Pub Date : 2022-09-05DOI: 10.59657/2837-2565.brs.22.003
The incidence of colorectal and small bowel cancers associated with CD development is often accompanied by chronic active inflammation at the site. Although the duodenum can be accessed easily during endoscopy, it is challenging to diagnose malignant transformation prior to the surgery. Early diagnosis of CD-associated cancers is necessary.
{"title":"A Case of Duodenal Cancer in a Patient with Prolonged Crohn's Disease","authors":"","doi":"10.59657/2837-2565.brs.22.003","DOIUrl":"https://doi.org/10.59657/2837-2565.brs.22.003","url":null,"abstract":"The incidence of colorectal and small bowel cancers associated with CD development is often accompanied by chronic active inflammation at the site. Although the duodenum can be accessed easily during endoscopy, it is challenging to diagnose malignant transformation prior to the surgery. Early diagnosis of CD-associated cancers is necessary.","PeriodicalId":10345,"journal":{"name":"Clinical Case Studies and Reports","volume":"98 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88531059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-05DOI: 10.59657/2837-2565.brs.22.002
{"title":"New Technology Launches and Investments to Accelerate In-Vitro Diagnostics Demand","authors":"","doi":"10.59657/2837-2565.brs.22.002","DOIUrl":"https://doi.org/10.59657/2837-2565.brs.22.002","url":null,"abstract":"","PeriodicalId":10345,"journal":{"name":"Clinical Case Studies and Reports","volume":"277 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76416184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zarrin Hossein-zadeh, Roberto River-Soto, Katherine Rivero-Soto, Lisa Chaohui Zhao
{"title":"Congenitally bilobed gallbladder with luminal bile stasis, acute on chronic cholecystitis, and two distinct luminal morphologies: A case report","authors":"Zarrin Hossein-zadeh, Roberto River-Soto, Katherine Rivero-Soto, Lisa Chaohui Zhao","doi":"10.15761/ccsr.1000171","DOIUrl":"https://doi.org/10.15761/ccsr.1000171","url":null,"abstract":"","PeriodicalId":10345,"journal":{"name":"Clinical Case Studies and Reports","volume":"11236 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76731586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Non-immune hydrops fetalis due to Turner syndrome is characterized by hydrops fetalis, cystic hygroma, ascites and eventual fetal demise in most cases. Case: We report on a patient with incidental non-immune hydrops fetalis due to Turner syndrome presenting with hydrops fetalis and ascites on ultrasound, a rare en-caul vaginal delivery, and cystic hygroma, confirmed by cell-free DNA chromosomal analysis. Conclusion: This rare case illustrates the adaptive patient management and interdisplinary coordination of care.
{"title":"Incidental en-caul hydrops fetalis due to trauma: Interdisciplinary continuity of care","authors":"Jonathan W. Meadows, S. F. Brown","doi":"10.15761/CCSR.1000161","DOIUrl":"https://doi.org/10.15761/CCSR.1000161","url":null,"abstract":"Background: Non-immune hydrops fetalis due to Turner syndrome is characterized by hydrops fetalis, cystic hygroma, ascites and eventual fetal demise in most cases. Case: We report on a patient with incidental non-immune hydrops fetalis due to Turner syndrome presenting with hydrops fetalis and ascites on ultrasound, a rare en-caul vaginal delivery, and cystic hygroma, confirmed by cell-free DNA chromosomal analysis. Conclusion: This rare case illustrates the adaptive patient management and interdisplinary coordination of care.","PeriodicalId":10345,"journal":{"name":"Clinical Case Studies and Reports","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84781790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Syphilis is a sexually transmitted disease. Sometimes, it is challenging to diagnose due to false negative serologic results. Therefore, the proper use and interpretation of diagnostic testing are important for optimal patient management. Prozone phenomenon is a very rare and false negative reaction and occurs due to disproportionately increased antibodies in a specimen. Immune system is responsible for excess antibodies. It is frequently seen in HIV, neurosyphilis, early syphilis (mainly secondary syphilis). This reaction causes delays in the diagnosis and treatment of the disease. Thus, in cases where VDRL is non-reactive, it is important for clinicians to consider prozone reaction in patients with clinical signs suggesting syphilis. Here, we present a case of secondary syphilis diagnosed late due to prozone phenomenon.
{"title":"Secondary syphilis: Hepatitis, rashes and prozone phenomenon","authors":"A. Kaya, S. Kaya, A. Kurt, M. Şahin, A. Can","doi":"10.15761/CCSR.1000160","DOIUrl":"https://doi.org/10.15761/CCSR.1000160","url":null,"abstract":"Syphilis is a sexually transmitted disease. Sometimes, it is challenging to diagnose due to false negative serologic results. Therefore, the proper use and interpretation of diagnostic testing are important for optimal patient management. Prozone phenomenon is a very rare and false negative reaction and occurs due to disproportionately increased antibodies in a specimen. Immune system is responsible for excess antibodies. It is frequently seen in HIV, neurosyphilis, early syphilis (mainly secondary syphilis). This reaction causes delays in the diagnosis and treatment of the disease. Thus, in cases where VDRL is non-reactive, it is important for clinicians to consider prozone reaction in patients with clinical signs suggesting syphilis. Here, we present a case of secondary syphilis diagnosed late due to prozone phenomenon.","PeriodicalId":10345,"journal":{"name":"Clinical Case Studies and Reports","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90457345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Weimer Le, Cattari G, Binelli A, F. E, Poddighe Af, Sensi F
{"title":"Impact on long-term respiratory and neurologic sequelae of Sars-Cov-2 in the first year of global pandemic era: A minireview","authors":"Weimer Le, Cattari G, Binelli A, F. E, Poddighe Af, Sensi F","doi":"10.15761/ccsr.1000163","DOIUrl":"https://doi.org/10.15761/ccsr.1000163","url":null,"abstract":"","PeriodicalId":10345,"journal":{"name":"Clinical Case Studies and Reports","volume":"274 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75134922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nayara Douat Hannegraf, Isabelle Bolfe, R. Dalmagro, Priscilla Dal Pra Campos, Tatiana Rosa Ogata Nakagawa, Francelise Bridi Cavassin
Alternative therapies, such as the use of vitamin D in high daily doses, are increasingly common and available for clinical practice in the treatment of autoimmune diseases. Its use requires caution due to the active role of vitamin D in immunomodulation and calcium absorption by the body. Here we describe a case report about a condition of hypercalcemia with evolution to acute renal failure after using high daily doses of vitamin D as recommended by the alternative Coimbra Protocol. A twenty-one-years old, Caucasian female patient, presented with acute renal failure after continuous and daily use of 120,000 IU of cholecalciferol, according to medical recommendation. She has evolved with hypercalcemia and digestive symptoms due to intoxication by hypervitaminosis D. Due to refractory hypercalcemia despite the measures imposed, zoledronic acid was added to the therapy, which proved to be effective in resolving the case. The treatment of autoimmune diseases based on the Coimbra Protocol lacks studies that prove its effectiveness. Evidence is undoubtedly needed to prove the benefits and establish the risks to which patients may be exposed when using high daily doses of vitamin D.
{"title":"Hypercalcemia with progression to Acute Kidney Injury (AKI) after daily use of 120,000 UI of Vitamin D: a case report","authors":"Nayara Douat Hannegraf, Isabelle Bolfe, R. Dalmagro, Priscilla Dal Pra Campos, Tatiana Rosa Ogata Nakagawa, Francelise Bridi Cavassin","doi":"10.15761/ccsr.1000164","DOIUrl":"https://doi.org/10.15761/ccsr.1000164","url":null,"abstract":"Alternative therapies, such as the use of vitamin D in high daily doses, are increasingly common and available for clinical practice in the treatment of autoimmune diseases. Its use requires caution due to the active role of vitamin D in immunomodulation and calcium absorption by the body. Here we describe a case report about a condition of hypercalcemia with evolution to acute renal failure after using high daily doses of vitamin D as recommended by the alternative Coimbra Protocol. A twenty-one-years old, Caucasian female patient, presented with acute renal failure after continuous and daily use of 120,000 IU of cholecalciferol, according to medical recommendation. She has evolved with hypercalcemia and digestive symptoms due to intoxication by hypervitaminosis D. Due to refractory hypercalcemia despite the measures imposed, zoledronic acid was added to the therapy, which proved to be effective in resolving the case. The treatment of autoimmune diseases based on the Coimbra Protocol lacks studies that prove its effectiveness. Evidence is undoubtedly needed to prove the benefits and establish the risks to which patients may be exposed when using high daily doses of vitamin D.","PeriodicalId":10345,"journal":{"name":"Clinical Case Studies and Reports","volume":"84 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85367214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Purpura Fulminans (PF) is a complication commonly associated with scarlet fever and meningococcal infection in infants but is also reported in adult patients. Limb ischemia is a devastating complication and amputation may be necessary to reduce mortality. Case report: We report a 49-year-old, previously healthy female patient, who presented with ulcerative colitis and underwent a colonoscopy. Post-operatively, she presented one week later with transverse colon perforation requiring subtotal colectomy, abdominal washout and ileostomy. Her case was further complicated by an intra-abdominal infection causing septic shock. She then developed purpuric skin patches, sparing the trunk, and severe ischemia of her distal extremities consistent with PF. Despite improved respiratory and hemodynamic status, her limb ischemia continued to progress, and she eventually underwent bilateral forearm amputations. Discussion and conclusion: This case presents an opportunity to discuss the importance of supportive care and hematological treatments to reduce the mortality and control the devastating complications of microvascular coagulation and limb ischemia associated with PF. Optimization of microcirculation, steroid treatment, immunomodulation, protein C zymogen, plasma exchange or replacement can potentially mitigate the injury and should be considered to improve outcome.
{"title":"A case of bilateral forearm amputation resulting from purpura fulminans following subtotal colectomy for perforated ulcerative colitis","authors":"Jialing Zhu, Shivali Mukerji, A. Nozari","doi":"10.15761/CCSR.1000158","DOIUrl":"https://doi.org/10.15761/CCSR.1000158","url":null,"abstract":"Introduction: Purpura Fulminans (PF) is a complication commonly associated with scarlet fever and meningococcal infection in infants but is also reported in adult patients. Limb ischemia is a devastating complication and amputation may be necessary to reduce mortality. Case report: We report a 49-year-old, previously healthy female patient, who presented with ulcerative colitis and underwent a colonoscopy. Post-operatively, she presented one week later with transverse colon perforation requiring subtotal colectomy, abdominal washout and ileostomy. Her case was further complicated by an intra-abdominal infection causing septic shock. She then developed purpuric skin patches, sparing the trunk, and severe ischemia of her distal extremities consistent with PF. Despite improved respiratory and hemodynamic status, her limb ischemia continued to progress, and she eventually underwent bilateral forearm amputations. Discussion and conclusion: This case presents an opportunity to discuss the importance of supportive care and hematological treatments to reduce the mortality and control the devastating complications of microvascular coagulation and limb ischemia associated with PF. Optimization of microcirculation, steroid treatment, immunomodulation, protein C zymogen, plasma exchange or replacement can potentially mitigate the injury and should be considered to improve outcome.","PeriodicalId":10345,"journal":{"name":"Clinical Case Studies and Reports","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88837702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Covid Lines","authors":"Paul H. Axelsen","doi":"10.15761/ccsr.1000168","DOIUrl":"https://doi.org/10.15761/ccsr.1000168","url":null,"abstract":"","PeriodicalId":10345,"journal":{"name":"Clinical Case Studies and Reports","volume":"80 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88999131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A rare cause of acute intestinal obstruction due to transanal small bowel evisceration caused by rectal laceration: case report","authors":"Muhaned Alhassan, Hatem Al-saeedi, A. Barghash","doi":"10.15761/ccsr.1000169","DOIUrl":"https://doi.org/10.15761/ccsr.1000169","url":null,"abstract":"","PeriodicalId":10345,"journal":{"name":"Clinical Case Studies and Reports","volume":"61 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77669698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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