{"title":"Treatment of Cancers with a Novel Combination of Re-PurposedPharmaceuticals and Some Nutriceuticals","authors":"R. Marsh, T. Itinteang","doi":"10.52845/cmi/2022-3-3-1","DOIUrl":"https://doi.org/10.52845/cmi/2022-3-3-1","url":null,"abstract":"","PeriodicalId":10419,"journal":{"name":"Clinical Medicine Insights. Cardiology","volume":"56 1","pages":""},"PeriodicalIF":3.0,"publicationDate":"2022-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77862301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Sacroiliitis in patients with low backache with Normal Lumbosacral spine MRI","authors":"Dr. Bushra Mohsen Abdulla","doi":"10.52845/cmi/2022-3-2-1","DOIUrl":"https://doi.org/10.52845/cmi/2022-3-2-1","url":null,"abstract":"","PeriodicalId":10419,"journal":{"name":"Clinical Medicine Insights. Cardiology","volume":"86 1","pages":""},"PeriodicalIF":3.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73041324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Charecteristics of Pressure Sore of Spinal Cord Injury Patients Attentded at Crp","authors":"Mahbub Hossain","doi":"10.52845/cmi/2022-3-2-5","DOIUrl":"https://doi.org/10.52845/cmi/2022-3-2-5","url":null,"abstract":"","PeriodicalId":10419,"journal":{"name":"Clinical Medicine Insights. Cardiology","volume":"35 1","pages":""},"PeriodicalIF":3.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78528454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Prevalence and Determinants of Retinopathy among Patients with Diabetes Mellitus: Thiqar 2022","authors":"Wajida Saa'd Bunyan","doi":"10.52845/cmi/2022-3-2-4","DOIUrl":"https://doi.org/10.52845/cmi/2022-3-2-4","url":null,"abstract":"","PeriodicalId":10419,"journal":{"name":"Clinical Medicine Insights. Cardiology","volume":"5 1","pages":""},"PeriodicalIF":3.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72759157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Clinical Outcome Of Corona Virus Disease-19 Patients In An Infectious Disease Center, Olodo, Ibadan, Oyo State, Nigeria","authors":"O. Alonge","doi":"10.52845/cmi/2022-3-2-2","DOIUrl":"https://doi.org/10.52845/cmi/2022-3-2-2","url":null,"abstract":"","PeriodicalId":10419,"journal":{"name":"Clinical Medicine Insights. Cardiology","volume":"71 1","pages":""},"PeriodicalIF":3.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74474142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
J. Lakey, Adam P Good, A. Wells, Ben Katz, Michael Alexander, D. Klokol, Mike K. S. Chan, M. Wong, D. Cox
{"title":"Maldi-Tof Analysis of Mitochondrial Peptides","authors":"J. Lakey, Adam P Good, A. Wells, Ben Katz, Michael Alexander, D. Klokol, Mike K. S. Chan, M. Wong, D. Cox","doi":"10.52845/cmi/2022-3-2-3","DOIUrl":"https://doi.org/10.52845/cmi/2022-3-2-3","url":null,"abstract":"","PeriodicalId":10419,"journal":{"name":"Clinical Medicine Insights. Cardiology","volume":"43 1","pages":""},"PeriodicalIF":3.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85590684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: There is limited data on the impact of comorbidity burden on clinical outcomes of patients undergoing cardiac implantable electronic devices (CIED) implantation. Objectives: Our aim was to assess trends in CIED implantations and explore the relationship between comorbidity burden and outcomes in patients undergoing de novo implantations. Methods: Using the National Inpatient Sample database from 2000 to 2014, we identified adults ⩾18 years undergoing de novo CIED procedures. Comorbidity burden was assessed by Charlson comorbidity Index (CCI), and patients were classified into 4 categories based on their CCI scores (CCI = 0, CCI = 1, CCI = 2, CCI ⩾3). Annual implantation trends were evaluated. Logistic regression was conducted to measure the association between categorized comorbidity burden and outcomes. Results: A total of 3 103 796 de-novo CIED discharge records were identified from the NIS database. About 22.4% had a CCI score of 0, 28.2% had a CCI score of 1, 22% had a CCI score of 2, and 27.4 % had a CCI score ⩾3. Annual de-novo CIED implantations peaked in 2006 and declined steadily from 2010 to 2014. Compared to CCI 0, CCI ⩾3 was independently associated with increased odds of in-hospital mortality, bleeding, pericardial, and cardiac complications (all P < .05). Length of stay and hospital charges increased with increasing comorbidity burden. Conclusions: CCI is a significant predictor of adverse outcomes after CIED implantation. Therefore, comorbidity burden needs to be considered in the decision-making process for CIED implant candidates.
背景:关于合并症负担对心脏植入式电子装置(CIED)植入术患者临床结果影响的数据有限。目的:我们的目的是评估CIED植入的趋势，并探讨接受重新植入的患者的合并症负担和结果之间的关系。方法:使用2000年至2014年的国家住院患者样本数据库，我们确定了接受新生CIED手术的未满18岁的成年人。通过Charlson合并症指数(CCI)评估合并症负担，并根据其CCI评分将患者分为4类(CCI = 0, CCI = 1, CCI = 2, CCI大于或等于3)。评估年度种植趋势。采用逻辑回归来衡量分类共病负担与结局之间的关系。结果:在NIS数据库中共检索到3 103 796例重新诊断的CIED出院记录。约22.4%的CCI得分为0,28.2%的CCI得分为1,22%的CCI得分为2,27.4%的CCI得分大于或等于3。每年重新植入的CIED在2006年达到顶峰，从2010年到2014年稳步下降。与CCI 0相比，CCI小于3与院内死亡率、出血、心包和心脏并发症的几率增加独立相关(所有P结论:CCI是CIED植入后不良结果的重要预测因子。因此，在选择CIED种植体候选人时，需要考虑合并症负担。
{"title":"Impact of Comorbidity Burden on Cardiac Implantable Electronic Devices Outcomes.","authors":"Temitope Ajibawo, Oluwatimilehin Okunowo, Adeniyi Okunade","doi":"10.1177/11795468221108212","DOIUrl":"https://doi.org/10.1177/11795468221108212","url":null,"abstract":"Background: There is limited data on the impact of comorbidity burden on clinical outcomes of patients undergoing cardiac implantable electronic devices (CIED) implantation. Objectives: Our aim was to assess trends in CIED implantations and explore the relationship between comorbidity burden and outcomes in patients undergoing de novo implantations. Methods: Using the National Inpatient Sample database from 2000 to 2014, we identified adults ⩾18 years undergoing de novo CIED procedures. Comorbidity burden was assessed by Charlson comorbidity Index (CCI), and patients were classified into 4 categories based on their CCI scores (CCI = 0, CCI = 1, CCI = 2, CCI ⩾3). Annual implantation trends were evaluated. Logistic regression was conducted to measure the association between categorized comorbidity burden and outcomes. Results: A total of 3 103 796 de-novo CIED discharge records were identified from the NIS database. About 22.4% had a CCI score of 0, 28.2% had a CCI score of 1, 22% had a CCI score of 2, and 27.4 % had a CCI score ⩾3. Annual de-novo CIED implantations peaked in 2006 and declined steadily from 2010 to 2014. Compared to CCI 0, CCI ⩾3 was independently associated with increased odds of in-hospital mortality, bleeding, pericardial, and cardiac complications (all P < .05). Length of stay and hospital charges increased with increasing comorbidity burden. Conclusions: CCI is a significant predictor of adverse outcomes after CIED implantation. Therefore, comorbidity burden needs to be considered in the decision-making process for CIED implant candidates.","PeriodicalId":10419,"journal":{"name":"Clinical Medicine Insights. Cardiology","volume":" ","pages":"11795468221108212"},"PeriodicalIF":3.0,"publicationDate":"2022-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/bf/f6/10.1177_11795468221108212.PMC9247999.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40467815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Is Spike Protein-Related Myocarditis Becoming a Common Disease?","authors":"Doepp, Manfred Md","doi":"10.52845/cmi/2022-3-1-5","DOIUrl":"https://doi.org/10.52845/cmi/2022-3-1-5","url":null,"abstract":"","PeriodicalId":10419,"journal":{"name":"Clinical Medicine Insights. Cardiology","volume":"33 1","pages":""},"PeriodicalIF":3.0,"publicationDate":"2022-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74494332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Primary malignant largeB-cell non-Hodgkin’s lymphoma of the scalpand cranial vault: a case report and an overview","authors":"Mehdi Borni","doi":"10.52845/cmi/2022-3-1-1","DOIUrl":"https://doi.org/10.52845/cmi/2022-3-1-1","url":null,"abstract":"","PeriodicalId":10419,"journal":{"name":"Clinical Medicine Insights. Cardiology","volume":"14 1","pages":""},"PeriodicalIF":3.0,"publicationDate":"2022-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78687028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Malnutrition, which is a powerful predictor of morbidity and mortality, is common in patients undergoing hemodialysis. There-fore, adequate nutrition is very important for such patients. Nutritional management in hemodialysis patients is a very important factor for prognosis , a better overall outcome and quality of life. Objectives: The current study mainly aimed to determine the nutritional status and prevalence of malnutrition and to investigate the relationship between nutritional markers, anthropometric parameters such as body mass index (BMI), and routine laboratory parameters with SGA in patients undergoing hemodialysis. Patients and Methods: A cross-sectional study was carried out on HD patients in Hawari Nephro Center and Nephro Unit of Beng-hazi Medical Center from December 2019 to January 2020. A total of 155 HD patients were recruited for this study and assessed for nutritional status include both Male and females aged 18 years and over with regular hemodialysis. Outcome measures: Measurements included questionnaire that elicited information on social demographic characteristics, Patient’s medical history , and duration of hemodialysis. Anthropometry, biochemical parameters were measured. Seven-Point Subjective Global Assessment (7-point SGA) was used to assess the nutritional state of HD patients. Biochemical tests were obtained during the study period from medical files of the studied patients. Data were analyzed using descriptive statistics. The Chi-Square test was applied to examine the study data. Results: Data shows that 58% of HDP were well-nourished while the remaining 39%, 3%had mild-to-severe malnutrition. Regarding the prevalence of malnutrition in both gender, males group was mor preva-lent of malnourished than female group. SGA score results indicated some significant correlations with patient’s post dialysis BMI and albumin ,however, there was a negative correlation between demographic characteristics as gender, income, education level, comorbid disease , clinical variable such as duration and frequency of HD and some biochemical tests as electrolytes, phosphorous ,hemoglobin, cholesterol with SGA scores. In addition, results show that insignificant correlation between nutrients intake, meals pattern of HD patients with SGA. Conclusions: Observations of nutritional status are necessary to maintain the health status of dialysis patients. Every strategy should be used to avoid complications of hemodialysis manifested in uremic state including anorexia, nausea, vomiting leading to malnutrition, fluid and electrolyte imbalance leading to volume overload, hyperkalemia, metabolic acidosis, and hyperphosphatemia, as well as abnormalities related to hormonal or systemic dysfunction such as hypertension, anemia, hyperlipidemia, and bone disease, Timely diagnosis of protein-energy-wasting (PEW) is important for early initiation of nutritional intervention and treatment. In addition, education plans should be prepared t
{"title":"Study of the nutritionalstatus of end-stage renal disease patients onmaintenance hemodialysis in Hawary Kidney center and nephrology unit atBenghazi Medical Center","authors":"Safia S. Elramli","doi":"10.52845/cmi/2022-3-1-4","DOIUrl":"https://doi.org/10.52845/cmi/2022-3-1-4","url":null,"abstract":"Background: Malnutrition, which is a powerful predictor of morbidity and mortality, is common in patients undergoing hemodialysis. There-fore, adequate nutrition is very important for such patients. Nutritional management in hemodialysis patients is a very important factor for prognosis , a better overall outcome and quality of life. Objectives: The current study mainly aimed to determine the nutritional status and prevalence of malnutrition and to investigate the relationship between nutritional markers, anthropometric parameters such as body mass index (BMI), and routine laboratory parameters with SGA in patients undergoing hemodialysis. Patients and Methods: A cross-sectional study was carried out on HD patients in Hawari Nephro Center and Nephro Unit of Beng-hazi Medical Center from December 2019 to January 2020. A total of 155 HD patients were recruited for this study and assessed for nutritional status include both Male and females aged 18 years and over with regular hemodialysis. Outcome measures: Measurements included questionnaire that elicited information on social demographic characteristics, Patient’s medical history , and duration of hemodialysis. Anthropometry, biochemical parameters were measured. Seven-Point Subjective Global Assessment (7-point SGA) was used to assess the nutritional state of HD patients. Biochemical tests were obtained during the study period from medical files of the studied patients. Data were analyzed using descriptive statistics. The Chi-Square test was applied to examine the study data. Results: Data shows that 58% of HDP were well-nourished while the remaining 39%, 3%had mild-to-severe malnutrition. Regarding the prevalence of malnutrition in both gender, males group was mor preva-lent of malnourished than female group. SGA score results indicated some significant correlations with patient’s post dialysis BMI and albumin ,however, there was a negative correlation between demographic characteristics as gender, income, education level, comorbid disease , clinical variable such as duration and frequency of HD and some biochemical tests as electrolytes, phosphorous ,hemoglobin, cholesterol with SGA scores. In addition, results show that insignificant correlation between nutrients intake, meals pattern of HD patients with SGA. Conclusions: Observations of nutritional status are necessary to maintain the health status of dialysis patients. Every strategy should be used to avoid complications of hemodialysis manifested in uremic state including anorexia, nausea, vomiting leading to malnutrition, fluid and electrolyte imbalance leading to volume overload, hyperkalemia, metabolic acidosis, and hyperphosphatemia, as well as abnormalities related to hormonal or systemic dysfunction such as hypertension, anemia, hyperlipidemia, and bone disease, Timely diagnosis of protein-energy-wasting (PEW) is important for early initiation of nutritional intervention and treatment. In addition, education plans should be prepared t","PeriodicalId":10419,"journal":{"name":"Clinical Medicine Insights. Cardiology","volume":"94 1","pages":""},"PeriodicalIF":3.0,"publicationDate":"2022-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90436484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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