Pub Date : 2026-01-14DOI: 10.1016/j.cgh.2025.12.025
Philippe Willems, Pierre-Emmanuel Rautou, Julien Bissonnette
{"title":"Portal Pressure Measurement: A Question of How or by Whom?","authors":"Philippe Willems, Pierre-Emmanuel Rautou, Julien Bissonnette","doi":"10.1016/j.cgh.2025.12.025","DOIUrl":"https://doi.org/10.1016/j.cgh.2025.12.025","url":null,"abstract":"","PeriodicalId":10347,"journal":{"name":"Clinical Gastroenterology and Hepatology","volume":"53 1","pages":""},"PeriodicalIF":12.6,"publicationDate":"2026-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145962455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-14DOI: 10.1016/j.cgh.2026.01.004
Amine Benmassaoud, Yen-I Chen
{"title":"REPLY TO WILLEMS ET AL.","authors":"Amine Benmassaoud, Yen-I Chen","doi":"10.1016/j.cgh.2026.01.004","DOIUrl":"https://doi.org/10.1016/j.cgh.2026.01.004","url":null,"abstract":"","PeriodicalId":10347,"journal":{"name":"Clinical Gastroenterology and Hepatology","volume":"12 1","pages":""},"PeriodicalIF":12.6,"publicationDate":"2026-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145962504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-14DOI: 10.1016/j.cgh.2025.12.024
Cyriac Abby Philips, Arif Hussain Theruvath, Tharun Tom Oommen
{"title":"Addressing the elephant in the room: Herbal liver injury is more severe and catastrophic than liver injury from conventional drugs","authors":"Cyriac Abby Philips, Arif Hussain Theruvath, Tharun Tom Oommen","doi":"10.1016/j.cgh.2025.12.024","DOIUrl":"https://doi.org/10.1016/j.cgh.2025.12.024","url":null,"abstract":"","PeriodicalId":10347,"journal":{"name":"Clinical Gastroenterology and Hepatology","volume":"63 1","pages":""},"PeriodicalIF":12.6,"publicationDate":"2026-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145962474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-13DOI: 10.1016/j.cgh.2025.12.021
Konstantinos Ouranos, Mark Michael, Evangelia K. Mylona, Fadi Shehadeh, Markos Kalligeros, Margaret L.P. Teng, Mark D. Muthiah, Mohammad S. Siddiqui, Sudha Kodali, Tamneet Basra, Michelle Jones-Pauley, David W. Victor, Eleftherios Mylonakis, Mazen Noureddin, Kavish R. Patidar
{"title":"Impact of 20% Change in VCTE-measured Liver Stiffness on Liver-related Outcomes: A systematic Review and Meta-Analysis","authors":"Konstantinos Ouranos, Mark Michael, Evangelia K. Mylona, Fadi Shehadeh, Markos Kalligeros, Margaret L.P. Teng, Mark D. Muthiah, Mohammad S. Siddiqui, Sudha Kodali, Tamneet Basra, Michelle Jones-Pauley, David W. Victor, Eleftherios Mylonakis, Mazen Noureddin, Kavish R. Patidar","doi":"10.1016/j.cgh.2025.12.021","DOIUrl":"https://doi.org/10.1016/j.cgh.2025.12.021","url":null,"abstract":"","PeriodicalId":10347,"journal":{"name":"Clinical Gastroenterology and Hepatology","volume":"32 1","pages":""},"PeriodicalIF":12.6,"publicationDate":"2026-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145961712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-12DOI: 10.1016/j.cgh.2025.12.006
Richard Y. Wu, Mingyue Xue, Qing Zhao, Sean Jeong, Anne M. Griffiths, Levinus A. Dieleman, A. Hillary Steinhart, Guy Aumais, Brian Bressler, Remo Panacionne, Colette Deslandres, David R. Mack, Charles N. Bernstein, John K. Marshall, Dan Turner, Wei Xu, Lennard W. Duck, Charles O. Elson, Williams Turpin, Sun-Ho Lee, Kenneth Croitoru
{"title":"Serum IgG Response to a Conserved Domain of Commensal Flagellins Predicts Future Risk of Crohn’s Disease in First-degree Relatives","authors":"Richard Y. Wu, Mingyue Xue, Qing Zhao, Sean Jeong, Anne M. Griffiths, Levinus A. Dieleman, A. Hillary Steinhart, Guy Aumais, Brian Bressler, Remo Panacionne, Colette Deslandres, David R. Mack, Charles N. Bernstein, John K. Marshall, Dan Turner, Wei Xu, Lennard W. Duck, Charles O. Elson, Williams Turpin, Sun-Ho Lee, Kenneth Croitoru","doi":"10.1016/j.cgh.2025.12.006","DOIUrl":"https://doi.org/10.1016/j.cgh.2025.12.006","url":null,"abstract":"","PeriodicalId":10347,"journal":{"name":"Clinical Gastroenterology and Hepatology","volume":"32 1","pages":""},"PeriodicalIF":12.6,"publicationDate":"2026-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145962473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-10DOI: 10.1016/j.cgh.2025.11.031
Patricia P. Bloom, Elliot B. Tapper, Sumeet K. Asrani, Anna S. Lok
{"title":"Animal Naming Test Predicts Future Overt Hepatic Encephalopathy","authors":"Patricia P. Bloom, Elliot B. Tapper, Sumeet K. Asrani, Anna S. Lok","doi":"10.1016/j.cgh.2025.11.031","DOIUrl":"https://doi.org/10.1016/j.cgh.2025.11.031","url":null,"abstract":"","PeriodicalId":10347,"journal":{"name":"Clinical Gastroenterology and Hepatology","volume":"3 1","pages":""},"PeriodicalIF":12.6,"publicationDate":"2026-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145947398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-10DOI: 10.1016/j.cgh.2025.11.007
Gursimran S. Kochhar, Nayantara Coelho-Prabhu, Jana G. Hashash, Bo Shen
The purpose of this American Gastroenterological Association (AGA) Institute Clinical Practice Update (CPU) Commentary is to discuss the different scenarios in which advanced therapeutic endoscopic procedures can be used for patients with inflammatory bowel diseases. The CPU will also inform clinical practice on when such procedures should and should not be considered.
{"title":"AGA Clinical Practice Update on the Role of Therapeutic Endoscopy in Inflammatory Bowel Disease: Commentary","authors":"Gursimran S. Kochhar, Nayantara Coelho-Prabhu, Jana G. Hashash, Bo Shen","doi":"10.1016/j.cgh.2025.11.007","DOIUrl":"https://doi.org/10.1016/j.cgh.2025.11.007","url":null,"abstract":"The purpose of this American Gastroenterological Association (AGA) Institute Clinical Practice Update (CPU) Commentary is to discuss the different scenarios in which advanced therapeutic endoscopic procedures can be used for patients with inflammatory bowel diseases. The CPU will also inform clinical practice on when such procedures should and should not be considered.","PeriodicalId":10347,"journal":{"name":"Clinical Gastroenterology and Hepatology","volume":"43 1","pages":""},"PeriodicalIF":12.6,"publicationDate":"2026-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145947400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-07DOI: 10.1016/j.cgh.2025.09.031
Kyle Staller, Leila Neshatian, Anthony Lembo, Adil E Bharucha
Description: Although most patients with chronic constipation respond to medical therapy, a subset experiences refractory constipation (RC), which poses unique diagnostic and therapeutic challenges. Because RC is relatively rare, clinicians should systematically (1) exclude correctable secondary causes such as medications, neurologic disorders, and defecatory disorders (DDs); (2) confirm the presence of slow colonic transit; and (3) ensure that patients have undergone adequate trials of over-the-counter and Food and Drug Administration-approved medications and nonpharmacologic therapies, including combinations thereof. Surgical treatments, such as colectomy, may be considered in patients who fail available treatments. However, surgical treatment of chronic constipation is associated with increased risk of complications and a not insignificant number of unsatisfactory outcomes. Prior to advising surgery, it is essential to confirm slow colonic transit, exclude concurrent DDs, and evaluate for severe, symptomatic delays in gastric emptying or small bowel dysmotility. Psychological comorbidities may exacerbate symptoms and adversely affect surgical outcomes. Hence, preoperative psychological evaluation is also advisable to assess suitability for surgery. Relative contraindications to surgical treatment of RC include clinically significant upper-gut dysmotility, severe, untreated psychiatric disease, and predominant complaints of bloating and/or abdominal pain. In uncertain cases, a temporary diverting loop ileostomy may help predict the potential response to colectomy. A colectomy with ileorectal anastomosis should only be offered to patients without ongoing DDs.
Methods: This expert review was commissioned and approved by the American Gastroenterological Association (AGA) Institute Clinical Practice Updates Committee and the AGA Governing Board to provide timely guidance on a topic of high clinical importance to the AGA membership, and underwent internal peer review by the Clinical Practice Updates Committee and external peer review through standard procedures of Clinical Gastroenterology and Hepatology. These Best Practice Advice statements were drawn from a review of the published literature and from expert opinion. Because systematic reviews were not performed, these Best Practice Advice statements do not carry formal ratings of the quality of evidence or strength of the presented considerations.
{"title":"AGA Clinical Practice Update on Evaluation and Management of Refractory Constipation: Expert Review.","authors":"Kyle Staller, Leila Neshatian, Anthony Lembo, Adil E Bharucha","doi":"10.1016/j.cgh.2025.09.031","DOIUrl":"10.1016/j.cgh.2025.09.031","url":null,"abstract":"<p><strong>Description: </strong>Although most patients with chronic constipation respond to medical therapy, a subset experiences refractory constipation (RC), which poses unique diagnostic and therapeutic challenges. Because RC is relatively rare, clinicians should systematically (1) exclude correctable secondary causes such as medications, neurologic disorders, and defecatory disorders (DDs); (2) confirm the presence of slow colonic transit; and (3) ensure that patients have undergone adequate trials of over-the-counter and Food and Drug Administration-approved medications and nonpharmacologic therapies, including combinations thereof. Surgical treatments, such as colectomy, may be considered in patients who fail available treatments. However, surgical treatment of chronic constipation is associated with increased risk of complications and a not insignificant number of unsatisfactory outcomes. Prior to advising surgery, it is essential to confirm slow colonic transit, exclude concurrent DDs, and evaluate for severe, symptomatic delays in gastric emptying or small bowel dysmotility. Psychological comorbidities may exacerbate symptoms and adversely affect surgical outcomes. Hence, preoperative psychological evaluation is also advisable to assess suitability for surgery. Relative contraindications to surgical treatment of RC include clinically significant upper-gut dysmotility, severe, untreated psychiatric disease, and predominant complaints of bloating and/or abdominal pain. In uncertain cases, a temporary diverting loop ileostomy may help predict the potential response to colectomy. A colectomy with ileorectal anastomosis should only be offered to patients without ongoing DDs.</p><p><strong>Methods: </strong>This expert review was commissioned and approved by the American Gastroenterological Association (AGA) Institute Clinical Practice Updates Committee and the AGA Governing Board to provide timely guidance on a topic of high clinical importance to the AGA membership, and underwent internal peer review by the Clinical Practice Updates Committee and external peer review through standard procedures of Clinical Gastroenterology and Hepatology. These Best Practice Advice statements were drawn from a review of the published literature and from expert opinion. Because systematic reviews were not performed, these Best Practice Advice statements do not carry formal ratings of the quality of evidence or strength of the presented considerations.</p>","PeriodicalId":10347,"journal":{"name":"Clinical Gastroenterology and Hepatology","volume":" ","pages":""},"PeriodicalIF":12.0,"publicationDate":"2026-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12788801/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145932443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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