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Associations Between Systemic Inflammatory Markers Based on Blood Cells and Polysomnographic Factors in Obstructive Sleep Apnea. 阻塞性睡眠呼吸暂停中基于血细胞和多导睡眠图因子的全身炎症标志物之间的关系。
IF 3 3区 医学 Q1 OTORHINOLARYNGOLOGY Pub Date : 2023-05-01 DOI: 10.21053/ceo.2022.01368
Minju Kim, Sung-Woo Cho, Tae-Bin Won, Chae-Seo Rhee, Jeong-Whun Kim

Objectives: Systemic inflammation plays a key role in the pathogenesis of obstructive sleep apnea (OSA); however, easy-to-use methods to evaluate the severity of systemic inflammation have yet to be developed. This study investigated the association between systemic inflammation markers that could be derived from the complete blood count (CBC) profile and sleep parameters in a large number of patients with OSA.

Methods: Patients who visited our hospital's Otorhinolaryngology Sleep Clinic between January 2017 and April 2022 underwent polysomnography and routine laboratory tests, including a CBC. Associations between three systemic inflammatory markers-the systemic immune-inflammation index (SII), neutrophil-lymphocyte ratio (NLR), and platelet-lymphocyte ratio (PLR)-and polysomnographic and demographic factors including age, sex, body mass index, the apnea-hypopnea index (AHI), the hypopnea index (HI), lowest oxygen saturation (%), the Pittsburgh Sleep Quality Index (PSQI), the Epworth Sleepiness Scale, and percentages of non-rapid eye movement (REM) sleep stage 3, REM sleep, and snoring time were analyzed. The inflammation markers were compared among OSA subgroups, and associations were also analyzed in subgroups with different OSA severities.

Results: In total, 1,102 patients (968 men and 134 women) were included, and their mean AHI was 33.0±24.3. PSQI was significantly associated with SII (P=0.027). No independent significant factors were identified for the NLR or PLR. Within the simple snoring and mild OSA subgroups, no significant association was found between sleep parameters and the SII. In the severe OSA subgroup, the AHI (P=0.004) and PSQI (P=0.012) were independently associated with the SII.

Conclusion: Our study analyzed systemic inflammatory markers based on the CBC, a simple, relatively cost-effective test, and showed that the AHI and SII were significantly correlated only in the severe OSA subgroup.

目的:全身性炎症在阻塞性睡眠呼吸暂停(OSA)的发病机制中起关键作用;然而,评估全身性炎症严重程度的简便方法尚未开发。本研究调查了大量OSA患者全血细胞计数(CBC)与睡眠参数之间的关系。方法:2017年1月至2022年4月至我院耳鼻喉科睡眠门诊就诊的患者进行了多导睡眠图和常规实验室检查,包括CBC。三种全身炎症标志物——全身免疫炎症指数(SII)、中性粒细胞-淋巴细胞比率(NLR)和血小板-淋巴细胞比率(PLR)——与多导睡眠图和人口统计学因素(包括年龄、性别、体重指数、呼吸暂停-低呼吸指数(AHI)、低呼吸指数(HI)、最低血氧饱和度(%)、匹兹堡睡眠质量指数(PSQI)、爱普沃斯嗜睡量表、非快速眼动(REM)睡眠阶段3、REM睡眠阶段、并对打鼾时间进行分析。比较不同OSA亚组间的炎症指标,并分析不同OSA严重程度亚组间的相关性。结果:共纳入1102例患者(男性968例,女性134例),平均AHI为33.0±24.3。PSQI与SII显著相关(P=0.027)。未发现影响NLR或PLR的独立显著因素。在单纯打鼾和轻度OSA亚组中,睡眠参数与SII之间未发现显著关联。在严重OSA亚组中,AHI (P=0.004)和PSQI (P=0.012)与SII独立相关。结论:我们的研究分析了基于CBC的全身性炎症标志物,这是一种简单、成本相对较低的测试,结果显示AHI和SII仅在严重OSA亚组中存在显著相关。
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引用次数: 1
Research Progress on Non-coding RNAs in Cholesteatoma of the Middle Ear. 中耳胆脂瘤非编码rna的研究进展。
IF 3 3区 医学 Q1 OTORHINOLARYNGOLOGY Pub Date : 2023-05-01 DOI: 10.21053/ceo.2022.01319
Dongliang Liu, Hang Zhang, Xiulan Ma, Yaodong Dong

Cholesteatoma of the middle ear is a common disease in otolaryngology that is receiving increasing attention. It is estimated that over five million people around the world have suffered from middle ear cholesteatoma. The annual incidence of middle ear cholesteatoma has been reported to be 9.2 per 100,000 in adults and 3 per 100,000 in children. Without timely discovery and intervention, cholesteatomas can become perilously large and damage intratemporal structures, causing various intracranial and extracranial complications. No practical nonsurgical treatments are currently available. Although multiple hypotheses exist, research directions have consistently focused on cell proliferation, apoptosis, and bone destruction. Non-coding RNAs (ncRNAs), especially microRNAs (miRNAs), long ncRNAs (lncRNAs), and circular RNAs (circRNAs), have recently received increasing attention because of their key roles in gene expression, cell cycle regulation, and the development of many diseases. Although ncRNAs are not involved in protein translation, they are abundant in the genome, with only approximately 2% of genes encoding proteins and the remaining approximately 98% encoding ncRNAs. The purpose of this review is to summarize the current state of knowledge regarding the specific role of ncRNAs in middle ear cholesteatoma.

中耳胆脂瘤是耳鼻喉科的一种常见病,越来越受到人们的重视。据估计,全世界有超过500万人患有中耳胆脂瘤。据报道,成人中耳胆脂瘤的年发病率为9.2 / 10万,儿童为3 / 10万。如果不及时发现和干预,胆脂瘤可能变得危险的大,损害颞内结构,引起各种颅内和颅外并发症。目前尚无实用的非手术治疗方法。虽然存在多种假设,但研究方向始终集中在细胞增殖、细胞凋亡和骨破坏方面。非编码rna (ncRNAs),特别是microRNAs (miRNAs)、long ncRNAs (lncRNAs)和环状rna (circRNAs),由于在基因表达、细胞周期调控和许多疾病的发生中发挥关键作用,近年来受到越来越多的关注。虽然ncRNAs不参与蛋白质翻译,但它们在基因组中含量丰富,只有约2%的基因编码蛋白质,其余约98%编码ncRNAs。这篇综述的目的是总结关于ncrna在中耳胆脂瘤中的具体作用的知识现状。
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引用次数: 1
Assessment of Esophageal Reconstruction via Bioreactor Cultivation of a Synthetic Scaffold in a Canine Model. 通过生物反应器培养合成支架在犬模型中重建食管的评估。
IF 3 3区 医学 Q1 OTORHINOLARYNGOLOGY Pub Date : 2023-05-01 DOI: 10.21053/ceo.2022.01522
In Gul Kim, Yanru Wu, Su A Park, Ji Suk Choi, Seong Keun Kwon, Seung Hong Choi, Kyeong Cheon Jung, Jung-Woog Shin, Eun-Jae Chung

Objectives: Using tissue-engineered materials for esophageal reconstruction is a technically challenging task in animals that requires bioreactor training to enhance cellular reactivity. There have been many attempts at esophageal tissue engineering, but the success rate has been limited due to difficulty in initial epithelialization in the special environment of peristalsis. The purpose of this study was to evaluate the potential of an artificial esophagus that can enhance the regeneration of esophageal mucosa and muscle through the optimal combination of a double-layered polymeric scaffold and a custom-designed mesenchymal stem cell-based bioreactor system in a canine model.

Methods: We fabricated a novel double-layered scaffold as a tissue-engineered esophagus using an electrospinning technique. Prior to transplantation, human-derived mesenchymal stem cells were seeded into the lumen of the scaffold, and bioreactor cultivation was performed to enhance cellular reactivity. After 3 days of cultivation using the bioreactor system, tissue-engineered artificial esophagus was transplanted into a partial esophageal defect (5×3 cm-long resection) in a canine model.

Results: Scanning electron microscopy (SEM) showed that the electrospun fibers in a tubular scaffold were randomly and circumferentially located toward the inner and outer surfaces. Complete recovery of the esophageal mucosa was confirmed by endoscopic analysis and SEM. Esophagogastroduodenoscopy and computed tomography also showed that there were no signs of leakage or stricture and that there was a normal lumen with complete epithelialization. Significant regeneration of the mucosal layer was observed by keratin-5 immunostaining. Alpha-smooth muscle actin immunostaining showed significantly greater esophageal muscle regeneration at 12 months than at 6 months.

Conclusion: Custom-designed bioreactor cultured electrospun polyurethane scaffolds can be a promising approach for esophageal tissue engineering.

目的:在动物中使用组织工程材料进行食管重建在技术上是一项具有挑战性的任务,需要生物反应器训练来增强细胞反应性。在食管组织工程方面已有许多尝试,但由于在特殊的蠕动环境下难以初始上皮化,成功率一直有限。本研究的目的是评估人工食管的潜力,通过双层聚合物支架和定制的间充质干细胞生物反应器系统的最佳组合,在犬模型中促进食管黏膜和肌肉的再生。方法:采用静电纺丝技术制备了一种新型双层支架作为组织工程食管。在移植之前,将人源间充质干细胞植入支架的管腔中,并进行生物反应器培养以增强细胞反应性。在生物反应器系统培养3天后,将组织工程人工食管移植到犬模型部分食管缺损(5×3 cm长切除)中。结果:扫描电镜(SEM)显示,管状支架内的静电纺丝纤维呈随机分布,呈周向内外表面分布。经内镜及扫描电镜检查证实食管黏膜完全恢复。食管胃十二指肠镜和计算机断层扫描也显示没有渗漏或狭窄的迹象,有一个完全上皮化的正常管腔。角蛋白-5免疫染色观察到粘膜层明显再生。α -平滑肌肌动蛋白免疫染色显示,12个月时食管肌再生明显高于6个月时。结论:生物反应器培养静电纺聚氨酯支架是一种很有前途的食管组织工程支架。
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引用次数: 1
Ghrelin Downregulates Lipopolysaccharide/ Leptin-Induced MUC5AC Expression in Human Nasal Epithelial Cells. 胃饥饿素下调脂多糖/瘦素诱导的人鼻上皮细胞MUC5AC表达
IF 3 3区 医学 Q1 OTORHINOLARYNGOLOGY Pub Date : 2023-02-01 DOI: 10.21053/ceo.2022.00857
Yoon Seok Choi, Hyung Gyun Na, Chang Hoon Bae, Si-Youn Song, Yong-Dae Kim

Objectives: Obesity, which induces chronic low-grade systemic inflammation in the human body, is a known risk factor for various diseases. Recent studies have shown associations between various otorhinolaryngological diseases and obesity. In particular, inflammatory sinonasal diseases have been found to be strongly associated with obesity-related proinflammatory mediators. Many studies have been conducted to identify therapeutic agents for controlling obesity-related inflammatory airway diseases. Ghrelin, an endogenous peptide from the stomach, has anti-inflammatory and antioxidative effects in a wide range of tissues. However, the effect of ghrelin on the regulation of mucus secretion has not yet been studied in the human nasal mucosa. Therefore, we investigated the effects of ghrelin on lipopolysaccharide (LPS)/leptin-mediated MUC5AC expression and mechanisms involved in human nasal epithelial cells (HNEpCs).

Methods: In HNEpCs, the effect and signaling pathways of ghrelin on LPS/leptin-induced MUC5AC expression were examined using reverse transcription polymerase chain reaction, real-time polymerase chain reaction, enzyme immunoassays, Western blotting, and immunofluorescence staining.

Results: Growth hormone secretagogue receptor 1a (GHSR1a) was expressed in the HNEpCs. Ghrelin downregulated LPS/leptin-induced MUC5AC expression, which was abolished by D-Lys-3-growth hormone-releasing peptide 6 (D-Lys-3-GHRP-6). Ghrelin significantly inhibited LPS/leptin-activated extracellular signal-regulated kinase 1/2 (ERK1/2) and p38 mitogen-activated protein kinases (MAPKs). These ghrelin-mediated changes in MAPK activation were abolished by D-Lys-3-GHRP-6. These.

Results: showed that ghrelin inhibits LPS/leptin-induced MUC5AC overexpression by modulating the ERK1/2 and p38 MAPK pathways in HNEpCs.

Conclusion: These findings suggest that ghrelin is a potential therapeutic agent for treating obesity-related inflammatory sinonasal diseases.

目的:肥胖可诱发人体慢性低度全身性炎症,是多种疾病的已知危险因素。最近的研究表明,各种耳鼻喉疾病与肥胖之间存在关联。特别是,炎症性鼻窦炎已被发现与肥胖相关的促炎介质密切相关。许多研究已经进行,以确定治疗药物控制肥胖相关的炎症性气道疾病。胃饥饿素是一种来自胃的内源性肽,在多种组织中具有抗炎和抗氧化作用。然而,胃饥饿素对人鼻黏膜粘液分泌的调节作用尚未被研究。因此,我们研究了胃饥饿素对脂多糖(LPS)/瘦素介导的MUC5AC表达的影响及其参与人鼻上皮细胞(HNEpCs)的机制。方法:采用逆转录聚合酶链反应、实时聚合酶链反应、酶免疫测定、Western blotting、免疫荧光染色等方法,检测ghrelin对LPS/leptin诱导的MUC5AC表达的影响及信号通路。结果:生长激素促分泌受体1a (GHSR1a)在HNEpCs中表达。Ghrelin下调LPS/ lepatin诱导的MUC5AC表达,而d - lys -3-生长激素释放肽6 (D-Lys-3-GHRP-6)可消除MUC5AC表达。Ghrelin显著抑制LPS/leptin激活的细胞外信号调节激酶1/2 (ERK1/2)和p38丝裂原激活蛋白激酶(MAPKs)。这些生长素介导的MAPK激活变化被D-Lys-3-GHRP-6所消除。这些。结果:ghrelin通过调节ERK1/2和p38 MAPK通路抑制LPS/leptin诱导的HNEpCs MUC5AC过表达。结论:胃饥饿素是治疗肥胖相关炎症性鼻窦疾病的潜在药物。
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引用次数: 0
Tongue Reduction Surgery Improves Mandibular Prognathism in Beckwith-Wiedemann Syndrome Without Compromising Tongue Function. 舌缩小手术在不影响舌功能的情况下改善Beckwith-Wiedemann综合征的下颌前伸症。
IF 3 3区 医学 Q1 OTORHINOLARYNGOLOGY Pub Date : 2023-02-01 DOI: 10.21053/ceo.2022.00976
Dowon Kim, Jeong Kyou Kim, Gene Huh, Doh Young Lee, Seong Keun Kwon

Objectives: This study evaluated the surgical outcomes of patients with Beckwith-Wiedemann syndrome who underwent tongue-reduction surgery and analyzed whether the malocclusion and mandibular prognathism caused by macroglossia could be improved.

Methods: A retrospective medical record review was performed for 11 patients with Beckwith-Wiedemann syndrome whose macroglossia was surgically treated. Demographic data, symptoms and signs, and intraoperative and postoperative surgical outcomes were evaluated. Surgery was performed by a single surgeon using the "keyhole" technique, involving midline elliptical excision and anterior wedge resection. Preoperative and postoperative plain skull lateral X-rays were evaluated to assess prognathism improvement.

Results: The median age at the time of surgery was 35.09 months, and the ratio of males to females was 4:7. The median surgical time was 98±31.45 minutes, and the median duration of the postoperative intensive care unit stay was 3.81±2.4 days. There were no airway complications. Two patients (18.2%) had postoperative wound dehiscence; however, there was no nerve damage, recurrence, or other complications. Among the five patients who underwent postoperative speech evaluation, all showed normal speech development, except one patient who had brain dysfunction and developmental delay. Measurements of the A point-nasion-B point (ANB) angles and sella-nasion-B point (SNB) angles (point A is the most concave point of the anterior maxilla; point B is the most concave point on the mandibular symphysis) on plain X-rays showed a significant decrease in the postoperative SNB angle (P <0.001) and a significant increase in the ANB angle (P <0.011).

Conclusion: Tongue-reduction surgery is an effective and safe technique for severe forms of macroglossia associated with Beckwith-Wiedemann syndrome. In addition, it improves mandibular prognathism in young Beckwith-Wiedemann syndrome patients with macroglossia.

目的:评价Beckwith-Wiedemann综合征患者行减舌术的手术效果,分析是否可以改善由大舌畸形引起的错颌畸形和下颌前突。方法:对11例经手术治疗的贝克威氏综合征患者的病历进行回顾性分析。评估人口统计学数据、症状和体征以及术中和术后手术结果。手术由一名外科医生使用“锁眼”技术进行,包括中线椭圆切除术和前楔切除术。术前和术后进行平头侧位x线片评估前凸的改善情况。结果:手术时中位年龄为35.09个月,男女比例为4:7。手术时间中位数为98±31.45分钟,术后重症监护时间中位数为3.81±2.4天。无呼吸道并发症。术后创面裂开2例(18.2%);然而,没有神经损伤、复发或其他并发症。5例术后言语评价患者除1例出现脑功能障碍及发育迟缓外,其余均表现为言语发育正常。A点鼻鼻- b点(ANB)角和鞍-鼻鼻- b点(SNB)角的测量(A点为上颌骨最凹点;B点是下颌联合上最凹的点)x线平片显示术后SNB角明显减小(P结论:舌瓣缩窄术是治疗伴有Beckwith-Wiedemann综合征的严重巨舌症的一种有效且安全的技术。此外,它还能改善年轻的贝克威氏综合征伴大舌畸形患者的下颌前突。
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引用次数: 2
The Effects of Statin Medications on Postoperative Outcomes in Patients With Chronic Rhinosinusitis. 他汀类药物对慢性鼻窦炎患者术后预后的影响。
IF 3 3区 医学 Q1 OTORHINOLARYNGOLOGY Pub Date : 2023-02-01 DOI: 10.21053/ceo.2022.00780
Hye Kyu Min, Hyun Ji Lee, Jeon Gang Doo, Sung Wan Kim, Jin Young Min
Copyright © 2023 by Korean Society of Otorhinolaryngology-Head and Neck Surgery. This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Clinical and Experimental Otorhinolaryngology Vol. 16, No. 1: 95-97, February 2023 https://doi.org/10.21053/ceo.2022.00780
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引用次数: 1
Guideline for the Surgical Management of Locally Invasive Differentiated Thyroid Cancer From the Korean Society of Head and Neck Surgery. 韩国头颈外科学会局部浸润性分化型甲状腺癌手术治疗指南。
IF 2.9 3区 医学 Q1 OTORHINOLARYNGOLOGY Pub Date : 2023-02-01 Epub Date: 2023-01-11 DOI: 10.21053/ceo.2022.01732
Jun-Ook Park, Joo Hyun Kim, Young Hoon Joo, Sang-Yeon Kim, Geun-Jeon Kim, Hyun Bum Kim, Dong-Hyun Lee, Hyun Jun Hong, Young Min Park, Eun-Jae Chung, Yong Bae Ji, Kyoung Ho Oh, Hyoung Shin Lee, Dong Kun Lee, Ki Nam Park, Myung Jin Ban, Bo Hae Kim, Do Hun Kim, Jae-Keun Cho, Dong Bin Ahn, Min-Su Kim, Jun Girl Seok, Jeon Yeob Jang, Hyo Geun Choi, Hee Jin Kim, Sung Joon Park, Eun Kyung Jung, Yeon Soo Kim, Yong Tae Hong, Young Chan Lee, Ho-Ryun Won, Sung-Chan Shin, Seung-Kuk Baek, Soon Young Kwon

The aim of this study was to develop evidence-based recommendations for determining the surgical extent in patients with locally invasive differentiated thyroid cancer (DTC). Locally invasive DTC with gross extrathyroidal extension invading surrounding anatomical structures may lead to several functional deficits and poor oncological outcomes. At present, the optimal extent of surgery in locally invasive DTC remains a matter of debate, and there are no adequate guidelines. On October 8, 2021, four experts searched the PubMed, Embase, and Cochrane Library databases; the identified papers were reviewed by 39 experts in thyroid and head and neck surgery. The Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach was used to assess the quality of evidence, and to develop and report recommendations. The strength of a recommendation reflects the confidence of a guideline panel that the desirable effects of an intervention outweigh any undesirable effects, across all patients for whom the recommendation is applicable. After completing the draft guidelines, Delphi questionnaires were completed by members of the Korean Society of Head and Neck Surgery. Twenty-seven evidence-based recommendations were made for several factors, including the preoperative workup; surgical extent of thyroidectomy; surgery for cancer invading the strap muscles, recurrent laryngeal nerve, laryngeal framework, trachea, or esophagus; and surgery for patients with central and lateral cervical lymph node involvement. Evidence-based guidelines were devised to help clinicians make safer and more efficient clinical decisions for the optimal surgical treatment of patients with locally invasive DTC.

本研究旨在为确定局部浸润性分化型甲状腺癌(DTC)患者的手术范围提出循证建议。局部浸润性分化型甲状腺癌如果严重向甲状腺外扩展并侵犯周围解剖结构,可能会导致多种功能障碍和不良的肿瘤预后。目前,局部浸润性 DTC 的最佳手术范围仍存在争议,也没有适当的指南。2021年10月8日,四位专家对PubMed、Embase和Cochrane图书馆数据库进行了检索;39位甲状腺和头颈外科专家对确定的论文进行了审阅。采用建议评估、制定和评价分级法(GRADE)评估证据质量,并制定和报告建议。建议的力度反映了指南小组对某项干预措施的理想效果大于任何不良效果的信心,适用于该建议所针对的所有患者。在完成指南草案后,韩国头颈外科学会成员完成了德尔菲问卷调查。针对术前检查;甲状腺切除术的手术范围;侵犯背带肌、喉返神经、喉框架、气管或食管的癌症手术;以及中央和外侧颈淋巴结受累患者的手术等多个因素提出了27项循证建议。该指南以证据为基础,旨在帮助临床医生做出更安全、更有效的临床决策,对局部浸润性 DTC 患者进行最佳手术治疗。
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引用次数: 0
SERPINE1 as an Independent Prognostic Marker and Therapeutic Target for Nicotine-Related Oral Carcinoma. SERPINE1作为尼古丁相关口腔癌的独立预后标志物和治疗靶点
IF 3 3区 医学 Q1 OTORHINOLARYNGOLOGY Pub Date : 2023-02-01 DOI: 10.21053/ceo.2022.01480
Xiaopeng Guo, Zhen Sun, Huarong Chen, Junjun Ling, Houyu Zhao, Aoshuang Chang, Xianlu Zhuo

Objectives: Nicotine is an ingredient of tobacco, and exposure to nicotine increases the risks of various cancers, including oral cancer. Previous studies have focused on the addictive properties of nicotine, but its carcinogenic mechanism has rarely been studied. We aimed to explore the key genes in the process through which nicotine promotes the occurrence and development of oral cancer via data mining and experimental verification.

Methods: This study involved three parts. First, key genes related to nicotine-related oral cancer were screened through data mining; second, the expression and clinical significance of a key gene in oral cancer tissues were verified by bioinformatics. Finally, the expression and clinical significance of the key gene in oral cancer were histologically investigated, and the effects of its expression on cell proliferation, invasion, and drug resistance were cytologically assessed.

Results: SERPINE1 was identified as the key gene, which was upregulated in nicotine-treated oral cells and may be an independent prognostic factor for oral cancer. SERPINE1 was enriched in various pathways, such as the tumor necrosis factor and apelin pathways, and was related to the infiltration of macrophages, CD4+T cells, and CD8+T cells. Overexpression of SERPINE1 was associated with N staging and may be involved in hypoxia, angiogenesis, and metastasis. Knockdown of SERPINE1 in oral cancer cells resulted in weakened cell proliferation and invasion ability and increased sensitivity to bleomycin and docetaxel.

Conclusion: This study revealed SERPINE1 as a key gene for nicotine-related oral cancer, indicating that SERPINE1 may be a novel prognostic indicator and therapeutic target for oral carcinoma.

目的:尼古丁是烟草的一种成分,接触尼古丁会增加患各种癌症的风险,包括口腔癌。以往的研究主要集中在尼古丁的成瘾性上,但其致癌机制却很少被研究。我们旨在通过数据挖掘和实验验证,探索尼古丁促进口腔癌发生发展过程中的关键基因。方法:本研究分为三部分。首先,通过数据挖掘筛选尼古丁相关性口腔癌相关的关键基因;其次,通过生物信息学验证某关键基因在口腔癌组织中的表达及临床意义。最后对该关键基因在口腔癌组织中的表达及临床意义进行组织学研究,并对其表达对细胞增殖、侵袭及耐药的影响进行细胞学评估。结果:SERPINE1被确定为关键基因,在尼古丁处理的口腔细胞中表达上调,可能是口腔癌的独立预后因素。SERPINE1在肿瘤坏死因子、apelin等多种通路富集,并与巨噬细胞、CD4+T细胞、CD8+T细胞的浸润有关。SERPINE1的过表达与N分期有关,可能与缺氧、血管生成和转移有关。在口腔癌细胞中,SERPINE1的敲低导致细胞增殖和侵袭能力减弱,对博来霉素和多西他赛的敏感性增加。结论:本研究显示SERPINE1是尼古丁相关口腔癌的关键基因,提示SERPINE1可能是口腔癌新的预后指标和治疗靶点。
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引用次数: 1
Improved Bone Conduction Hearing After Middle Ear Surgery: Investigation of the Improvement Mechanism. 中耳手术后骨传导听力改善机制的探讨。
IF 3 3区 医学 Q1 OTORHINOLARYNGOLOGY Pub Date : 2023-02-01 DOI: 10.21053/ceo.2022.01039
Hantai Kim, Jungho Ha, Ga Young Gu, Yun-Hoon Choung

Objectives: When performing middle ear operations, such as ossiculoplasty or stapes surgery, patients and surgeons expect an improvement in air conduction (AC) hearing, but generally not in bone conduction (BC). However, BC improvement has often been observed after surgery, and the present study investigated this phenomenon.

Methods: We reviewed the preoperative and postoperative surgical outcomes of 583 patients who underwent middle ear surgery. BC improvement was defined as a BC threshold decrease of >15 dB at two or more frequencies. Subjects in group A underwent staged ossiculoplasty after canal wall up mastoidectomy (CWUM), group B underwent staged ossiculoplasty after canal wall down mastoidectomy (CWDM), group C underwent ossiculoplasty only (thus, they had no prior history of CWUM or CWDM), and group D received stapes surgery. We created a hypothetical circuit model to explain this phenomenon.

Results: BC improvement was detected in 12.8% of group A, 9.1% of group B, and 8.5% of group C. The improvement was more pronounced in group D (27.0%). A larger gain in AC hearing was weakly correlated with greater BC improvement (Pearson's r=0.395 in group A, P<0.001; r=0.375 in group B, P<0.001; r=0.296 in group C, P<0.001; r=0.422 in group D, P=0.009). Notably, patients with otosclerosis even experienced postoperative BC improvements as large as 10.0 dB, from a mean value of 30.3 dB (standard error [SE], 3.2) preoperatively to 20.3 dB (SE, 3.2) postoperatively, at 1,000 Hz, as well as an improvement of 9.2 dB at 2,000 Hz, from 37.8 dB (SE, 2.6) to 28.6 dB (SE, 3.1).

Conclusion: BC improvement may be explained by a hypothetical circuit model applying the third window theory. Surgeons should keep in mind the possibility of BC improvement when making a management plan.

目的:当进行中耳手术,如听骨成形术或镫骨手术时,患者和外科医生期望空气传导(AC)听力的改善,但通常不会改善骨传导(BC)。然而,手术后经常观察到BC的改善,本研究调查了这一现象。方法:回顾583例中耳手术患者的术前及术后手术结果。BC改善被定义为在两个或多个频率下BC阈值降低>15 dB。A组患者行椎管上壁乳突切除术(CWUM)后的分阶段听骨成形术,B组患者行椎管下壁乳突切除术(CWDM)后的分阶段听骨成形术,C组患者仅行听骨成形术(既往无椎管上壁乳突切除术或CWDM病史),D组患者行镫骨手术。我们创建了一个假设的电路模型来解释这一现象。结果:A组12.8%、B组9.1%、c组8.5%患者BC改善,D组改善更明显(27.0%)。AC听力增加越大,BC改善越明显(A、p组Pearson’s r=0.395)。结论:BC改善可以通过应用第三窗口理论的假设电路模型来解释。外科医生在制定治疗计划时应考虑到BC改善的可能性。
{"title":"Improved Bone Conduction Hearing After Middle Ear Surgery: Investigation of the Improvement Mechanism.","authors":"Hantai Kim,&nbsp;Jungho Ha,&nbsp;Ga Young Gu,&nbsp;Yun-Hoon Choung","doi":"10.21053/ceo.2022.01039","DOIUrl":"https://doi.org/10.21053/ceo.2022.01039","url":null,"abstract":"<p><strong>Objectives: </strong>When performing middle ear operations, such as ossiculoplasty or stapes surgery, patients and surgeons expect an improvement in air conduction (AC) hearing, but generally not in bone conduction (BC). However, BC improvement has often been observed after surgery, and the present study investigated this phenomenon.</p><p><strong>Methods: </strong>We reviewed the preoperative and postoperative surgical outcomes of 583 patients who underwent middle ear surgery. BC improvement was defined as a BC threshold decrease of >15 dB at two or more frequencies. Subjects in group A underwent staged ossiculoplasty after canal wall up mastoidectomy (CWUM), group B underwent staged ossiculoplasty after canal wall down mastoidectomy (CWDM), group C underwent ossiculoplasty only (thus, they had no prior history of CWUM or CWDM), and group D received stapes surgery. We created a hypothetical circuit model to explain this phenomenon.</p><p><strong>Results: </strong>BC improvement was detected in 12.8% of group A, 9.1% of group B, and 8.5% of group C. The improvement was more pronounced in group D (27.0%). A larger gain in AC hearing was weakly correlated with greater BC improvement (Pearson's r=0.395 in group A, P<0.001; r=0.375 in group B, P<0.001; r=0.296 in group C, P<0.001; r=0.422 in group D, P=0.009). Notably, patients with otosclerosis even experienced postoperative BC improvements as large as 10.0 dB, from a mean value of 30.3 dB (standard error [SE], 3.2) preoperatively to 20.3 dB (SE, 3.2) postoperatively, at 1,000 Hz, as well as an improvement of 9.2 dB at 2,000 Hz, from 37.8 dB (SE, 2.6) to 28.6 dB (SE, 3.1).</p><p><strong>Conclusion: </strong>BC improvement may be explained by a hypothetical circuit model applying the third window theory. Surgeons should keep in mind the possibility of BC improvement when making a management plan.</p>","PeriodicalId":10318,"journal":{"name":"Clinical and Experimental Otorhinolaryngology","volume":"16 1","pages":"20-27"},"PeriodicalIF":3.0,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/e0/55/ceo-2022-01039.PMC9985987.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10842889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of Occupational Noise Exposure on the Prevalence of Benign Vocal Fold Lesions: A Nationwide Population-Based Study. 职业性噪声暴露对良性声带病变患病率的影响:一项基于全国人群的研究。
IF 3 3区 医学 Q1 OTORHINOLARYNGOLOGY Pub Date : 2023-02-01 DOI: 10.21053/ceo.2022.01298
Ji-Sun Kim, Sukil Kim, Tae-Hoon Moon, Soomin Park, Seung Hwa Kim, Subin Kim, Dong-Hyun Lee, Byung Guk Kim, Ki-Hong Chang, Jun-Ook Park

Objectives: Voice abuse in noisy environments can result in voice disorders. However, insufficient studies have sought to differentiate vocal cord lesions through laryngoscopic examinations among workers in noisy environments. This study investigated the relationship between a history of noise exposure in the workplace and benign vocal fold lesions (BVFLs).

Methods: We used Korea National Health and Nutrition Examination Survey data from 2010 to 2012. The chi-square test was used to compare characteristics between two groups according to the presence or absence of BVFLs. To investigate the association between BVFLs and noise exposure in the workplace, we calculated adjusted odds ratios and 95% confidence intervals (CIs) using multiple logistic regression analysis.

Results: In total, 10,170 participants with available laryngoscopy.

Results: were enrolled. Smoking history, hypertension, diabetes, and exposure to noise for more than 3 months at the workplace were significantly more common in participants with BVFLs. After adjusting for age, sex, smoking, drinking, obesity, hypertension, diabetes, income, education, and occupation as confounders, we confirmed that BVFLs were 1.52 times more likely (95% CI, 1.157-1.990) to occur in individuals with occupational noise exposure.

Conclusion: Working in a noisy environment could induce BVFLs in workers through voice abuse. Social recognition that a noisy environment is a risk factor for BVFLs needs to be improved, and preventive measures should be implemented.

目的:在嘈杂的环境中滥用语音会导致语音障碍。然而,没有足够的研究试图通过喉镜检查来区分嘈杂环境中工人的声带病变。本研究调查了工作场所噪声暴露史与良性声带病变(bvfl)之间的关系。方法:采用2010 ~ 2012年韩国国家健康与营养调查数据。根据是否存在bvfl,采用卡方检验比较两组间的特征。为了研究bvfl与工作场所噪声暴露之间的关系,我们使用多元逻辑回归分析计算了调整优势比和95%置信区间(ci)。结果:共有10170名参与者接受了喉镜检查。结果:入选。吸烟史、高血压、糖尿病和在工作场所接触噪音超过3个月在bvfl参与者中更为常见。在调整了年龄、性别、吸烟、饮酒、肥胖、高血压、糖尿病、收入、教育和职业等混杂因素后,我们证实,职业性噪声暴露的个体发生bvfl的可能性高出1.52倍(95% CI, 1.157-1.990)。结论:在嘈杂环境中工作可通过声音虐待诱发bvfl。社会对噪声环境是bvfl风险因素的认识有待提高,并应采取预防措施。
{"title":"Effect of Occupational Noise Exposure on the Prevalence of Benign Vocal Fold Lesions: A Nationwide Population-Based Study.","authors":"Ji-Sun Kim,&nbsp;Sukil Kim,&nbsp;Tae-Hoon Moon,&nbsp;Soomin Park,&nbsp;Seung Hwa Kim,&nbsp;Subin Kim,&nbsp;Dong-Hyun Lee,&nbsp;Byung Guk Kim,&nbsp;Ki-Hong Chang,&nbsp;Jun-Ook Park","doi":"10.21053/ceo.2022.01298","DOIUrl":"https://doi.org/10.21053/ceo.2022.01298","url":null,"abstract":"<p><strong>Objectives: </strong>Voice abuse in noisy environments can result in voice disorders. However, insufficient studies have sought to differentiate vocal cord lesions through laryngoscopic examinations among workers in noisy environments. This study investigated the relationship between a history of noise exposure in the workplace and benign vocal fold lesions (BVFLs).</p><p><strong>Methods: </strong>We used Korea National Health and Nutrition Examination Survey data from 2010 to 2012. The chi-square test was used to compare characteristics between two groups according to the presence or absence of BVFLs. To investigate the association between BVFLs and noise exposure in the workplace, we calculated adjusted odds ratios and 95% confidence intervals (CIs) using multiple logistic regression analysis.</p><p><strong>Results: </strong>In total, 10,170 participants with available laryngoscopy.</p><p><strong>Results: </strong>were enrolled. Smoking history, hypertension, diabetes, and exposure to noise for more than 3 months at the workplace were significantly more common in participants with BVFLs. After adjusting for age, sex, smoking, drinking, obesity, hypertension, diabetes, income, education, and occupation as confounders, we confirmed that BVFLs were 1.52 times more likely (95% CI, 1.157-1.990) to occur in individuals with occupational noise exposure.</p><p><strong>Conclusion: </strong>Working in a noisy environment could induce BVFLs in workers through voice abuse. Social recognition that a noisy environment is a risk factor for BVFLs needs to be improved, and preventive measures should be implemented.</p>","PeriodicalId":10318,"journal":{"name":"Clinical and Experimental Otorhinolaryngology","volume":"16 1","pages":"87-94"},"PeriodicalIF":3.0,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/3e/c4/ceo-2022-01298.PMC9985988.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9106326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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Clinical and Experimental Otorhinolaryngology
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