Pub Date : 1985-01-01DOI: 10.1007/978-1-4684-4931-0_8
M F Fer, R K Oldham
{"title":"Protein A immunoadsorption/immunoactivation: a critical review.","authors":"M F Fer, R K Oldham","doi":"10.1007/978-1-4684-4931-0_8","DOIUrl":"https://doi.org/10.1007/978-1-4684-4931-0_8","url":null,"abstract":"","PeriodicalId":10609,"journal":{"name":"Contemporary topics in immunobiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15012510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1985-01-01DOI: 10.1007/978-1-4684-4931-0
F. A. Salinas, M. Hanna
{"title":"Immune Complexes and Human Cancer","authors":"F. A. Salinas, M. Hanna","doi":"10.1007/978-1-4684-4931-0","DOIUrl":"https://doi.org/10.1007/978-1-4684-4931-0","url":null,"abstract":"","PeriodicalId":10609,"journal":{"name":"Contemporary topics in immunobiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78253853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Immune complexes and human cancer.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":10609,"journal":{"name":"Contemporary topics in immunobiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15141340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1985-01-01DOI: 10.1007/978-1-4684-4931-0_7
F R MacKintosh, K Bennett, S W Hall
The data presented here indicate that patients with advanced cancer exhibit a modest but definite objective response rate to biweekly infusions of autologous plasma treated with purified, covalently bound staphylococcal protein A in a relatively nontoxic treatment program. The possibility that responses could be enhanced by alteration of treatment parameters, improved patient selection, and/or combined therapy remains to be explored. In vitro studies indicate that tumor cell killing can be produced in an ovarian cancer cell line using ascitic fluid of some ovarian cancer patients that has been treated with small amounts of protein A covalently linked to silica gel or agarose. This may be a suitable model system for exploration of possible humoral mechanisms of protein A-associated tumoricidal effects. The available literature indicates an antitumor effect of protein A-treated patient plasma in a variety of in vitro systems, as well as in animal and human tumors in vivo. Preliminary investigations of the mechanism of these effects are inconsistent and support the view that several different mechanisms of tumor cell killing may be operative in different settings.
{"title":"Trials of staphylococcal protein A-treated plasma infusions in cancer therapy: clinical effects and implications for mode of action.","authors":"F R MacKintosh, K Bennett, S W Hall","doi":"10.1007/978-1-4684-4931-0_7","DOIUrl":"https://doi.org/10.1007/978-1-4684-4931-0_7","url":null,"abstract":"<p><p>The data presented here indicate that patients with advanced cancer exhibit a modest but definite objective response rate to biweekly infusions of autologous plasma treated with purified, covalently bound staphylococcal protein A in a relatively nontoxic treatment program. The possibility that responses could be enhanced by alteration of treatment parameters, improved patient selection, and/or combined therapy remains to be explored. In vitro studies indicate that tumor cell killing can be produced in an ovarian cancer cell line using ascitic fluid of some ovarian cancer patients that has been treated with small amounts of protein A covalently linked to silica gel or agarose. This may be a suitable model system for exploration of possible humoral mechanisms of protein A-associated tumoricidal effects. The available literature indicates an antitumor effect of protein A-treated patient plasma in a variety of in vitro systems, as well as in animal and human tumors in vivo. Preliminary investigations of the mechanism of these effects are inconsistent and support the view that several different mechanisms of tumor cell killing may be operative in different settings.</p>","PeriodicalId":10609,"journal":{"name":"Contemporary topics in immunobiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15012509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1985-01-01DOI: 10.1007/978-1-4684-4931-0_2
F A Salinas, K H Wee, H K Silver
{"title":"Clinical relevance of immune complexes, associated antigen, and antibody in cancer.","authors":"F A Salinas, K H Wee, H K Silver","doi":"10.1007/978-1-4684-4931-0_2","DOIUrl":"https://doi.org/10.1007/978-1-4684-4931-0_2","url":null,"abstract":"","PeriodicalId":10609,"journal":{"name":"Contemporary topics in immunobiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15012511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1985-01-01DOI: 10.1007/978-1-4684-4931-0_5
P K Ray
In tumor-bearing hosts both cellular and humoral tumor-growth-enhancing factors are present. They cause immunosuppression and facilitate the growth of tumors. Very early during tumor growth these factors are either elicited by the tumor cells or induced by the host immunocytes. Among these immunosuppressive agents, circulating immune complexes appear to play a predominant role. They also activate suppressor cell activity. Plasma adsorption of CIC and IgG by protein A of Staphylococcus aureus has been reported to cause tumor regression. Plasma adsorption with protein A-collodion charcoal, protein A-silica, or protein A-Sepharose also induced tumorilytic reactions. Even direct infusion of protein A induced tumor regressions in rat mammary tumors. Recent studies showing tumor regressions following S. aureus Wood 46 plasma adsorption or infusion of normal plasma adsorbed over S. aureus indicate that specific blocking factor removal by plasma adsorption may not be the mechanism for causing tumor destruction. Results indicate that S. aureus plasma adsorption leaches a number of staphylococcal agents. Thus, it appears that staphylococcal agents, protein A, enterotoxin, and other factors are responsible for the induction of reactions leading to tumor destruction. A unified mechanism explaining the results obtained with plasma adsorption using protein A of S. aureus, or S. aureus Wood, or direct protein A infusion, was presented.
{"title":"Immunosuppressor control as a modality of cancer treatment: effect of plasma adsorption with Staphylococcus aureus protein A.","authors":"P K Ray","doi":"10.1007/978-1-4684-4931-0_5","DOIUrl":"https://doi.org/10.1007/978-1-4684-4931-0_5","url":null,"abstract":"<p><p>In tumor-bearing hosts both cellular and humoral tumor-growth-enhancing factors are present. They cause immunosuppression and facilitate the growth of tumors. Very early during tumor growth these factors are either elicited by the tumor cells or induced by the host immunocytes. Among these immunosuppressive agents, circulating immune complexes appear to play a predominant role. They also activate suppressor cell activity. Plasma adsorption of CIC and IgG by protein A of Staphylococcus aureus has been reported to cause tumor regression. Plasma adsorption with protein A-collodion charcoal, protein A-silica, or protein A-Sepharose also induced tumorilytic reactions. Even direct infusion of protein A induced tumor regressions in rat mammary tumors. Recent studies showing tumor regressions following S. aureus Wood 46 plasma adsorption or infusion of normal plasma adsorbed over S. aureus indicate that specific blocking factor removal by plasma adsorption may not be the mechanism for causing tumor destruction. Results indicate that S. aureus plasma adsorption leaches a number of staphylococcal agents. Thus, it appears that staphylococcal agents, protein A, enterotoxin, and other factors are responsible for the induction of reactions leading to tumor destruction. A unified mechanism explaining the results obtained with plasma adsorption using protein A of S. aureus, or S. aureus Wood, or direct protein A infusion, was presented.</p>","PeriodicalId":10609,"journal":{"name":"Contemporary topics in immunobiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14290656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1985-01-01DOI: 10.1007/978-1-4684-4931-0_1
R K Gupta, D L Morton
{"title":"Clinical significance and nature of circulating immune complexes in melanoma patients.","authors":"R K Gupta, D L Morton","doi":"10.1007/978-1-4684-4931-0_1","DOIUrl":"https://doi.org/10.1007/978-1-4684-4931-0_1","url":null,"abstract":"","PeriodicalId":10609,"journal":{"name":"Contemporary topics in immunobiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15012508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1985-01-01DOI: 10.1007/978-1-4684-4931-0_4
D Cupissol, C Thierry, B C Serrou
{"title":"Immune complexes in patients bearing solid tumors.","authors":"D Cupissol, C Thierry, B C Serrou","doi":"10.1007/978-1-4684-4931-0_4","DOIUrl":"https://doi.org/10.1007/978-1-4684-4931-0_4","url":null,"abstract":"","PeriodicalId":10609,"journal":{"name":"Contemporary topics in immunobiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15141341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1985-01-01DOI: 10.1007/978-1-4684-4931-0_6
K E Hellström, I Hellström, H W Snyder, J P Balint, F R Jones
{"title":"Blocking (suppressor) factors, immune complexes, and extracorporeal immunoadsorption in tumor immunity.","authors":"K E Hellström, I Hellström, H W Snyder, J P Balint, F R Jones","doi":"10.1007/978-1-4684-4931-0_6","DOIUrl":"https://doi.org/10.1007/978-1-4684-4931-0_6","url":null,"abstract":"","PeriodicalId":10609,"journal":{"name":"Contemporary topics in immunobiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14126411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1985-01-01DOI: 10.1007/978-1-4684-4931-0_3
T M Phillips, T V Holohan, S Korac, N S More, W D Queen
{"title":"The pathophysiology of circulating immune complexes: their role in host-tumor interactions and removal by immunoadsorption therapy.","authors":"T M Phillips, T V Holohan, S Korac, N S More, W D Queen","doi":"10.1007/978-1-4684-4931-0_3","DOIUrl":"https://doi.org/10.1007/978-1-4684-4931-0_3","url":null,"abstract":"","PeriodicalId":10609,"journal":{"name":"Contemporary topics in immunobiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14290655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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