Pub Date : 2025-11-07DOI: 10.1016/j.matdes.2025.115077
Wenjing Chen, Xiaoshuang Song, Zhenhong Li, Ziyuan Wang, Yubin Lin, Jianan Zhang, Fan Gao, Wei Zhang, Chunlai Nie, Dunfang Zhang
• Systemic administration of cisplatin suppresses anti-infective T-cell immunity. • CDDP@AHIC achieves potent antitumor efficacy without causing immunosuppression. • Preserving host immunity is key to developing safer, more effective chemotherapy.. In clinical settings, cisplatin (CDDP) administration causes immune suppression, rendering patients more susceptible to infection. Herein, systemic administration of CDDP substantially reduced the number and proliferative capacity of cluster of differentiation (CD)4 + and CD8 + T cells in the periphery of mice, and reduced the secretion of proinflammatory cytokines, such as interferon (IFN)-γ. To alleviate these toxic side effects, an injectable hydrogel was designed for the topical administration and sustained release of CDDP. The hydrogel was based on iminodiacetic acid-modified oxidized hyaluronic acid cross-linked with carboxymethyl chitosan (AHIC) and named CDDP@AHIC. The hydrogel exhibited promising anti-tumor effects, prevented damage, and suppressed the systemic protective immune response in tumor-bearing mice injected with B16 melanoma cells. When tumor-bearing mice treated with CDDP@AHIC were challenged with Listeria monocytogenes , mouse mortality was considerably inhibited. Notably, mice topically administered CDDP@AHIC had the same levels of IFN-γ production as the control mice, whereas mice systemically administered CDDP had impaired T cell immunity. Overall, CDDP@AHIC provides an alternative strategy for inhibiting tumor growth while maintaining protective T-cell immunity to resist infections. In addition, this drug release system may be useful for local treatment with other chemotherapeutic drugs.
{"title":"An injectable cisplatin hydrogel effectively suppresses tumors while preserving anti-infective immunity","authors":"Wenjing Chen, Xiaoshuang Song, Zhenhong Li, Ziyuan Wang, Yubin Lin, Jianan Zhang, Fan Gao, Wei Zhang, Chunlai Nie, Dunfang Zhang","doi":"10.1016/j.matdes.2025.115077","DOIUrl":"https://doi.org/10.1016/j.matdes.2025.115077","url":null,"abstract":"• Systemic administration of cisplatin suppresses anti-infective T-cell immunity. • CDDP@AHIC achieves potent antitumor efficacy without causing immunosuppression. • Preserving host immunity is key to developing safer, more effective chemotherapy.. In clinical settings, cisplatin (CDDP) administration causes immune suppression, rendering patients more susceptible to infection. Herein, systemic administration of CDDP substantially reduced the number and proliferative capacity of cluster of differentiation (CD)4 + and CD8 + T cells in the periphery of mice, and reduced the secretion of proinflammatory cytokines, such as interferon (IFN)-γ. To alleviate these toxic side effects, an injectable hydrogel was designed for the topical administration and sustained release of CDDP. The hydrogel was based on iminodiacetic acid-modified oxidized hyaluronic acid cross-linked with carboxymethyl chitosan (AHIC) and named CDDP@AHIC. The hydrogel exhibited promising anti-tumor effects, prevented damage, and suppressed the systemic protective immune response in tumor-bearing mice injected with B16 melanoma cells. When tumor-bearing mice treated with CDDP@AHIC were challenged with Listeria monocytogenes , mouse mortality was considerably inhibited. Notably, mice topically administered CDDP@AHIC had the same levels of IFN-γ production as the control mice, whereas mice systemically administered CDDP had impaired T cell immunity. Overall, CDDP@AHIC provides an alternative strategy for inhibiting tumor growth while maintaining protective T-cell immunity to resist infections. In addition, this drug release system may be useful for local treatment with other chemotherapeutic drugs.","PeriodicalId":101318,"journal":{"name":"MATERIALS & DESIGN","volume":"260 1","pages":"115077-115077"},"PeriodicalIF":0.0,"publicationDate":"2025-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147332180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-04DOI: 10.1016/j.matdes.2025.115075
Huan Zhou, Ang Gao, Yulong Liang, Cunhong Yin, Junhua Wu, Junfei Zhang, Guangming Chen, Lijun Peng, Xixia Liu
• PCL/MXene nerve guidance conduits (NGCs) with integrated topographical guidance and non-invasive electrical stimulation were fabricated using phase-separation 3D printing. • A non-invasive electrical stimulation (ES) model was established to evaluate the proliferation and differentiation behaviors of PC12 cells under microcurrent exposure. • The micro-grooved nerve conduits effectively guided directional PC12 cell growth. The clinical repair of peripheral nerve injury (PNI) presents high complexity, while neural conduits (NGCs) implantation serves as a potential strategy to promote peripheral nerve regeneration. However, integrating multiple factors such as three-dimensional microscopic porous structures, improved mechanical properties, surface topological features, and electrical stimulation (ES) to regulate the neural cell fate and reconstruct the regeneration microenvironment remains a significant challenge. Here, we successfully fabricated the PCL/MXene NGCs featuring microgroove structures and electrical conductivity using phase separation 3D printing technology. The NGCs demonstrate excellent mechanical properties (Young’s modulus: 12.78 ± 0.38 MPa) and electrical conductivity (5.68 ± 0.48 S/m), meeting the requirements for clinical application. Additionally, we incorporated electromagnetic induction technology to achieve synergistic modulation of directional guidance and non-invasive ES on rat pheochromocytoma (PC12) cells growth. In vitro cell culture experiments demonstrated that the PCL/MXene NGCs significantly guided the axonal orientation of PC12 with at 54.56 ± 4.84 % axons aligning within 0-30°. This magneto-induced, non-invasive ES further promoted cell proliferation and axonal growth, with the axonal length increased by approximately 31 % compared to the non-ES groups. This conductive grooved the PCL/MXene NGCs, constructed based on phase separation 3D printing and electromagnetic induction technology, holds promise for investigating nerve cell behaviors and offers innovative approaches for treating PNI.
{"title":"Research on the characteristics of nerve guidance conduits based on phase separation 3D printing and electromagnetic induction technology","authors":"Huan Zhou, Ang Gao, Yulong Liang, Cunhong Yin, Junhua Wu, Junfei Zhang, Guangming Chen, Lijun Peng, Xixia Liu","doi":"10.1016/j.matdes.2025.115075","DOIUrl":"https://doi.org/10.1016/j.matdes.2025.115075","url":null,"abstract":"• PCL/MXene nerve guidance conduits (NGCs) with integrated topographical guidance and non-invasive electrical stimulation were fabricated using phase-separation 3D printing. • A non-invasive electrical stimulation (ES) model was established to evaluate the proliferation and differentiation behaviors of PC12 cells under microcurrent exposure. • The micro-grooved nerve conduits effectively guided directional PC12 cell growth. The clinical repair of peripheral nerve injury (PNI) presents high complexity, while neural conduits (NGCs) implantation serves as a potential strategy to promote peripheral nerve regeneration. However, integrating multiple factors such as three-dimensional microscopic porous structures, improved mechanical properties, surface topological features, and electrical stimulation (ES) to regulate the neural cell fate and reconstruct the regeneration microenvironment remains a significant challenge. Here, we successfully fabricated the PCL/MXene NGCs featuring microgroove structures and electrical conductivity using phase separation 3D printing technology. The NGCs demonstrate excellent mechanical properties (Young’s modulus: 12.78 ± 0.38 MPa) and electrical conductivity (5.68 ± 0.48 S/m), meeting the requirements for clinical application. Additionally, we incorporated electromagnetic induction technology to achieve synergistic modulation of directional guidance and non-invasive ES on rat pheochromocytoma (PC12) cells growth. In vitro cell culture experiments demonstrated that the PCL/MXene NGCs significantly guided the axonal orientation of PC12 with at 54.56 ± 4.84 % axons aligning within 0-30°. This magneto-induced, non-invasive ES further promoted cell proliferation and axonal growth, with the axonal length increased by approximately 31 % compared to the non-ES groups. This conductive grooved the PCL/MXene NGCs, constructed based on phase separation 3D printing and electromagnetic induction technology, holds promise for investigating nerve cell behaviors and offers innovative approaches for treating PNI.","PeriodicalId":101318,"journal":{"name":"MATERIALS & DESIGN","volume":"260 1","pages":"115075-115075"},"PeriodicalIF":0.0,"publicationDate":"2025-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147332129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
• A SBMA/PVA-based semi-IPN hydrogel coating was developed for hemodialysis catheters. • The hydrogel coatings significantly enhanced hydrophilicity, reduced COF, inhibited bacterial/platelet adhesion and improved anticoagulation. • The hydrogel coatings exhibited excellent structural stability and hemocompatibility. • This study provides a novel functionalized strategy to reduce catheter complications and improve long-term dialysis outcomes. Hemodialysis catheters are prone to catheter-related complications due to their rough surface microstructure and poor lubrication, yet clinical solutions remain limited. This study developed a facile three-dimensional semi-interpenetrating polymer network (semi-IPN) hydrogel coating based on sulfobetaine methacrylate (SBMA) and polyvinyl alcohol (PVA) for surface lubrication of hemodialysis catheters. The hydrogel coating was characterized via Fourier-transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), and atomic force microscopy (AFM). Swelling tests, shear resistance assays, and hemolysis experiments confirmed its structural stability and blood compatibility. Hydrophilicity and lubricity were validated through water contact angle measurements and friction coefficient analyses. Anti-bacterial adhesion, anti-platelet adhesion, and ex vivo circulation experiments demonstrated its anti-infective and anticoagulant capabilities. This study proposes a novel functional coating strategy to reduce catheter-related complications in hemodialysis, offering significant potential for clinical translation.
{"title":"Lubricious hydrogel coating based on sulfobetaine methacrylate/polyvinyl alcohol for hemodialysis catheters","authors":"Zhaoxing Wang, Qiqi Han, Saijun Zhou, Jinfeng Xing, Pei Yu","doi":"10.1016/j.matdes.2025.114945","DOIUrl":"https://doi.org/10.1016/j.matdes.2025.114945","url":null,"abstract":"• A SBMA/PVA-based semi-IPN hydrogel coating was developed for hemodialysis catheters. • The hydrogel coatings significantly enhanced hydrophilicity, reduced COF, inhibited bacterial/platelet adhesion and improved anticoagulation. • The hydrogel coatings exhibited excellent structural stability and hemocompatibility. • This study provides a novel functionalized strategy to reduce catheter complications and improve long-term dialysis outcomes. Hemodialysis catheters are prone to catheter-related complications due to their rough surface microstructure and poor lubrication, yet clinical solutions remain limited. This study developed a facile three-dimensional semi-interpenetrating polymer network (semi-IPN) hydrogel coating based on sulfobetaine methacrylate (SBMA) and polyvinyl alcohol (PVA) for surface lubrication of hemodialysis catheters. The hydrogel coating was characterized via Fourier-transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), and atomic force microscopy (AFM). Swelling tests, shear resistance assays, and hemolysis experiments confirmed its structural stability and blood compatibility. Hydrophilicity and lubricity were validated through water contact angle measurements and friction coefficient analyses. Anti-bacterial adhesion, anti-platelet adhesion, and ex vivo circulation experiments demonstrated its anti-infective and anticoagulant capabilities. This study proposes a novel functional coating strategy to reduce catheter-related complications in hemodialysis, offering significant potential for clinical translation.","PeriodicalId":101318,"journal":{"name":"MATERIALS & DESIGN","volume":"259 1","pages":"114945-114945"},"PeriodicalIF":0.0,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147330637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
• Hollow ZIF-8 loaded with PAH-ACP for adhesive interfaces. • Induction of the intrafibrillar mineralization of collagen fibrils. • Robust antibacterial activity and enhanced odontoinductive activity. • Demonstrates promising applications in adhesive dentistry and biomaterial design. Resin-bonded restorations, a prevalent treatment modality for dental defects, are prone to complications including nanoleakage, secondary caries, and pulpal pathology over extended service periods. To address these challenges, this study developed a multifunctional biomaterial, HZN@PAH-ACP, specifically designed for application at the dentin bonding interface. The material was fabricated by etching ZIF-8 with tannic acid to produce HZN, which was subsequently loaded with poly(allylamine)-stabilized amorphous calcium phosphate (PAH-ACP). The structure and formation mechanism of this biomaterial were thoroughly investigated using electron microscopy and molecular dynamics simulations. Meanwhile, HZN@PAH-ACP effectively induced intrafibrillar mineralization of collagen fibers and promoted remineralization of demineralized dentin, significantly reducing nanoleakage within the hybrid layer. Furthermore, the material inhibited the activity of Streptococcus mutans and exhibits excellent biocompatibility, while simultaneously enhancing the odontogenic differentiation and mineralization of human dental pulp stem cells. All powered by the simultaneous release of calcium, phosphate, zinc ions, and tannic acid, and the reduction in pH further accelerates this process. The development of this biocompatible, multifunctional repair biomaterial presents considerable clinical potential, as it addresses multiple challenges concurrently through a single application, that can be used in adhesive primers and pulp capping agents, offering a promising solution for dental restoration.
{"title":"Hollow ZIF-8 nanoparticles Delivering PAH-ACP for multifunctional dentin Repair: Simultaneous Remineralization, antibacterial Activity, and Odontoinduction","authors":"Haowen Qi, Tao Xue, Xinyu Yang, Suqin Zhang, Shujing Wang, Changyu Shao, Chen Chen, Hua Xie","doi":"10.1016/j.matdes.2025.114928","DOIUrl":"https://doi.org/10.1016/j.matdes.2025.114928","url":null,"abstract":"• Hollow ZIF-8 loaded with PAH-ACP for adhesive interfaces. • Induction of the intrafibrillar mineralization of collagen fibrils. • Robust antibacterial activity and enhanced odontoinductive activity. • Demonstrates promising applications in adhesive dentistry and biomaterial design. Resin-bonded restorations, a prevalent treatment modality for dental defects, are prone to complications including nanoleakage, secondary caries, and pulpal pathology over extended service periods. To address these challenges, this study developed a multifunctional biomaterial, HZN@PAH-ACP, specifically designed for application at the dentin bonding interface. The material was fabricated by etching ZIF-8 with tannic acid to produce HZN, which was subsequently loaded with poly(allylamine)-stabilized amorphous calcium phosphate (PAH-ACP). The structure and formation mechanism of this biomaterial were thoroughly investigated using electron microscopy and molecular dynamics simulations. Meanwhile, HZN@PAH-ACP effectively induced intrafibrillar mineralization of collagen fibers and promoted remineralization of demineralized dentin, significantly reducing nanoleakage within the hybrid layer. Furthermore, the material inhibited the activity of Streptococcus mutans and exhibits excellent biocompatibility, while simultaneously enhancing the odontogenic differentiation and mineralization of human dental pulp stem cells. All powered by the simultaneous release of calcium, phosphate, zinc ions, and tannic acid, and the reduction in pH further accelerates this process. The development of this biocompatible, multifunctional repair biomaterial presents considerable clinical potential, as it addresses multiple challenges concurrently through a single application, that can be used in adhesive primers and pulp capping agents, offering a promising solution for dental restoration.","PeriodicalId":101318,"journal":{"name":"MATERIALS & DESIGN","volume":"259 1","pages":"114928-114928"},"PeriodicalIF":0.0,"publicationDate":"2025-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147330442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
PG-CDs prepared from hydrothermal approach exhibit excellent performance to extraction socket healing based on the multifunctional illustration. • Guanidylated carbon dots (PG-CDs) with multifunction were synthesized via a controllably hydrothermal method. • PG-CDs combat pathogens containing Streptococcus mutans and MRSA via membrane-disruptive mechanism. • PG-CDs exhibit appreciable osteoinductive potential and immunomodulatory effects. • PG-CDs demonstrate effective prevention of bacterial infection and promotion of bone healing in extraction sockets. • PG-CDs offer a promising strategy for post-extraction healing and long-term ridge preservation. The extraction of a non-restorable tooth, required due to severe caries, periodontitis, or trauma, is a common precursor to dental implantation. Following tooth extraction, physiological bone resorption occurs, and even infections can disrupt the immune microenvironment, further exacerbating bone loss. Some approaches with sophisticated antibacterial and immunomodulatory functions are required to prevent infection and orchestrate favorable tissue regeneration. Herein, guanidylated carbon dots (PG-CDs) with stable physicochemical properties and antibacterial–immunomodulatory functions were synthesized via a controllably hydrothermal method using citric acid and polyhexamethylene guanidine (PHMG) as precursors. PG-CDs possessed uniform spherical morphology, and surface functional groups including –NH 2 and guanidyl moieties. PG-CDs displayed potent efficacy against a broad spectrum of bacteria containing oral bacteria and their biofilms via membrane disruption, coupled with high stability and little risk of resistance development. The PG-CDs possessed biocompatibility and effectively promoted a pro-regenerative microenvironment by accelerating osteogenic differentiation and guiding macrophage polarization towards the M2 phenotype. In vivo results further implied that PG-CDs effectively enhanced bone regeneration, effectively reduced oral pathogenic bacterial load, and facilitated extraction socket healing. Collectively, these findings suggest that PG-CDs represent a promising nanomedicine for maintaining alveolar bone height post-extraction and offer an effective therapeutic strategy for bone tissue regeneration.
{"title":"Multifunctional carbon dots promote post-extraction bone regeneration for alveolar ridge preservation","authors":"Lingling Huang, Yiyang Wang, Yanjuan Huang, Menghan Zhang, Li Chen, Yue Tang, Shanshan Liu, Lisong Lin, Shaohuang Weng, Xiaofeng Zhu","doi":"10.1016/j.matdes.2025.114883","DOIUrl":"https://doi.org/10.1016/j.matdes.2025.114883","url":null,"abstract":"PG-CDs prepared from hydrothermal approach exhibit excellent performance to extraction socket healing based on the multifunctional illustration. • Guanidylated carbon dots (PG-CDs) with multifunction were synthesized via a controllably hydrothermal method. • PG-CDs combat pathogens containing Streptococcus mutans and MRSA via membrane-disruptive mechanism. • PG-CDs exhibit appreciable osteoinductive potential and immunomodulatory effects. • PG-CDs demonstrate effective prevention of bacterial infection and promotion of bone healing in extraction sockets. • PG-CDs offer a promising strategy for post-extraction healing and long-term ridge preservation. The extraction of a non-restorable tooth, required due to severe caries, periodontitis, or trauma, is a common precursor to dental implantation. Following tooth extraction, physiological bone resorption occurs, and even infections can disrupt the immune microenvironment, further exacerbating bone loss. Some approaches with sophisticated antibacterial and immunomodulatory functions are required to prevent infection and orchestrate favorable tissue regeneration. Herein, guanidylated carbon dots (PG-CDs) with stable physicochemical properties and antibacterial–immunomodulatory functions were synthesized via a controllably hydrothermal method using citric acid and polyhexamethylene guanidine (PHMG) as precursors. PG-CDs possessed uniform spherical morphology, and surface functional groups including –NH 2 and guanidyl moieties. PG-CDs displayed potent efficacy against a broad spectrum of bacteria containing oral bacteria and their biofilms via membrane disruption, coupled with high stability and little risk of resistance development. The PG-CDs possessed biocompatibility and effectively promoted a pro-regenerative microenvironment by accelerating osteogenic differentiation and guiding macrophage polarization towards the M2 phenotype. In vivo results further implied that PG-CDs effectively enhanced bone regeneration, effectively reduced oral pathogenic bacterial load, and facilitated extraction socket healing. Collectively, these findings suggest that PG-CDs represent a promising nanomedicine for maintaining alveolar bone height post-extraction and offer an effective therapeutic strategy for bone tissue regeneration.","PeriodicalId":101318,"journal":{"name":"MATERIALS & DESIGN","volume":"259 1","pages":"114883-114883"},"PeriodicalIF":0.0,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147330773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-04DOI: 10.1016/j.matdes.2025.114839
Shengxi Wu, Di You, Youbai Chen, Hongqi Meng, Huidong Zhou, Guokun Zhang, М. И. Воевода, Lichen Wang, Wenlai Guo, Wenrui Qu
• The microneedle patch consist of ARA290-loaded hydrogel-forming tips and a soluble backing. • The microneedle patch exhibits high biocompatibility, and minimal skin irritation. • Sustained ARA290 release via microneedles promotes M2 microglia polarization and reduces neuroinflammation. • The microneedle patch effectively alleviates allodynia and improves nerve morphology in a diabetic neuropathy rat model. Diabetic peripheral neuropathy (DPN) causes persistent pain and sensory dysfunction due to neuroinflammation, where pro-inflammatory microglial polarization is a key therapeutic target. ARA290, a peptide derived from erythropoietin with non-hematopoietic activity, offers neuroprotection and pain relief. However, its clinical utility has been constrained by intrinsic peptide limitations in administration and pharmacokinetics. To overcome this, we developed a biocompatible polymeric microneedle (MN) patch. This patch features hydrogel-forming tips loaded with ARA290 and a soluble backing, enabling sustained drug release upon dermal insertion with minimal irritation. In DPN model rats, the MN patches induced significantly early reductions in allodynia and hyperalgesia. Electrophysiological and histological assessments showed improved nerve conduction velocity and intraepidermal nerve density, respectively. Notably, sustained release promoted anti-inflammatory (M2) microglial polarization, reducing central neuroinflammation. Collectively, this MN patch-based strategy effectively alleviates peripheral neuropathy and inhibits central sensitization, offering a promising approach for advanced DPN treatment.
{"title":"ARA290 microneedle patch modulate microglia polarization and mitigate diabetic peripheral neuropathy","authors":"Shengxi Wu, Di You, Youbai Chen, Hongqi Meng, Huidong Zhou, Guokun Zhang, М. И. Воевода, Lichen Wang, Wenlai Guo, Wenrui Qu","doi":"10.1016/j.matdes.2025.114839","DOIUrl":"https://doi.org/10.1016/j.matdes.2025.114839","url":null,"abstract":"• The microneedle patch consist of ARA290-loaded hydrogel-forming tips and a soluble backing. • The microneedle patch exhibits high biocompatibility, and minimal skin irritation. • Sustained ARA290 release via microneedles promotes M2 microglia polarization and reduces neuroinflammation. • The microneedle patch effectively alleviates allodynia and improves nerve morphology in a diabetic neuropathy rat model. Diabetic peripheral neuropathy (DPN) causes persistent pain and sensory dysfunction due to neuroinflammation, where pro-inflammatory microglial polarization is a key therapeutic target. ARA290, a peptide derived from erythropoietin with non-hematopoietic activity, offers neuroprotection and pain relief. However, its clinical utility has been constrained by intrinsic peptide limitations in administration and pharmacokinetics. To overcome this, we developed a biocompatible polymeric microneedle (MN) patch. This patch features hydrogel-forming tips loaded with ARA290 and a soluble backing, enabling sustained drug release upon dermal insertion with minimal irritation. In DPN model rats, the MN patches induced significantly early reductions in allodynia and hyperalgesia. Electrophysiological and histological assessments showed improved nerve conduction velocity and intraepidermal nerve density, respectively. Notably, sustained release promoted anti-inflammatory (M2) microglial polarization, reducing central neuroinflammation. Collectively, this MN patch-based strategy effectively alleviates peripheral neuropathy and inhibits central sensitization, offering a promising approach for advanced DPN treatment.","PeriodicalId":101318,"journal":{"name":"MATERIALS & DESIGN","volume":"259 1","pages":"114839-114839"},"PeriodicalIF":0.0,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147333093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
• A novel corrosion-resistant SiC wire-mesh structured packing was proposed and prepared. • The effect of corrugated sheet characteristic parameters on compression strength was investigated by FEM method. • Compression strength was significantly improved by constructing a corrugated sheets-flat sheets composite configuration. • The SiC wire-mesh structured packings were utilized in chemical industry and operated stably for over 3 years. Wire-mesh structured packings are essential mass-transfer components in chemical rectification/separation processes. However, their inherent high-porosity design and delicate thin-structure characteristic typically result in compromised mechanical properties. Furthermore, conventional metallic structured packings exhibit quite limited corrosion resistance when exposed to either oxidizing or reducing acidic environments. In this study, a hybrid process combining template replication and reaction sintering was developed, enabling the fabrication of SiC wire-mesh structured packings. A synergistic approach combining finite element analysis (FEM) and experimental validation was applied to optimize the traditional wire-mesh structural parameters. Mechanical performance was further enhanced by strategically inserting planar SiC sheets between adjacent corrugated layers, resulting in a remarkable 12-fold increase in compressive strength (from 1.8 MPa to 21.4 MPa). The fabricated wire-mesh SiC also exhibited superior anti-acid corrosion ability compared with the metallic counterparts. The corresponding industrial products have been commercialized and operated stably for over 3 years.
{"title":"SiC wire-mesh structured packing for chemical rectification: structural design for optimizing mechanical properties and acid corrosion resistance","authors":"Yichen Xu, Shihao Sun, Yong Gao, Chong Tian, Zhenming Yang, Xiaodan Yang, Jinsong Zhang","doi":"10.1016/j.matdes.2025.114862","DOIUrl":"https://doi.org/10.1016/j.matdes.2025.114862","url":null,"abstract":"• A novel corrosion-resistant SiC wire-mesh structured packing was proposed and prepared. • The effect of corrugated sheet characteristic parameters on compression strength was investigated by FEM method. • Compression strength was significantly improved by constructing a corrugated sheets-flat sheets composite configuration. • The SiC wire-mesh structured packings were utilized in chemical industry and operated stably for over 3 years. Wire-mesh structured packings are essential mass-transfer components in chemical rectification/separation processes. However, their inherent high-porosity design and delicate thin-structure characteristic typically result in compromised mechanical properties. Furthermore, conventional metallic structured packings exhibit quite limited corrosion resistance when exposed to either oxidizing or reducing acidic environments. In this study, a hybrid process combining template replication and reaction sintering was developed, enabling the fabrication of SiC wire-mesh structured packings. A synergistic approach combining finite element analysis (FEM) and experimental validation was applied to optimize the traditional wire-mesh structural parameters. Mechanical performance was further enhanced by strategically inserting planar SiC sheets between adjacent corrugated layers, resulting in a remarkable 12-fold increase in compressive strength (from 1.8 MPa to 21.4 MPa). The fabricated wire-mesh SiC also exhibited superior anti-acid corrosion ability compared with the metallic counterparts. The corresponding industrial products have been commercialized and operated stably for over 3 years.","PeriodicalId":101318,"journal":{"name":"MATERIALS & DESIGN","volume":"259 1","pages":"114862-114862"},"PeriodicalIF":0.0,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147331273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-09-27DOI: 10.1016/j.matdes.2025.114854
Han Chen, Yang Pu, Yikun Ju, Songjie Li, Xin Dan, Peng Xue, Xianhe Huang, Lanjie Lei, Xing Fan, Yang Li
• Designed PRP-Cu-TCPP-Mn hydrogel with strong antimicrobial and healing effects. • Hydrogel mimics SOD and catalase to reduce ROS and inflammation in wounds. • Modulated macrophage polarization to accelerate tissue regeneration. • Exhibits injectability, self-healing, and shape-memory for wound adaptability. • Demonstrates superior healing in infected wounds through in vivo validation. The management of infectious wounds is still a critical clinical challenge. This study introduces a multifunctional hydrogel composed of oxidized hyaluronic acid (OHA) and carboxymethyl chitosan (CMCS), enhanced with platelet-rich plasma (PRP) and copper-tetra(4-carboxyphenyl)porphyrin-manganese (Cu-TCPP-Mn) nanozymes for advanced wound-healing applications. The hydrogel was synthesized via a Schiff base reaction, crosslinking the aldehyde groups of OHA with the carboxymethyl groups of CMCS to create a dynamic network with tunable rheological properties and excellent biocompatibility. Incorporation of PRP enriched the hydrogel with growth factors, markedly promoting tissue regeneration, whereas Cu-TCPP-Mn nanozymes effectively scavenged reactive oxygen species by mimicking superoxide dismutase and catalase activities. Furthermore, the hydrogel modulated macrophage polarization, and the synergistic effects of PRP and Cu-TCPP-Mn helped to alleviate persistent inflammation in infected wounds. A series of experiments showed that the CHPM hydrogel enhanced cell proliferation, migration, and differentiation, modulated inflammatory responses, and accelerated wound healing. The hydrogel also exhibited superior swelling capacity, self-healing behavior, and shape-memory functionality. These results underscore the potential of this hydrogel to be an innovative bioactive dressing for infectious wound healing with substantial promise for clinical antibacterial applications.
{"title":"Cu-TCPP-Mn nanozymes composite platelet-rich plasma hydrogel for infected wound healing","authors":"Han Chen, Yang Pu, Yikun Ju, Songjie Li, Xin Dan, Peng Xue, Xianhe Huang, Lanjie Lei, Xing Fan, Yang Li","doi":"10.1016/j.matdes.2025.114854","DOIUrl":"https://doi.org/10.1016/j.matdes.2025.114854","url":null,"abstract":"• Designed PRP-Cu-TCPP-Mn hydrogel with strong antimicrobial and healing effects. • Hydrogel mimics SOD and catalase to reduce ROS and inflammation in wounds. • Modulated macrophage polarization to accelerate tissue regeneration. • Exhibits injectability, self-healing, and shape-memory for wound adaptability. • Demonstrates superior healing in infected wounds through in vivo validation. The management of infectious wounds is still a critical clinical challenge. This study introduces a multifunctional hydrogel composed of oxidized hyaluronic acid (OHA) and carboxymethyl chitosan (CMCS), enhanced with platelet-rich plasma (PRP) and copper-tetra(4-carboxyphenyl)porphyrin-manganese (Cu-TCPP-Mn) nanozymes for advanced wound-healing applications. The hydrogel was synthesized via a Schiff base reaction, crosslinking the aldehyde groups of OHA with the carboxymethyl groups of CMCS to create a dynamic network with tunable rheological properties and excellent biocompatibility. Incorporation of PRP enriched the hydrogel with growth factors, markedly promoting tissue regeneration, whereas Cu-TCPP-Mn nanozymes effectively scavenged reactive oxygen species by mimicking superoxide dismutase and catalase activities. Furthermore, the hydrogel modulated macrophage polarization, and the synergistic effects of PRP and Cu-TCPP-Mn helped to alleviate persistent inflammation in infected wounds. A series of experiments showed that the CHPM hydrogel enhanced cell proliferation, migration, and differentiation, modulated inflammatory responses, and accelerated wound healing. The hydrogel also exhibited superior swelling capacity, self-healing behavior, and shape-memory functionality. These results underscore the potential of this hydrogel to be an innovative bioactive dressing for infectious wound healing with substantial promise for clinical antibacterial applications.","PeriodicalId":101318,"journal":{"name":"MATERIALS & DESIGN","volume":"259 1","pages":"114854-114854"},"PeriodicalIF":0.0,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147330324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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