Pub Date : 2026-01-26DOI: 10.1016/j.matdes.2026.115559
Lina Sun, Huahua Li, Chunyu Zhao, Zhou Shu, Mengting Xu, Y Wang, Lili Yue, Yining Zhang, Xinying Lu, Yanjie Guo, S Du, Xinran Wang, Jie Bai
• Localized melanoma treatment offers distinct advantages. • The microneedle delivery system exhibits a dual synergistic effect of cell wall disruption and drug release. • Combining Traditional Chinese Medicine Components with Chemotherapy Drugs to Enhance Efficacy and Reduce Toxicity. • Nucleus-shell nanomedicines enable tiered treatment combining chemotherapy, immunotherapy, and anti-inflammatory effects. Melanoma, the most lethal skin disease with steadily rising incidence rates, demands safer, more precise, and intelligently effective combination therapies. By utilizing traditional Chinese medicine polysaccharides as the microneedle matrix, we developed dual-layer microneedles incorporating multi-core–shell structured nanoparticles and anti-inflammatory immune nanoparticles loaded with both chemical and herbal components. These dual-layer microneedles demonstrate superior synergistic antitumor and anti-inflammatory effects both in vivo and in vitro. Following local administration, they achieve a 95.6% inhibition rate against melanoma, effectively inhibiting tumor growth and invasion. They significantly enhance the activation and immune function of tumor-targeting T cells, increase the proportion of CD8 + T cells, and simultaneously activate innate immune functions in immune organs. This approach boosts the proportion of immune T cells and NK cells in the spleen, promotes T cell secretion of TNF-α to achieve anti-tumor immune activation, and enhances systemic anti-inflammatory immune responses. Simultaneously, it reduces drug concentration in non-targeted areas, minimizing systemic toxicity and side effects. This achieves a tiered drug delivery effect combining “chemotherapy-immunotherapy-anti-inflammation,” realizing a three-pronged synergistic anti-tumor effect through “break the skin barrier −drug release-immune coordination.” It provides a reference for developing new formulations for microneedle local administration and topical anti-tumor preparations.
{"title":"Construction of a dual-layer microneedle drug delivery system based on “chemotherapy-immunity-anti-inflammatory” for melanoma research","authors":"Lina Sun, Huahua Li, Chunyu Zhao, Zhou Shu, Mengting Xu, Y Wang, Lili Yue, Yining Zhang, Xinying Lu, Yanjie Guo, S Du, Xinran Wang, Jie Bai","doi":"10.1016/j.matdes.2026.115559","DOIUrl":"https://doi.org/10.1016/j.matdes.2026.115559","url":null,"abstract":"• Localized melanoma treatment offers distinct advantages. • The microneedle delivery system exhibits a dual synergistic effect of cell wall disruption and drug release. • Combining Traditional Chinese Medicine Components with Chemotherapy Drugs to Enhance Efficacy and Reduce Toxicity. • Nucleus-shell nanomedicines enable tiered treatment combining chemotherapy, immunotherapy, and anti-inflammatory effects. Melanoma, the most lethal skin disease with steadily rising incidence rates, demands safer, more precise, and intelligently effective combination therapies. By utilizing traditional Chinese medicine polysaccharides as the microneedle matrix, we developed dual-layer microneedles incorporating multi-core–shell structured nanoparticles and anti-inflammatory immune nanoparticles loaded with both chemical and herbal components. These dual-layer microneedles demonstrate superior synergistic antitumor and anti-inflammatory effects both in vivo and in vitro. Following local administration, they achieve a 95.6% inhibition rate against melanoma, effectively inhibiting tumor growth and invasion. They significantly enhance the activation and immune function of tumor-targeting T cells, increase the proportion of CD8 + T cells, and simultaneously activate innate immune functions in immune organs. This approach boosts the proportion of immune T cells and NK cells in the spleen, promotes T cell secretion of TNF-α to achieve anti-tumor immune activation, and enhances systemic anti-inflammatory immune responses. Simultaneously, it reduces drug concentration in non-targeted areas, minimizing systemic toxicity and side effects. This achieves a tiered drug delivery effect combining “chemotherapy-immunotherapy-anti-inflammation,” realizing a three-pronged synergistic anti-tumor effect through “break the skin barrier −drug release-immune coordination.” It provides a reference for developing new formulations for microneedle local administration and topical anti-tumor preparations.","PeriodicalId":101318,"journal":{"name":"MATERIALS & DESIGN","volume":"262 1","pages":"115559-115559"},"PeriodicalIF":0.0,"publicationDate":"2026-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147381654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Schematic illustration depicting the preparation of methacrylate-modified carboxymethyl chitosan hydrogel enriched with endothelial cell derivatives (ECd@M−CMCS) and its application in promoting angiogenesis and facilitating full-thickness wound healing. • The hydrogel scaffold containing specific ECM within M−CMCS was successfully prepared. • It features a loose porous 3D structure, excellent hydrophilicity, and water absorption. • It enables adaptability to wound shapes and a moist healing microenvironment. • It demonstrates strong antimicrobial activity and has multiple biological functions. • It enhances wound healing and improves both healing speed and quality. Wound self-repair is prone to forming hard-to-heal chronic wounds due to infections, vascular damage, diabetes and other factors. Selecting the appropriate treatment and dressing can help prevent the deterioration of chronic wounds and facilitate the restoration of normal structure and function. Carboxymethyl chitosan (CMCS)-modified hydrogels can promote tissue repair, while human umbilical vein endothelial cell derivatives (ECd) enhance self-repair. In this study, ECd was prepared into lyophilized powder using vacuum freeze-drying to preserve its original active ingredients. In vitro experimental results revealed that a specific concentration of ECd effectively supported cell proliferation, migration and angiogenesis. ECd was further encapsulated in the designed glycidyl methacrylate-modified carboxymethyl chitosan (M−CMCS) hydrogel. The optimal combination of ECd and M−CMCS hydrogel (ECd@M−CMCS) was evaluated by testing the material properties, analyzing cellular behaviors and assessing antimicrobial effects. Sprague Dawley rat models (tail-breaking, liver incision, skin whole-layer defect) demonstrated ECd@M−CMCS exhibited good biocompatibility and enhanced wound healing and hemostasis in vivo .
{"title":"Carboxymethyl chitosan hydrogel reinforced by endothelial cell derivatives for angiogenesis and full-thickness wound healing","authors":"Na Liu, Ziyi Zhou, Xiaopei Zhang, Qingxia Guo, Yuying Yan, Manfei Fu, Yawen Wang, Yuanfei Wang, Tong Wu, Yuanfei Wang, Tong Wu","doi":"10.1016/j.matdes.2025.115242","DOIUrl":"https://doi.org/10.1016/j.matdes.2025.115242","url":null,"abstract":"Schematic illustration depicting the preparation of methacrylate-modified carboxymethyl chitosan hydrogel enriched with endothelial cell derivatives (ECd@M−CMCS) and its application in promoting angiogenesis and facilitating full-thickness wound healing. • The hydrogel scaffold containing specific ECM within M−CMCS was successfully prepared. • It features a loose porous 3D structure, excellent hydrophilicity, and water absorption. • It enables adaptability to wound shapes and a moist healing microenvironment. • It demonstrates strong antimicrobial activity and has multiple biological functions. • It enhances wound healing and improves both healing speed and quality. Wound self-repair is prone to forming hard-to-heal chronic wounds due to infections, vascular damage, diabetes and other factors. Selecting the appropriate treatment and dressing can help prevent the deterioration of chronic wounds and facilitate the restoration of normal structure and function. Carboxymethyl chitosan (CMCS)-modified hydrogels can promote tissue repair, while human umbilical vein endothelial cell derivatives (ECd) enhance self-repair. In this study, ECd was prepared into lyophilized powder using vacuum freeze-drying to preserve its original active ingredients. In vitro experimental results revealed that a specific concentration of ECd effectively supported cell proliferation, migration and angiogenesis. ECd was further encapsulated in the designed glycidyl methacrylate-modified carboxymethyl chitosan (M−CMCS) hydrogel. The optimal combination of ECd and M−CMCS hydrogel (ECd@M−CMCS) was evaluated by testing the material properties, analyzing cellular behaviors and assessing antimicrobial effects. Sprague Dawley rat models (tail-breaking, liver incision, skin whole-layer defect) demonstrated ECd@M−CMCS exhibited good biocompatibility and enhanced wound healing and hemostasis in vivo .","PeriodicalId":101318,"journal":{"name":"MATERIALS & DESIGN","volume":"260 1","pages":"115242-115242"},"PeriodicalIF":0.0,"publicationDate":"2025-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147332272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-28DOI: 10.1016/j.matdes.2025.115243
Chengyi Huang, Xiang Zhang, Kangkang Huang, Yang Yu, Lei Lu, Lin Huang, Dan Zhou, Y.Y Li, Hao Liu, Decheng Wu, Hao Liu
• Designed a hierarchical micro-nano platform integrating ECM-mimetic microspheres and MPNs. • Introduced a strontium-tannic acid metal-phenolic “armor” for broad-spectrum ROS scavenging. • Enabled sustained release of puerarin nanoparticles for prolonged anti-inflammatory action. • Achieved triple-targeted therapy to disrupt ROS/inflammation/ECM degradation feedback loop. • Demonstrated minimally invasive, injectable treatment enabling disc regeneration and pain relief in vivo. To disrupt the pathogenic cycle of inflammation and oxidative stress driving intervertebral disc degeneration (IDD), we engineered a hierarchical micro-nano therapeutic platform (CPM). This system integrates Chondroitin sulfate methacrylate (ChsMA) hydrogel microspheres mimicking the extracellular matrix (ECM), Pluronic F-127 nanoparticles encapsulating anti-inflammatory puerarin for sustained release (52.6 % over 28 days), and a metal-phenolic network (MPN) “armor” of tannic acid (TA) and strontium ions (Sr 2+ ) providing broad-spectrum reactive oxygen species (ROS) scavenging (>83 % clearance) and enzyme-mimetic activity. CPM synergistically neutralizes oxidative stress, suppresses inflammation, and protects ECM integrity. In vitro, CPM demonstrates excellent biocompatibility and multi-target efficacy, concurrently suppressing inflammation, scavenging ROS, restoring mitochondrial function, and promoting ECM regeneration in stressed nucleus pulposus cells. In a rat IDD model, a single minimally invasive injection of CPM provides sustained drug retention (38.1 % at 2 weeks), preserves disc structure and proteoglycan content, and restores T2-MRI signals. This triple-synergistic strategy represents a promising therapeutic paradigm for arresting IDD progression.
{"title":"Micro-nano therapeutic platform combats disc degeneration: ChsMA microspheres with ROS-scavenging metal-phenolic armor and puerarin nanocargo for triple-targeted ECM regeneration","authors":"Chengyi Huang, Xiang Zhang, Kangkang Huang, Yang Yu, Lei Lu, Lin Huang, Dan Zhou, Y.Y Li, Hao Liu, Decheng Wu, Hao Liu","doi":"10.1016/j.matdes.2025.115243","DOIUrl":"https://doi.org/10.1016/j.matdes.2025.115243","url":null,"abstract":"• Designed a hierarchical micro-nano platform integrating ECM-mimetic microspheres and MPNs. • Introduced a strontium-tannic acid metal-phenolic “armor” for broad-spectrum ROS scavenging. • Enabled sustained release of puerarin nanoparticles for prolonged anti-inflammatory action. • Achieved triple-targeted therapy to disrupt ROS/inflammation/ECM degradation feedback loop. • Demonstrated minimally invasive, injectable treatment enabling disc regeneration and pain relief in vivo. To disrupt the pathogenic cycle of inflammation and oxidative stress driving intervertebral disc degeneration (IDD), we engineered a hierarchical micro-nano therapeutic platform (CPM). This system integrates Chondroitin sulfate methacrylate (ChsMA) hydrogel microspheres mimicking the extracellular matrix (ECM), Pluronic F-127 nanoparticles encapsulating anti-inflammatory puerarin for sustained release (52.6 % over 28 days), and a metal-phenolic network (MPN) “armor” of tannic acid (TA) and strontium ions (Sr 2+ ) providing broad-spectrum reactive oxygen species (ROS) scavenging (>83 % clearance) and enzyme-mimetic activity. CPM synergistically neutralizes oxidative stress, suppresses inflammation, and protects ECM integrity. In vitro, CPM demonstrates excellent biocompatibility and multi-target efficacy, concurrently suppressing inflammation, scavenging ROS, restoring mitochondrial function, and promoting ECM regeneration in stressed nucleus pulposus cells. In a rat IDD model, a single minimally invasive injection of CPM provides sustained drug retention (38.1 % at 2 weeks), preserves disc structure and proteoglycan content, and restores T2-MRI signals. This triple-synergistic strategy represents a promising therapeutic paradigm for arresting IDD progression.","PeriodicalId":101318,"journal":{"name":"MATERIALS & DESIGN","volume":"260 1","pages":"115243-115243"},"PeriodicalIF":0.0,"publicationDate":"2025-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147330606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-22DOI: 10.1016/j.matdes.2025.115169
Zhongjie Cheng, Yulin Niu, Yuan Yue, Wenfei Shen, Zhonglin Du, Yanxin Wang, Yao Wang, Jun Li, Christopher D. Snow, Matt J. Kipper, Soo Wohn Lee, Laurence A. Belfiore, Jianguo Tang
{"title":"High mechanical and luminescent properties of polyethylene terephthalate doped with Eu3+-induced nanoaggregates of polystyrene-block-polyacrylic acid","authors":"Zhongjie Cheng, Yulin Niu, Yuan Yue, Wenfei Shen, Zhonglin Du, Yanxin Wang, Yao Wang, Jun Li, Christopher D. Snow, Matt J. Kipper, Soo Wohn Lee, Laurence A. Belfiore, Jianguo Tang","doi":"10.1016/j.matdes.2025.115169","DOIUrl":"https://doi.org/10.1016/j.matdes.2025.115169","url":null,"abstract":"","PeriodicalId":101318,"journal":{"name":"MATERIALS & DESIGN","volume":"260 1","pages":"115169-115169"},"PeriodicalIF":0.0,"publicationDate":"2025-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147332766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-20DOI: 10.1016/j.matdes.2025.115165
Heng Gong, Yang Liu, Xi-Kun Ma, Tingjiang Gan, Ye Wu, Hui Zhang, Yueying Li
• Injectable, self-healing hydrogel interrupts AGEs–RAGE–ROS cycle to restore diabetic wound microenvironment • MnO 2 @PCA–QCMC matrix provides antibacterial, ROS-scavenging, oxygenation, and pro-angiogenic actions. • In vitro/in vivo studies show accelerated healing, reduced inflammation, and enhanced collagen deposition. Chronic diabetic wounds (CDWs) are refractory lesions characterized by oxidative stress, persistent infection, inflammation, ischemia, and excessive advanced glycation end products (AGEs). Binding of AGEs to their receptor (RAGE) triggers inflammatory and oxidative pathways, reinforcing a vicious cycle that impedes healing. Here, we developed a multifunctional hydrogel by crosslinking aldehyde-rich MnO 2 @protocatechualdehyde (PCA) nanoparticles with quaternized carboxymethyl chitosan (QCMC) via a Schiff base reaction, incorporating molybdenum disulfide (MoS 2 ) quantum dots. This hydrogel exhibits antibacterial activity, scavenges reactive oxygen species (ROS), reduces AGEs and RAGE expression, alleviates hypoxia, and promotes angiogenesis. In vitro and in vivo experiments demonstrated that it effectively inhibits bacterial growth, mitigates inflammation, enhances neovascularization, and accelerates CDW healing. This work offers a promising strategy for multi-target regulation of diabetic wound microenvironments.
{"title":"Multi-target hydrogel therapy to disrupt the AGEs–RAGE–ROS cycle in chronic diabetic wound healing","authors":"Heng Gong, Yang Liu, Xi-Kun Ma, Tingjiang Gan, Ye Wu, Hui Zhang, Yueying Li","doi":"10.1016/j.matdes.2025.115165","DOIUrl":"https://doi.org/10.1016/j.matdes.2025.115165","url":null,"abstract":"• Injectable, self-healing hydrogel interrupts AGEs–RAGE–ROS cycle to restore diabetic wound microenvironment • MnO 2 @PCA–QCMC matrix provides antibacterial, ROS-scavenging, oxygenation, and pro-angiogenic actions. • In vitro/in vivo studies show accelerated healing, reduced inflammation, and enhanced collagen deposition. Chronic diabetic wounds (CDWs) are refractory lesions characterized by oxidative stress, persistent infection, inflammation, ischemia, and excessive advanced glycation end products (AGEs). Binding of AGEs to their receptor (RAGE) triggers inflammatory and oxidative pathways, reinforcing a vicious cycle that impedes healing. Here, we developed a multifunctional hydrogel by crosslinking aldehyde-rich MnO 2 @protocatechualdehyde (PCA) nanoparticles with quaternized carboxymethyl chitosan (QCMC) via a Schiff base reaction, incorporating molybdenum disulfide (MoS 2 ) quantum dots. This hydrogel exhibits antibacterial activity, scavenges reactive oxygen species (ROS), reduces AGEs and RAGE expression, alleviates hypoxia, and promotes angiogenesis. In vitro and in vivo experiments demonstrated that it effectively inhibits bacterial growth, mitigates inflammation, enhances neovascularization, and accelerates CDW healing. This work offers a promising strategy for multi-target regulation of diabetic wound microenvironments.","PeriodicalId":101318,"journal":{"name":"MATERIALS & DESIGN","volume":"260 1","pages":"115165-115165"},"PeriodicalIF":0.0,"publicationDate":"2025-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147330566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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