Pub Date : 2025-07-08DOI: 10.1016/j.supmat.2025.100115
Jianbing Liu , Peng Zhao , Yizheng Tan , Huaping Xu
Fluorescent polymeric materials have recently gained significant attention in diverse fields, including biological imaging, luminescent sensing, encryption, and anti-counterfeiting. However, the patterning of many materials mentioned above has primarily been achieved through soft lithography technology using ultraviolet light, which can cause unnecessary damage to the materials and is limited by a shallow penetration depth. Herein, we introduce oligo(p-phenylene vinylene) derivatives (cyano-OPVs) as fluorescent molecules into diselenide-containing polyurethane (PUSeSe). Upon swelling, OPV molecules transition from aggregates to monomers, resulting in a blue shift in fluorescence spectra. By leveraging diselenide metathesis within the material, we successfully stabilized the monomeric state of OPV, enabling the inscription of green fluorescent images in illuminated regions, distinct from the original orange emission of the aggregated state. These materials can be effectively patterned within ten minutes under gentle and harmless visible light illumination. This visible light-induced fluorescence patterning method offers a convenient approach for designing advanced anti-counterfeiting materials with broader applications.
{"title":"Fluorescent patterning via visible light-triggered dynamic diselenide exchange","authors":"Jianbing Liu , Peng Zhao , Yizheng Tan , Huaping Xu","doi":"10.1016/j.supmat.2025.100115","DOIUrl":"10.1016/j.supmat.2025.100115","url":null,"abstract":"<div><div>Fluorescent polymeric materials have recently gained significant attention in diverse fields, including biological imaging, luminescent sensing, encryption, and anti-counterfeiting. However, the patterning of many materials mentioned above has primarily been achieved through soft lithography technology using ultraviolet light, which can cause unnecessary damage to the materials and is limited by a shallow penetration depth. Herein, we introduce oligo(p-phenylene vinylene) derivatives (cyano-OPVs) as fluorescent molecules into diselenide-containing polyurethane (PUSeSe). Upon swelling, OPV molecules transition from aggregates to monomers, resulting in a blue shift in fluorescence spectra. By leveraging diselenide metathesis within the material, we successfully stabilized the monomeric state of OPV, enabling the inscription of green fluorescent images in illuminated regions, distinct from the original orange emission of the aggregated state. These materials can be effectively patterned within ten minutes under gentle and harmless visible light illumination. This visible light-induced fluorescence patterning method offers a convenient approach for designing advanced anti-counterfeiting materials with broader applications.</div></div>","PeriodicalId":101187,"journal":{"name":"Supramolecular Materials","volume":"4 ","pages":"Article 100115"},"PeriodicalIF":0.0,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145415144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-06-16DOI: 10.1016/j.supmat.2025.100113
Haonan Ma , Yifan Jin , Jintao Li , Xuedong Xiao , Chengfei Liu , Wei Tian
Combination chemotherapy has been considered a crucial approach in cancer treatment to address the limitations of traditional single-drug therapy. However, the common strategies that encapsulate therapeutic agents with different mechanisms into a single “package” often lead to unsatisfactory anticancer activity because of the relatively low loading capacities, inconsistent reproducibility, and unpredictable release kinetics. In this study, we reported the construction of ruthenium (II)-coordinated supramolecular drug self-delivery systems. These systems are proposed to provide a stable and efficient transport platform for delivering drugs, thereby enhancing the effectiveness of combination chemotherapy. Ruthenium (II)-coordinated supramolecular polymer (RuSP) was first formed through host-guest interaction between β-cyclodextrin (β-CD) units grafted onto a hyaluronic acid chain (HA-CD) and (Benzene)Ru(curcuminato)Cl (Ru-Cur). The obtained RuSP then further self-assembled into ruthenium (II)-coordinated supramolecular drug self-assemblies (RuSDSAs). Upon internalization into cancer cells, RuSDSAs could be effectively degraded in acidic tumor microenvironment as for the smart dissociation of host-guest interaction, allowing for the controlled release of Ru-Cur and enhancing the efficacy of combination chemotherapy. Biological evaluation demonstrated that RuSDSAs achieved good anticancer effects and are biologically safe.
{"title":"Ruthenium (II)-coordinated supramolecular drug self-assembly for efficient combination chemotherapy","authors":"Haonan Ma , Yifan Jin , Jintao Li , Xuedong Xiao , Chengfei Liu , Wei Tian","doi":"10.1016/j.supmat.2025.100113","DOIUrl":"10.1016/j.supmat.2025.100113","url":null,"abstract":"<div><div>Combination chemotherapy has been considered a crucial approach in cancer treatment to address the limitations of traditional single-drug therapy. However, the common strategies that encapsulate therapeutic agents with different mechanisms into a single “package” often lead to unsatisfactory anticancer activity because of the relatively low loading capacities, inconsistent reproducibility, and unpredictable release kinetics. In this study, we reported the construction of ruthenium (II)-coordinated supramolecular drug self-delivery systems. These systems are proposed to provide a stable and efficient transport platform for delivering drugs, thereby enhancing the effectiveness of combination chemotherapy. Ruthenium (II)-coordinated supramolecular polymer (RuSP) was first formed through host-guest interaction between <em>β</em>-cyclodextrin (<em>β</em>-CD) units grafted onto a hyaluronic acid chain (HA-CD) and (Benzene)Ru(curcuminato)Cl (Ru-Cur). The obtained RuSP then further self-assembled into ruthenium (II)-coordinated supramolecular drug self-assemblies (RuSDSAs). Upon internalization into cancer cells, RuSDSAs could be effectively degraded in acidic tumor microenvironment as for the smart dissociation of host-guest interaction, allowing for the controlled release of Ru-Cur and enhancing the efficacy of combination chemotherapy. Biological evaluation demonstrated that RuSDSAs achieved good anticancer effects and are biologically safe.</div></div>","PeriodicalId":101187,"journal":{"name":"Supramolecular Materials","volume":"4 ","pages":"Article 100113"},"PeriodicalIF":0.0,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144679659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-06-13DOI: 10.1016/j.supmat.2025.100114
Zhi-Min Lv , Yue-Yang Liu , Shang-Bo Yu , Jia Tian , Yun-Xiang Xu , Zhan-Ting Li
Polyrotaxanes (PRs) are mechanically interlocked supramolecular systems with the ring components threading linear axle component. When two rings are connected with a covalent linker and incorporating PRs into main-chain or side-chain polymers, the sliding of the rings over the threaded covalent networks produces pulley effect, by which the polymer chains can pass through the rings to equalize the tensions cooperatively and avoid localization of the stress. Since the pioneering work on the α−CD/polyethylene glycol-composed system by Okumura and Ito in 2001, such slide-ring supramolecular polymers (SRSPs) have been developed as a new kind of mechanically interlocked materials that display specific conformational freedom, high movability, as well as exceptional mechanic performances, which include enhanced toughness, stretchability, recoverability and self-healing ability. In addition to α−CD, β−CD, crown ethers, pillar[5]arene, and discrete macrocycles have been used as the ring components. A diversity of sliding and interpenetrating patterns has also been developed. With the establishment of the preparation methods and structure-property relationship evaluations, SRSPs have been vigorously explored as promising materials for a variety of functions and applications, including anti-scratch, anti-fracture, anti-puncture and anti-impact, as well as enhanced hydrogels, rubbers and elastomers. In this review, we summarize recent progresses, mainly those obtained in the past five years, in the preparations, structures, functions and applications of this family of supramolecular polymers. In the final section, we give our perspectives of future research and challenges.
{"title":"Polyrotaxanes in motion: recent advances in slide-ring supramolecular polymers","authors":"Zhi-Min Lv , Yue-Yang Liu , Shang-Bo Yu , Jia Tian , Yun-Xiang Xu , Zhan-Ting Li","doi":"10.1016/j.supmat.2025.100114","DOIUrl":"10.1016/j.supmat.2025.100114","url":null,"abstract":"<div><div>Polyrotaxanes (PRs) are mechanically interlocked supramolecular systems with the ring components threading linear axle component. When two rings are connected with a covalent linker and incorporating PRs into main-chain or side-chain polymers, the sliding of the rings over the threaded covalent networks produces pulley effect, by which the polymer chains can pass through the rings to equalize the tensions cooperatively and avoid localization of the stress. Since the pioneering work on the α−CD/polyethylene glycol-composed system by Okumura and Ito in 2001, such slide-ring supramolecular polymers (SRSPs) have been developed as a new kind of mechanically interlocked materials that display specific conformational freedom, high movability, as well as exceptional mechanic performances, which include enhanced toughness, stretchability, recoverability and self-healing ability. In addition to α−CD, β−CD, crown ethers, pillar[5]arene, and discrete macrocycles have been used as the ring components. A diversity of sliding and interpenetrating patterns has also been developed. With the establishment of the preparation methods and structure-property relationship evaluations, SRSPs have been vigorously explored as promising materials for a variety of functions and applications, including anti-scratch, anti-fracture, anti-puncture and anti-impact, as well as enhanced hydrogels, rubbers and elastomers. In this review, we summarize recent progresses, mainly those obtained in the past five years, in the preparations, structures, functions and applications of this family of supramolecular polymers. In the final section, we give our perspectives of future research and challenges.</div></div>","PeriodicalId":101187,"journal":{"name":"Supramolecular Materials","volume":"5 ","pages":"Article 100114"},"PeriodicalIF":0.0,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145748196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-06-06DOI: 10.1016/j.supmat.2025.100111
G.S. Gopika Krishnan, K. Muraleedharan
Understanding how the bis-urea macrocycle molecules can sense different invited anionic substances is becoming increasingly crucial. In this context, we have theoretically studied a new host-guest such as the interaction of 7,13-dibromo-1,4,8,11-tetraazacyclotetradecane-5,12‑dione (BUM) with the anions like SO42−, SO32−, CH3COO−, NO2−, and NO3−. DFT and TD-DFT are used to calculate thermodynamics, electronic structure, electric-field induced properties, and photo-physical characteristics in order to investigate the mechanism of selective sensing of these anions. The free energy change (ΔGads) and adsorption energies (Eads) suggest that these anionic interactions are thermodynamically feasible with strong to moderate adsorption energy with the receptor. The conductivity and sensitivity between the anions can be improved by the external electric field regulated investigation. Because of the intramolecular charge transfer transitions, internal conversions, and related configurational modifications, BUM-SO32− exhibits good fluorescence in the BUM-anion complexes, indicating its significance for practical utility.
{"title":"Unravelling the sensing mechanism of bis-urea macrocycle-based anion receptor: a theoretical study","authors":"G.S. Gopika Krishnan, K. Muraleedharan","doi":"10.1016/j.supmat.2025.100111","DOIUrl":"10.1016/j.supmat.2025.100111","url":null,"abstract":"<div><div>Understanding how the bis-urea macrocycle molecules can sense different invited anionic substances is becoming increasingly crucial. In this context, we have theoretically studied a new host-guest such as the interaction of 7,13-dibromo-1,4,8,11-tetraazacyclotetradecane-5,12‑dione (BUM) with the anions like SO<sub>4</sub><sup>2−</sup>, SO<sub>3</sub><sup>2−</sup>, CH<sub>3</sub>COO<sup>−</sup>, NO<sub>2</sub><sup>−</sup>, and NO<sub>3</sub><sup>−</sup>. DFT and TD-DFT are used to calculate thermodynamics, electronic structure, electric-field induced properties, and photo-physical characteristics in order to investigate the mechanism of selective sensing of these anions. The free energy change (ΔG<sub>ads</sub>) and adsorption energies (E<sub>ads</sub>) suggest that these anionic interactions are thermodynamically feasible with strong to moderate adsorption energy with the receptor. The conductivity and sensitivity between the anions can be improved by the external electric field regulated investigation. Because of the intramolecular charge transfer transitions, internal conversions, and related configurational modifications, BUM-SO<sub>3</sub><sup>2−</sup> exhibits good fluorescence in the BUM-anion complexes, indicating its significance for practical utility.</div></div>","PeriodicalId":101187,"journal":{"name":"Supramolecular Materials","volume":"4 ","pages":"Article 100111"},"PeriodicalIF":0.0,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144502761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-06-06DOI: 10.1016/j.supmat.2025.100112
Dongdong Yan , Shilei Zhu , Hongyao Zhao , Shanhao Feng , Beibei Kang , Xin Yang , Yanjing Zhang , Zhuangzhuang Li , Wenwen Yu , Ya Nan Ye
Conventional artificial nanocomposites often rely on simple blending, which can lead to agglomeration and interfacial incompatibility between the organic and inorganic phases. In contrast, natural mineralized tissues like bone and teeth exhibit outstanding mechanical performance through nanoscale, interpenetrating organic-inorganic networks. Inspired by these naturally integrated architectures, we report a double-network (DN) organic-inorganic organogel composite formed by topologically interweaving self-assembled polyoxometalate sub-nanowires (SNWs) with a poly(tert‑butyl acrylate) (PtBA) matrix. The SNWs feature sub-nanometer diameters and flexibility similar to polymer chains, enabling them to form an inorganic network that seamlessly integrates with the organic phase. This continuous, interpenetrating DN structure enhanced key mechanical properties—including tensile strength, stiffness, and toughness—while simultaneously regulating dielectric properties such as dielectric permittivity and electrical breakdown strength, yielding a versatile, multifunctional platform. Overall, this design strategy paves the way for bioinspired advanced materials that merge mechanical robustness with customizable functionalities derived from inorganic components, promising applications in flexible electronics and functional structural materials.
{"title":"Organic-inorganic nanocomposite organogel with double-network topology for enhanced mechanical and dielectric properties","authors":"Dongdong Yan , Shilei Zhu , Hongyao Zhao , Shanhao Feng , Beibei Kang , Xin Yang , Yanjing Zhang , Zhuangzhuang Li , Wenwen Yu , Ya Nan Ye","doi":"10.1016/j.supmat.2025.100112","DOIUrl":"10.1016/j.supmat.2025.100112","url":null,"abstract":"<div><div>Conventional artificial nanocomposites often rely on simple blending, which can lead to agglomeration and interfacial incompatibility between the organic and inorganic phases. In contrast, natural mineralized tissues like bone and teeth exhibit outstanding mechanical performance through nanoscale, interpenetrating organic-inorganic networks. Inspired by these naturally integrated architectures, we report a double-network (DN) organic-inorganic organogel composite formed by topologically interweaving self-assembled polyoxometalate sub-nanowires (SNWs) with a poly(tert‑butyl acrylate) (PtBA) matrix. The SNWs feature sub-nanometer diameters and flexibility similar to polymer chains, enabling them to form an inorganic network that seamlessly integrates with the organic phase. This continuous, interpenetrating DN structure enhanced key mechanical properties—including tensile strength, stiffness, and toughness—while simultaneously regulating dielectric properties such as dielectric permittivity and electrical breakdown strength, yielding a versatile, multifunctional platform. Overall, this design strategy paves the way for bioinspired advanced materials that merge mechanical robustness with customizable functionalities derived from inorganic components, promising applications in flexible electronics and functional structural materials.</div></div>","PeriodicalId":101187,"journal":{"name":"Supramolecular Materials","volume":"4 ","pages":"Article 100112"},"PeriodicalIF":0.0,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144480812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-05-31DOI: 10.1016/j.supmat.2025.100110
Moses Kumi , Zishuo Hou , Yibo Zhang , Yutian Yang , Chang Han , Tengjiao Wang , Peng Li
Enhanced bioelectrical stimulation near wound sites plays a crucial role in promoting the wound healing cascade, such as, supporting regular collagen deposition, proper extracellular matrix (ECM) remodeling. This study presents an antimicrobial porous flexible hydrogel electrode (APFE) for personalized electrical stimulation (ES) therapy, targeting infected diabetic wound healing. The APFE addresses these limitations by combining the antimicrobial properties of quaternary ammonium-modified chitin with the conductive polymer PEDOT: PSS, creating a flexible, wound-conforming electrode. Fabricated using 3D printing technology, the APFE can be tailored to conform to the unique anatomical contours of a patient’s wound, thereby enhancing its ability to support cell migration and proliferation– critical processes that ultimately accelerate wound healing. Characterization studies show that the APFE exhibits a tensile strength around ≈2.43± 0.57 MPa, and a stretchability of approximately ≈48.91 ± 2.84 %, closely matching skin flexibility (54 ± 17 %). The electrode’s porous and hydrophilic structure enhances moisture retention, making it suitable for diverse wound environments. In vitro results demonstrated good cell viability and around 85.71 % and 93.65 % bacterial inhibition for pathogens like Methicillin-resistant Staphylococcus aureus (MRSA) and Escherichia coli (E. coli) respectively in APFE 3. In vivo studies using infected diabetic mouse wounds demonstrated accelerated wound closure approaching 98.99 % in APFE 3 by Day 14, compared to 79.53 % in controls. Histological analysis confirmed increased re-epithelialization and collagen deposition, key histopathological markers of tissue regeneration, drive improved repair mechanisms and ultimately promote wound healing. These results reinforce the potential of the APFE as a customizable, scalable solution for diabetic wound care.
{"title":"3D printed chitosan-based flexible electrode with antimicrobial properties for electrical stimulation therapy in wound healing","authors":"Moses Kumi , Zishuo Hou , Yibo Zhang , Yutian Yang , Chang Han , Tengjiao Wang , Peng Li","doi":"10.1016/j.supmat.2025.100110","DOIUrl":"10.1016/j.supmat.2025.100110","url":null,"abstract":"<div><div>Enhanced bioelectrical stimulation near wound sites plays a crucial role in promoting the wound healing cascade, such as, supporting regular collagen deposition, proper extracellular matrix (ECM) remodeling. This study presents an antimicrobial porous flexible hydrogel electrode (APFE) for personalized electrical stimulation (ES) therapy, targeting infected diabetic wound healing. The APFE addresses these limitations by combining the antimicrobial properties of quaternary ammonium-modified chitin with the conductive polymer PEDOT: PSS, creating a flexible, wound-conforming electrode. Fabricated using 3D printing technology, the APFE can be tailored to conform to the unique anatomical contours of a patient’s wound, thereby enhancing its ability to support cell migration and proliferation– critical processes that ultimately accelerate wound healing. Characterization studies show that the APFE exhibits a tensile strength around ≈2.43± 0.57 MPa, and a stretchability of approximately ≈48.91 ± 2.84 %, closely matching skin flexibility (54 ± 17 %). The electrode’s porous and hydrophilic structure enhances moisture retention, making it suitable for diverse wound environments. <em>In vitro</em> results demonstrated good cell viability and around 85.71 % and 93.65 % bacterial inhibition for pathogens like Methicillin-resistant <em>Staphylococcus aureus (</em>MRSA<em>)</em> and <em>Escherichia coli (E. coli)</em> respectively in APFE 3<em>. In vivo</em> studies using infected diabetic mouse wounds demonstrated accelerated wound closure approaching 98.99 % in APFE 3 by Day 14, compared to 79.53 % in controls. Histological analysis confirmed increased re-epithelialization and collagen deposition, key histopathological markers of tissue regeneration, drive improved repair mechanisms and ultimately promote wound healing. These results reinforce the potential of the APFE as a customizable, scalable solution for diabetic wound care.</div></div>","PeriodicalId":101187,"journal":{"name":"Supramolecular Materials","volume":"4 ","pages":"Article 100110"},"PeriodicalIF":0.0,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144632312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-05-30DOI: 10.1016/j.supmat.2025.100109
Yongsheng Li , Kan Yang , Luyang Zhao
Melanoma therapy faces critical challenges due to melanin-mediated resistance mechanisms. The use of tyrosinase inhibitors to suppress tyrosinase activity and reduce melanogenesis, thereby sensitizing melanoma cells, represents a highly promising strategy for adjuvant melanoma therapy. However, most current review articles on tyrosinase inhibitors are primarily focused on discussing molecular inhibitor design and their depigmentation effects, while comprehensive reviews addressing their melanoma-sensitizing potential remain scarce. In this review, we systematically summarized recent development of tyrosinase inhibitor-mediated melanoma therapeutic treatment. Firstly we introduced the inhibiting mechanism of tyrosinase inhibitors and their development with various chemical structures and supramolecular assembly strategy. Then the tyrosinase inhibitor sensitization to irradiation/photodynamic therapy, chemotherapy, and immunotherapy was reviewed in detail, respectively, where the unique role of tyrosinase inhibitor in these therapeutic schemes are highlighted. Finally, we discuss potential optimization strategies for employing tyrosinase inhibitors in melanoma sensitization. This review timely addresses the critical gap in literature regarding tyrosinase inhibitor-mediated melanoma sensitization. It not only provides perspectives for clinical melanoma treatment but also facilitates the expansion of tyrosinase inhibitors' biomedical applications, thereby advancing the development of next-generation tyrosinase-targeted therapeutics.
{"title":"Tyrosinase inhibitors as melanoma sensitizers: Boosting therapeutic efficacy","authors":"Yongsheng Li , Kan Yang , Luyang Zhao","doi":"10.1016/j.supmat.2025.100109","DOIUrl":"10.1016/j.supmat.2025.100109","url":null,"abstract":"<div><div>Melanoma therapy faces critical challenges due to melanin-mediated resistance mechanisms. The use of tyrosinase inhibitors to suppress tyrosinase activity and reduce melanogenesis, thereby sensitizing melanoma cells, represents a highly promising strategy for adjuvant melanoma therapy. However, most current review articles on tyrosinase inhibitors are primarily focused on discussing molecular inhibitor design and their depigmentation effects, while comprehensive reviews addressing their melanoma-sensitizing potential remain scarce. In this review, we systematically summarized recent development of tyrosinase inhibitor-mediated melanoma therapeutic treatment. Firstly we introduced the inhibiting mechanism of tyrosinase inhibitors and their development with various chemical structures and supramolecular assembly strategy. Then the tyrosinase inhibitor sensitization to irradiation/photodynamic therapy, chemotherapy, and immunotherapy was reviewed in detail, respectively, where the unique role of tyrosinase inhibitor in these therapeutic schemes are highlighted. Finally, we discuss potential optimization strategies for employing tyrosinase inhibitors in melanoma sensitization. This review timely addresses the critical gap in literature regarding tyrosinase inhibitor-mediated melanoma sensitization. It not only provides perspectives for clinical melanoma treatment but also facilitates the expansion of tyrosinase inhibitors' biomedical applications, thereby advancing the development of next-generation tyrosinase-targeted therapeutics.</div></div>","PeriodicalId":101187,"journal":{"name":"Supramolecular Materials","volume":"4 ","pages":"Article 100109"},"PeriodicalIF":0.0,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144587673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-05-27DOI: 10.1016/j.supmat.2025.100108
Huacheng He , Yijing Tang , Manhui Zheng , Yung Chang , Hong Chen , Jialun Wei , Jiang Wu , Jie Zheng
Zwitterionic hydrogels, synthesized from zwitterions such as sulfobetaine, carboxybetaine, and phosphorylcholine, feature a balanced mix of positive and negative charges within the same polymer chains. They exhibit excellent antifouling properties, superior hydration, distinctive anti-polyelectrolyte behavior, tunable mechanical strength, and low immunogenicity, all of which create an environment that mimics the extracellular matrix, facilitating faster wound healing. This review examines the development and applications of zwitterionic hydrogels in wound care, highlighting their potential to enhance healing processes and reduce complications in both acute and chronic wounds. Zwitterionic hydrogels are presented with distinct functionalities such as antibacterial activity, hemostatic properties, anti-inflammatory and antioxidant effects, and adaptability to the wound environment, all contributing to improved wound healing from various perspectives. Additionally, innovative approaches enhance zwitterionic hydrogels in wound care by integrating them with various bioactive compounds, photothermal therapy, and smart materials. These enhancements enable the effective delivery of therapeutic agents directly to the wound site and facilitate responsiveness to specific wound cues, providing a comprehensive multimodal therapeutic strategy. Further, the potential challenges and future perspectives in the field are addressed, including the need for advanced material design/synthesis and the integration of machine learning to optimize hydrogel design. By exploring both current applications and forward-looking innovations, this review underscores the significance of zwitterionic hydrogels and the vast potential for their future development in revolutionizing wound care, promising not only enhanced clinical outcomes but also broad applicative potentials in medicine.
{"title":"Zwitterionic hydrogels from material design to wound dressing applications","authors":"Huacheng He , Yijing Tang , Manhui Zheng , Yung Chang , Hong Chen , Jialun Wei , Jiang Wu , Jie Zheng","doi":"10.1016/j.supmat.2025.100108","DOIUrl":"10.1016/j.supmat.2025.100108","url":null,"abstract":"<div><div>Zwitterionic hydrogels, synthesized from zwitterions such as sulfobetaine, carboxybetaine, and phosphorylcholine, feature a balanced mix of positive and negative charges within the same polymer chains. They exhibit excellent antifouling properties, superior hydration, distinctive anti-polyelectrolyte behavior, tunable mechanical strength, and low immunogenicity, all of which create an environment that mimics the extracellular matrix, facilitating faster wound healing. This review examines the development and applications of zwitterionic hydrogels in wound care, highlighting their potential to enhance healing processes and reduce complications in both acute and chronic wounds. Zwitterionic hydrogels are presented with distinct functionalities such as antibacterial activity, hemostatic properties, anti-inflammatory and antioxidant effects, and adaptability to the wound environment, all contributing to improved wound healing from various perspectives. Additionally, innovative approaches enhance zwitterionic hydrogels in wound care by integrating them with various bioactive compounds, photothermal therapy, and smart materials. These enhancements enable the effective delivery of therapeutic agents directly to the wound site and facilitate responsiveness to specific wound cues, providing a comprehensive multimodal therapeutic strategy. Further, the potential challenges and future perspectives in the field are addressed, including the need for advanced material design/synthesis and the integration of machine learning to optimize hydrogel design. By exploring both current applications and forward-looking innovations, this review underscores the significance of zwitterionic hydrogels and the vast potential for their future development in revolutionizing wound care, promising not only enhanced clinical outcomes but also broad applicative potentials in medicine.</div></div>","PeriodicalId":101187,"journal":{"name":"Supramolecular Materials","volume":"4 ","pages":"Article 100108"},"PeriodicalIF":0.0,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144312934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-05-14DOI: 10.1016/j.supmat.2025.100107
Chunhong Liu , Leyong Wang , Zhouyu Wang , Wanhua Wu , Cheng Yang
Chiral sensing is crucial for understanding and controlling the biological activity of chiral molecule such as carbohydrates, amino acids, and proteins. It also plays a vital role in asymmetric synthesis, drug development, and the advancement of functional materials. Supramolecular macrocycle-based chiral sensors offer unique advantages over traditional small-molecule chiral sensors. This review highlights recent advancements in chiral sensing using supramolecular macrocycles, categorizing them into two primary groups: achiral and chiral macrocycles, based on their configurational features. Furthermore, it systematically outlines the synthetic strategies for these macrocycles, emphasizing their applications in chiral recognition and sensing.
{"title":"Recent advances in chirality sensing/recognition using supramolecular macrocycles","authors":"Chunhong Liu , Leyong Wang , Zhouyu Wang , Wanhua Wu , Cheng Yang","doi":"10.1016/j.supmat.2025.100107","DOIUrl":"10.1016/j.supmat.2025.100107","url":null,"abstract":"<div><div>Chiral sensing is crucial for understanding and controlling the biological activity of chiral molecule such as carbohydrates, amino acids, and proteins. It also plays a vital role in asymmetric synthesis, drug development, and the advancement of functional materials. Supramolecular macrocycle-based chiral sensors offer unique advantages over traditional small-molecule chiral sensors. This review highlights recent advancements in chiral sensing using supramolecular macrocycles, categorizing them into two primary groups: achiral and chiral macrocycles, based on their configurational features. Furthermore, it systematically outlines the synthetic strategies for these macrocycles, emphasizing their applications in chiral recognition and sensing.</div></div>","PeriodicalId":101187,"journal":{"name":"Supramolecular Materials","volume":"4 ","pages":"Article 100107"},"PeriodicalIF":0.0,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143950382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-05-09DOI: 10.1016/j.supmat.2025.100105
Depeng Liu , Jiaying Zhou , Longqiang Li , Min Qi , Wuzhen Luo , Guangqiang Yin , Tao Chen
Organic room temperature phosphorescent (RTP) materials have emerged as a prominent research area due to their unique luminescent properties and wide applications. However, it remains a great challenge to realize a distinct RTP modulation by one stimulus, although it is highly desirable for developing high-level information encryption. Herein, we fabricate two distinct RTP films by incorporating terpyridine (Tpy) derivatives with a carboxylic or amine group into polyvinyl alcohol (PVA), exhibiting entirely different optical responses upon the introduction of dynamic lanthanide (Ln) coordination. The RTP film fabricated by carboxylic group-functionalized Tpy derivative shows significant changes in fluorescence and RTP emissions upon the addition of Ln3+ due to efficient triplet-to-singlet Förster resonance energy transfer (TS-FRET). On the contrary, the RTP film prepared by amine group-functionalized Tpy derivative demonstrates almost unchanged optical properties after introducing Ln3+. Encouraged by such a distinct Ln3+ modulation, multi-level information encryption is well demonstrated with a largely improved security level. This study not only contributes to the development of modulable RTP materials but also promotes the advancement of high-level information encryption.
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