Pub Date : 2016-04-01DOI: 10.7861/clinmedicine.16-2-103
Jennifer K Harrison, Iona K McKay, Patrick Grant, Jean Hannah, Terence J Quinn
Unscheduled hospital admissions from care homes are common and potentially avoidable but little guidance is available as to what constitutes an appropriate hospital admission. We surveyed healthcare professionals' opinions on a range of common scenarios affecting care-home residents. We developed seven clinical vignettes and an accompanying questionnaire. We used purposive sampling to obtain opinions from relevant primary care and secondary care teams. We asked assessors to comment on whether they would favour hospital admission and to justify their response using pre-selected options and/or free text. Admission to hospital was judged inappropriate in 54.6% of responses. Opinion on admission varied according to the case, with fewer than half of respondents agreeing for three of the seven cases. Recurring themes were uncertainty around services available to care homes and anticipatory care planning. The lack of consensus suggests that concepts surrounding inappropriate care-home admission are not shared by staff who provide care for this patient group.
{"title":"Appropriateness of unscheduled hospital admissions from care homes.","authors":"Jennifer K Harrison, Iona K McKay, Patrick Grant, Jean Hannah, Terence J Quinn","doi":"10.7861/clinmedicine.16-2-103","DOIUrl":"10.7861/clinmedicine.16-2-103","url":null,"abstract":"<p><p>Unscheduled hospital admissions from care homes are common and potentially avoidable but little guidance is available as to what constitutes an appropriate hospital admission. We surveyed healthcare professionals' opinions on a range of common scenarios affecting care-home residents. We developed seven clinical vignettes and an accompanying questionnaire. We used purposive sampling to obtain opinions from relevant primary care and secondary care teams. We asked assessors to comment on whether they would favour hospital admission and to justify their response using pre-selected options and/or free text. Admission to hospital was judged inappropriate in 54.6% of responses. Opinion on admission varied according to the case, with fewer than half of respondents agreeing for three of the seven cases. Recurring themes were uncertainty around services available to care homes and anticipatory care planning. The lack of consensus suggests that concepts surrounding inappropriate care-home admission are not shared by staff who provide care for this patient group. </p>","PeriodicalId":10674,"journal":{"name":"Collection of Czechoslovak Chemical Communications","volume":"70 1","pages":"103-8"},"PeriodicalIF":4.4,"publicationDate":"2016-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4952960/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85736847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
J. Charvátová, V. Kašička, T. Barth, Z. Deyl, I. Mikšík, V. Král
{"title":"Separation of structurally related peptides by open-tubular capillary electrochromatography using (metallo)porphyrins as the adsorbed stationary phase","authors":"J. Charvátová, V. Kašička, T. Barth, Z. Deyl, I. Mikšík, V. Král","doi":"10.1135/CSS200306007","DOIUrl":"https://doi.org/10.1135/CSS200306007","url":null,"abstract":"","PeriodicalId":10674,"journal":{"name":"Collection of Czechoslovak Chemical Communications","volume":"6 1","pages":"7-11"},"PeriodicalIF":0.0,"publicationDate":"2016-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63706880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
G. Oliviero, Jussara Amato, S. D’Errico, G. Piccialli, P. Mailliet, F. Rosu, E. Pauw, V. Gabélica
{"title":"Ligand binding to tetra-end-linked (TGGGGT) 4 G-quadruplexes: an electrospray mass spectrometry study","authors":"G. Oliviero, Jussara Amato, S. D’Errico, G. Piccialli, P. Mailliet, F. Rosu, E. Pauw, V. Gabélica","doi":"10.1135/CSS200810333","DOIUrl":"https://doi.org/10.1135/CSS200810333","url":null,"abstract":"","PeriodicalId":10674,"journal":{"name":"Collection of Czechoslovak Chemical Communications","volume":"10 1","pages":"333-335"},"PeriodicalIF":0.0,"publicationDate":"2015-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63709947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Martin Kögler, Bart Vanderhoydonck, S. D. Jonghe, Jean Herman, T. Louat, K. V. Belle, J. Rozenski, P. Herdewijn
Synthesis and Evaluation of 5-Substituted 20-deoxyuridine Monophosphate Analogues As Inhibitors of Flavin-Dependent Thymidylate Synthase in Mycobacterium tuberculosis Martin K€ogler, Bart Vanderhoydonck, Steven De Jonghe, Jef Rozenski, Kristien Van Belle, Jean Herman, Thierry Louat, Anastasia Parchina, Carol Sibley, Eveline Lescrinier, and Piet Herdewijn* Katholieke Universiteit Leuven, Rega Institute for Medical Research, Laboratory of Medicinal Chemistry, Minderbroedersstraat 10, 3000 Leuven, Belgium Katholieke Universiteit Leuven, Interface Valorisation Platform (IVAP), Kapucijnenvoer 33, 3000 Leuven, Belgium Department of Genome Sciences, University of Washington, Seattle, Washington, United States
Martin K€ogler, Bart Vanderhoydonck, Steven De Jonghe, Jef Rozenski, Kristien Van Belle, Jean Herman, Thierry Louat, Anastasia Parchina, Carol Sibley, Eveline Lescrinier，和Piet Herdewijn*天主教鲁芬大学，Rega医学研究所，药物化学实验室，minderbroederstraat 103000 Leuven，比利时天主教鲁汶大学，界面评估平台(IVAP)， Kapucijnenvoer 33,3000 Leuven，比利时，华盛顿大学基因组科学系，西雅图，华盛顿，美国
{"title":"Synthesis and evaluation of 5-substituted-2'-deoxyuridine monophosphate analogues as inhibitors of flavin-dependent thymidylate synthase in Mycobacterium tuberculosis","authors":"Martin Kögler, Bart Vanderhoydonck, S. D. Jonghe, Jean Herman, T. Louat, K. V. Belle, J. Rozenski, P. Herdewijn","doi":"10.1135/CSS201112364","DOIUrl":"https://doi.org/10.1135/CSS201112364","url":null,"abstract":"Synthesis and Evaluation of 5-Substituted 20-deoxyuridine Monophosphate Analogues As Inhibitors of Flavin-Dependent Thymidylate Synthase in Mycobacterium tuberculosis Martin K€ogler, Bart Vanderhoydonck, Steven De Jonghe, Jef Rozenski, Kristien Van Belle, Jean Herman, Thierry Louat, Anastasia Parchina, Carol Sibley, Eveline Lescrinier, and Piet Herdewijn* Katholieke Universiteit Leuven, Rega Institute for Medical Research, Laboratory of Medicinal Chemistry, Minderbroedersstraat 10, 3000 Leuven, Belgium Katholieke Universiteit Leuven, Interface Valorisation Platform (IVAP), Kapucijnenvoer 33, 3000 Leuven, Belgium Department of Genome Sciences, University of Washington, Seattle, Washington, United States","PeriodicalId":10674,"journal":{"name":"Collection of Czechoslovak Chemical Communications","volume":"12 1","pages":"364-366"},"PeriodicalIF":0.0,"publicationDate":"2015-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63711617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Vasilyeva, A. S. Kuznetsova, Juliya G. Khalyavina, V. Glazunova, A. Shtil, L. M. Gornostaev, V. Silnikov
{"title":"Novel fluorescent pyrimidine nucleosides containing 2,1,3-benzoxadiazole and naphtho-[1,2,3-cd]indole-6 (2h)-one fragments","authors":"S. Vasilyeva, A. S. Kuznetsova, Juliya G. Khalyavina, V. Glazunova, A. Shtil, L. M. Gornostaev, V. Silnikov","doi":"10.1135/css201414396","DOIUrl":"https://doi.org/10.1135/css201414396","url":null,"abstract":"","PeriodicalId":10674,"journal":{"name":"Collection of Czechoslovak Chemical Communications","volume":"14 1","pages":"396-398"},"PeriodicalIF":0.0,"publicationDate":"2015-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63713691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Towards a DNA based asymmetric catalyst based on a tetraaza crown ether macrocycle","authors":"M. Dalager, S. Vogel","doi":"10.1135/css201414242","DOIUrl":"https://doi.org/10.1135/css201414242","url":null,"abstract":"","PeriodicalId":10674,"journal":{"name":"Collection of Czechoslovak Chemical Communications","volume":"14 1","pages":"242-243"},"PeriodicalIF":0.0,"publicationDate":"2014-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63713033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Modified nucleoside triphosphates in rolling circle amplification","authors":"M. Hollenstein","doi":"10.1135/CSS201414103","DOIUrl":"https://doi.org/10.1135/CSS201414103","url":null,"abstract":"","PeriodicalId":10674,"journal":{"name":"Collection of Czechoslovak Chemical Communications","volume":"14 1","pages":"103-106"},"PeriodicalIF":0.0,"publicationDate":"2014-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63713101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Antiviral activity of 5-halofuropyrimidine nucleosides","authors":"Craig D. Sergeant, J. Balzarini, R. Dembinski","doi":"10.1135/CSS201414209","DOIUrl":"https://doi.org/10.1135/CSS201414209","url":null,"abstract":"","PeriodicalId":10674,"journal":{"name":"Collection of Czechoslovak Chemical Communications","volume":"14 1","pages":"209-212"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63712758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A study of characteristics of silica or glass surfaces to increase efficiency of nucleic acid synthesis using the solid phase approach","authors":"Sandra Bałabańska, R. Przekop, M. Chmielewski","doi":"10.1135/CSS201414227","DOIUrl":"https://doi.org/10.1135/CSS201414227","url":null,"abstract":"","PeriodicalId":10674,"journal":{"name":"Collection of Czechoslovak Chemical Communications","volume":"88 1","pages":"227-228"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63712906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jana Balintová, M. Brázdová, L. Havran, M. Fojta, Michal Hocek
{"title":"Redox labeling and redox coding of nucleic acids","authors":"Jana Balintová, M. Brázdová, L. Havran, M. Fojta, Michal Hocek","doi":"10.1135/CSS201414229","DOIUrl":"https://doi.org/10.1135/CSS201414229","url":null,"abstract":"","PeriodicalId":10674,"journal":{"name":"Collection of Czechoslovak Chemical Communications","volume":"14 1","pages":"229-230"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63712919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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