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Deterioration of Hearing Due to Hearing Aids. 助听器导致听力下降。
IF 3 3区 医学 Q1 OTORHINOLARYNGOLOGY Pub Date : 2024-05-01 Epub Date: 2024-05-07 DOI: 10.21053/ceo.2023.00024
Yujin Heo, Yang-Sun Cho

Objectives: A primary reason for the low adoption of hearing aids (HAs) among the large population with sensorineural hearing loss is the perception that these devices may negatively impact remaining hearing ability. Research addressing this issue has yielded conflicting results. This study examined the long-term effects of HAs on standard audiometric changes in individuals with sensorineural hearing loss.

Methods: We retrospectively analyzed patients who acquired unilateral HAs between 2015 and 2017 and demonstrated consistent use over a 5-year period. We examined demographics, medical comorbidities, audiometric data, and questionnaire results from the Hearing Handicap Inventory for the Elderly and the International Outcome Inventory for Hearing Aids. Additionally, we reviewed each patient's history of noise exposure and prior HA use.

Results: The study included 55 patients who used unilateral HAs, with a mean follow-up period of 5.32 years. Among them, 31 patients (56.4%) used the HA on the right side. Audiometric data from the aided side showed no significant difference from the unaided side in either the pre-fit pure-tone average of air conduction (AC) or word recognition score (WRS) (P =0.73 and P =0.11, respectively). Similarly, no significant differences were noted in the 5-year follow-up audiometry of AC and WRS (P=0.98 and P=0.07, respectively) or in the change from pre-fit to final audiometry for either parameter (AC, P=0.58; WRS, P=0.70). Eleven patients (20%) exhibited a deterioration in hearing (as measured by AC) of 5 dB or greater on the aided side compared with the unaided side, while 23 (53.5%) showed greater WRS deterioration on the aided side. No significant factors were found to contribute to the difference in hearing deterioration between groups for either AC or WRS.

Conclusion: No significant factors were identified as contributing to hearing deterioration after prolonged HA use. Overall, the use of HAs did not adversely impact residual hearing.

目的:在众多感音神经性听力损失患者中,助听器(HA)采用率不足的主要原因之一是社会担心助听器可能会对剩余听力能力产生负面影响。迄今为止,关于这一问题的研究很少,结果也存在争议。本研究探讨了助听器对感音神经性听力损失患者标准听力变化的长期影响:研究回顾性分析了 2015 年至 2017 年间新获得单侧 HA 并显示持续使用五年的患者。研究对象包括人口统计学、合并症、听力数据、老年人听力障碍量表(HHIE)和国际助听器结果量表(IOI-HA)的问卷调查结果、噪声暴露史以及之前使用过助听器:55 名患者使用了单侧助听器,平均随访时间为 5.32 年。31名患者(56.4%)在右侧使用助听器。受助侧的听力数据与未受助侧相比,在矫治前的纯音平均气导(AC)和单词识别分数(WRS)(P= 0.73,0.11,分别为0.73和0.11)、AC和WRS的五年随访听力(P=0.98,0.07)或AC和WRS从最后一次到矫治前的听力变化(P=0.58,0.70)方面均无显著差异。如果将助听侧与非助听侧听力下降 5 分贝或更多的患者进行比较,有 11 名患者(20%)的助听侧 AC 出现恶化,23 名患者(53.5%)的助听侧 WRS 出现进一步恶化。两组患者在 AC 或 WRS 方面的听力恶化差异均无明显因素:结论:长期使用助听器后,听力恶化没有明显的诱因,总体而言,助听器的使用不会对残余听力产生负面影响。
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引用次数: 0
Electrically Evoked Auditory Brainstem Response Using Extracochlear Stimulation at Different Cochlear Sites: A Comparison With Intracochlear Stimulation. 使用不同耳蜗部位的耳外刺激诱发听性脑干反应:与蜗内刺激的比较。
IF 3 3区 医学 Q1 OTORHINOLARYNGOLOGY Pub Date : 2024-05-01 Epub Date: 2024-01-26 DOI: 10.21053/ceo.2023.00034
Woongsang Sunwoo, Woonhoe Goo, Seung-Ha Oh

Objectives: The distribution and extent of excitable spiral ganglion neurons (SGNs) have been investigated using the electrically evoked auditory brainstem response (EABR) during preoperative and perioperative periods. In this study, we investigated the EABR with extracochlear stimulation (eEABR) as a preoperative test to estimate these factors.

Methods: Sixteen male Sprague-Dawley rats were used in this study. Experiments were conducted in nine rats with normal hearing and seven rats that were partially deafened with ouabain treatment. Each experiment involved the following steps: extracochlear stimulating electrode placement at three different sites along the axis of the cochlea and eEABR recordings; cochleostomy and four-channel intracochlear array implantation, followed by EABR recordings with various electrode pair combinations; and after electrophysiological measurements, harvest of the cochleae for histopathological evaluation. The slope characteristics of the amplitude growth function measured from eEABR and EABR, frequency-specific auditory thresholds, and the density of SGNs were compared.

Results: Similar trends were observed in slope changes on different sites of stimulation with both types of stimulation in normal-hearing animals-specifically, a monotonically increasing slope with increasing distance between bipolar pairs. In addition, eEABR slopes showed significant correlations with EABR slopes when the expected cochlear regions of stimulation were similar in normal-hearing animals. In partially deaf animals, the auditory thresholds at several frequencies had a significant correlation with the eEABR slopes of each extracochlear electrode at the apical, middle, and basal cochlear positions. This indicated that increasing the regions of cochlear stimulation had a differential impact on eEABR slopes, depending on the neural conditions.

Conclusion: Our results indicated that eEABR slopes showed significant spatial correlations with the functionality of the auditory nerve. Therefore, eEABR tests at various cochlear positions might be used for estimating the extent of excitable SGNs in cochlear implant candidates prior to implantation.

目的:有学者利用电诱发听性脑干反应(EABR)对术前或围术期可兴奋螺旋神经节神经元(SGN)的分布和范围进行了研究。在本研究中,我们将耳外刺激诱发听性脑干反应(EABR)作为一种术前测试工具来估算这些因素:本研究使用了 16 只雄性 Sprague-Dawley 大鼠。方法:本研究使用了 16 只雄性 Sprague-Dawley 大鼠,其中 9 只听力正常,7 只经欧氨酯治疗后部分失聪。每项实验均包括以下步骤:(1)沿耳蜗轴线在三个不同位置放置蜗外刺激电极,并进行电子脑电图记录。(2)耳蜗造口术和 4 通道耳蜗内阵列植入。然后,使用不同的电极对组合进行 EABR 记录。(3) 电生理测量后,采集耳蜗进行组织病理学评估。比较了 eEABR 和 EABR 测量的振幅增长函数的斜率特征、频率特异性听阈和 SGN 的密度:结果:在听力正常的动物身上,两种刺激方式在不同刺激部位的斜率变化趋势相似,都是随着双极对之间距离的增加而单调增加。此外,当正常听力动物的预期耳蜗刺激区域相似时,eEABR 斜率与 EABR 斜率显示出显著的相关性。在偏聋动物中,多个频率的听阈与每个耳蜗外电极在耳尖、中间和基底位置的 eEABR 斜率有显著相关性。这表明,根据神经条件的不同,耳蜗刺激区域的增加对 eEABR 斜率的影响也不同:我们的研究结果表明,eEABR 斜率与听神经的功能有显著的空间相关性。因此,在植入人工耳蜗前,在不同耳蜗位置进行的 eEABR 测试可用于估计人工耳蜗植入者听神经兴奋的程度。
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引用次数: 0
Perinatal Risk Factors in Relation to Asthma and Allergic Rhinitis in Children and Adolescents. 与儿童和青少年哮喘和过敏性鼻炎有关的围产期风险因素。
IF 3 3区 医学 Q1 OTORHINOLARYNGOLOGY Pub Date : 2024-04-08 DOI: 10.21053/ceo.2024.00024
Se Hwan Hwang, Hyesoo Shin, Gulnaz Stybayeva, Do Hyun Kim
To evaluate the associations between birth-related exposures and postnasal factors and risk for allergic rhinitis and asthma in children and adolescents.
评估与出生有关的暴露和鼻后因素与儿童和青少年过敏性鼻炎和哮喘风险之间的关联。
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引用次数: 0
Treatment Outcome of Olfactory Neuroblastoma: A Multicenter Study by the Korean Sinonasal Tumor and Skull Base Surgery Study Group. 嗅神经母细胞瘤的治疗结果:韩国鼻窦肿瘤和颅底手术研究小组的一项多中心研究。
IF 3 3区 医学 Q1 OTORHINOLARYNGOLOGY Pub Date : 2024-02-26 DOI: 10.21053/ceo.2023.00089
Sang Duk Hong, Song I Park, Ji Heui Kim, Sung Jae Heo, Sung-Woo Cho, Tae-Bin Won, Hyun-Jin Cho, Dong Hoon Lee, Sue Jean Mun, Soo Kyoung Park, Yong-Wan Kim, Dong-Young Kim
Due to the rarity of olfactory neuroblastoma (ONB), there is an ongoing debate about optimal treatment strategies, especially for early staged or locally advanced cases. Therefore, our study aims to explore experiences from multiple centers, focusing on factors that influence the oncological outcomes of ONB.
由于嗅神经母细胞瘤(ONB)的罕见性,关于最佳治疗策略的争论一直没有停止过,尤其是对于早期分期或局部晚期病例。因此,我们的研究旨在探索多个中心的经验,重点关注影响嗅神经母细胞瘤肿瘤治疗效果的因素。
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引用次数: 0
Hair Cell Regeneration: From Animals to Humans. 毛细胞再生:从动物到人类
IF 3 3区 医学 Q1 OTORHINOLARYNGOLOGY Pub Date : 2024-02-01 Epub Date: 2024-01-19 DOI: 10.21053/ceo.2023.01382
Sung-Won Choi, Julia M Abitbol, Alan G Cheng

Cochlear hair cells convert sound into electrical signals that are relayed via the spiral ganglion neurons to the central auditory pathway. Hair cells are vulnerable to damage caused by excessive noise, aging, and ototoxic agents. Non-mammals can regenerate lost hair cells by mitotic regeneration and direct transdifferentiation of surrounding supporting cells. However, in mature mammals, damaged hair cells are not replaced, resulting in permanent hearing loss. Recent studies have uncovered mechanisms by which sensory organs in non-mammals and the neonatal mammalian cochlea regenerate hair cells, and outlined possible mechanisms why this ability declines rapidly with age in mammals. Here, we review similarities and differences between avian, zebrafish, and mammalian hair cell regeneration. Moreover, we discuss advances and limitations of hair cell regeneration in the mature cochlea and their potential applications to human hearing loss.

耳蜗毛细胞是将声音转换成电信号的关键,这些电信号通过螺旋神经节神经元传递到中央听觉通路。毛细胞很容易受到过度噪音、老化和耳毒性药物的损害。非哺乳动物可以通过有丝分裂再生和周围支持细胞的直接转分化来再生失去的毛细胞。然而,在成熟的哺乳动物中,受损的毛细胞不会被替换,从而导致永久性听力损失。最近的研究揭示了非哺乳动物感觉器官和新生哺乳动物耳蜗再生毛细胞的机制,并概述了哺乳动物这种能力随年龄迅速下降的可能机制。在此,我们回顾了鸟类、斑马鱼和哺乳动物毛细胞再生的异同。此外,我们还讨论了成熟耳蜗中毛细胞再生的进展和局限性,以及它们在人类听力损失中的潜在应用。
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引用次数: 0
Early Postoperative Benefits in Receptive and Expressive Language Development After Cochlear Implantation Under 9 Months of Age in Comparison to Implantation at Later Ages. 与较晚植入人工耳蜗的患者相比,9 个月以下植入人工耳蜗的患者术后早期在接受性和表达性 1 语言发展方面受益匪浅。
IF 3 3区 医学 Q1 OTORHINOLARYNGOLOGY Pub Date : 2024-02-01 Epub Date: 2024-02-08 DOI: 10.21053/ceo.2024.00011
Seung Jae Lee, Heonjeong Oh, Kyu Ha Shin, Sung-Min Park, Yun Kyeong Kim, Do Hyun Jung, Jiyeon Yang, Yejun Chun, Min Young Kim, Jin Hee Han, Ju Ang Kim, Ngoc-Trinh Tran, Bong Jik Kim, Byung Yoon Choi

Objectives: The recent expansion of eligibility for cochlear implantation (CI) by the U.S. Food and Drug Administration (FDA) to include infants as young as 9 months has reignited debates concerning the clinically appropriate cut-off age for pediatric CI. Our study compared the early postoperative trajectories of receptive and expressive language development in children who received CI before 9 months of age with those who received it between 9 and 12 months. This study involved a unique pediatric cohort with documented etiology, where the timing of CI was based on objective criteria and efforts were made to minimize the influence of parental socioeconomic status.

Methods: A retrospective review of 98 pediatric implantees recruited at a tertiary referral center was conducted. The timing of CI was based on auditory and language criteria focused on the extent of delay corresponding to the bottom 1st percentile of language development among age-matched controls, with patients categorized into very early (CI at <9 months), early (CI at 9-12 months) and delayed (CI at 12-18 months) CI groups. Postoperative receptive/expressive language development was assessed using the Sequenced Language Scale for Infants receptive and expressive standardized scores and percentiles.

Results: Only the very early CI group showed significant improvements in receptive language starting at 3 months post-CI, aligning with normal-hearing peers by 9 months and maintaining this level until age 2 years. During this period (<2 years), all improvements were more pronounced in receptive language than in expressive language.

Conclusion: CI before 9 months of age significantly improved receptive language development compared to later CI, with improvements sustained at least up to the age of 2. This study supports the consideration of earlier CI, beyond pediatric Food and Drug Administration labeling criteria (>9 months), in children with profound deafness who have a clear deafness etiology and language development delays (<1st percentile).

目的:最近,美国食品和药物管理局(FDA)将人工耳蜗植入(CI)的资格扩大到 9 个月大的婴儿,这再次引发了关于小儿 CI 临床合适截止年龄的争论。我们的研究旨在比较 9 个月前和 9 至 12 个月之间植入人工耳蜗的婴儿术后早期接受/表达语言发展的轨迹,这些婴儿的病因有据可查,植入人工耳蜗的时机是根据客观标准决定的,同时尽量减少父母的社会经济影响:方法:对一家三级转诊中心招募的 98 名儿科植入者进行了回顾性审查。CI 时机的选择以听觉和语言标准为基础,重点关注与最低百分位数相对应的发育迟缓程度:只有极早期 CI 组从 CI 后 3 个月开始在接受性语言方面有明显改善,到 9 个月时与听力正常的同龄人一致,并将这一水平保持到两岁。在此期间(结论:与较晚植入的 CI 相比,9 个月前植入的 CI 能明显促进接受性语言的发展,至少能维持到 2 岁。这项研究支持对有明确耳聋病因和语言发育迟缓的重度耳聋儿童,在超出儿科 FDA 标签标准(大于 9 个月)的情况下,考虑更早地植入 CI。
{"title":"Early Postoperative Benefits in Receptive and Expressive Language Development After Cochlear Implantation Under 9 Months of Age in Comparison to Implantation at Later Ages.","authors":"Seung Jae Lee, Heonjeong Oh, Kyu Ha Shin, Sung-Min Park, Yun Kyeong Kim, Do Hyun Jung, Jiyeon Yang, Yejun Chun, Min Young Kim, Jin Hee Han, Ju Ang Kim, Ngoc-Trinh Tran, Bong Jik Kim, Byung Yoon Choi","doi":"10.21053/ceo.2024.00011","DOIUrl":"10.21053/ceo.2024.00011","url":null,"abstract":"<p><strong>Objectives: </strong>The recent expansion of eligibility for cochlear implantation (CI) by the U.S. Food and Drug Administration (FDA) to include infants as young as 9 months has reignited debates concerning the clinically appropriate cut-off age for pediatric CI. Our study compared the early postoperative trajectories of receptive and expressive language development in children who received CI before 9 months of age with those who received it between 9 and 12 months. This study involved a unique pediatric cohort with documented etiology, where the timing of CI was based on objective criteria and efforts were made to minimize the influence of parental socioeconomic status.</p><p><strong>Methods: </strong>A retrospective review of 98 pediatric implantees recruited at a tertiary referral center was conducted. The timing of CI was based on auditory and language criteria focused on the extent of delay corresponding to the bottom 1st percentile of language development among age-matched controls, with patients categorized into very early (CI at <9 months), early (CI at 9-12 months) and delayed (CI at 12-18 months) CI groups. Postoperative receptive/expressive language development was assessed using the Sequenced Language Scale for Infants receptive and expressive standardized scores and percentiles.</p><p><strong>Results: </strong>Only the very early CI group showed significant improvements in receptive language starting at 3 months post-CI, aligning with normal-hearing peers by 9 months and maintaining this level until age 2 years. During this period (<2 years), all improvements were more pronounced in receptive language than in expressive language.</p><p><strong>Conclusion: </strong>CI before 9 months of age significantly improved receptive language development compared to later CI, with improvements sustained at least up to the age of 2. This study supports the consideration of earlier CI, beyond pediatric Food and Drug Administration labeling criteria (>9 months), in children with profound deafness who have a clear deafness etiology and language development delays (<1st percentile).</p>","PeriodicalId":10318,"journal":{"name":"Clinical and Experimental Otorhinolaryngology","volume":" ","pages":"46-55"},"PeriodicalIF":3.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10933813/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139702039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development and Validation of a Pathomics Model Using Machine Learning to Predict CXCL8 Expression and Prognosis in Head and Neck Cancer. 开发和验证病理组学模型,利用机器学习预测头颈癌中 CXCL8 的表达和预后。
IF 3 3区 医学 Q1 OTORHINOLARYNGOLOGY Pub Date : 2024-02-01 Epub Date: 2024-01-22 DOI: 10.21053/ceo.2023.00026
Weihua Wang, Suyu Ruan, Yuhang Xie, Shengjian Fang, Junxian Yang, Xueyan Li, Yu Zhang

Objectives: The necessity to develop a method for prognostication and to identify novel biomarkers for personalized medicine in patients with head and neck squamous cell carcinoma (HNSCC) cannot be overstated. Recently, pathomics, which relies on quantitative analysis of medical imaging, has come to the forefront. CXCL8, an essential inflammatory cytokine, has been shown to correlate with overall survival (OS). This study examined the relationship between CXCL8 mRNA expression and pathomics features and aimed to explore the biological underpinnings of CXCL8.

Methods: Clinical information and transcripts per million mRNA sequencing data were obtained from The Cancer Genome Atlas (TCGA)-HNSCC dataset. We identified correlations between CXCL8 mRNA expression and patient survival rates using a Kaplan-Meier survival curve. A retrospective analysis of 313 samples diagnosed with HNSCC in the TCGA database was conducted. Pathomics features were extracted from hematoxylin and eosin-stained images, and then the minimum redundancy maximum relevance, with recursive feature elimination (mRMR-RFE) method was applied, followed by screening with the logistic regression algorithm.

Results: Kaplan-Meier curves indicated that high expression of CXCL8 was significantly associated with decreased OS. The logistic regression pathomics model incorporated 16 radiomics features identified by the mRMR-RFE method in the training set and demonstrated strong performance in the testing set. Calibration plots showed that the probability of high gene expression predicted by the pathomics model was in good agreement with actual observations, suggesting the model's high clinical applicability.

Conclusion: The pathomics model of CXCL8 mRNA expression serves as an effective tool for predicting prognosis in patients with HNSCC and can aid in clinical decision-making. Elevated levels of CXCL8 expression may lead to reduced DNA damage and are associated with a pro-inflammatory tumor microenvironment, offering a potential therapeutic target.

目的:为头颈部鳞状细胞癌(HNSCC)患者的个性化医疗寻找新的生物标志物,研究一种预后指示方法势在必行。最近出现了基于定量医学影像分析的病理组学。CXCL8是一种重要的炎性细胞因子,可反映总生存率(OS)。本研究旨在探讨CXCL8 mRNA表达与病理特征的关联,并研究CXCL8的潜在生物学特性:方法:从TCGA TCGA- HNSCC数据集中获取临床信息和TPM(每百万转录本)mRNA测序数据。采用Kaplan Kaplan-Meier生存曲线确定CXCL8 mRNA表达与患者生存率之间的相关性。我们回顾性分析了TCGA数据库中确诊的313例HNSCC样本。从HE图像中提取病理组学特征,然后使用mRMR_RFE方法和逻辑回归(LR)算法进行筛选:结果:根据Kaplan Kaplan-Meier曲线,CXCL8的高表达与OS恶化有显著相关性。LR病理组学模型在训练集中整合了mRMR_RFE方法识别出的16个放射组学特征,在测试集中表现良好。校准图显示,病理组学模型预测的高基因表达概率与实际观察结果相当吻合。该模型具有较高的临床实用性:结论:CXCL8 mRNA表达所反映的病理组学模型是预测HNSCC患者预后的有效工具,可辅助临床决策。CXCL8的高表达可能有助于减少DNA损伤,并与促炎微环境相关联,为肿瘤治疗提供了潜在靶点。
{"title":"Development and Validation of a Pathomics Model Using Machine Learning to Predict CXCL8 Expression and Prognosis in Head and Neck Cancer.","authors":"Weihua Wang, Suyu Ruan, Yuhang Xie, Shengjian Fang, Junxian Yang, Xueyan Li, Yu Zhang","doi":"10.21053/ceo.2023.00026","DOIUrl":"10.21053/ceo.2023.00026","url":null,"abstract":"<p><strong>Objectives: </strong>The necessity to develop a method for prognostication and to identify novel biomarkers for personalized medicine in patients with head and neck squamous cell carcinoma (HNSCC) cannot be overstated. Recently, pathomics, which relies on quantitative analysis of medical imaging, has come to the forefront. CXCL8, an essential inflammatory cytokine, has been shown to correlate with overall survival (OS). This study examined the relationship between CXCL8 mRNA expression and pathomics features and aimed to explore the biological underpinnings of CXCL8.</p><p><strong>Methods: </strong>Clinical information and transcripts per million mRNA sequencing data were obtained from The Cancer Genome Atlas (TCGA)-HNSCC dataset. We identified correlations between CXCL8 mRNA expression and patient survival rates using a Kaplan-Meier survival curve. A retrospective analysis of 313 samples diagnosed with HNSCC in the TCGA database was conducted. Pathomics features were extracted from hematoxylin and eosin-stained images, and then the minimum redundancy maximum relevance, with recursive feature elimination (mRMR-RFE) method was applied, followed by screening with the logistic regression algorithm.</p><p><strong>Results: </strong>Kaplan-Meier curves indicated that high expression of CXCL8 was significantly associated with decreased OS. The logistic regression pathomics model incorporated 16 radiomics features identified by the mRMR-RFE method in the training set and demonstrated strong performance in the testing set. Calibration plots showed that the probability of high gene expression predicted by the pathomics model was in good agreement with actual observations, suggesting the model's high clinical applicability.</p><p><strong>Conclusion: </strong>The pathomics model of CXCL8 mRNA expression serves as an effective tool for predicting prognosis in patients with HNSCC and can aid in clinical decision-making. Elevated levels of CXCL8 expression may lead to reduced DNA damage and are associated with a pro-inflammatory tumor microenvironment, offering a potential therapeutic target.</p>","PeriodicalId":10318,"journal":{"name":"Clinical and Experimental Otorhinolaryngology","volume":" ","pages":"85-97"},"PeriodicalIF":3.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10933807/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139511918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Downregulation of TET2 contributes to nasal polypogenesis through HIF1 TET2 的下调通过 HIF1 促进鼻息肉发生
IF 3 3区 医学 Q1 OTORHINOLARYNGOLOGY Pub Date : 2023-12-28 DOI: 10.21053/ceo.2023.01340
Yu Xu
Background: Hypoxia-inducible factor (HIF) 1
背景:缺氧诱导因子(HIF)1
{"title":"Downregulation of TET2 contributes to nasal polypogenesis through HIF1","authors":"Yu Xu","doi":"10.21053/ceo.2023.01340","DOIUrl":"https://doi.org/10.21053/ceo.2023.01340","url":null,"abstract":"Background: Hypoxia-inducible factor (HIF) 1","PeriodicalId":10318,"journal":{"name":"Clinical and Experimental Otorhinolaryngology","volume":"1 7","pages":""},"PeriodicalIF":3.0,"publicationDate":"2023-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139148847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Changes in Revision Cochlear Implantation and Device Failure Profiles 人工耳蜗翻修和设备故障情况的变化
IF 3 3区 医学 Q1 OTORHINOLARYNGOLOGY Pub Date : 2023-12-28 DOI: 10.21053/ceo.2023.00010
Bokhyun Song, Subi Oh, Doyun Kim, Young Sang Cho, Il Joon Moon
Objective. With rapid innovation in and expanding indications for cochlear implantation (CI), changes in the features of revision CI (RCI) appear to be emerging. This study aims to investigate the changes in RCI profile and discuss their clinical significance. Methods. A retrospective chart review was performed for all CIs performed at a tertiary medical institution between October 2001 and January 2023. The rate and reasons for RCI were evaluated and examined in terms of the manufacturer and device model. The Kaplan-Meier curve was used to examine the cumulative and device survival curves. In addition, the cumulative and device survivals were further analyzed based on age group, time period of primary CI, and manufacturer. Cox proportional hazards model was used to evaluate the association between RCI and manufacturers. Results. Among 1,430 CIs, 73 RCIs were conducted (5.1%). Device failure was the most common cause of RCI (40 of 73 RCIs [54.8%]), with an overall device failure rate of 2.8%, followed by flap-associated problems and migration (9 of 73 RCIs each [12.3%]). Flap retention problem appeared as a new cause in three cases (two CI 632 and one SYNCHRONY 2), and six electrode tip fold-over occurred (four CI 600 series and two CI 500 series). The 10-year overall cumulative and device survival rates were 93.4% and 95.8%, respectively. After excluding the models with recall issues, cumulative (P= 0.010) and device survival curves ( P= 0.001) revealed significant differences by manufacturer.
目的。随着人工耳蜗植入术(CI)的快速创新和适应症的不断扩大,修正 CI(RCI)的特征似乎正在发生变化。本研究旨在调查 RCI 特征的变化并讨论其临床意义。研究方法对一家三级医疗机构在 2001 年 10 月至 2023 年 1 月期间进行的所有 CI 进行了回顾性病历审查。根据制造商和设备型号评估并检查了 RCI 的发生率和原因。采用 Kaplan-Meier 曲线来研究累积存活率和设备存活率曲线。此外,还根据年龄组、主要 CI 时间段和制造商对累积存活率和设备存活率进行了进一步分析。采用 Cox 比例危险模型评估 RCI 与制造商之间的关联。结果。在 1,430 例 CI 中,有 73 例进行了 RCI(5.1%)。设备故障是导致 RCI 的最常见原因(73 例 RCI 中有 40 例 [54.8%]),设备总体故障率为 2.8%,其次是皮瓣相关问题和移位(73 例 RCI 中各有 9 例 [12.3%])。有三个病例(两个 CI 632 和一个 SYNCHRONY 2)出现了皮瓣滞留问题,有六个病例(四个 CI 600 系列和两个 CI 500 系列)出现了电极尖端折叠。10 年总体累积存活率和设备存活率分别为 93.4% 和 95.8%。在排除有召回问题的型号后,累积存活率(P= 0.010)和设备存活率曲线(P= 0.001)显示出不同制造商之间的显著差异。
{"title":"Changes in Revision Cochlear Implantation and Device Failure Profiles","authors":"Bokhyun Song, Subi Oh, Doyun Kim, Young Sang Cho, Il Joon Moon","doi":"10.21053/ceo.2023.00010","DOIUrl":"https://doi.org/10.21053/ceo.2023.00010","url":null,"abstract":"Objective. With rapid innovation in and expanding indications for cochlear implantation (CI), changes in the features of revision CI (RCI) appear to be emerging. This study aims to investigate the changes in RCI profile and discuss their clinical significance. Methods. A retrospective chart review was performed for all CIs performed at a tertiary medical institution between October 2001 and January 2023. The rate and reasons for RCI were evaluated and examined in terms of the manufacturer and device model. The Kaplan-Meier curve was used to examine the cumulative and device survival curves. In addition, the cumulative and device survivals were further analyzed based on age group, time period of primary CI, and manufacturer. Cox proportional hazards model was used to evaluate the association between RCI and manufacturers. Results. Among 1,430 CIs, 73 RCIs were conducted (5.1%). Device failure was the most common cause of RCI (40 of 73 RCIs [54.8%]), with an overall device failure rate of 2.8%, followed by flap-associated problems and migration (9 of 73 RCIs each [12.3%]). Flap retention problem appeared as a new cause in three cases (two CI 632 and one SYNCHRONY 2), and six electrode tip fold-over occurred (four CI 600 series and two CI 500 series). The 10-year overall cumulative and device survival rates were 93.4% and 95.8%, respectively. After excluding the models with recall issues, cumulative (P= 0.010) and device survival curves ( P= 0.001) revealed significant differences by manufacturer.","PeriodicalId":10318,"journal":{"name":"Clinical and Experimental Otorhinolaryngology","volume":"58 11","pages":""},"PeriodicalIF":3.0,"publicationDate":"2023-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139150488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison of partial and superficial or total parotidectomies for superficial T1-2 primary parotid cancers 浅表 T1-2 原发性腮腺癌部分切除术与浅表或全腮腺切除术的比较
IF 3 3区 医学 Q1 OTORHINOLARYNGOLOGY Pub Date : 2023-12-26 DOI: 10.21053/ceo.2023.00014
Seung Hoon Han, Jihae Lee, Jeong Wook Kang, Heejin Kim, Dong Jin Lee, Jin Hwan Kim, Il Seok Park
Objective: This study aimed to compare the oncological outcomes of partial and superficial or total parotidectomies for superficial T1 or T2 primary parotid cancers and investigate their prognostic factors and recurrence patterns. Methods: The medical records of 77 patients with T1–2 primary parotid malignancies between May 2003 and March 2022 were retrospectively reviewed. Univariate and multivariate analyses were performed to evaluate the prognostic factors associated with overall survival, disease-free survival, and local and distant recurrences. Results: The average follow-up duration was 70.2 months (range,12–202 months). The 5-year overall and disease-free survival rates were 88.7% and 77.1%, respectively. Twenty-two patients underwent partial parotidectomy, and 55 underwent superficial or total parotidectomy. There were no significant differences in the disease recurrence ( p =0.320) and mortality rates ( p =0.884) of the partial and superficial or total parotidectomy groups. The mean duration of surgery was shorter and the overall complication rates were significantly lower for the partial group than for the superficial or total parotidectomy group ( p =0.049). Sixteen cases of recurrence occurred during the study period (20.8%). Univariate analyses showed that high-grade tumors ( p =0.006), lymphovascular invasion ( p =0.046), and regional lymph node metastasis ( p =0.010) were significant risk factors for disease recurrence. Multivariate analysis identified regional lymph node metastasis as an independent prognostic factor for disease recurrence ( p =0.027), and lymphovascular invasion as an independent prognostic factor for overall survival ( p =0.033). Conclusions: The conservative surgical approach of partial parotidectomy can yield oncologic outcomes comparable to superficial or total parotidectomies under careful patient
研究目的本研究旨在比较浅表 T1 或 T2 原发性腮腺癌部分切除术和浅表或全腮腺切除术的肿瘤学疗效,并探讨其预后因素和复发模式。方法回顾性分析2003年5月至2022年3月期间77例T1-2原发性腮腺恶性肿瘤患者的病历。进行单变量和多变量分析,评估与总生存期、无病生存期、局部和远处复发相关的预后因素。结果显示平均随访时间为70.2个月(12-202个月)。5年总生存率和无病生存率分别为88.7%和77.1%。22名患者接受了腮腺部分切除术,55名患者接受了腮腺表层或全部切除术。腮腺部分切除术组与腮腺表层或全部切除术组的疾病复发率(P =0.320)和死亡率(P =0.884)无明显差异。腮腺部分切除术组的平均手术时间较短,总体并发症发生率明显低于腮腺表层或全部切除术组(P =0.049)。研究期间有16例复发(20.8%)。单变量分析显示,高级别肿瘤(P =0.006)、淋巴管侵犯(P =0.046)和区域淋巴结转移(P =0.010)是疾病复发的重要风险因素。多变量分析发现,区域淋巴结转移是疾病复发的独立预后因素(p =0.027),淋巴管侵犯是总生存期的独立预后因素(p =0.033)。结论腮腺部分切除术这种保守的手术方法在仔细观察病人的情况下,可以获得与浅表或全部腮腺切除术相当的肿瘤治疗效果。
{"title":"Comparison of partial and superficial or total parotidectomies for superficial T1-2 primary parotid cancers","authors":"Seung Hoon Han, Jihae Lee, Jeong Wook Kang, Heejin Kim, Dong Jin Lee, Jin Hwan Kim, Il Seok Park","doi":"10.21053/ceo.2023.00014","DOIUrl":"https://doi.org/10.21053/ceo.2023.00014","url":null,"abstract":"Objective: This study aimed to compare the oncological outcomes of partial and superficial or total parotidectomies for superficial T1 or T2 primary parotid cancers and investigate their prognostic factors and recurrence patterns. Methods: The medical records of 77 patients with T1–2 primary parotid malignancies between May 2003 and March 2022 were retrospectively reviewed. Univariate and multivariate analyses were performed to evaluate the prognostic factors associated with overall survival, disease-free survival, and local and distant recurrences. Results: The average follow-up duration was 70.2 months (range,12–202 months). The 5-year overall and disease-free survival rates were 88.7% and 77.1%, respectively. Twenty-two patients underwent partial parotidectomy, and 55 underwent superficial or total parotidectomy. There were no significant differences in the disease recurrence ( p =0.320) and mortality rates ( p =0.884) of the partial and superficial or total parotidectomy groups. The mean duration of surgery was shorter and the overall complication rates were significantly lower for the partial group than for the superficial or total parotidectomy group ( p =0.049). Sixteen cases of recurrence occurred during the study period (20.8%). Univariate analyses showed that high-grade tumors ( p =0.006), lymphovascular invasion ( p =0.046), and regional lymph node metastasis ( p =0.010) were significant risk factors for disease recurrence. Multivariate analysis identified regional lymph node metastasis as an independent prognostic factor for disease recurrence ( p =0.027), and lymphovascular invasion as an independent prognostic factor for overall survival ( p =0.033). Conclusions: The conservative surgical approach of partial parotidectomy can yield oncologic outcomes comparable to superficial or total parotidectomies under careful patient","PeriodicalId":10318,"journal":{"name":"Clinical and Experimental Otorhinolaryngology","volume":"15 1","pages":""},"PeriodicalIF":3.0,"publicationDate":"2023-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139157474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Clinical and Experimental Otorhinolaryngology
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