{"title":"Best of the other journals","authors":"E. Harnik, N. Patel","doi":"10.1111/cea.13608","DOIUrl":"https://doi.org/10.1111/cea.13608","url":null,"abstract":"","PeriodicalId":10148,"journal":{"name":"Clinical & Experimental Allergy","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78616663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
V. Pivniouk, João Antônio Gimenes Júnior, L. Honeker, D. Vercelli
Asthma, a complex, chronic disease characterized by airway inflammation, hyperresponsiveness and remodelling, affects over 300 million people worldwide. While the disease is typically associated with exaggerated allergen‐induced type 2 immune responses, these responses are strongly influenced by environmental exposures that stimulate innate immune pathways capable of promoting or protecting from asthma. The dual role played by innate immunity in asthma pathogenesis offers multiple opportunities for both research and clinical interventions and is the subject of this review.
{"title":"The role of innate immunity in asthma development and protection: Lessons from the environment","authors":"V. Pivniouk, João Antônio Gimenes Júnior, L. Honeker, D. Vercelli","doi":"10.1111/cea.13508","DOIUrl":"https://doi.org/10.1111/cea.13508","url":null,"abstract":"Asthma, a complex, chronic disease characterized by airway inflammation, hyperresponsiveness and remodelling, affects over 300 million people worldwide. While the disease is typically associated with exaggerated allergen‐induced type 2 immune responses, these responses are strongly influenced by environmental exposures that stimulate innate immune pathways capable of promoting or protecting from asthma. The dual role played by innate immunity in asthma pathogenesis offers multiple opportunities for both research and clinical interventions and is the subject of this review.","PeriodicalId":10148,"journal":{"name":"Clinical & Experimental Allergy","volume":"19 1","pages":"282 - 290"},"PeriodicalIF":0.0,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77735830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
F. Vega, M. Múgica, R. Bazire, L. Argiz, M. Belver, A. Friera, C. Blanco
Iodinated contrast media (ICM) were introduced into clinical practice to improve both diagnostic imaging and therapeutic procedures. Current ICM formulations are based on tri-iodobenzoic acid ring. Incidence of adverse reactions (AR) to ICM was 15% in 1975, but nowadays it has been reduced to 3% by using low-osmolarity and non-ionic ICM.
{"title":"Adverse reactions to iodinated contrast media: Safety of a study protocol that includes fast full‐dose parenteral challenge tests searching for an alternative contrast media","authors":"F. Vega, M. Múgica, R. Bazire, L. Argiz, M. Belver, A. Friera, C. Blanco","doi":"10.1111/cea.13518","DOIUrl":"https://doi.org/10.1111/cea.13518","url":null,"abstract":"Iodinated contrast media (ICM) were introduced into clinical practice to improve both diagnostic imaging and therapeutic procedures. Current ICM formulations are based on tri-iodobenzoic acid ring. Incidence of adverse reactions (AR) to ICM was 15% in 1975, but nowadays it has been reduced to 3% by using low-osmolarity and non-ionic ICM.","PeriodicalId":10148,"journal":{"name":"Clinical & Experimental Allergy","volume":"21 1","pages":"271 - 274"},"PeriodicalIF":0.0,"publicationDate":"2020-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81080820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fredrik Sundbom, A. Malinovschi, E. Lindberg, C. Almqvist, C. Janson
Insomnia symptoms are common with asthma. The aim of the study was to analyse the associations between insomnia symptoms and asthma control, asthma severity, and asthma‐related comorbidity in a community‐based population.
{"title":"Insomnia symptoms and asthma control—Interrelations and importance of comorbidities","authors":"Fredrik Sundbom, A. Malinovschi, E. Lindberg, C. Almqvist, C. Janson","doi":"10.1111/cea.13517","DOIUrl":"https://doi.org/10.1111/cea.13517","url":null,"abstract":"Insomnia symptoms are common with asthma. The aim of the study was to analyse the associations between insomnia symptoms and asthma control, asthma severity, and asthma‐related comorbidity in a community‐based population.","PeriodicalId":10148,"journal":{"name":"Clinical & Experimental Allergy","volume":"83 1","pages":"170 - 177"},"PeriodicalIF":0.0,"publicationDate":"2020-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77683412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
G. Patel, Jiexue Pan, Longyun Ye, Xiaofei Shen, D. Rosloff, Shanti S. D’Souza, I. Fung, Jocylen Celstin, Wei Sun, Poornima Sankar, Yuanyue Zhang, M. Pasha, Qi Yang
Asthma is a complicated chronic airway inflammatory disorder. In addition to standard steroid treatment, biologic therapies targeting specific cytokines have emerged to reduce exacerbation and improve lung function. Neutralizing antibodies against IL-5, a critical growth factor for eosinophils, reduced asthma exacerbation in patients with severe eosinophilic asthma.1 Blockade of IL4Rα, the receptor to IL-4 and IL-13, also lowered exacerbation rates and improved lung function in moderate to severe uncontrolled asthma.2 While these biologic therapies are now used as add-on maintenance treatment of moderate to severe asthma, the effects of these biologic therapies on human immune responses are yet to be better understood.
{"title":"Blockade of IL‐4Rα inhibits group 2 innate lymphoid cell responses in asthma patients","authors":"G. Patel, Jiexue Pan, Longyun Ye, Xiaofei Shen, D. Rosloff, Shanti S. D’Souza, I. Fung, Jocylen Celstin, Wei Sun, Poornima Sankar, Yuanyue Zhang, M. Pasha, Qi Yang","doi":"10.1111/cea.13514","DOIUrl":"https://doi.org/10.1111/cea.13514","url":null,"abstract":"Asthma is a complicated chronic airway inflammatory disorder. In addition to standard steroid treatment, biologic therapies targeting specific cytokines have emerged to reduce exacerbation and improve lung function. Neutralizing antibodies against IL-5, a critical growth factor for eosinophils, reduced asthma exacerbation in patients with severe eosinophilic asthma.1 Blockade of IL4Rα, the receptor to IL-4 and IL-13, also lowered exacerbation rates and improved lung function in moderate to severe uncontrolled asthma.2 While these biologic therapies are now used as add-on maintenance treatment of moderate to severe asthma, the effects of these biologic therapies on human immune responses are yet to be better understood.","PeriodicalId":10148,"journal":{"name":"Clinical & Experimental Allergy","volume":"40 1","pages":"267 - 270"},"PeriodicalIF":0.0,"publicationDate":"2020-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77974273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-18DOI: 10.1101/2020.01.16.20017772
G. Hurault, Elisa Domínguez-Hüttinger, S. Langan, H. Williams, R. Tanaka
Atopic dermatitis (AD) is a chronic inflammatory skin disease with periods of flares and remission. Designing personalized treatment strategies for AD is challenging, given the apparent unpredictability and large variation in AD symptoms and treatment responses within and across individuals. Better prediction of AD severity over time for individual patients could help to select optimum timing and type of treatment for improving disease control.
{"title":"Personalized prediction of daily eczema severity scores using a mechanistic machine learning model","authors":"G. Hurault, Elisa Domínguez-Hüttinger, S. Langan, H. Williams, R. Tanaka","doi":"10.1101/2020.01.16.20017772","DOIUrl":"https://doi.org/10.1101/2020.01.16.20017772","url":null,"abstract":"Atopic dermatitis (AD) is a chronic inflammatory skin disease with periods of flares and remission. Designing personalized treatment strategies for AD is challenging, given the apparent unpredictability and large variation in AD symptoms and treatment responses within and across individuals. Better prediction of AD severity over time for individual patients could help to select optimum timing and type of treatment for improving disease control.","PeriodicalId":10148,"journal":{"name":"Clinical & Experimental Allergy","volume":"22 1","pages":"1258 - 1266"},"PeriodicalIF":0.0,"publicationDate":"2020-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74300741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：