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Contemporary topics in immunobiology最新文献

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Systemic and local immunity in allograft and cancer rejection. 异体移植物和癌症排斥反应的全身和局部免疫。
Contemporary topics in immunobiology
Pub Date : 1978-01-01 DOI: 10.1007/978-1-4684-0922-2_5
J S Haskill, P Häyry, L A Radov
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引用次数: 43
In vitro induction and expression of T-cell immunity to tumor-associated antigens. 肿瘤相关抗原t细胞免疫的体外诱导和表达。
Contemporary topics in immunobiology
Pub Date : 1978-01-01 DOI: 10.1007/978-1-4684-0922-2_4
R C Burton, S E Chism, N L Warner
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引用次数: 17
Allotypes of IgM and IgD receptors in the mouse: a probe for lymphocyte differentiation. 小鼠IgM和IgD受体的异型:淋巴细胞分化的探针。
Contemporary topics in immunobiology
Pub Date : 1978-01-01 DOI: 10.1007/978-1-4684-0922-2_7
J W Goding

Antibodies to IgD and IgM are present in many mouse alloantisera made against lymphocytes. Antibodies to IgM are also present in a small minority of conventional antiallotype sera made against pertussis/anti-pertussis complexes. These antibodies reflect different allelic forms of IgD and IgM in different mouse strains, and allowed the mapping of the delta- and mu-chain genes (Ig-5 and Ig-6, respectively) to the heavy-chain complex. The variable portions of IgM and IgD receptors on individual cells bearing both chains are similar or identical. Both receptors show allelic exclusion and come from the same chromosome on individual cells (haplotype exclusion). It is suggested that very early in B lymphocyte differentiation there is a commitment to a given chromosome, and translocation of one copy of a given variable region gene to each heavy-chain gene. Subsequent switches of immunoglobulin class then involve differential gene activation. Immature B cells possess IgM receptors only and mature into cells bearing both IgM and IgD receptors. After activation with antigen, IgD is probably lost. These findings are discussed within the framework of the clonal abortion theory of B-lymphocyte tolerance.

许多针对淋巴细胞的小鼠同种异体抗血清中存在IgD和IgM抗体。IgM抗体也存在于少数常规抗百日咳/抗百日咳复合物的抗异体血清中。这些抗体反映了不同小鼠品系中IgD和IgM的不同等位基因形式，并允许将δ链和mu链基因(分别为Ig-5和Ig-6)映射到重链复合物上。携带这两条链的单个细胞上的IgM和IgD受体的可变部分是相似或相同的。这两种受体都表现出等位基因排斥，并且来自单个细胞上的同一染色体(单倍型排斥)。这表明，在B淋巴细胞分化的早期，有一个特定染色体的承诺，一个特定可变区基因的一个拷贝易位到每个重链基因。随后的免疫球蛋白类转换涉及到差异基因激活。未成熟的B细胞仅具有IgM受体，成熟后同时具有IgM和IgD受体。在被抗原激活后，IgD可能丢失。这些发现在b淋巴细胞耐受克隆流产理论的框架内进行了讨论。
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引用次数: 35
Major transplantation antigens, viruses, and specificity of surveillance T cells. 主要的移植抗原、病毒和特异性监视T细胞。
Contemporary topics in immunobiology
Pub Date : 1977-01-01 DOI: 10.1007/978-1-4684-3054-7_5
R M Zinkernagel, P C Doherty
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引用次数: 124
Significance of the major histocompatibility complex as assessed by T-cell-mediated lympholysis involving syngeneic stimulating cells. 主要组织相容性复合体的意义，通过t细胞介导的涉及同源刺激细胞的淋巴溶解来评估。
Contemporary topics in immunobiology
Pub Date : 1977-01-01 DOI: 10.1007/978-1-4684-3054-7_6
G M Shearer, A M Schmitt-Verhulst, T G Rehn
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引用次数: 27
Mechanism of specific tumor-cell lysis by alloimmune T lymphocytes: resolution and characterization of discrete steps in the cellular interaction. 同种免疫T淋巴细胞特异性肿瘤细胞溶解的机制:细胞相互作用中离散步骤的解析和表征。
Contemporary topics in immunobiology
Pub Date : 1977-01-01 DOI: 10.1007/978-1-4684-3054-7_9
E Martz
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引用次数: 242
Mechanism of T-cell-mediated cytolysis: the lethal hit stage. t细胞介导的细胞溶解机制:致命打击阶段。
Contemporary topics in immunobiology
Pub Date : 1977-01-01 DOI: 10.1007/978-1-4684-3054-7_8
P Golstein, E T Smith
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引用次数: 103
Functional analysis of distinct human T-cell subsets bearing unique differentiation antigens. 携带独特分化抗原的不同人t细胞亚群的功能分析。
Contemporary topics in immunobiology
Pub Date : 1977-01-01 DOI: 10.1007/978-1-4684-3054-7_10
L Chess, S F Schlossman
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引用次数: 30
Immunogenicity and MuMTV-like antigenicity of human breast cancer tissues. 人乳腺癌组织的免疫原性和mumtv样抗原性。
Contemporary topics in immunobiology
Pub Date : 1977-01-01 DOI: 10.1007/978-1-4684-3051-6_9
M M Black
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引用次数: 7
Immunity to leukemia, lymphoma, and fibrosarcoma in cats: a case for immunosurveillance. 猫对白血病、淋巴瘤和纤维肉瘤的免疫:免疫监测一例。
Contemporary topics in immunobiology
Pub Date : 1977-01-01 DOI: 10.1007/978-1-4684-3051-6_2
M Essex
{"title":"Immunity to leukemia, lymphoma, and fibrosarcoma in cats: a case for immunosurveillance.","authors":"M Essex","doi":"10.1007/978-1-4684-3051-6_2","DOIUrl":"https://doi.org/10.1007/978-1-4684-3051-6_2","url":null,"abstract":"","PeriodicalId":10609,"journal":{"name":"Contemporary topics in immunobiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1977-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11410768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 26
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