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The Glymphatic System and New Etiopathogenic Hypotheses Concerning Glaucoma Based on Pilot Study on Glaucoma Patients Who Underwent Osteopathic Manipulative Treatment (OMT) 青光眼的淋巴系统及新的发病假说——基于青光眼骨疗法(OMT)患者的初步研究
D. Paoli, L. Michelin, F. Vassallo, Luigi Ciullo, P. Brusini, L. Torelli
Purpose Malfunction of the lymphatic or glymphatic system recently shown in the brain, seems to play an important role in central neurodegenerative pathologies through a build-up of neurotoxins. Recent studies have shown functional links between aqueous humour and cerebrospinal fluid via the glymphatic system, offering new perspectives and unifying theories on the vascular, biomechanical and biochemical causes of chronic and open angle glaucoma (POAG). The aim of this randomized pilot study is to compare the variations in intraocular pressure between 20 cases of compensated POAG under pharmacological therapy and 20 glaucoma patients undergoing osteopathic treatment, hypothesizing that this manipulation can influence intraocular pressure. Materials and Methods The 40 patients under study, all covered by the Helsinki convention, were randomly divided into 2 groups (treated group or TG and control group or CG). The 40 patients were chosen from compensated glaucoma sufferers, who required neither changes in therapy nor operations which would affect their eye pressure which was measured both before and after manipulative osteopathic treatment scheduled into 4 sessions at intervals of 7.3 and 150 days, then compared with the control group (20 patients) who were undergoing pharmacological treatment only. Results The average IOP in the TG was compared with the CG throughout the entire treatment cycle showing a statistically inconclusive reduction in the right eye RE P-value (0.0561), while for the left eye a significant effect was shown LE (0.0073). The difference between the reduction in IOP between TG and CG was observable 10 months after the first session or rather 5 months after the last, and demonstrable during a check-up 13 months after the beginning of the study, or rather 8 months in absence of treatment with a highly significant statistical p-value (0.000434). Conclusions This study has shown that manipulative osteopathic treatment can affect intraocular pressure after each session and that the pressure is significantly lower even months after the last treatment session.
目的最近在大脑中显示的淋巴或淋巴系统的功能障碍,似乎通过神经毒素的积累在中枢神经退行性病变中起重要作用。近年来的研究表明,脑脊液通过淋巴系统与脑脊液之间存在功能联系,为慢性开角型青光眼(POAG)的血管、生物力学和生化原因提供了新的视角和统一的理论。本随机先导研究的目的是比较20例代偿POAG患者在药物治疗下和20例青光眼患者在骨疗法治疗下的眼压变化,假设骨疗法可以影响眼压。材料与方法将40例纳入赫尔辛基公约的患者随机分为治疗组(TG)和对照组(CG)。这40名患者选自代偿性青光眼患者,他们既不需要改变治疗方法,也不需要进行会影响他们眼压的手术。眼压是在手法整骨疗法治疗前后测量的,治疗前后分为4期,间隔7.3天和150天,然后与对照组(20名患者)进行比较。结果TG组与CG组在整个治疗周期内的平均IOP比较,右眼RE p值降低(0.0561),而左眼RE p值降低(0.0073),差异无统计学意义。TG和CG之间IOP降低的差异在第一次治疗后10个月或最后一次治疗后5个月可以观察到,在研究开始后13个月的检查中可以证明,或者在没有治疗的情况下8个月,具有高度显著的统计学p值(0.000434)。结论:本研究显示手法整骨疗法可影响每次治疗后的眼压,甚至在最后一次治疗数月后眼压显著降低。
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引用次数: 0
Establishment of “Retinoblastoma center” in A Tertiary Eye Care Center of Bangladesh – A New Hope for Retinoblastoma Patients 在孟加拉国三级眼科中心建立“视网膜母细胞瘤中心”——视网膜母细胞瘤患者的新希望
Rani Roy Soma
Retinoblastoma is the most common primary intraocular tumor in children with an incidence of 1:16,000 to 18,000 live birth. Worldwide newly detected cases per year are about 8000 and in India above 1400. It represents 11% of cancer that develops in the first year of life. The revolutionary management strategy has increased the survival rate of retinoblastoma above 95% in developed countries, and this rate is the highest among all pediatric cancers. But still, it is deadly cancer worldwide. Survival from retinoblastoma based on income >90% vs. 40% (in high to low-income countries). The incidence of metastasis is more in lower-income countries (32% vs. 12% in middle-income). Notably, Forty-three percent of the world’s estimated cases reside in only 6 countries in Asia (China, Indonesia, Philippines, India, Pakistan, and Bangladesh). The mortality rate varies on different continents. Worldwide estimated death from retinoblastoma is more than 40%, and most of them are from Asia and Africa. Bangladesh is one of the developing countries in the South-East Asia region, and retinoblastoma constitutes 83% of all pediatric cancer under 4 years of age. For proper management of retinoblastoma with an international standard, the establishment of a retinoblastoma center consisting of ocular oncologist, clinical oncologist, radiation oncologist, pediatrician, oculoplastic surgeon, retina specialist, pediatric ophthalmologist, and ocularist is needed. Management includes proper diagnosis, treatment of the disease, genetic counseling, regular follow-up, rehabilitation of survivors, and screening of siblings. Chittagong Eye Infirmary & Training Complex is a tertiary eye care center and one of the referral centers of Bangladesh and is treating retinoblastoma since its inception. Due to the demand of time, the hospital has been reorganized with various facilities to serve retinoblastoma patients with a team approach in 2017. From January 2017 to March 2022, a total of 304 patients were diagnosed. Among them, 132 received vincristine, etoposide, and carboplatin (VEC) chemotherapy from this center, and 79 underwent enucleation with the long optic nerve. Besides treatment, the hospital is conducting sibling screening, visual and psycho-social rehabilitation for the RB survivors, and community awareness programs.
视网膜母细胞瘤是儿童中最常见的原发性眼内肿瘤,其活产率为1:16 000至18000。全世界每年新发现的病例约为8000例,印度超过1400例。它占出生后第一年发生的癌症的11%。在发达国家,这种革命性的治疗策略使视网膜母细胞瘤的存活率提高到95%以上,是所有儿童癌症中最高的。但它仍然是世界范围内致命的癌症。基于收入的视网膜母细胞瘤存活率为90% vs. 40%(在高收入和低收入国家)。转移的发生率在低收入国家更高(32%对12%的中等收入国家)。值得注意的是,全世界估计病例的43%仅居住在亚洲6个国家(中国、印度尼西亚、菲律宾、印度、巴基斯坦和孟加拉国)。各大洲的死亡率各不相同。全世界视网膜母细胞瘤的死亡率估计超过40%,其中大多数来自亚洲和非洲。孟加拉国是东南亚地区的发展中国家之一,视网膜母细胞瘤占所有4岁以下儿童癌症的83%。为使视网膜母细胞瘤的治疗达到国际标准,需要建立一个由眼科肿瘤学家、临床肿瘤学家、放射肿瘤学家、儿科医生、眼整形外科医生、视网膜专科医生、儿童眼科医生和眼科医生组成的视网膜母细胞瘤中心。管理包括适当的诊断、疾病治疗、遗传咨询、定期随访、幸存者康复和兄弟姐妹筛查。吉大港眼科医院和培训中心是一个三级眼科保健中心,也是孟加拉国的转诊中心之一,自成立以来一直在治疗视网膜母细胞瘤。由于时间的需要,医院于2017年进行了重组,配备了各种设施,以团队方式为视网膜母细胞瘤患者提供服务。2017年1月至2022年3月,共诊断304例患者。其中132例在该中心接受长春新碱、依托泊苷、卡铂(VEC)化疗,79例视神经长段去核。除了治疗之外,医院还开展了兄弟姐妹筛查、RB幸存者的视觉和心理社会康复以及社区意识项目。
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引用次数: 0
Mobility Performance in Retinitis Pigmentosa Under Different Lighting Simulation Conditions 不同光照模拟条件下色素性视网膜炎的运动性能
R. Omar
This study examined the mobility performance in retinitis pigmentosa (RP) under different simulation lighting conditions. A total of twenty-one subjects with RP and twenty-one age-matched controls were enrolled. Preferred Walking Speed (PWS) were determined using a simple mobility course at 61 cd/m2 while Percentage of Preferred Walking Speed (PPWS) and error score were determined at five different illumination level which were 62, 47, 20, 6 and 1 cd/m2 using a complex mobility course. RP and normal people had similar mobility performances in simple mobility situations at a constant high light level. In lower light levels as well as in complex mobility situations, RP subjects demonstrated markedly reduced mobility performance. The relationship between PPWS and luminance was linear, with the PPWS decreasing significantly when the mobility course luminance dropped below the illumination of 20 cd/m2 . The Error score was also noted to be linearly related to log luminance. A luminance level of 20 cd/m2 may provide a useful decision point in setting indoor light levels for clinical mobility courses.
研究了不同模拟光照条件下色素性视网膜炎(RP)的运动性能。共有21名RP患者和21名年龄匹配的对照组被纳入研究。在61 cd/m2的简单光照条件下测定首选步行速度(PWS),在62、47、20、6和1 cd/m2的复杂光照条件下测定首选步行速度百分比(PPWS)和误差评分。在恒定的强光下,RP和正常人在简单的活动情况下的活动表现相似。在较低的光照水平和复杂的移动情况下,RP受试者表现出明显降低的移动性能。PPWS与亮度呈线性关系,当迁移过程亮度低于20 cd/m2时,PPWS显著降低。错误分数也被注意到与对数亮度线性相关。20 cd/m2的亮度水平可以为临床流动课程设置室内光线水平提供一个有用的决策点。
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引用次数: 0
Churg-Strauss syndrome presented as Pseudo-Foster-Kennedy syndrome: a case report Churg-Strauss综合征表现为伪福斯特-肯尼迪综合征:1例报告
Pub Date : 1900-01-01 DOI: 10.54646/bijcroo.2023.29
S. Roy, S. Biswas
A 52-year-old woman with bronchial asthma, frequent sneezing, and a skin lesion has suddenly developed poor vision for 15 days in the left eye. Her presenting vision was 6/18 and perception of light was positive in the right and left eyes, respectively, with mild pallor in the right optic disc and disc swelling in the left eye. She had a high eosinophil count, positive ANCA, and a skin biopsy in favor of Churg-Strauss disease. The patient was diagnosed with left optic neuropathy as a result of arteritis, which is a component of Churg-Strauss syndrome (CSS), and was treated with Inj. Methylprednisolone pulse therapy, followed by oral prednisolone but preceded to no perception of light in the left eye after 7 days of follow-up. Although CSS is a rare disease, routine checkup by an ophthalmologist can save vision and identify the high-risk group for proper referral to prevent unwanted morbidity and mortality.
一名52岁女性,患有支气管哮喘、频繁打喷嚏和皮肤病变,左眼视力突然下降,持续15天。她的呈现视力为6/18,右眼和左眼光感均为阳性,右视盘轻度苍白,左眼视盘肿胀。她嗜酸性粒细胞计数高,ANCA阳性,皮肤活检显示为丘格-施特劳斯病。患者被诊断为由动脉炎引起的左视神经病变,这是Churg-Strauss综合征(CSS)的一个组成部分,并接受注射治疗。甲强的松龙脉冲治疗,随后口服强的松龙,但在随访7天后左眼无光感。虽然CSS是一种罕见的疾病,但眼科医生的常规检查可以挽救视力,并确定高危人群,以适当转诊,以防止不必要的发病率和死亡率。
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引用次数: 0
Spontaneous Globe Subluxation in a Neonate: A Case Report with Literature Review 新生儿自发性全球半脱位1例并文献复习
S. Roy, Md. Asrarul Hoque
Globe subluxation is a medical emergency and a frightening condition. The spontaneous subluxation is the rarest of the subluxations, with fewer than 40 cases reported to date. This condition is extremely rare in children, with the most recent reported age being 8 months. However, Crouzon syndrome in infants is also less reported. Here we report a case of neonatal Crouzon syndrome with spontaneous globe subluxation and its surgical management.
全球半脱位是一种医疗紧急情况,也是一种可怕的情况。自发性半脱位是半脱位中最罕见的,迄今为止报道的病例不到40例。这种情况在儿童中极为罕见,最近报道的年龄为8个月。然而,婴儿Crouzon综合征的报道也较少。在这里,我们报告一例新生儿克鲁松综合征自发性球半脱位及其手术治疗。
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引用次数: 0
Phenotypic Analysis of A Case of ‘3MC Syndrome’ with Review of Literature 1例“3MC综合征”的表型分析并文献复习
Rani Roy Soma, Kader Md. Sazzad
3MC syndrome is a very rare entity. It’s prevalence is unknown but most cases are reported from Middle East. First case was reported in 1978 and named as Michel syndrome and recently with other three syndromes together these syndromes are named as 3 MC syndrome. All are autosomal recessive disorder and reported from both consanguineous and non- consanguineous parents. Here we phenotypically analyzed a case presented with the features of blepharophimosis syndrome associated with craniosynostosis suggestive of Mischel syndrome which is a part of ‘3 MC syndrome’.
3MC综合征是一种非常罕见的疾病。它的流行程度尚不清楚,但大多数病例报告来自中东。首例病例于1978年报道,并命名为米歇尔综合征,最近与其他三种综合征一起被命名为3mc综合征。所有病例均为常染色体隐性遗传病,据报道均来自近亲和非近亲父母。在这里,我们从表型上分析了一个病例,该病例表现为睑下垂综合征合并颅缝闭锁,提示米歇尔综合征,这是“3mc综合征”的一部分。
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引用次数: 0
Panophthalmitis After Aurolab Aqueous Drainage Implant (AADI) in Refractory Glaucoma with Vogt-Koyanagi-Harada Syndrome (VKH): A Case Report 难治性青光眼合并Vogt-Koyanagi-Harada综合征(VKH)术后全眼炎1例
Md Iftekher Iqbal, S. Kabir, B. Sarker
This case of Vogt-Koyanagi-Harada (VKH) disease underwent Aurolab Aqueous Drainage Implant (AADI) for refractory glaucoma. Later, developed postoperative (2 months) panophthalmitis characterized by sudden visual loss, moderate pain, redness, and purulent discharge. Systemic, topical, and intravitreal antibiotic therapy was started immediately, and evisceration was performed.
本病例为Vogt-Koyanagi-Harada (VKH)病,接受光实验室水引流植入治疗难治性青光眼。术后(2个月)发展为全眼炎,表现为突然视力丧失、中度疼痛、红肿和脓性分泌物。立即开始全身、局部和玻璃体内抗生素治疗,并进行内脏切除。
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引用次数: 0
Management Challenge: A Case of Aniridia and Aphakia with Secondary Glaucoma in Sclerokeratoplasty 管理挑战:无虹膜无晶状体伴继发性青光眼1例
S. Thatte, Komal Jaiswal, Radhika Maheshwari
A patient presented to us with post-infectious keratitis and a large anterior staphyloma in the left eye with vision as low as only the perception of light and accurately determining the projection of rays. A B-scan showed no abnormality in the posterior segment. Sclerokeratoplasty with an 11-mm graft with aniridia and aphakia was done. On 4 weeks of follow-up, intraocular pressure (IOP) was 39 mmHg on applanation tonometry, for which medical management was tried using a combination regime that was insufficient, following which a series of management approaches like trabeculectomy and Ahmed glaucoma valve (AGV) implant was done (in superotemporal quadrant). Unfortunately, recurrent exposures of the AGV tube were encountered, which were managed using different graft materials one after the other but were unsuccessful. Ultimately, AGV explantation and reinsertion at another site (in inferotemporal quadrant) was tried, which led to salvaging the eye with well controlled IOP, clear graft, and good visual function (best corrected visual acuity of 6/12p with +12.00/+1.50 × 90◦ ). The purpose of this article was to highlight that despite multiple complications encountered in a single case, a careful sequential approach, good surgical skills, and a never giving up attitude lead to excellent results.
我们的病人提出了感染后角膜炎和一个大的前葡萄肿在左眼视力低到只有光的感知和准确地确定射线的投影。b线扫描显示后段未见异常。采用11mm无虹膜无晶状体移植巩膜成形术。随访4周,眼压计眼压(IOP)为39 mmHg,尝试联合用药治疗,但效果不理想,随后行小梁切除术和Ahmed青光眼瓣膜(AGV)植入(颞上象限)等一系列治疗方法。不幸的是,AGV管反复暴露,使用不同的移植材料一个接一个地进行处理,但都没有成功。最终,我们尝试将AGV移植到另一个部位(颞下象限),挽救了眼,IOP控制良好,移植物清晰,视觉功能良好(最佳矫正视力为6/12p, +12.00/+1.50 × 90◦)。本文的目的是强调,尽管在单个病例中遇到多种并发症,但谨慎的顺序方法,良好的手术技巧和永不放弃的态度会导致良好的结果。
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引用次数: 0
Efficacy of Autologous Blood Clot in Primary Pterygium Surgery Compared With Suture Technique in a Tertiary Hospital of Bangladesh 孟加拉某三级医院自体血凝块在原发性翼状胬肉手术中的疗效比较
Md Iftekher Iqbal, Fariah Osman, Md. Firoz Kabir, S. Parvez
Purpose: The aim of this study is to assess the efficacy among patients undergoing pterygium excision and conjunctival autograft utilizing autologous blood or sutures. Methods: A randomized controlled trial of 1 year and 5 months, with 60 eyes from 60 patients having primary nasal pterygium. As indicated by inclusion criteria, they were chosen and randomized into two arms for conjunctival autograft: treated arm A (30) with autologous blood and arm B (30) with stitches (10-0 monofilament nylon). Preoperative and postoperative results were assessed and analyzed statistically. Follow-up was done at first, seventh, 1-month, 3-month, and half-year postoperative days. Resulting factors were total surgical time, postoperative comfort, graft stability, and recurrence. Results: 60 patients; mean age of 46.77 ± 7.04 (SD) in arm A (30) and 46.17±7.53 (SD) in arm B (30). In arm A, 22 males (73.3%) and 8 females (26.7%) where arm B had 20 males (66.7%) and 10 females (33.3%). Total surgical time in arm A was 24.73 ± 3.69 (SD) minutes and in arm B was 32.23 ± 4.59 (SD) minutes (p < 0.001). Follow-up at the 1st and 7th POD showed significant discomfort in arm B (mean ranks 41.82 and 40.62) compared to arm A (mean ranks 19.18 and 20.38), respectively (p < 0.001). At 1st POD, only 3 (10%) graft retractions in arm A. Within 6 months of follow-up, all grafts were stable; 1 (3.3%) recurrence and 1 (3.3%) granuloma in arm B only. Conclusion: In primary pterygium surgery, autologous blood showed excellent postoperative results with no recurrence and reduced surgical time. So, it seems to be an effective surgical means to treat primary pterygium.
目的:本研究的目的是评估翼状胬肉切除和自体结膜移植使用自体血液或缝合线的疗效。方法:对60例原发性鼻翼状胬肉患者60只眼进行1年5个月的随机对照试验。根据纳入标准,他们被随机分为两组进行自体结膜移植:用自体血液治疗的A臂(30例)和用缝线(10-0单丝尼龙)缝合的B臂(30例)。对术前、术后结果进行评估和统计分析。术后第1天、第7天、1个月、3个月、半年随访。影响因素包括手术总时间、术后舒适度、移植物稳定性和复发率。结果:60例;A组(30岁)平均年龄46.77±7.04 (SD), B组(30岁)平均年龄46.17±7.53 (SD)。A组男性22人(73.3%),女性8人(26.7%),B组男性20人(66.7%),女性10人(33.3%)。A组总手术时间为24.73±3.69 (SD) min, B组总手术时间为32.23±4.59 (SD) min (p < 0.001)。在第1和第7次POD随访时,B组(平均评分为41.82和40.62)明显高于A组(平均评分为19.18和20.38)(p < 0.001)。在第1次POD时,a臂只有3例(10%)移植物缩回,随访6个月,所有移植物均稳定;B组复发1例(3.3%),肉芽肿1例(3.3%)。结论:自体血液在原发性翼状胬肉手术中具有良好的术后效果,无复发,缩短手术时间。因此,它似乎是治疗原发性翼状胬肉的一种有效的手术手段。
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引用次数: 0
Dried Scleral Patch Graft: A Temporary Measure of Corneal Perforation Prior Keratoplasty-Two Case Reports 干巩膜贴片移植:角膜移植前角膜穿孔的临时措施-两例报告
Biswas Sujit Kumar, A. S. M. Mahbubul Alam, Ahmed Ria Tanjila, Matin Bhuiyan Abdul
Aim: To describe the temporary management of corneal perforation by using dried sclera patch graft prior keratoplasty when donor tissue not available. Case report: Two cases of corneal perforation (>2mm) of various causes presented with severely decreased vision and shallow anterior chamber and soft eye ball. Both needed immediate therapeutic keratoplasty to save the globe and restore the vision. Due to unavailability of donor cornea, both patients were surgically managed with dried scleral patch graft temporarily to save the globe. Both patients underwent therapeutic keratoplasty one moth and one and half months respectively. Both patients gained better vision (6/18 and 6/24 respectively), quiet anterior chamber and no secondary glucoma after 6 month of keratoplasty. Conclusion: Dried sclera patch graft is a good option for temporary management of corneal perforation of various causes until a donor cornea is available. These patch grafts prevent ocular hypotony, posterior synechiea and secondary glucoma.
目的:探讨在角膜移植前无供体组织的情况下,采用干巩膜补片临时治疗角膜穿孔的方法。病例报告:2例各种原因的角膜穿孔(>2mm),表现为视力严重下降,前房浅,眼球软。两人都需要立即进行治疗性角膜移植术以挽救眼球并恢复视力。由于无法获得供体角膜,两例患者均暂时采用干巩膜贴片手术治疗以挽救眼球。两例患者分别于1个月和1个半月接受治疗性角膜移植。6个月后,两例患者均获得较好的视力(分别为6/18和6/24),前房安静,无继发眼角膜。结论:在找到供角膜之前,干巩膜贴片移植是暂时治疗各种原因的角膜穿孔的良好选择。这些小片移植物可预防眼斜视、后连和继发性眼瘤。
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引用次数: 0
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BOHR International Journal of Current Research in Optometry and Ophthalmology
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