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Dietary antioxidant capacity, genetic susceptibility and polymorphism, and inflammatory bowel disease risk in a prospective cohort. 前瞻性队列中的膳食抗氧化能力、遗传易感性和多态性与炎症性肠病风险。
IF 11.6 1区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2024-11-05 DOI: 10.1016/j.cgh.2024.09.033
Jie Chen, Lintao Dan, Shuai Yuan, Tian Fu, Jiangwei Sun, Alicja Wolk, Jonas F Ludvigsson, Xue Li, Xiaoyan Wang, Susanna C Larsson

Background and aims: Oxidative stress is an essential factor in the pathogenesis of inflammatory bowel disease (IBD). A previous study found protective potential of some antioxidative nutrients against IBD. However, the association between total antioxidant capacity (TAC) of the diet and incident IBD is unclear.

Methods: We conducted a prospective cohort study including 186,195 IBD-free participants at baseline from the UK Biobank. We calculated dietary TAC using the oxygen radical absorbance capacity method based on repeated online 24-hour dietary recalls. Crohn's disease (CD) and ulcerative colitis (UC) were identified via inpatient register and primary care data. Genetic susceptibility for IBD was assessed by a polygenic risk score. Cox proportional hazard models were applied to estimate multivariable-adjusted hazard ratios (aHRs) and 95% confidence intervals (CIs).

Results: During a median follow-up of 11.4 years, we identified 396 CD and 809 UC incident cases. Individuals with the highest quintile of dietary TAC had a lower risk of CD (27.0 vs 17.0 cases/100,000 person-years; aHR 0.66, 95% CI 0.49-0.90) but not UC (46.7 vs 35.5 cases/100,000 person-years; aHR 0.85, 95% CI 0.69-1.06) compared with the lowest group. We observed interactions between TAC and genetic susceptibility at both multiplicative (P-interaction=0.008/0.063 for CD/UC) and additive (both P values>1) scales. Additionally, a polymorphism of the endogenous antioxidant enzyme gene SOD2 (rs4880) modified the dietary TAC-UC association (P-interaction=0.039).

Conclusion: This study suggests that a diet with high TAC may help prevent the development of IBD, particularly in individuals at high genetic risk of IBD and in mutation carriers of rs4880 in SOD2.

背景和目的:氧化应激是炎症性肠病(IBD)发病机制中的一个重要因素。先前的一项研究发现,一些抗氧化营养素对 IBD 具有保护作用。然而,膳食总抗氧化能力(TAC)与IBD发病之间的关系尚不清楚:我们进行了一项前瞻性队列研究,研究对象包括英国生物库中的 186195 名基线无 IBD 的参与者。我们使用氧自由基吸收能力法计算了膳食中的总抗氧化能力,该方法基于重复在线 24 小时膳食回忆。克罗恩病(CD)和溃疡性结肠炎(UC)是通过住院登记和初级保健数据确定的。IBD的遗传易感性通过多基因风险评分进行评估。采用 Cox 比例危险模型估算多变量调整危险比 (aHR) 和 95% 置信区间 (CI):在中位 11.4 年的随访期间,我们发现了 396 例 CD 和 809 例 UC 病例。与最低组相比,膳食中TAC含量最高的五分位数人群罹患CD的风险较低(27.0 vs 17.0例/100,000人-年;aHR 0.66,95% CI 0.49-0.90),但罹患UC的风险较低(46.7 vs 35.5例/100,000人-年;aHR 0.85,95% CI 0.69-1.06)。我们观察到 TAC 与遗传易感性之间在乘法(P-interaction=0.008/0.063,CD/UC)和加法(P 值均大于 1)两个尺度上的相互作用。此外,内源性抗氧化酶基因 SOD2 的多态性(rs4880)改变了膳食中 TAC 与UC 的相关性(P-交互作用=0.039):本研究表明,高TAC饮食可能有助于预防IBD的发生,尤其是对于IBD遗传风险高的人群和SOD2基因rs4880突变携带者。
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引用次数: 0
Pancreatic panniculitis. 胰腺炎
IF 11.6 1区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2024-11-05 DOI: 10.1016/j.cgh.2024.08.052
M Aourag, E T T L Tjwa, M Te Groen
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引用次数: 0
Risk of incident cancer in patients with Inflammatory Bowel Disease with prior breast cancer: a multicenter cohort study. 曾患乳腺癌的炎症性肠病患者罹患癌症的风险:一项多中心队列研究。
IF 11.6 1区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2024-11-04 DOI: 10.1016/j.cgh.2024.09.034
Guillaume Le Cosquer, Julien Kirchgesner, Cyrielle Gilletta De Saint Joseph, Philippe Seksik, Aurélien Amiot, David Laharie, Maria Nachury, Cléa Rouillon, Vered Abitbol, Alexandre Nuzzo, Stéphane Nancey, Mathurin Fumery, Amélie Biron, Nicolas Richard, Romain Altwegg, Driffa Moussata, Benedicte Caron, Mathias Vidon, Catherine Reenaers, Mathieu Uzzan, Jean-Marie Reimund, Mélanie Serrero, Marion Simon, Alban Benezech, Félix Goutorbe, Anne-Laure Pelletier, Ludovic Caillo, Charlotte Vaysse, Florian Poullenot

Background and aims: Breast cancer is the most common malignancy observed in patients with inflammatory bowel diseases (IBD). The aim of our study was to evaluate incident cancer rate (recurrence or new-onset cancer) in a cohort of IBD patients with a history of breast cancer according to the subsequent IBD treatment provided.

Methods: A multicenter retrospective study included consecutive IBD patients with prior breast cancer. The inclusion date corresponded to the diagnosis of index malignancy. Follow-up lasted from cancer diagnosis until the occurrence of incident cancer.

Results: Among 207 patients included (median disease duration: 13 years [IQR 6 - 21]), first line treatment (median interval of 28 months [IQR 7 - 64]) was a conventional immunosuppressant in 19.3 % of patients, anti-TNF in 19.8 %, vedolizumab in 7.2 % and ustekinumab in 1.9 %. After a median follow-up of 71 months [IQR, 34 - 148], 42 (20%) incident cancers were observed (34 breast cancer recurrences). Adjusted incidence rates per 1000 person-years were 10.2 (95%CI 6.0- 16.4) for the untreated arm and 28.9 (95%CI 11.6-59.6) for exposed patients (p= 0.0519). There was no significant difference between treated patients and controls regarding incident-cancer free survival rates (p=0.4796). In multivariable analysis, factors associated with incident cancer were stage T4d (p=0.036), triple negative tumor (p=0.016) and follow-up of less than 71 months (p=0.005).

Conclusion: We did not find a statistically significant increase in incident breast cancer related to IBD treatment beyond the already known poor prognostic factors of breast cancer.

背景和目的:乳腺癌是炎症性肠病(IBD)患者最常见的恶性肿瘤。我们的研究旨在根据随后提供的 IBD 治疗,评估一组有乳腺癌病史的 IBD 患者的癌症发生率(复发或新发癌症):一项多中心回顾性研究纳入了曾患乳腺癌的连续 IBD 患者。纳入日期与恶性肿瘤的诊断日期一致。随访时间从癌症诊断开始,直至发生癌症:在纳入的207名患者中(中位病程:13年 [IQR 6 - 21]),19.3%的患者接受了常规免疫抑制剂一线治疗(中位间隔为28个月 [IQR 7 - 64]),19.8%接受了抗肿瘤坏死因子治疗,7.2%接受了维多珠单抗治疗,1.9%接受了乌司替尼治疗。在中位随访 71 个月[IQR,34 - 148]后,观察到 42 例(20%)癌症患者(34 例乳腺癌复发)。未经治疗组的调整后每千人年发病率为 10.2(95%CI 6.0-16.4),暴露患者的调整后每千人年发病率为 28.9(95%CI 11.6-59.6)(P= 0.0519)。在无偶发癌症生存率方面,接受治疗的患者与对照组之间没有明显差异(p=0.4796)。在多变量分析中,与癌症发生相关的因素有T4d期(p=0.036)、三阴性肿瘤(p=0.016)和随访时间少于71个月(p=0.005):结论:除了已知的乳腺癌预后不良因素外,我们并未发现与肠道疾病治疗相关的乳腺癌发病率有统计学意义的显著增加。
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引用次数: 0
Peripheral tumor necrosis factor production is a predictor for remission under adalimumab in Crohn's disease. 外周肿瘤坏死因子的产生可预测阿达木单抗对克罗恩病的缓解作用。
IF 11.6 1区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2024-11-02 DOI: 10.1016/j.cgh.2024.10.008
B Jessen, M T Tordai, B Siegmund
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引用次数: 0
The role of piecemeal endoscopic mucosal resection for low risk larget than 20 mm nonpedunculated polyps in the right colon. 片状内窥镜粘膜切除术在治疗右侧结肠中大于 20 毫米的低风险非截茎息肉中的作用。
IF 11.6 1区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2024-11-01 DOI: 10.1016/j.cgh.2024.10.009
Alberto Murino, Alessandro Rimondi, Edward John Despott
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引用次数: 0
Artificial Intelligence Chatbots Not Yet Ready for Celiac Disease Patient Care. 人工智能聊天机器人尚未准备好用于乳糜泻患者护理。
IF 11.6 1区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2024-11-01 DOI: 10.1016/j.cgh.2024.10.012
Claire L Jansson-Knodell, David Gardinier, Kendra Weekley, Qijun Yang, Alberto Rubio-Tapia
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引用次数: 0
Evaluating FIB-4 Risk Stratification In the AGA/AASLD Clinical Care Pathway. 评估 AGA/AASLD 临床护理路径中的 FIB-4 风险分层。
IF 11.6 1区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2024-10-30 DOI: 10.1016/j.cgh.2024.10.011
Madeleine Chang, Mazen Noureddin
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引用次数: 0
Prevalence and costs of eosinophilic esophagitis in the United States. 美国嗜酸性粒细胞食管炎的发病率和费用。
IF 11.6 1区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2024-10-30 DOI: 10.1016/j.cgh.2024.09.031
Hannah L Thel, Chelsea Anderson, Angela Z Xue, Elisabeth T Jensen, Evan S Dellon

Background and aims: Eosinophilic esophagitis (EoE) has been continually increasing in prevalence but current estimates are lacking. We aimed to determine updated estimates of the prevalence and medical costs associated with EoE in the United States.

Methods: We used two large administrative databases, MarketScan and Medicare, and International Classification of Disease codes to calculate annual prevalence of EoE, as well as age- and sex- stratified estimates, standardized to the U.S.

Population: Health care utilization, including medications and endoscopic procedures was quantified, and annual EoE-associated costs were estimated.

Results: We identified 20,435 EoE cases in MarketScan in 2022 and 1,913 EoE cases in Medicare in 2017. This translated to prevalences of 163.08 cases/100,000 and 64.83 cases/ 100,000 in MarketScan and Medicare, respectively. There was a 5-fold increase in prevalence in both databases since 2009. In MarketScan, prevalence was higher among males (204.45/100,000 vs 122.06/100,000 among females); for both sexes, peak prevalence was from 40-44years. Standardized to the U.S. population, the prevalence of EoE was 142.5/100,000, extrapolating to 472,380 cases. Total EoE-associated healthcare costs were estimated to be $1.32 billion in 2024 dollars after accounting for inflation.

Conclusions: The prevalence of EoE continues to increase, with a rate of 1 in 617 in 2022 in those <65 years of age, and 1 in 1562 in 2017 those ≥65 years. Standardized to the U.S. population, the overall prevalence was approximately 1 in 700. EoE-associated annual costs were estimated to be $1.3 billion in 2024 dollars, representing a substantial financial burden.

背景和目的:嗜酸性粒细胞食管炎(EoE)的发病率一直在持续上升,但目前缺乏相关的估计数据。我们旨在确定美国嗜酸性粒细胞食管炎患病率和相关医疗费用的最新估计值:我们使用了两个大型行政数据库(MarketScan 和医疗保险)以及国际疾病分类代码,以美国人口为标准,计算出每年的肠易激综合征患病率以及按年龄和性别分层的估计值:对包括药物和内窥镜手术在内的医疗保健使用情况进行了量化,并估算了每年与肠易激综合征相关的费用:2022年,我们在MarketScan中发现了20,435例EoE病例,2017年在Medicare中发现了1,913例EoE病例。这意味着 MarketScan 和 Medicare 的患病率分别为 163.08 例/100,000 人和 64.83 例/100,000 人。自 2009 年以来,这两个数据库中的患病率均增长了 5 倍。在MarketScan中,男性发病率较高(204.45例/100,000人,女性为122.06例/100,000人);男女发病高峰期均为40-44岁。按照美国人口的标准,肠易激综合征的发病率为 142.5/100,000,推断出 472,380 个病例。在考虑通货膨胀因素后,以 2024 年美元计算,与肠易激综合征相关的医疗总成本估计为 13.2 亿美元:肠易激综合征的发病率持续上升,在 2022 年,每 617 人中就有 1 人患有肠易激综合征。
{"title":"Prevalence and costs of eosinophilic esophagitis in the United States.","authors":"Hannah L Thel, Chelsea Anderson, Angela Z Xue, Elisabeth T Jensen, Evan S Dellon","doi":"10.1016/j.cgh.2024.09.031","DOIUrl":"https://doi.org/10.1016/j.cgh.2024.09.031","url":null,"abstract":"<p><strong>Background and aims: </strong>Eosinophilic esophagitis (EoE) has been continually increasing in prevalence but current estimates are lacking. We aimed to determine updated estimates of the prevalence and medical costs associated with EoE in the United States.</p><p><strong>Methods: </strong>We used two large administrative databases, MarketScan and Medicare, and International Classification of Disease codes to calculate annual prevalence of EoE, as well as age- and sex- stratified estimates, standardized to the U.S.</p><p><strong>Population: </strong>Health care utilization, including medications and endoscopic procedures was quantified, and annual EoE-associated costs were estimated.</p><p><strong>Results: </strong>We identified 20,435 EoE cases in MarketScan in 2022 and 1,913 EoE cases in Medicare in 2017. This translated to prevalences of 163.08 cases/100,000 and 64.83 cases/ 100,000 in MarketScan and Medicare, respectively. There was a 5-fold increase in prevalence in both databases since 2009. In MarketScan, prevalence was higher among males (204.45/100,000 vs 122.06/100,000 among females); for both sexes, peak prevalence was from 40-44years. Standardized to the U.S. population, the prevalence of EoE was 142.5/100,000, extrapolating to 472,380 cases. Total EoE-associated healthcare costs were estimated to be $1.32 billion in 2024 dollars after accounting for inflation.</p><p><strong>Conclusions: </strong>The prevalence of EoE continues to increase, with a rate of 1 in 617 in 2022 in those <65 years of age, and 1 in 1562 in 2017 those ≥65 years. Standardized to the U.S. population, the overall prevalence was approximately 1 in 700. EoE-associated annual costs were estimated to be $1.3 billion in 2024 dollars, representing a substantial financial burden.</p>","PeriodicalId":10347,"journal":{"name":"Clinical Gastroenterology and Hepatology","volume":" ","pages":""},"PeriodicalIF":11.6,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142564004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Risk of Hepatocellular Carcinoma in Subcentimeter Liver Nodules Identified on Surveillance Ultrasound: A Systematic Review. 监测超声发现的亚厘米肝结节发生肝细胞癌的风险:系统回顾。
IF 11.6 1区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2024-10-29 DOI: 10.1016/j.cgh.2024.08.051
Eden Koo, Karim Seif El Dahan, Darine Daher, Nicole E Rich, Sukul Mittal, Ju Dong Yang, Neehar D Parikh, Amit G Singal

Introduction: Guidelines recommend that subcentimeter nodules on ultrasound be followed with short-interval surveillance ultrasound given assumed low risk of hepatocellular carcinoma (HCC) and suboptimal diagnostic imaging performance in lesions < 1cm. We performed a systematic review to estimate HCC risk among patients with cirrhosis and subcentimeter nodules detected on ultrasound.

Methods: We systematically searched Ovid MEDLINE and EMBASE databases for relevant articles published between January 2005 and July 2024. A random-effects model was used to calculate the pooled proportion of incident HCC.

Results: We identified 9 eligible studies, of which 5 provided both lesion- and patient-level data (n=354 patients), 2 patient-level alone (n=888 patients), and 2 lesion-level alone (n=69 lesions). The pooled proportion of incident HCC was 31.9% (95%CI: 8.7-69.7%) on a lesion-level and 21.3% (95%CI: 6.0-53.6%) on a patient-level; however, pooled estimates were limited by high heterogeneity (I2 >90%). Among two studies with study periods post-dating 2015, HCC developed in only ∼5% of patients during a median follow-up of 2 years. Risk factors associated with incident HCC were older age, male sex, elevated AFP levels, thrombocytopenia, and Child Pugh B cirrhosis. Limitations of studies included small sample sizes, selection bias, ascertainment bias for HCC, and failure to report factors associated with HCC.

Conclusion: Up to one-fifth of patients with subcentimeter nodules may develop HCC, although contemporary cohorts report a substantially lower risk. Older patients and those with elevated AFP levels or poorer liver function are at greatest risk of HCC, highlighting an unmet need for better risk stratification models.

导言:鉴于假定肝细胞癌(HCC)的风险较低,且小于 1 厘米的病变的成像诊断效果不佳,指南建议对超声检查发现的亚厘米结节进行短间隔监测超声检查。我们进行了一项系统性回顾,以估计肝硬化患者和超声检查发现的亚厘米结节的 HCC 风险:我们系统检索了 Ovid MEDLINE 和 EMBASE 数据库中 2005 年 1 月至 2024 年 7 月间发表的相关文章。结果:我们发现了9项符合条件的研究,其中1项研究发现了HCC:我们确定了9项符合条件的研究,其中5项同时提供了病灶和患者层面的数据(n=354例患者),2项仅提供了患者层面的数据(n=888例患者),2项仅提供了病灶层面的数据(n=69例病灶)。病变层面的HCC事件汇总比例为31.9%(95%CI:8.7-69.7%),患者层面的汇总比例为21.3%(95%CI:6.0-53.6%);但是,汇总估计值受到高度异质性(I2>90%)的限制。两项研究的研究时间均在2015年之后,在中位随访2年期间,仅有5%的患者发生了HCC。与发生HCC相关的风险因素包括年龄较大、男性、甲胎蛋白水平升高、血小板减少和Child Pugh B肝硬化。研究的局限性包括样本量小、选择偏倚、HCC的确定偏倚以及未报告与HCC相关的因素:结论:多达五分之一的亚厘米结节患者可能会发展为 HCC,尽管现代队列报告的风险要低得多。年龄较大、甲胎蛋白水平升高或肝功能较差的患者罹患 HCC 的风险最大,这说明对更好的风险分层模型的需求尚未得到满足。
{"title":"Risk of Hepatocellular Carcinoma in Subcentimeter Liver Nodules Identified on Surveillance Ultrasound: A Systematic Review.","authors":"Eden Koo, Karim Seif El Dahan, Darine Daher, Nicole E Rich, Sukul Mittal, Ju Dong Yang, Neehar D Parikh, Amit G Singal","doi":"10.1016/j.cgh.2024.08.051","DOIUrl":"https://doi.org/10.1016/j.cgh.2024.08.051","url":null,"abstract":"<p><strong>Introduction: </strong>Guidelines recommend that subcentimeter nodules on ultrasound be followed with short-interval surveillance ultrasound given assumed low risk of hepatocellular carcinoma (HCC) and suboptimal diagnostic imaging performance in lesions < 1cm. We performed a systematic review to estimate HCC risk among patients with cirrhosis and subcentimeter nodules detected on ultrasound.</p><p><strong>Methods: </strong>We systematically searched Ovid MEDLINE and EMBASE databases for relevant articles published between January 2005 and July 2024. A random-effects model was used to calculate the pooled proportion of incident HCC.</p><p><strong>Results: </strong>We identified 9 eligible studies, of which 5 provided both lesion- and patient-level data (n=354 patients), 2 patient-level alone (n=888 patients), and 2 lesion-level alone (n=69 lesions). The pooled proportion of incident HCC was 31.9% (95%CI: 8.7-69.7%) on a lesion-level and 21.3% (95%CI: 6.0-53.6%) on a patient-level; however, pooled estimates were limited by high heterogeneity (I<sup>2</sup> >90%). Among two studies with study periods post-dating 2015, HCC developed in only ∼5% of patients during a median follow-up of 2 years. Risk factors associated with incident HCC were older age, male sex, elevated AFP levels, thrombocytopenia, and Child Pugh B cirrhosis. Limitations of studies included small sample sizes, selection bias, ascertainment bias for HCC, and failure to report factors associated with HCC.</p><p><strong>Conclusion: </strong>Up to one-fifth of patients with subcentimeter nodules may develop HCC, although contemporary cohorts report a substantially lower risk. Older patients and those with elevated AFP levels or poorer liver function are at greatest risk of HCC, highlighting an unmet need for better risk stratification models.</p>","PeriodicalId":10347,"journal":{"name":"Clinical Gastroenterology and Hepatology","volume":" ","pages":""},"PeriodicalIF":11.6,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142557309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Multisociety Clinical Practice Guidance for the Safe Use of Glucagon-like Peptide-1 Receptor Agonists in the Perioperative Period. 在围手术期安全使用胰高血糖素样肽-1 受体激动剂的多协会临床实践指南》。
IF 11.6 1区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2024-10-29 DOI: 10.1016/j.cgh.2024.10.003
Tammy L Kindel, Andrew Y Wang, Anupama Wadhwa, Allison R Schulman, Reem Z Sharaiha, Matthew Kroh, Omar M Ghanem, Shauna Levy, Girish P Joshi, Teresa L LaMasters
{"title":"Multisociety Clinical Practice Guidance for the Safe Use of Glucagon-like Peptide-1 Receptor Agonists in the Perioperative Period.","authors":"Tammy L Kindel, Andrew Y Wang, Anupama Wadhwa, Allison R Schulman, Reem Z Sharaiha, Matthew Kroh, Omar M Ghanem, Shauna Levy, Girish P Joshi, Teresa L LaMasters","doi":"10.1016/j.cgh.2024.10.003","DOIUrl":"https://doi.org/10.1016/j.cgh.2024.10.003","url":null,"abstract":"","PeriodicalId":10347,"journal":{"name":"Clinical Gastroenterology and Hepatology","volume":" ","pages":""},"PeriodicalIF":11.6,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142544100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Clinical Gastroenterology and Hepatology
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