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Co-Existing Non-Occlusive Splenic Vein and Superior Mesenteric Vein Thrombosis in an Acute Necrotic Pancreatitis Patient—A Case Report
IF 0.6 Q3 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-11-27 DOI: 10.1002/ccr3.9643
Andreea Irina Ghiță, Arina Ilinca Gheorghe, Georgiana Elena Beteringhe, Andreea Ramona Treteanu, Mihai Radu Pahomeanu

Case report of a case of acute pancreatitis (AP) at a patient previously known with essential thrombocytosis (ET). The most redoubtable complications of AP in this case were: pancreatic necrosis and splahnic vein thrombosis (SVT). Patient was followed-up for 3 months with complete resolution of SVT under anticoagulation. As far as we know this is the first case ever published suffering simultaneously from AP and ET, both conditions known for their increased risk of developing thrombi.

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引用次数: 0
Schwannoma of the Soft Palate: A Rare Case Report
IF 0.6 Q3 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-11-27 DOI: 10.1002/ccr3.9619
Manoj Adhikari, Kanistika Jha, Shova Kunwar, K.C. Sarita, Mallika Rayamajhi

Oral schwannomas are rare, with only 18 cases of soft palate involvement reported since 1985. We report a case of a 15-year-old male with a soft palate schwannoma who was successfully treated by surgical excision and had no complications over a one-year follow-up. Histologically, schwannomas exhibit Antoni A and B patterns.

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引用次数: 0
Interposition of the Fracture Fragment of a Vitamin E-Blended, Highly Crosslinked Polyethylene Liner After Total Hip Arthroplasty: A Case Report
IF 0.6 Q3 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-11-27 DOI: 10.1002/ccr3.9561
Hiromasa Tanino, Ryo Mitsutake, Hiroshi Ito

This is the first case report of a vitamin E-blended polyethylene liner fracture after total hip arthroplasty. Our case highlights the importance of considering a vitamin E-blended polyethylene liner fracture, the interposition of fracture fragments between the articulating surfaces after dislocation and blocked successful reduction.

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引用次数: 0
Giant Cysticercosis of the Right Kidney: A Case Report
IF 0.6 Q3 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-11-27 DOI: 10.1002/ccr3.9624
Yumeng Zhang, Huaqing Tan, Xukun Gao, Yuxuan Wang, Yuntai Cao

Cysticercosis, although reported in several parts of the body, especially the liver, lesions occurring in the kidney are particularly rare. We report a 58-year-old female patient with intermittent epigastric pain, who was found to have a huge occupancy of the right kidney on computed tomography (CT) and magnetic resonance imaging (MRI), which was confirmed to have a predominantly cystic component, with no clear enhancement on CT images after injection of contrast medium, and significant enhancement of the peritoneum and septum visible on MRI. This case reports a case and its rarity of cysticercosis occurring in the kidney.

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引用次数: 0
Rheumatoid arthritis and PLA2R-associated mebranous nephropathy. Cause or coincidence?
IF 0.6 Q3 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-11-27 DOI: 10.1002/ccr3.9516
Lara Perea-Ortega, Ana Muñoz-Sánchez, Myriam León-Fradejas, Remedios Toledo Rojas, Pedro Ruiz-Esteban, Verónica López-Jiménez
<div> <section> <h3> Key Clinical Message</h3> <p>The coexistence of rheumatoid arthritis (RA) and PLA2R-associated membranous nephropathy (MN) is uncommon. It is difficult to demonstrate whether the mechanisms of renal pathology are triggered by RA, but it has been observed that the pro-inflammatory molecules present in RA increase the expression of PLA2R. Rituximab could be effective in both conditions.</p> </section> <section> <p>RA affects 0.5% of adults in our country. It is an inflammatory disease that predominantly affects the joints causing destruction of the articular cartilage. Approximately 50% of patients present extra-articular manifestations. Renal involvement is relatively frequent and clinically significant because it worsens the course and mortality of the primary disease. The histological renal damage observed in these patients includes a wide variety of entities and histological patterns with both glomerular and tubulointerstitial involvement, with secondary MN being one of the most frequent. Coexistence with primary MN is rare. We present the case of a 46-year-old male recently diagnosed with RA who was referred to the nephrology department for renal function deterioration and subnephrotic proteinuria. The autoimmune study showed positive anti-PLA2R. Due to the unusual association between both entities, it was decided to perform a renal biopsy which showed abundant spikes. The immunofluorescence study showed contiguous parietal IgG positivity (3+). Immunohistochemistry showed positive granular IgG4, confirming the diagnosis of PLA2R-associated MN. MN is one of the most common causes of nephrotic syndrome in adults. The determination of anti-PLA2R has been a great advance in the rapid differential diagnosis of MN. In recent years, new target antigens associated with certain underlying pathologies have been discovered. However, PLA2R is not associated with any disease or exposure and therefore remains the antigen responsible for 80% of primary NMs. Anti-PLA2R antibodies can be produced by loss of central or peripheral tolerance. Whether these mechanisms are triggered by RA itself is difficult to prove. The cytokine TNF-like weak inducer of apoptosis (TWEAK) has been associated with RA. This proinflammatory molecule increases the expression of PLA2R in podocytes, sensitizing them to the damaging action of anti-PLA2Rs, which could justify a causal relationship between the two pathologies. The anti-PLA2R positivity in a patient with membranous nephropathy should not be sufficient to refrain from searching for a secondary cause, as a kidney biopsy is mandatory when another underlying disease coexists. Treatment should be tailored to the individual risk profile for progression. Rituximab could be an optimal option for both entities.</p> </section>
{"title":"Rheumatoid arthritis and PLA2R-associated mebranous nephropathy. Cause or coincidence?","authors":"Lara Perea-Ortega,&nbsp;Ana Muñoz-Sánchez,&nbsp;Myriam León-Fradejas,&nbsp;Remedios Toledo Rojas,&nbsp;Pedro Ruiz-Esteban,&nbsp;Verónica López-Jiménez","doi":"10.1002/ccr3.9516","DOIUrl":"https://doi.org/10.1002/ccr3.9516","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Key Clinical Message&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;The coexistence of rheumatoid arthritis (RA) and PLA2R-associated membranous nephropathy (MN) is uncommon. It is difficult to demonstrate whether the mechanisms of renal pathology are triggered by RA, but it has been observed that the pro-inflammatory molecules present in RA increase the expression of PLA2R. Rituximab could be effective in both conditions.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 \u0000 &lt;p&gt;RA affects 0.5% of adults in our country. It is an inflammatory disease that predominantly affects the joints causing destruction of the articular cartilage. Approximately 50% of patients present extra-articular manifestations. Renal involvement is relatively frequent and clinically significant because it worsens the course and mortality of the primary disease. The histological renal damage observed in these patients includes a wide variety of entities and histological patterns with both glomerular and tubulointerstitial involvement, with secondary MN being one of the most frequent. Coexistence with primary MN is rare. We present the case of a 46-year-old male recently diagnosed with RA who was referred to the nephrology department for renal function deterioration and subnephrotic proteinuria. The autoimmune study showed positive anti-PLA2R. Due to the unusual association between both entities, it was decided to perform a renal biopsy which showed abundant spikes. The immunofluorescence study showed contiguous parietal IgG positivity (3+). Immunohistochemistry showed positive granular IgG4, confirming the diagnosis of PLA2R-associated MN. MN is one of the most common causes of nephrotic syndrome in adults. The determination of anti-PLA2R has been a great advance in the rapid differential diagnosis of MN. In recent years, new target antigens associated with certain underlying pathologies have been discovered. However, PLA2R is not associated with any disease or exposure and therefore remains the antigen responsible for 80% of primary NMs. Anti-PLA2R antibodies can be produced by loss of central or peripheral tolerance. Whether these mechanisms are triggered by RA itself is difficult to prove. The cytokine TNF-like weak inducer of apoptosis (TWEAK) has been associated with RA. This proinflammatory molecule increases the expression of PLA2R in podocytes, sensitizing them to the damaging action of anti-PLA2Rs, which could justify a causal relationship between the two pathologies. The anti-PLA2R positivity in a patient with membranous nephropathy should not be sufficient to refrain from searching for a secondary cause, as a kidney biopsy is mandatory when another underlying disease coexists. Treatment should be tailored to the individual risk profile for progression. Rituximab could be an optimal option for both entities.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000","PeriodicalId":10327,"journal":{"name":"Clinical Case Reports","volume":"12 12","pages":""},"PeriodicalIF":0.6,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ccr3.9516","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142748931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unraveling Heart Inflammation: Recurrent Myopericarditis Caused by Coxsackie A Virus—A Case Report
IF 0.6 Q3 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-11-27 DOI: 10.1002/ccr3.9630
Maisha Maliha, Vikyath Satish, Kuan Yu Chi, Nishat Shama, Sananda Halder, Sumaiya Monjur Oishy, Amrin Kharawala, Dimitrios Varrias, Robert T. Fallaice

Acute recurrent myopericarditis, characterized by the occurrence of a new myopericarditis event following a symptom-free interval of 4–6 weeks, is relatively rare lacking definitive guidelines for management. Understanding its prevalence, causes, and optimal management is challenging due to limited data and insufficient guidelines. This case outlines the diagnostic work-up and different management modalities for recurrent myopericarditis. A 44-year-old African American man with a past medical history of myopericarditis a year ago presented with fever and chest pain for 4 days. The patient was found to have elevated troponin, CRP, and ESR; pericardial effusion along with a Coxsackie A virus titer of 1:800, suggestive of Coxsackie A virus–induced recurrent myopericarditis. The patient responded well to colchicine and a tapering dose of ibuprofen, achieving significant resolution in the pericardial effusion. Recurrent myopericarditis caused by Coxsackie A virus is a relatively rare phenomenon. New onset myopericarditis can be caused by various factors such as infections, autoimmune disorders, neoplasms, metabolic issues, trauma, and drugs, with recurrence rates of 15%–50% in pericarditis patients. Coxsackie A virus is an important and rare etiology of recurrent myopericarditis due to its unique immune evasive traits. The treatment modalities guided by definitive guidelines for recurrent pericarditis can be applied in recurrent myopericarditis with significant resolution of symptoms. Although there are no specific guidelines for managing recurrent myopericarditis, using approaches designed for recurrent pericarditis has shown promising results, and the immune evasive nature of Coxsackie A virus underscores the need for further research to improve our understanding and treatment of this condition.

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引用次数: 0
Correction to Anatomical Variant of Anteriorly Extending Mental Foramen: A Case Report 矫正前伸齿孔的解剖变异:病例报告
IF 0.6 Q3 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-11-26 DOI: 10.1002/ccr3.9562

G. Habash, K. R. Beshtawi, S. N. Jayash, “Anatomical Variant of Anteriorly Extending Mental Foramen: A Case Report,” Clinical Case Reports 12, no. 1 (2024): e8341.

In the funding information section, the text “We are grateful to the Biotechnology and Biological Sciences Research Council (BBSRC) for Institute Strategic Programme Grant Funding BB/J004316/1 to SNJ” was incorrect. This should have read: “We are grateful to the Biotechnology and Biological Sciences Research Council (BBSRC) for Institute Strategic Programme Grant Funding (BBS/E/RL/230001C), which provided salary support to Soher Nagi Jayash during manuscript writing.”

We apologize for this error.

G. Habash, K. R. Beshtawi, S. N. Jayash, "Anatomical Variant of Anteriorly Extending Mental Foramen:A Case Report," Clinical Case Reports 12,no. 1 (2024):e8341.在资助信息部分,"我们感谢生物技术和生物科学研究委员会(BBSRC)为 SNJ 提供的研究所战略计划资助 BB/J004316/1 "有误。应改为"我们感谢生物技术与生物科学研究理事会(BBSRC)的研究所战略计划资助基金(BBS/E/RL/230001C),该基金在Soher Nagi Jayash撰写手稿期间为其提供了薪金支持。"我们对这一错误表示歉意。
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引用次数: 0
Possible Factor Xa Resistance in a Patient Who Failed Apixaban and Rivaroxaban 一名阿哌沙班和利伐沙班治疗失败的患者可能存在因子 Xa 抗药性
IF 0.6 Q3 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-11-26 DOI: 10.1002/ccr3.9623
Ola Ali, Awab Elnaeem, Manmeet Kaur, Nitisha Thatikonda, Julia Aigbogun, A. K. M. Muktadir

This article aims to discuss the literature on switching to an anticoagulant with a different mechanism of action in case of treatment failure. We present a patient with atrial fibrillation who incurred an embolic stroke despite adequate anticoagulation with apixaban and developed a new symptomatic ischemic stroke during the same admission after switching to rivaroxaban, a factor Xa inhibitor with a similar mechanism of action. He had no new events at 3-months after switching to dabigatran, a direct thrombin inhibitor. We identified no apparent reason for anticoagulation failure in our patient. The literature on switching anticoagulants in case of failure is inconclusive with no strong supportive evidence. More research is needed to define anticoagulation failure and identify cases with factor Xa inhibitor resistance, in which switching to a different mechanism of anticoagulation may be appropriate.

本文旨在讨论在治疗失败的情况下改用作用机制不同的抗凝剂的文献。我们介绍了一名心房颤动患者,尽管他使用阿哌沙班进行了充分的抗凝治疗,但仍发生了栓塞性脑卒中,在改用具有类似作用机制的 Xa 因子抑制剂利伐沙班治疗后,他在入院的同一天又发生了新的症状性缺血性脑卒中。在改用达比加群(一种直接凝血酶抑制剂)3 个月后,他没有发生新的事件。我们没有发现患者抗凝失败的明显原因。关于在抗凝失败的情况下更换抗凝药物的文献尚无定论,也没有有力的支持证据。需要开展更多研究来定义抗凝失败,并确定 Xa 因子抑制剂耐药的病例,在这些病例中,换用不同的抗凝机制可能是合适的。
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引用次数: 0
Respiratory Failure Following a Venomous Snakebite: Importance of Ambu Bag Ventilation in a Poor-Resource Setting 毒蛇咬伤后呼吸衰竭:救护袋通气在资源匮乏环境中的重要性
IF 0.6 Q3 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-11-26 DOI: 10.1002/ccr3.9627
Abdul Matin, Sarwar Alam Sobuj, Prity Saha, Chowdhury Adnan Sami

Venomous snakebites are critical medical emergency. Most fatalities resulted from respiratory failure attributable to abrupt neuromuscular paralysis. A 35-year-old male was treated for a snakebite on the dorsum of his right foot, which occurred seven hours prior to hospital admission during sleep. The patient exhibited symptoms of headache, myalgia, extremity weakness, and altered consciousness. No hemorrhagic or myotoxic symptoms were observed. He subsequently had respiratory failure, necessitating emergency bedside intubation with an Ambu bag, followed by treatment initiated in the district hospital and continued in the intensive care unit of a medical college hospital. Timely diagnosis, immediate transport to a medical facility, and rapid bedside intubation can save the lives of individuals experiencing respiratory failure due to venomous snake bites.

毒蛇咬伤是一种严重的急症。大多数死亡病例都是由于神经肌肉突然麻痹导致呼吸衰竭。一名 35 岁的男性因右脚脚背被蛇咬伤接受治疗,该蛇咬伤发生在入院前 7 小时的睡眠中。患者表现出头痛、肌痛、四肢无力和意识改变等症状。未发现出血或肌中毒症状。随后,他出现呼吸衰竭,需要使用安舒袋进行紧急床旁插管,随后在地区医院开始治疗,并在一家医学院附属医院的重症监护室继续治疗。及时诊断、立即送往医疗机构并迅速进行床旁插管可以挽救因毒蛇咬伤而出现呼吸衰竭者的生命。
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引用次数: 0
Spigelian Hernia Unveiled: A Case Report of Unexpectedly Extended Hernial Sac and Successful Surgical Intervention Spigelian Hernia Unveiled:意外扩展的疝囊和成功手术干预的病例报告
IF 0.6 Q3 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-11-26 DOI: 10.1002/ccr3.9605
Marah Mansour, Yaman Saiouf, Karim Gharib, Dani Deeb, Mohammad Yaman Almokdad

Spigelian hernia is a rare type of abdominal hernia; diagnosis is primarily through computed tomography, which is crucial for accurate diagnosis and planning early surgical intervention to preserve the herniated sac's contents.

Spigelian 疝是一种罕见的腹股沟疝,主要通过计算机断层扫描进行诊断,这对于准确诊断和计划早期手术治疗以保留疝囊内容物至关重要。
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引用次数: 0
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Clinical Case Reports
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