G. Pouessel, Matthieu Antoine, S. Lejeune, F. Dubos, A. Pierache, A. Deschildre, S. Akitani, M. Amani, H. Audry‐Degardin, C. Bonnel, M. Boulyana, M. Chenaud, E. Cixous, F. Chagnon, S. Combes, F. Delepoule, C. Delvart, T. Dhaoui, M. Glowacki, M. Gnansounou, O. Guilluy, T. Heuclin, N. Kalach, A. Le Mée, S. Louf, A. Martinot, A. Martinet, S. Mitha, D. Penel, M. Scalbert, C. Thumerelle, C. Trochu
The most current clinical definition of anaphylaxis is that proposed by Sampson et al. and different scoring systems have been proposed to assess its severity [1,2]. Anaphylaxis symptoms range from mild, self-limiting local reactions to life-threatening anaphylaxis. All anaphylaxis guidelines emphasize early recognition and the need for prompt intramuscular adrenaline injection as the first-line treatment [3]. However, adrenaline for anaphylaxis is underused by patients, families and even by health professionals. In the European anaphylaxis registry, 27% of patients treated by a health professional received adrenaline [4].
{"title":"The time course of anaphylaxis manifestations in children is diverse and unpredictable","authors":"G. Pouessel, Matthieu Antoine, S. Lejeune, F. Dubos, A. Pierache, A. Deschildre, S. Akitani, M. Amani, H. Audry‐Degardin, C. Bonnel, M. Boulyana, M. Chenaud, E. Cixous, F. Chagnon, S. Combes, F. Delepoule, C. Delvart, T. Dhaoui, M. Glowacki, M. Gnansounou, O. Guilluy, T. Heuclin, N. Kalach, A. Le Mée, S. Louf, A. Martinot, A. Martinet, S. Mitha, D. Penel, M. Scalbert, C. Thumerelle, C. Trochu","doi":"10.1111/cea.13510","DOIUrl":"https://doi.org/10.1111/cea.13510","url":null,"abstract":"The most current clinical definition of anaphylaxis is that proposed by Sampson et al. and different scoring systems have been proposed to assess its severity [1,2]. Anaphylaxis symptoms range from mild, self-limiting local reactions to life-threatening anaphylaxis. All anaphylaxis guidelines emphasize early recognition and the need for prompt intramuscular adrenaline injection as the first-line treatment [3]. However, adrenaline for anaphylaxis is underused by patients, families and even by health professionals. In the European anaphylaxis registry, 27% of patients treated by a health professional received adrenaline [4].","PeriodicalId":10148,"journal":{"name":"Clinical & Experimental Allergy","volume":"29 1","pages":"117 - 120"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80791342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
E. Brandt, Paige E. Bolcas, Brandy P. Ruff, G. K. Khurana Hershey
Numerous epidemiologic studies have reported associations between exposure to air pollutant and increased risk of allergic diseases, with a recent study estimating that 8-20% of asthma emergency room visits worldwide could be attributed to ozone exposure and 4-9% to exposure to particulate matter smaller than 2.5µm (PM2.5 ). Traffic pollution derived diesel particles represent a major source of PM2.5 in large urban centers and have been linked to increased susceptibility to asthma development and asthma exacerbations.
{"title":"TSLP contributes to allergic airway inflammation induced by diesel exhaust particle exposure in an experimental model of severe asthma","authors":"E. Brandt, Paige E. Bolcas, Brandy P. Ruff, G. K. Khurana Hershey","doi":"10.1111/cea.13512","DOIUrl":"https://doi.org/10.1111/cea.13512","url":null,"abstract":"Numerous epidemiologic studies have reported associations between exposure to air pollutant and increased risk of allergic diseases, with a recent study estimating that 8-20% of asthma emergency room visits worldwide could be attributed to ozone exposure and 4-9% to exposure to particulate matter smaller than 2.5µm (PM2.5 ). Traffic pollution derived diesel particles represent a major source of PM2.5 in large urban centers and have been linked to increased susceptibility to asthma development and asthma exacerbations.","PeriodicalId":10148,"journal":{"name":"Clinical & Experimental Allergy","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76748652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
microRNA (miR)‐218‐5p is involved in cigarette smoke‐induced airway inflammation. In our earlier asthma epithelial miRNA profiling data, miR‐218‐5p was the top 2 down‐regulated miRNA. We hypothesize that miR‐218‐5p plays a role in asthma airway inflammation.
{"title":"microRNA‐218‐5p plays a protective role in eosinophilic airway inflammation via targeting δ‐catenin, a novel catenin in asthma","authors":"Yuxia Liang, Yuchen Feng, Wenliang Wu, Chenli Chang, Dian Chen, Shengchong Chen, G. Zhen","doi":"10.1111/cea.13498","DOIUrl":"https://doi.org/10.1111/cea.13498","url":null,"abstract":"microRNA (miR)‐218‐5p is involved in cigarette smoke‐induced airway inflammation. In our earlier asthma epithelial miRNA profiling data, miR‐218‐5p was the top 2 down‐regulated miRNA. We hypothesize that miR‐218‐5p plays a role in asthma airway inflammation.","PeriodicalId":10148,"journal":{"name":"Clinical & Experimental Allergy","volume":"48 1","pages":"29 - 40"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89219317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01Epub Date: 2019-11-26DOI: 10.1111/cea.13527
Nathalie J Plundrich, Andrew R Smith, Luke B Borst, Douglas B Snider, Tobias Käser, Evan S Dellon, Anthony T Blikslager, Jack Odle, Mary Ann Lila, Scott M Laster
Background: Esophagitis with eosinophilia, inflammation, and fibrosis represent a chronic condition in humans with food allergies.
Objective: In this investigation, we asked whether esophagitis with an eosinophilic component is observed in young pigs rendered allergic to hen egg white protein (HEWP).
Methods: Food allergy was induced in young pigs using two protocols. In one protocol, sensitized pigs were challenged by gavage with a single dose of HEWP. Clinical signs were monitored for 24 hours, and then, gastrointestinal (GI) tissues were collected for histological examination. The phenotype of circulating, ovalbumin (OVA)-specific T cells also was examined in HEWP challenged animals. In the second protocol, sensitized animals were fed HEWP for 28 days. Animals were then examined by endoscopy and gastrointestinal tissues collected for histological examination.
Results: In pigs challenged by gavage with HEWP, clinical signs were noted in 5/6 pigs including diarrhoea, emesis, and skin rash. Clinical signs were not seen in any control group. Histological analysis revealed significant levels of oesophageal eosinophilic infiltration (P < .05) in 4/6 of these animals, with two also displaying eosinophilic infiltration in the stomach. Eosinophils were not increased in ileum or colon samples. Increased numbers of circulating, OVA-specific CD4+ T cells also were observed in pigs that received HEWP by gavage. In the group of animals fed HEWP, endoscopy revealed clinical signs of esophagitis including oedema, granularity, white spots, and furrowing, while histology revealed oedema, immune cell infiltration, and basal zone hyperplasia.
Conclusions and clinical relevance: Food allergy in the pig can be associated with esophagitis based on histological and endoscopic findings, including eosinophilic infiltration. The young pig may, therefore, be a useful large animal model for the study of eosinophilic esophagitis in humans.
{"title":"Oesophageal eosinophilia accompanies food allergy to hen egg white protein in young pigs.","authors":"Nathalie J Plundrich, Andrew R Smith, Luke B Borst, Douglas B Snider, Tobias Käser, Evan S Dellon, Anthony T Blikslager, Jack Odle, Mary Ann Lila, Scott M Laster","doi":"10.1111/cea.13527","DOIUrl":"10.1111/cea.13527","url":null,"abstract":"<p><strong>Background: </strong>Esophagitis with eosinophilia, inflammation, and fibrosis represent a chronic condition in humans with food allergies.</p><p><strong>Objective: </strong>In this investigation, we asked whether esophagitis with an eosinophilic component is observed in young pigs rendered allergic to hen egg white protein (HEWP).</p><p><strong>Methods: </strong>Food allergy was induced in young pigs using two protocols. In one protocol, sensitized pigs were challenged by gavage with a single dose of HEWP. Clinical signs were monitored for 24 hours, and then, gastrointestinal (GI) tissues were collected for histological examination. The phenotype of circulating, ovalbumin (OVA)-specific T cells also was examined in HEWP challenged animals. In the second protocol, sensitized animals were fed HEWP for 28 days. Animals were then examined by endoscopy and gastrointestinal tissues collected for histological examination.</p><p><strong>Results: </strong>In pigs challenged by gavage with HEWP, clinical signs were noted in 5/6 pigs including diarrhoea, emesis, and skin rash. Clinical signs were not seen in any control group. Histological analysis revealed significant levels of oesophageal eosinophilic infiltration (P < .05) in 4/6 of these animals, with two also displaying eosinophilic infiltration in the stomach. Eosinophils were not increased in ileum or colon samples. Increased numbers of circulating, OVA-specific CD4<sup>+</sup> T cells also were observed in pigs that received HEWP by gavage. In the group of animals fed HEWP, endoscopy revealed clinical signs of esophagitis including oedema, granularity, white spots, and furrowing, while histology revealed oedema, immune cell infiltration, and basal zone hyperplasia.</p><p><strong>Conclusions and clinical relevance: </strong>Food allergy in the pig can be associated with esophagitis based on histological and endoscopic findings, including eosinophilic infiltration. The young pig may, therefore, be a useful large animal model for the study of eosinophilic esophagitis in humans.</p>","PeriodicalId":10148,"journal":{"name":"Clinical & Experimental Allergy","volume":"19 1","pages":"95-104"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6930966/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84719275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
P. Koźlik, J. Żuk, S. Bartyzel, J. Zarychta, K. Okoń, L. Zarȩba, Jan G. Bazan, J. Kosałka, J. Soja, J. Musial, S. Bazan-Socha
Airway structural changes are important in asthma pathology and require further investigations.
气道结构改变在哮喘病理中很重要，需要进一步研究。
{"title":"The relationship of airway structural changes to blood and bronchoalveolar lavage biomarkers, and lung function abnormalities in asthma","authors":"P. Koźlik, J. Żuk, S. Bartyzel, J. Zarychta, K. Okoń, L. Zarȩba, Jan G. Bazan, J. Kosałka, J. Soja, J. Musial, S. Bazan-Socha","doi":"10.1111/cea.13501","DOIUrl":"https://doi.org/10.1111/cea.13501","url":null,"abstract":"Airway structural changes are important in asthma pathology and require further investigations.","PeriodicalId":10148,"journal":{"name":"Clinical & Experimental Allergy","volume":"60 1","pages":"15 - 28"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75816753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
G. Liccioli, F. Mori, P. Parronchi, M. Capone, L. Filì, S. Barni, L. Sarti, M. Giovannini, M. Resti, E. Novembre
Severe cutaneous adverse reactions (SCARs) are delayed‐type hypersensitivity reactions to drugs including as follows: Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS), Stevens‐Johnson syndrome (SJS), Toxic Epidermal Necrolysis (TEN) and Acute Generalized Exanthematous Pustulosis (AGEP). Incidence, triggers and management of SCARs have not been investigated in large‐scale epidemiological studies on children.
{"title":"Aetiopathogenesis of severe cutaneous adverse reactions (SCARs) in children: A 9‐year experience in a tertiary care paediatric hospital setting","authors":"G. Liccioli, F. Mori, P. Parronchi, M. Capone, L. Filì, S. Barni, L. Sarti, M. Giovannini, M. Resti, E. Novembre","doi":"10.1111/cea.13513","DOIUrl":"https://doi.org/10.1111/cea.13513","url":null,"abstract":"Severe cutaneous adverse reactions (SCARs) are delayed‐type hypersensitivity reactions to drugs including as follows: Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS), Stevens‐Johnson syndrome (SJS), Toxic Epidermal Necrolysis (TEN) and Acute Generalized Exanthematous Pustulosis (AGEP). Incidence, triggers and management of SCARs have not been investigated in large‐scale epidemiological studies on children.","PeriodicalId":10148,"journal":{"name":"Clinical & Experimental Allergy","volume":"26 1","pages":"61 - 73"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87904454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
R. Ose, J. Tu, Anne-Kathrin Schink, J. Maxeiner, Petra Schuster, K. Lucas, J. Saloga, I. Bellinghausen
Ceylon cinnamon has been shown to possess anti‐inflammatory properties in many diseases including allergic inflammation.
锡兰肉桂已被证明在许多疾病中具有抗炎特性，包括过敏性炎症。
{"title":"Cinnamon extract inhibits allergen‐specific immune responses in human and murine allergy models","authors":"R. Ose, J. Tu, Anne-Kathrin Schink, J. Maxeiner, Petra Schuster, K. Lucas, J. Saloga, I. Bellinghausen","doi":"10.1111/cea.13507","DOIUrl":"https://doi.org/10.1111/cea.13507","url":null,"abstract":"Ceylon cinnamon has been shown to possess anti‐inflammatory properties in many diseases including allergic inflammation.","PeriodicalId":10148,"journal":{"name":"Clinical & Experimental Allergy","volume":"12 1","pages":"41 - 50"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79083463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Hadjigol, Keilah G. Netto, S. Maltby, H. Tay, T. H. Nguyen, Nicole G. Hansbro, F. Eyers, P. Hansbro, Ming Yang, P. Foster
Acute exacerbations of asthma represent a major burden of disease and are often caused by respiratory infections. Viral infections are recognized as significant triggers of exacerbations; however, less is understood about the how microbial bioproducts such as the endotoxin (lipopolysaccharide (LPS)) trigger episodes. Indeed, increased levels of LPS have been linked to asthma onset, severity and steroid resistance.
{"title":"Lipopolysaccharide induces steroid‐resistant exacerbations in a mouse model of allergic airway disease collectively through IL‐13 and pulmonary macrophage activation","authors":"S. Hadjigol, Keilah G. Netto, S. Maltby, H. Tay, T. H. Nguyen, Nicole G. Hansbro, F. Eyers, P. Hansbro, Ming Yang, P. Foster","doi":"10.1111/cea.13505","DOIUrl":"https://doi.org/10.1111/cea.13505","url":null,"abstract":"Acute exacerbations of asthma represent a major burden of disease and are often caused by respiratory infections. Viral infections are recognized as significant triggers of exacerbations; however, less is understood about the how microbial bioproducts such as the endotoxin (lipopolysaccharide (LPS)) trigger episodes. Indeed, increased levels of LPS have been linked to asthma onset, severity and steroid resistance.","PeriodicalId":10148,"journal":{"name":"Clinical & Experimental Allergy","volume":"10 1","pages":"82 - 94"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72843606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
G. Pouessel, Charlotte Jean-Bart, A. Deschildre, X. Van der Brempt, L. Tanno, P. Beaumont, P. Dumond, D. Sabouraud-Leclerc, E. Beaudouin, N. Ramdane, V. Liabeuf, J. Renaudin
Little is known regarding food anaphylaxis in infancy. We aimed to describe specificities of food anaphylaxis in infants (≤12 months) as compared to preschool children (1‐6 years).
{"title":"Food‐induced anaphylaxis in infancy compared to preschool age: A retrospective analysis","authors":"G. Pouessel, Charlotte Jean-Bart, A. Deschildre, X. Van der Brempt, L. Tanno, P. Beaumont, P. Dumond, D. Sabouraud-Leclerc, E. Beaudouin, N. Ramdane, V. Liabeuf, J. Renaudin","doi":"10.1111/cea.13519","DOIUrl":"https://doi.org/10.1111/cea.13519","url":null,"abstract":"Little is known regarding food anaphylaxis in infancy. We aimed to describe specificities of food anaphylaxis in infants (≤12 months) as compared to preschool children (1‐6 years).","PeriodicalId":10148,"journal":{"name":"Clinical & Experimental Allergy","volume":"3 1","pages":"74 - 81"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78289312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：