.1016/j.supmat.2025.100095
Yu Yin , Wu Wei , Kai Zhang
Chiral mesoporous silica nanoparticles (CMSNs) are a distinct subset of mesoporous silica nanoparticles, combining the favorable physicochemical properties of MSNs with unique chiral architectures at both molecular and macroscopic scales. These helical structures endow CMSNs with specialized functionalities, enabling their applications in chiral catalysis, enantioselective recognition, chiral separation, drug delivery, and optical devices, making them a focal point in materials and biomedical research. Significant progress has been achieved in the synthesis of CMSNs, particularly in understanding the mechanisms of chirality formation and the critical role of surfactant templates in guiding chiral structures. This review summarizes these advancements, emphasizing experimental and theoretical insights. Key applications of CMSNs, especially in drug delivery systems, are explored in detail, highlighting their potential to enhance bioavailability and therapeutic efficacy. Looking ahead, CMSN research presents exciting opportunities, including precise control over chiral structures, the development of novel templating strategies, and the exploration of broader applications. These advancements are expected to drive progress in nanoporous silica technologies and open new frontiers in materials science and nanomedicine.
{"title":"Engineering chiral mesoporous silica nanoparticles: Template design and structural control for advanced applications","authors":"Yu Yin , Wu Wei , Kai Zhang","doi":"10.1016/j.supmat.2025.100095","DOIUrl":"10.1016/j.supmat.2025.100095","url":null,"abstract":"<div><div>Chiral mesoporous silica nanoparticles (CMSNs) are a distinct subset of mesoporous silica nanoparticles, combining the favorable physicochemical properties of MSNs with unique chiral architectures at both molecular and macroscopic scales. These helical structures endow CMSNs with specialized functionalities, enabling their applications in chiral catalysis, enantioselective recognition, chiral separation, drug delivery, and optical devices, making them a focal point in materials and biomedical research. Significant progress has been achieved in the synthesis of CMSNs, particularly in understanding the mechanisms of chirality formation and the critical role of surfactant templates in guiding chiral structures. This review summarizes these advancements, emphasizing experimental and theoretical insights. Key applications of CMSNs, especially in drug delivery systems, are explored in detail, highlighting their potential to enhance bioavailability and therapeutic efficacy. Looking ahead, CMSN research presents exciting opportunities, including precise control over chiral structures, the development of novel templating strategies, and the exploration of broader applications. These advancements are expected to drive progress in nanoporous silica technologies and open new frontiers in materials science and nanomedicine.</div></div>","PeriodicalId":101187,"journal":{"name":"Supramolecular Materials","volume":"4 ","pages":"Article 100095"},"PeriodicalIF":0.0,"publicationDate":"2025-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143101770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-18DOI: 10.1016/j.supmat.2025.100096
Runi Hou, Lijian Xu, Maolin Yu, Zengmin Tang, Bin Zhou, Qiao Zhang, Na Li, Jianxiong Xu
The pursuit of nanogenerators with superior electrical output performance is crucial for advancing high-performance self-powered sensors, yet enhancing their performance through effective strategies remains a formidable challenge. Herein, a kind of piezoelectric-triboelectric hybrid nanogenerator (PTENG) utilizing a tough, stretchable BaTiO3 doped hydrogel was developed. To this end, a functional hydrogel of oxidized sodium alginate (OSA) crosslinked poly(acrylic acid-co-acrylamide) (P(AA-co-AM)) in the presence of BaTiO3 (BTO) nanoparticles was initially prepared and then immersed in FeCl3 solution to form OSA/P(AA-co-AM)/Fe3+-BTO (O/P/Fe-BTO) hydrogels. Due to the multiple interaction (such as dynamic Schiff base cross-linking bond, metal coordination and hydrogen bonding), along with the synergistic contributions of each component, the as-prepared O/P/Fe-BTO hydrogels displayed outstanding mechanical property (tensile stress of 2.14 MPa, tensile strain of 876 %, toughness of 9.96 MJ/m3), good conductivity (0.14 S/m) and excellent antibacterial activity. Subsequently, a kind of PTENG was constructed by employing the O/P/Fe-BTO hydrogels as electrode materials. Leveraging both triboelectric and piezoelectric effects, the PTENG demonstrated excellent electrical output performance (open-circuit voltage of 222 V and short-circuit current of 5.35 μA). As a practical demonstration, the application of PTENG in self-powered strain and tactile sensors was demonstrated, manifesting their promising potential in self-powered sensing system. Overall, this work represents a noteworthy advancement in the domain of self-powered flexible electronics, with the potential for application in a wide range of complex scenarios.
{"title":"Piezoelectric-triboelectric hybrid nanogenerator based on tough, stretchable BaTiO3 doped antibacterial hydrogel for self-powered sensors","authors":"Runi Hou, Lijian Xu, Maolin Yu, Zengmin Tang, Bin Zhou, Qiao Zhang, Na Li, Jianxiong Xu","doi":"10.1016/j.supmat.2025.100096","DOIUrl":"10.1016/j.supmat.2025.100096","url":null,"abstract":"<div><div>The pursuit of nanogenerators with superior electrical output performance is crucial for advancing high-performance self-powered sensors, yet enhancing their performance through effective strategies remains a formidable challenge. Herein, a kind of piezoelectric-triboelectric hybrid nanogenerator (PTENG) utilizing a tough, stretchable BaTiO<sub>3</sub> doped hydrogel was developed. To this end, a functional hydrogel of oxidized sodium alginate (OSA) crosslinked poly(acrylic acid-<em>co</em>-acrylamide) (P(AA-<em>co</em>-AM)) in the presence of BaTiO<sub>3</sub> (BTO) nanoparticles was initially prepared and then immersed in FeCl<sub>3</sub> solution to form OSA/P(AA-<em>co</em>-AM)/Fe<sup>3+</sup>-BTO (O/P/Fe-BTO) hydrogels. Due to the multiple interaction (such as dynamic Schiff base cross-linking bond, metal coordination and hydrogen bonding), along with the synergistic contributions of each component, the as-prepared O/P/Fe-BTO hydrogels displayed outstanding mechanical property (tensile stress of 2.14 MPa, tensile strain of 876 %, toughness of 9.96 MJ/m<sup>3</sup>), good conductivity (0.14 S/m) and excellent antibacterial activity. Subsequently, a kind of PTENG was constructed by employing the O/P/Fe-BTO hydrogels as electrode materials. Leveraging both triboelectric and piezoelectric effects, the PTENG demonstrated excellent electrical output performance (open-circuit voltage of 222 V and short-circuit current of 5.35 μA). As a practical demonstration, the application of PTENG in self-powered strain and tactile sensors was demonstrated, manifesting their promising potential in self-powered sensing system. Overall, this work represents a noteworthy advancement in the domain of self-powered flexible electronics, with the potential for application in a wide range of complex scenarios.</div></div>","PeriodicalId":101187,"journal":{"name":"Supramolecular Materials","volume":"4 ","pages":"Article 100096"},"PeriodicalIF":0.0,"publicationDate":"2025-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143102218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-14DOI: 10.1016/j.supmat.2025.100094
Hui-Shuang Li , Hao-jie Bai , Yi Li , Yuqing Wu
While the studies have revealed that the type and content of ingredients are crucial factors in determining the quality and taste of alcoholic beverages, the liquid-liquid condensed phase of the supramolecular network of ethanol-water clusters (E-Wc) have been demonstrated playing important influence either. The supramolecular clusters in alcoholic beverages, especially the intrinsic hydrogen-bondings (HBs) to organoleptic sensing and quality assessment, have gradually been elucidated recently. The veiling concealed on the supramolecular entities as a key proportion of the ethanol-water solution (E-Ws) starts to be disclosed with the discrete achievements in this research area. To build a full understanding of the cluster driving in versatile alcoholic beverages via unique techniques for characterization, this review summarizes the involved supramolecular E-Wc by fluorescence emission and NMR spectra. In particular, the two-dimensional correlation (2D-COS) analysis has been introduced as a powerful tool for characterizing the important structural profiles in clusters. With the help of carving important supramolecular E-Wc, it is hoped that the prospects and challenges in this field will be clearer and that such kinds of condensed liquid phases can possess the potential as supramolecular material additives to modulate the products with various tastes and quality in the alcoholic industry.
{"title":"Supramolecular ethanol-water clusters in alcoholic beverages: Review on 2D correlation fluorescence and NMR spectral characterizations","authors":"Hui-Shuang Li , Hao-jie Bai , Yi Li , Yuqing Wu","doi":"10.1016/j.supmat.2025.100094","DOIUrl":"10.1016/j.supmat.2025.100094","url":null,"abstract":"<div><div>While the studies have revealed that the type and content of ingredients are crucial factors in determining the quality and taste of alcoholic beverages, the liquid-liquid condensed phase of the supramolecular network of ethanol-water clusters (E-Wc) have been demonstrated playing important influence either. The supramolecular clusters in alcoholic beverages, especially the intrinsic hydrogen-bondings (HBs) to organoleptic sensing and quality assessment, have gradually been elucidated recently. The veiling concealed on the supramolecular entities as a key proportion of the ethanol-water solution (E-Ws) starts to be disclosed with the discrete achievements in this research area. To build a full understanding of the cluster driving in versatile alcoholic beverages <em>via</em> unique techniques for characterization, this review summarizes the involved supramolecular E-Wc by fluorescence emission and NMR spectra. In particular, the two-dimensional correlation (2D-COS) analysis has been introduced as a powerful tool for characterizing the important structural profiles in clusters. With the help of carving important supramolecular E-Wc, it is hoped that the prospects and challenges in this field will be clearer and that such kinds of condensed liquid phases can possess the potential as supramolecular material additives to modulate the products with various tastes and quality in the alcoholic industry.</div></div>","PeriodicalId":101187,"journal":{"name":"Supramolecular Materials","volume":"4 ","pages":"Article 100094"},"PeriodicalIF":0.0,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143101768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-11DOI: 10.1016/j.supmat.2025.100093
Beibei Lu , Zhenyuan Wang , Ying Xu , Yue Liu , Bo Ruan , Jichuan Zhang , Jianglin Zhang , Jiaheng Zhang , Tao Zhang
Bakuchiol, as a derivative of retinol, has attracted attention due to its strong anti-aging ability on the skin. However, how to solve its irritability and low permeability is a challenge in the field of skin anti-aging. This study used matrine and lauric acid to prepare an ionic liquid to enhance transdermal permeability and solve irritation. The results of the monomer of bakuchiol showed that the ionic liquid-loaded bakuchiol significantly improved the skin permeability of bakuchiol and completely solved the problem of low irritation of bakuchiol. As a single component, its penetration rate is 4.17 times that of retinol and 3.48 times that of bakuchiol, therefore it has a stronger inflammation inhibition rate and collagen expression ability (increasing the expression of col 1a1a, col 1a1b, and col 1a2). As a substitute for retinol, bakuchiol has great potential in anti-aging applications.
{"title":"Anti-aging and anti-inflammatory fulfilled through the delivery of supramolecular bakuchiol in ionic liquid","authors":"Beibei Lu , Zhenyuan Wang , Ying Xu , Yue Liu , Bo Ruan , Jichuan Zhang , Jianglin Zhang , Jiaheng Zhang , Tao Zhang","doi":"10.1016/j.supmat.2025.100093","DOIUrl":"10.1016/j.supmat.2025.100093","url":null,"abstract":"<div><div>Bakuchiol, as a derivative of retinol, has attracted attention due to its strong anti-aging ability on the skin. However, how to solve its irritability and low permeability is a challenge in the field of skin anti-aging. This study used matrine and lauric acid to prepare an ionic liquid to enhance transdermal permeability and solve irritation. The results of the monomer of bakuchiol showed that the ionic liquid-loaded bakuchiol significantly improved the skin permeability of bakuchiol and completely solved the problem of low irritation of bakuchiol. As a single component, its penetration rate is 4.17 times that of retinol and 3.48 times that of bakuchiol, therefore it has a stronger inflammation inhibition rate and collagen expression ability (increasing the expression of <em>col 1a1a, col 1a1b</em>, and <em>col 1a2</em>). As a substitute for retinol, bakuchiol has great potential in anti-aging applications.</div></div>","PeriodicalId":101187,"journal":{"name":"Supramolecular Materials","volume":"4 ","pages":"Article 100093"},"PeriodicalIF":0.0,"publicationDate":"2025-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143102217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-06DOI: 10.1016/j.supmat.2025.100092
Pin-Wen Huang , Cong-Zhi Wang , Zhe Su , De-Xiang Jiang , Jun-Li Wang , Qun-Yan Wu , Jian-Hui Lan , Wei-Qun Shi
In the advanced spent fuel wet reprocessing process, mutual separation of trivalent actinide ions (An3+) and lanthanide ions (Ln3+) is extremely challenging. The development of back-extraction separation ligands is considered to be a viable alternative to realized efficient An/Ln separation. Using density functional theory (DFT) calculations, we have studied the back-extraction behaviours and Am/Eu separation capabilities of three ethylenediamine N-heterocyclic carboxylate ligands including N, N, N’-tris (2-pyridylmethyl)-N’-(ethylacetate) ethylenediamine (HL3py), N, N, N’-tris (2-pyrazinylmethyl)-N’-(ethylacetate) ethylenediamine (HL3pz), and N, N, N’-tris (2-triazinylmethy)-N’-(ethylacetate) ethylenediamine (HL3tz). Although HL3pz is softer than HL3py, HL3py shows slightly better Am3+ selectivity over Eu3+compared to HL3pz. This inverse relationship between ligands’ softness and their Am/Eu separation capabilities was explored through bonding nature analyses and back-extraction reactions. Though small in magnitude, Am-Nring and Eu-Nring bonds in the studied extraction complexes possess different extend of covalent component, and this difference may be the key mechanism of these back extractants for Am/Eu separation. Due to the hydrogen bonding and intermolecular interactions, the Am, Eu ions and extractants usually assemble in organic diluent forming supramolecular complexes. In this work, the thermodynamic properties of back-extraction from Am/Eu-DMDOHEMA and Am/Eu-HDEHP supramolecular species have been explored for the first time through quantum chemical calculations, which well reproduced the relative differences in selectivity Am3+ back extraction with HL3py and HL3pz, offering an explanation for the inverse relationship between ligand's softness and its Am3+ preference.
在先进乏燃料湿式后处理工艺中，三价锕系离子（An3+）和镧系离子（Ln3+）的相互分离极具挑战性。反萃取分离配体的发展被认为是实现An/Ln高效分离的可行选择。利用密度泛函理论（DFT）计算，研究了N， N, N ' -三（2-吡啶基甲基）-N ' -（乙酸乙酯）乙二胺（HL3py）、N， N, N ' -三（2-吡嗪基甲基）-N ' -（乙酸乙酯）乙二胺（HL3pz）和N， N, N ' -三（2-三嗪基甲基）-N ' -（乙酸乙酯）乙二胺（HL3tz）三种乙二胺N-杂环羧酸配体的反萃取行为和Am/Eu分离能力。虽然HL3pz比HL3py软，但HL3py对Am3+的选择性比HL3pz稍好。通过键性质分析和反萃取反应，探讨了配体的柔软度与其Am/Eu分离能力之间的反比关系。所研究的萃取物中Am- nring和Eu- nring键虽然大小不大，但共价组分的延伸却不同，这种差异可能是这两种背萃取剂分离Am/Eu的关键机理。由于氢键和分子间相互作用，Am、Eu离子和萃取剂通常在有机稀释剂中聚集形成超分子配合物。本文首次通过量子化学计算探索了Am/Eu-DMDOHEMA和Am/Eu-HDEHP超分子物种反萃取的热力学性质，较好地再现了HL3py和HL3pz对Am3+反萃取选择性的相对差异，为配体柔软度与其Am3+偏好之间的反比关系提供了解释。
{"title":"Uncovering the inverse relationship between Am/Eu separation capability and softness of N-heterocyclic carboxylate ligands","authors":"Pin-Wen Huang , Cong-Zhi Wang , Zhe Su , De-Xiang Jiang , Jun-Li Wang , Qun-Yan Wu , Jian-Hui Lan , Wei-Qun Shi","doi":"10.1016/j.supmat.2025.100092","DOIUrl":"10.1016/j.supmat.2025.100092","url":null,"abstract":"<div><div>In the advanced spent fuel wet reprocessing process, mutual separation of trivalent actinide ions (An<sup>3+</sup>) and lanthanide ions (Ln<sup>3+</sup>) is extremely challenging. The development of back-extraction separation ligands is considered to be a viable alternative to realized efficient An/Ln separation. Using density functional theory (DFT) calculations, we have studied the back-extraction behaviours and Am/Eu separation capabilities of three ethylenediamine N-heterocyclic carboxylate ligands including N, N, N’-tris (2-pyridylmethyl)-N’-(ethylacetate) ethylenediamine (HL<sup>3py</sup>), N, N, N’-tris (2-pyrazinylmethyl)-N’-(ethylacetate) ethylenediamine (HL<sup>3pz</sup>), and N, N, N’-tris (2-triazinylmethy)-N’-(ethylacetate) ethylenediamine (HL<sup>3tz</sup>). Although HL<sup>3pz</sup> is softer than HL<sup>3py</sup>, HL<sup>3py</sup> shows slightly better Am<sup>3+</sup> selectivity over Eu<sup>3+</sup>compared to HL<sup>3pz</sup>. This inverse relationship between ligands’ softness and their Am/Eu separation capabilities was explored through bonding nature analyses and back-extraction reactions. Though small in magnitude, Am-N<sub>ring</sub> and Eu-N<sub>ring</sub> bonds in the studied extraction complexes possess different extend of covalent component, and this difference may be the key mechanism of these back extractants for Am/Eu separation. Due to the hydrogen bonding and intermolecular interactions, the Am, Eu ions and extractants usually assemble in organic diluent forming supramolecular complexes. In this work, the thermodynamic properties of back-extraction from Am/Eu-DMDOHEMA and Am/Eu-HDEHP supramolecular species have been explored for the first time through quantum chemical calculations, which well reproduced the relative differences in selectivity Am<sup>3+</sup> back extraction with HL<sup>3py</sup> and HL<sup>3pz</sup>, offering an explanation for the inverse relationship between ligand's softness and its Am<sup>3+</sup> preference.</div></div>","PeriodicalId":101187,"journal":{"name":"Supramolecular Materials","volume":"4 ","pages":"Article 100092"},"PeriodicalIF":0.0,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143102216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-21DOI: 10.1016/j.supmat.2024.100090
Haoqi Zhu , Zhongyi Wang , Luofei Li , Liang Dong , Ying Li , Bin Xue , Yi Cao
The design and development of supramolecular materials are hindered by complex non-covalent interactions and a lack of comprehensive rational design theories. Traditional "trial-and-error" methods are inefficient and labor-intensive, slowing progress in creating materials with precise tunability, robust stability, multifunctionality, and dynamic behavior. This perspective highlights major difficulties in supramolecular materials research and the transformative potential of artificial intelligence (AI) and machine learning (ML) in revolutionizing the field. Key challenges in applying AI include limited data availability, data quality issues, and the path-dependent nature of assembly processes. To overcome data scarcity, we discuss strategies such as transfer learning, data augmentation, and federated learning to enhance model performance with small datasets. We propose developing Intelligent Data Manufacturing Platforms—advanced laboratory automation systems designed to generate large volumes of high-quality data. By integrating AI algorithms with robotics in a closed-loop experimental system, these platforms enable high-throughput experimentation, autonomous decision-making, and iterative refinement of AI models through continuous data acquisition. This accelerates the design-build-test-learn cycle, fostering innovation and facilitating the development of next-generation supramolecular materials. By establishing standardized data repositories and encouraging global collaboration, this framework propels the field toward a data-intensive paradigm.
{"title":"Revolutionizing supramolecular materials design with artificial intelligence","authors":"Haoqi Zhu , Zhongyi Wang , Luofei Li , Liang Dong , Ying Li , Bin Xue , Yi Cao","doi":"10.1016/j.supmat.2024.100090","DOIUrl":"10.1016/j.supmat.2024.100090","url":null,"abstract":"<div><div>The design and development of supramolecular materials are hindered by complex non-covalent interactions and a lack of comprehensive rational design theories. Traditional \"trial-and-error\" methods are inefficient and labor-intensive, slowing progress in creating materials with precise tunability, robust stability, multifunctionality, and dynamic behavior. This perspective highlights major difficulties in supramolecular materials research and the transformative potential of artificial intelligence (AI) and machine learning (ML) in revolutionizing the field. Key challenges in applying AI include limited data availability, data quality issues, and the path-dependent nature of assembly processes. To overcome data scarcity, we discuss strategies such as transfer learning, data augmentation, and federated learning to enhance model performance with small datasets. We propose developing Intelligent Data Manufacturing Platforms—advanced laboratory automation systems designed to generate large volumes of high-quality data. By integrating AI algorithms with robotics in a closed-loop experimental system, these platforms enable high-throughput experimentation, autonomous decision-making, and iterative refinement of AI models through continuous data acquisition. This accelerates the design-build-test-learn cycle, fostering innovation and facilitating the development of next-generation supramolecular materials. By establishing standardized data repositories and encouraging global collaboration, this framework propels the field toward a data-intensive paradigm.</div></div>","PeriodicalId":101187,"journal":{"name":"Supramolecular Materials","volume":"4 ","pages":"Article 100090"},"PeriodicalIF":0.0,"publicationDate":"2024-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143101771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-01DOI: 10.1016/j.supmat.2024.100080
Changping Wang , Xin Gao , Zhan Li , Xinyu Wang , Yiwen Li , Yiyun Cheng
Lipidation is a well-established post-translational modification strategy to modulate the structure and function of proteins and peptides. Lipids can improve the overall or local hydrophobicity of the biomolecule, boosting its affinity with the cell membranes. Lipidation, despite its great potential, remains an underutilized technique for translating bioactive molecules into the clinic. Herein, we have optimized the lipidation strategy by involving the fluorous lipidation combined with supramolecular engineering, which can be facilely achieved by grafting an anticancer peptide drug (bortezomib, BTZ) with a series of fluorous lipids bearing a catechol moiety via the dynamic catechol-boronate ester bond. Compared with BTZ, the fluorous-tagged BTZ nanomedicine exhibited an on-demand and traceless release behavior, and enhanced therapeutic effect and biocompatibility. More importantly, the fluorous tag could improve the serum stability of the supramolecular nanomedicine, which allowed efficient in vivo utilization of BTZ to kill cancer cells. This work introduces a novel lipidation strategy for bioactive peptides via the integration of fluorination chemistry and supramolecular engineering strategies.
{"title":"Fluorous-tagged bortezomib supramolecular nanomedicine for cancer therapy","authors":"Changping Wang , Xin Gao , Zhan Li , Xinyu Wang , Yiwen Li , Yiyun Cheng","doi":"10.1016/j.supmat.2024.100080","DOIUrl":"10.1016/j.supmat.2024.100080","url":null,"abstract":"<div><div>Lipidation is a well-established post-translational modification strategy to modulate the structure and function of proteins and peptides. Lipids can improve the overall or local hydrophobicity of the biomolecule, boosting its affinity with the cell membranes. Lipidation, despite its great potential, remains an underutilized technique for translating bioactive molecules into the clinic. Herein, we have optimized the lipidation strategy by involving the fluorous lipidation combined with supramolecular engineering, which can be facilely achieved by grafting an anticancer peptide drug (bortezomib, BTZ) with a series of fluorous lipids bearing a catechol moiety <em>via</em> the dynamic catechol-boronate ester bond. Compared with BTZ, the fluorous-tagged BTZ nanomedicine exhibited an on-demand and traceless release behavior, and enhanced therapeutic effect and biocompatibility. More importantly, the fluorous tag could improve the serum stability of the supramolecular nanomedicine, which allowed efficient <em>in vivo</em> utilization of BTZ to kill cancer cells. This work introduces a novel lipidation strategy for bioactive peptides <em>via</em> the integration of fluorination chemistry and supramolecular engineering strategies.</div></div>","PeriodicalId":101187,"journal":{"name":"Supramolecular Materials","volume":"3 ","pages":"Article 100080"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142744028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-30DOI: 10.1016/j.supmat.2024.100081
Shalini Balakrishnan , Revathy Remesh , Krishnan Kartha Kalathil , Anie Y
Wound healing is a dynamic process involving four phases such as hemostasis, inflammation, proliferation, and remodeling of tissue at the wound site. Diabetes patients are more susceptible to the development of chronic wounds as high blood glucose levels in them cause increased chances of infection and disrupted tissue regeneration. Therefore, effective treatments are essential for the successful management of diabetic wounds. Among various methods, hydrogel-based treatments have gained popularity as it is biocompatible and economically viable. In addition, hydrogels enhance wound repair by providing a moist environment and by acting like the extracellular matrix. The development of stimuli-responsive supramolecular hydrogels that can encapsulate and release drugs, antioxidants, enzymes, or cells under specific conditions has expanded remarkably the treatment options for healing difficult wounds. Recent advancement in this area of research has added many features to stimuli-responsive supramolecular hydrogel in ensuring their sustained release in a controlled manner under the influence of specific pathophysiological conditions. This helps in correcting the wound environment by quenching reactive oxygen species (ROS), balancing pH, or acting as a scaffold for the formation of a matrix. Therefore, such stimuli-responsive supramolecular hydrogels have been termed as ‘smart’ materials in many places. In this review, we look into the recent developments in the fabrication of smart supramolecular hydrogels that detect the physiological changes in diabetic wound and adapt to the environment by undergoing structural or functional changes that are important in tackling many issues related to diabetic wound treatment.
{"title":"Responsive to adaptive supramolecular hydrogels for diabetic wound treatment","authors":"Shalini Balakrishnan , Revathy Remesh , Krishnan Kartha Kalathil , Anie Y","doi":"10.1016/j.supmat.2024.100081","DOIUrl":"10.1016/j.supmat.2024.100081","url":null,"abstract":"<div><div>Wound healing is a dynamic process involving four phases such as hemostasis, inflammation, proliferation, and remodeling of tissue at the wound site. Diabetes patients are more susceptible to the development of chronic wounds as high blood glucose levels in them cause increased chances of infection and disrupted tissue regeneration. Therefore, effective treatments are essential for the successful management of diabetic wounds. Among various methods, hydrogel-based treatments have gained popularity as it is biocompatible and economically viable. In addition, hydrogels enhance wound repair by providing a moist environment and by acting like the extracellular matrix. The development of stimuli-responsive supramolecular hydrogels that can encapsulate and release drugs, antioxidants, enzymes, or cells under specific conditions has expanded remarkably the treatment options for healing difficult wounds. Recent advancement in this area of research has added many features to stimuli-responsive supramolecular hydrogel in ensuring their sustained release in a controlled manner under the influence of specific pathophysiological conditions. This helps in correcting the wound environment by quenching reactive oxygen species (ROS), balancing pH, or acting as a scaffold for the formation of a matrix. Therefore, such stimuli-responsive supramolecular hydrogels have been termed as ‘smart’ materials in many places. In this review, we look into the recent developments in the fabrication of <em>smart supramolecular hydrogels</em> that detect the physiological changes in diabetic wound and adapt to the environment by undergoing structural or functional changes that are important in tackling many issues related to diabetic wound treatment.</div></div>","PeriodicalId":101187,"journal":{"name":"Supramolecular Materials","volume":"4 ","pages":"Article 100081"},"PeriodicalIF":0.0,"publicationDate":"2024-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143101767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-30DOI: 10.1016/j.supmat.2024.100082
Li Dong , Liangjie Shan , Yafei Wang, Ji Liu
The development of biodegradable power sources has opened new avenues for transient bioelectronics, offering temporary energy solutions for implantable medical devices. This review presents a systematic overview on the design, materials, and functionalities of biodegradable devices for energy storage, harvesting, and transfer. Biodegradable batteries and supercapacitors provide reliable, short-term energy for implantable devices, while triboelectric and piezoelectric nanogenerators enable continuous energy harvesting from biomechanical sources. Additionally, wireless energy transfer systems enable safe power delivery without direct contact with biological tissues, broadening the scope of implantable bioelectronics. Future research should prioritize enhancing biocompatibility, increasing energy density, and refining degradation control to extend the practical applications of biodegradable power sources in bioelectronics.
{"title":"Biodegradable power sources for transient bioelectronics","authors":"Li Dong , Liangjie Shan , Yafei Wang, Ji Liu","doi":"10.1016/j.supmat.2024.100082","DOIUrl":"10.1016/j.supmat.2024.100082","url":null,"abstract":"<div><div>The development of biodegradable power sources has opened new avenues for transient bioelectronics, offering temporary energy solutions for implantable medical devices. This review presents a systematic overview on the design, materials, and functionalities of biodegradable devices for energy storage, harvesting, and transfer. Biodegradable batteries and supercapacitors provide reliable, short-term energy for implantable devices, while triboelectric and piezoelectric nanogenerators enable continuous energy harvesting from biomechanical sources. Additionally, wireless energy transfer systems enable safe power delivery without direct contact with biological tissues, broadening the scope of implantable bioelectronics. Future research should prioritize enhancing biocompatibility, increasing energy density, and refining degradation control to extend the practical applications of biodegradable power sources in bioelectronics.</div></div>","PeriodicalId":101187,"journal":{"name":"Supramolecular Materials","volume":"4 ","pages":"Article 100082"},"PeriodicalIF":0.0,"publicationDate":"2024-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143102215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-10DOI: 10.1016/j.supmat.2024.100079
Junxiao Qiu , Hude Ma , Mutian Yao , Manting Song , Liping Zhang , Jingkun Xu , Ximei Liu , Baoyang Lu
Electromyography (EMG) monitoring has been extensively employed for critical applications in medicine, sports science, and rehabilitation. However, the mechanical mismatch between conventional EMG electrodes and the skin can lead to electrode detachment upon significant skin deformation. To address this limitation, we develop a PEDOT:PSS-based hydrogel electrical bioadhesive interface (EBI) that incorporates molecular doping and robust adhesion strategies to achieve excellent mechanical compatibility with biological tissues. This hydrogel EBI is fabricated using direct writing of printable inks followed by in-situ thermal initiation, enabling the creation of customizable patterns with high shape fidelity. The resultant 3D-printed PEDOT:PSS-based hydrogel EBI exhibits supersoft properties (Young's modulus 5–8.5 kPa), ultra-stretchability (1175 % strain), robust adhesion (>133 kPa), and outstanding electrochemical performance (CIC reduction by 0.45 % over 1,000,000 cycles). Additionally, we further develop a PEDOT:PSS-based hydrogel electrode specifically for stable EMG signal recording. This electrode outperforms superior signal-to-noise ratio (SNR) performance compared to commercial electrodes in EMG monitoring.
{"title":"Design of a supersoft, ultra-stretchable, and 3D printable hydrogel electrical bioadhesive interface for electromyography monitoring","authors":"Junxiao Qiu , Hude Ma , Mutian Yao , Manting Song , Liping Zhang , Jingkun Xu , Ximei Liu , Baoyang Lu","doi":"10.1016/j.supmat.2024.100079","DOIUrl":"10.1016/j.supmat.2024.100079","url":null,"abstract":"<div><div>Electromyography (EMG) monitoring has been extensively employed for critical applications in medicine, sports science, and rehabilitation. However, the mechanical mismatch between conventional EMG electrodes and the skin can lead to electrode detachment upon significant skin deformation. To address this limitation, we develop a PEDOT:PSS-based hydrogel electrical bioadhesive interface (EBI) that incorporates molecular doping and robust adhesion strategies to achieve excellent mechanical compatibility with biological tissues. This hydrogel EBI is fabricated using direct writing of printable inks followed by in-situ thermal initiation, enabling the creation of customizable patterns with high shape fidelity. The resultant 3D-printed PEDOT:PSS-based hydrogel EBI exhibits supersoft properties (Young's modulus 5–8.5 kPa), ultra-stretchability (1175 % strain), robust adhesion (>133 kPa), and outstanding electrochemical performance (CIC reduction by 0.45 % over 1,000,000 cycles). Additionally, we further develop a PEDOT:PSS-based hydrogel electrode specifically for stable EMG signal recording. This electrode outperforms superior signal-to-noise ratio (SNR) performance compared to commercial electrodes in EMG monitoring.</div></div>","PeriodicalId":101187,"journal":{"name":"Supramolecular Materials","volume":"3 ","pages":"Article 100079"},"PeriodicalIF":0.0,"publicationDate":"2024-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142703232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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