首页 > 最新文献

Clinical EEG and Neuroscience最新文献

英文 中文
Polyspikes and Rhythmic Polyspikes During Volatile Induction of General Anesthesia With Sevoflurane Result in Bispectral Index Variations. 七氟醚全麻挥发性诱导时的多峰和节律性多峰导致双谱指数变化。
IF 2 4区 医学 Q2 Medicine Pub Date : 2023-05-01 DOI: 10.1177/1550059420974571
Michał J Stasiowski, Anna Duława, Seweryn Król, Radosław Marciniak, Wojciech Kaspera, Ewa Niewiadomska, Lech Krawczyk, Piotr Ładziński, Beniamin O Grabarek, Przemysław Jałowiecki

Background: Although electroencephalography (EEG)-based indices may show artifactual values, raw EEG signal is seldom used to monitor the depth of volatile induction of general anesthesia (VIGA). The current analysis aimed to identify whether bispectral index (BIS) variations reliably reflect the actual depth of general anesthesia during presence of different types of epileptiform patterns (EPs) in EEGs during induction of general anesthesia.

Methods: Sixty patients receiving either VIGA with sevoflurane using increasing concentrations (group VIMA) or vital capacity (group VCRII) technique or intravenous single dose of propofol (group PROP) were included. Monitoring included facial electromyography (fEMG), fraction of inspired sevoflurane (FiAA), fraction of expired sevoflurane (FeAA), minimal alveolar concentration (MAC) of sevoflurane, BIS, standard EEG, and hemodynamic parameters.

Results: In the PROP group no EPs were observed. During different stages of VIGA with sevoflurane in the VIMA and VCRII groups, presence of polyspikes and rhythmic polyspikes in patients' EEGs resulted in artifactual BIS values indicating a false awareness/wakefulness from anesthesia, despite no concomitant change of FiAA, FeAA, and MAC of sevoflurane. Periodic epileptiform discharges did not result in aberrant BIS values.

Conclusion: Our results suggest that raw EEG correlate it with values of BIS, FiAA, FeAA, and MAC of sevoflurane during VIGA. It seems that because artifactual BIS values indicating false awareness/wakefulness as a result of presence of polyspikes and rhythmic polyspikes in patients' EEGs may be misleading to an anesthesiologist, leading to unintentional administration of toxic concentration of sevoflurane in ventilation gas.

背景:虽然基于脑电图(EEG)的指标可能显示人工值,但原始脑电图信号很少用于监测全身麻醉(vaga)的挥发性诱导深度。当前的分析旨在确定在全麻诱导时脑电图中存在不同类型的癫痫样模式(EPs)时,双谱指数(BIS)变化是否可靠地反映了全麻的实际深度。方法:采用七氟醚增加浓度(VIMA组)或肺活量(VCRII组)技术或单次静脉注射异丙酚(PROP组)的患者共60例。监测包括面肌电图(fEMG)、吸入七氟醚分数(FiAA)、过期七氟醚分数(FeAA)、七氟醚最小肺泡浓度(MAC)、BIS、标准EEG和血流动力学参数。结果:PROP组未见EPs。在VIMA组和VCRII组的七氟醚VIGA的不同阶段,尽管七氟醚的FiAA、FeAA和MAC没有变化,但患者脑电图中存在多峰峰和节律性多峰峰,导致假BIS值,表明麻醉后的假意识/清醒。周期性癫痫样放电不会导致BIS值异常。结论:我们的结果表明,原始脑电图与VIGA期间七氟醚的BIS、FiAA、FeAA和MAC值具有相关性。由于患者脑电图中存在多峰峰和节律性多峰峰,因此人工BIS值表明错误的意识/清醒可能会误导麻醉师,导致在通气气体中无意中使用有毒浓度的七氟醚。
{"title":"Polyspikes and Rhythmic Polyspikes During Volatile Induction of General Anesthesia With Sevoflurane Result in Bispectral Index Variations.","authors":"Michał J Stasiowski,&nbsp;Anna Duława,&nbsp;Seweryn Król,&nbsp;Radosław Marciniak,&nbsp;Wojciech Kaspera,&nbsp;Ewa Niewiadomska,&nbsp;Lech Krawczyk,&nbsp;Piotr Ładziński,&nbsp;Beniamin O Grabarek,&nbsp;Przemysław Jałowiecki","doi":"10.1177/1550059420974571","DOIUrl":"https://doi.org/10.1177/1550059420974571","url":null,"abstract":"<p><strong>Background: </strong>Although electroencephalography (EEG)-based indices may show artifactual values, raw EEG signal is seldom used to monitor the depth of volatile induction of general anesthesia (VIGA). The current analysis aimed to identify whether bispectral index (BIS) variations reliably reflect the actual depth of general anesthesia during presence of different types of epileptiform patterns (EPs) in EEGs during induction of general anesthesia.</p><p><strong>Methods: </strong>Sixty patients receiving either VIGA with sevoflurane using increasing concentrations (group VIMA) or vital capacity (group VCRII) technique or intravenous single dose of propofol (group PROP) were included. Monitoring included facial electromyography (fEMG), fraction of inspired sevoflurane (FiAA), fraction of expired sevoflurane (FeAA), minimal alveolar concentration (MAC) of sevoflurane, BIS, standard EEG, and hemodynamic parameters.</p><p><strong>Results: </strong>In the PROP group no EPs were observed. During different stages of VIGA with sevoflurane in the VIMA and VCRII groups, presence of polyspikes and rhythmic polyspikes in patients' EEGs resulted in artifactual BIS values indicating a false awareness/wakefulness from anesthesia, despite no concomitant change of FiAA, FeAA, and MAC of sevoflurane. Periodic epileptiform discharges did not result in aberrant BIS values.</p><p><strong>Conclusion: </strong>Our results suggest that raw EEG correlate it with values of BIS, FiAA, FeAA, and MAC of sevoflurane during VIGA. It seems that because artifactual BIS values indicating false awareness/wakefulness as a result of presence of polyspikes and rhythmic polyspikes in patients' EEGs may be misleading to an anesthesiologist, leading to unintentional administration of toxic concentration of sevoflurane in ventilation gas.</p>","PeriodicalId":10682,"journal":{"name":"Clinical EEG and Neuroscience","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1550059420974571","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9314877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Neuroimaging and Electroencephalographic Correlation in Patients with Transient Global Amnesia: Clinical Case Series. 短暂性全身性遗忘患者的神经影像学和脑电图相关性:临床病例系列。
IF 2 4区 医学 Q2 Medicine Pub Date : 2023-05-01 DOI: 10.1177/15500594221101399
Georgios-Theofilos Theodorou, Elisavet Psoma, Aikaterini Terzoudi, Xanthipi Mavropoulou, Ioannis Roilidis, Konstantinos Vadikolias, Martha Spilioti

Objective. To determine if there is any correlation between the electroencephalographic and neuroimaging findings in patients with Transient Global Amnesia (TGA). Methods: We retrospectively reviewed files of the First Department of Neurology of AHEPA University Hospital, including patients with a clinical diagnosis of TGA. Only patients who had the characteristic high signal in the temporal lobes in the DWI MRI and those who underwent electroencephalographic recording (EEG) were selected. Results: Out of 28 patients, 8 were selected. We found that 6 out of 8 patients (75%) who had imaging findings in DWI, in at least one medial temporal lobe, also had had intermittent slow theta waves on the electroencephalographic recording. Of these 6 patients, 3 (50%) had bilateral EEG findings, 2 patients (33,3%) only had findings on the left hemisphere and 1 (17%) had on the right hemisphere. 3 out of 6 patients (50%) had electroencephalographic dominance on the left, while 2 out of the 6 (33%) had on the right. In 2 patients with imaging findings in DWI no anomalies were demonstrated on EEG. In 3 out of 8 patients, both MRI and EEG findings correlated on the same side, while 1 patient had opposite findings, depending on which hemisphere the EEG anomalies dominated. Conclusions: There is no absolute matching between the DWI MRI and EEG findings in patients with the clinical diagnosis of TGA. However, there is some degree of correlation, when we focus on the focal dominance of the EEG anomalies, although not statistically significant.

目标。目的:确定短暂性全身性遗忘(TGA)患者的脑电图和神经影像学表现之间是否存在相关性。方法:我们回顾性分析了AHEPA大学医院神经内科一科的资料,包括临床诊断为TGA的患者。仅选择DWI MRI表现为颞叶高信号特征性的患者和行脑电图记录的患者。结果:28例患者中,入选8例。我们发现8例患者中有6例(75%)在DWI上有影像学发现,至少在一个内侧颞叶,在脑电图记录上也有间歇性的慢θ波。6例患者中3例(50%)有双侧脑电图,2例(33.3%)只有左脑,1例(17%)有右脑。6例患者中3例(50%)为左侧脑电图优势,2例(33%)为右侧脑电图优势。2例DWI有影像学表现,脑电图未见异常。在8例患者中,3例MRI和EEG的结果在同一侧相关,而1例患者的结果相反,这取决于脑电图异常占主导地位的哪个半球。结论:临床诊断为TGA的患者,DWI MRI与EEG表现不存在绝对匹配。然而,当我们关注脑电图异常的局灶优势时,存在一定程度的相关性,尽管没有统计学意义。
{"title":"Neuroimaging and Electroencephalographic Correlation in Patients with Transient Global Amnesia: Clinical Case Series.","authors":"Georgios-Theofilos Theodorou,&nbsp;Elisavet Psoma,&nbsp;Aikaterini Terzoudi,&nbsp;Xanthipi Mavropoulou,&nbsp;Ioannis Roilidis,&nbsp;Konstantinos Vadikolias,&nbsp;Martha Spilioti","doi":"10.1177/15500594221101399","DOIUrl":"https://doi.org/10.1177/15500594221101399","url":null,"abstract":"<p><p><i>Objective</i>. To determine if there is any correlation between the electroencephalographic and neuroimaging findings in patients with Transient Global Amnesia (TGA). <b>Methods:</b> We retrospectively reviewed files of the First Department of Neurology of AHEPA University Hospital, including patients with a clinical diagnosis of TGA. Only patients who had the characteristic high signal in the temporal lobes in the DWI MRI and those who underwent electroencephalographic recording (EEG) were selected. <b>Results:</b> Out of 28 patients, 8 were selected. We found that 6 out of 8 patients (75%) who had imaging findings in DWI, in at least one medial temporal lobe, also had had intermittent slow theta waves on the electroencephalographic recording. Of these 6 patients, 3 (50%) had bilateral EEG findings, 2 patients (33,3%) only had findings on the left hemisphere and 1 (17%) had on the right hemisphere. 3 out of 6 patients (50%) had electroencephalographic dominance on the left, while 2 out of the 6 (33%) had on the right. In 2 patients with imaging findings in DWI no anomalies were demonstrated on EEG. In 3 out of 8 patients, both MRI and EEG findings correlated on the same side, while 1 patient had opposite findings, depending on which hemisphere the EEG anomalies dominated. <b>Conclusions:</b> There is no absolute matching between the DWI MRI and EEG findings in patients with the clinical diagnosis of TGA. However, there is some degree of correlation, when we focus on the focal dominance of the EEG anomalies, although not statistically significant.</p>","PeriodicalId":10682,"journal":{"name":"Clinical EEG and Neuroscience","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9616277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An Extraordinary EEG Phenomenon Misdiagnosed as Nonconvulsive Status Epilepticus: Frequent Subclinical Periodic Discharges Terminated by Sudden Auditory Stimuli. 误诊为非惊厥性癫痫持续状态的异常脑电图现象:频繁的亚临床周期性放电被突然的听觉刺激终止。
IF 2 4区 医学 Q2 Medicine Pub Date : 2023-03-01 DOI: 10.1177/15500594221129965
Emel Oguz-Akarsu, Barıs Salman, Sibel Ugur-Iseri, Betul Baykan

Triggering or modulation of seizures and rhythmic EEG patterns by external stimuli are well-known with the most common clinical appearance of stimulus induced periodic discharges (SI- PDs) patterns which are elicited by physical or auditory stimulation. However, stimulus terminated periodic discharges (ST-PDs), in other words, the periodic discharges stopped by external stimuli is an extremely rare electroencephalographic (EEG) finding. We report a 20-year-old woman with a marked psychomotor developmental delay of unknown cause, with frequent EEG patterns of long-lasting (10-60 s) bilateral paroxysmal high-voltage slow waves with occasional spikes, misdiagnosed as non-convulsive status epilepticus. However, no apparent clinical change was noted by the technician, physician, and her mother during these subclinical ictal EEG recordings. Interestingly, however, these epileptic discharges were abruptly interrupted by sudden verbal stimuli on the EEG, repeatedly. Whole exome sequencing and genotyping were performed to investigate possible genetic etiology that revealed two sequence variants, a frameshift variant of CACNA1H NM_021098.3:c.1701del;p.Asp568ThrfsTer15 and a missense variant of GRIN2D NM_000836.4:c.1783A>T;p.Thr595Ser as well as a copy number variant part deletion of ATP6V1A gene arr [hg19]3q13.31(113,499,698_113,543,081)x1 as possible pathogenic candidates. The subclinical periodic discharges terminated by verbal stimuli, is a very rare manifestation and needs particular attention. External modulation of ictal-appearing EEG patterns is important to identify stimulus terminated EEG patterns.

外界刺激触发或调节癫痫发作和节律性脑电图模式是众所周知的,最常见的临床表现是由物理或听觉刺激引起的刺激诱发周期性放电(SI- pd)模式。然而,刺激终止周期性放电(st - pd),换句话说,由外部刺激停止的周期性放电是一种极其罕见的脑电图(EEG)发现。我们报告了一位20岁的女性,她有明显的精神运动性发育延迟,原因不明,脑电图模式频繁出现长时间(10-60秒)的双侧阵发性高电压慢波,偶尔有尖峰,被误诊为非惊厥性癫痫持续状态。然而,在这些亚临床关键期脑电图记录中,技术人员、医生和她的母亲没有注意到明显的临床变化。然而,有趣的是,这些癫痫放电在脑电图上被突然的言语刺激反复打断。全外显子组测序和基因分型研究了可能的遗传病因,发现了两个序列变异,CACNA1H NM_021098.3:c.1701del;Asp568ThrfsTer15和GRIN2D NM_000836.4错义变体:c.1783A>T;Thr595Ser以及ATP6V1A基因arr [hg19]3q13.31(113,499,698_113,543,081)x1的拷贝数变异部分缺失作为可能的致病候点。亚临床周期性放电终止的言语刺激,是一个非常罕见的表现,需要特别注意。外部调制的初始脑电图模式是重要的识别刺激终止脑电图模式。
{"title":"An Extraordinary EEG Phenomenon Misdiagnosed as Nonconvulsive Status Epilepticus: Frequent Subclinical Periodic Discharges Terminated by Sudden Auditory Stimuli.","authors":"Emel Oguz-Akarsu,&nbsp;Barıs Salman,&nbsp;Sibel Ugur-Iseri,&nbsp;Betul Baykan","doi":"10.1177/15500594221129965","DOIUrl":"https://doi.org/10.1177/15500594221129965","url":null,"abstract":"<p><p>Triggering or modulation of seizures and rhythmic EEG patterns by external stimuli are well-known with the most common clinical appearance of stimulus induced periodic discharges (SI- PDs) patterns which are elicited by physical or auditory stimulation. However, stimulus terminated periodic discharges (ST-PDs), in other words, the periodic discharges stopped by external stimuli is an extremely rare electroencephalographic (EEG) finding. We report a 20-year-old woman with a marked psychomotor developmental delay of unknown cause, with frequent EEG patterns of long-lasting (10-60 s) bilateral paroxysmal high-voltage slow waves with occasional spikes, misdiagnosed as non-convulsive status epilepticus. However, no apparent clinical change was noted by the technician, physician, and her mother during these subclinical ictal EEG recordings. Interestingly, however, these epileptic discharges were abruptly interrupted by sudden verbal stimuli on the EEG, repeatedly. Whole exome sequencing and genotyping were performed to investigate possible genetic etiology that revealed two sequence variants, a frameshift variant of <i>CACNA1H</i> NM_021098.3:c.1701del;p.Asp568ThrfsTer15 and a missense variant of <i>GRIN2D</i> NM_000836.4:c.1783A>T;p.Thr595Ser as well as a copy number variant part deletion of <i>ATP6V1A</i> gene arr [hg19]3q13.31(113,499,698_113,543,081)x1 as possible pathogenic candidates. The subclinical periodic discharges terminated by verbal stimuli, is a very rare manifestation and needs particular attention. External modulation of ictal-appearing EEG patterns is important to identify stimulus terminated EEG patterns.</p>","PeriodicalId":10682,"journal":{"name":"Clinical EEG and Neuroscience","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10486494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Deficiency in Re-Orienting of Attention in Adults with Attention-Deficit Hyperactivity Disorder. 成人注意缺陷多动障碍的注意再定向缺陷。
IF 2 4区 医学 Q2 Medicine Pub Date : 2023-03-01 DOI: 10.1177/15500594221115737
Valentina Gumenyuk, Oleg Korzyukov, Natalie Tapaskar, Michael Wagner, Charles R Larson, Michael J Hammer

Objective: To characterize potential brain indexes of attention deficit hyperactivity disorder (ADHD) in adults. Methods: In an effort to develop objective, laboratory-based tests that can help to establish ADHD diagnosis, the brain indexes of distractibility was investigated in a group of adults. We used event-related brain potentials (ERPs) and performance measures in a forced-choice visual task. Results: Behaviorally aberrant distractibility in the ADHD group was significantly higher. Across three ERP components of distraction: N1 enhancement, P300 (P3a), and Reorienting Negativity (RON) the significant difference between ADHD and matched controls was found in the amplitude of the RON. We used non-parametric randomization tests, enabling us to statistically validated this difference between-group. Conclusions: Our main results of this feasibility study suggest that among other ERP components associated with auditory distraction, the RON response is promising index for a potential biomarker of deficient re-orienting of attention in adults s with ADHD.

目的:探讨成人注意缺陷多动障碍(ADHD)的脑电位指标。方法:为了开发客观的、基于实验室的测试,以帮助建立ADHD诊断,对一组成年人的大脑分神指标进行了调查。我们在一个强迫选择的视觉任务中使用了事件相关脑电位(ERPs)和表现测量。结果:ADHD组行为异常注意力不集中显著增高。在分心的三个ERP成分:N1增强、P300 (P3a)和重新定向负性(RON)中,ADHD和匹配对照组在RON的振幅上存在显著差异。我们使用非参数随机化测试,使我们能够在统计上验证组间差异。结论:我们这项可行性研究的主要结果表明,在与听觉分心相关的其他ERP成分中,RON反应是有希望的指标,可以作为成人ADHD患者注意力重新定向缺陷的潜在生物标志物。
{"title":"Deficiency in Re-Orienting of Attention in Adults with Attention-Deficit Hyperactivity Disorder.","authors":"Valentina Gumenyuk,&nbsp;Oleg Korzyukov,&nbsp;Natalie Tapaskar,&nbsp;Michael Wagner,&nbsp;Charles R Larson,&nbsp;Michael J Hammer","doi":"10.1177/15500594221115737","DOIUrl":"https://doi.org/10.1177/15500594221115737","url":null,"abstract":"<p><p><b>Objective:</b> To characterize potential brain indexes of attention deficit hyperactivity disorder (ADHD) in adults. <b>Methods:</b> In an effort to develop objective, laboratory-based tests that can help to establish ADHD diagnosis, the brain indexes of distractibility was investigated in a group of adults. We used event-related brain potentials (ERPs) and performance measures in a forced-choice visual task. <b>Results:</b> Behaviorally aberrant distractibility in the ADHD group was significantly higher. Across three ERP components of distraction: N1 enhancement, P300 (P3a), and Reorienting Negativity (RON) the significant difference between ADHD and matched controls was found in the amplitude of the RON. We used non-parametric randomization tests, enabling us to statistically validated this difference between-group. <b>Conclusions:</b> Our main results of this feasibility study suggest that among other ERP components associated with auditory distraction, the RON response is promising index for a potential biomarker of deficient re-orienting of attention in adults s with ADHD.</p>","PeriodicalId":10682,"journal":{"name":"Clinical EEG and Neuroscience","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10494435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Quantitative EEG Analysis in Angelman Syndrome: Candidate Method for Assessing Therapeutics. Angelman综合征的定量脑电图分析:评估治疗方法的候选方法。
IF 2 4区 医学 Q2 Medicine Pub Date : 2023-03-01 DOI: 10.1177/1550059420973095
Luis A Martinez, Heather A Born, Sarah Harris, Angelique Regnier-Golanov, Joseph C Grieco, Edwin J Weeber, Anne E Anderson

The goal of these studies was to use quantitative (q)EEG techniques on data from children with Angelman syndrome (AS) using spectral power analysis, and to evaluate this as a potential biomarker and quantitative method to evaluate therapeutics. Although characteristic patterns are evident in visual inspection, using qEEG techniques has the potential to provide quantitative evidence of treatment efficacy. We first assessed spectral power from baseline EEG recordings collected from children with AS compared to age-matched neurotypical controls, which corroborated the previously reported finding of increased total power driven by elevated delta power in children with AS. We then retrospectively analyzed data collected during a clinical trial evaluating the safety and tolerability of minocycline (3 mg/kg/d) to compare pretreatment recordings from children with AS (4-12 years of age) to EEG activity at the end of treatment and following washout for EEG spectral power and epileptiform events. At baseline and during minocycline treatment, the AS subjects demonstrated increased delta power; however, following washout from minocycline treatment the AS subjects had significantly reduced EEG spectral power and epileptiform activity. Our findings support the use of qEEG analysis in evaluating AS and suggest that this technique may be useful to evaluate therapeutic efficacy in AS. Normalizing EEG power in AS therefore may become an important metric in screening therapeutics to gauge overall efficacy. As therapeutics transition from preclinical to clinical studies, it is vital to establish outcome measures that can quantitatively evaluate putative treatments for AS and neurological disorders with distinctive EEG patterns.

这些研究的目的是使用定量(q)脑电图技术对Angelman综合征(AS)儿童的数据进行谱功率分析,并评估其作为潜在的生物标志物和定量方法来评估治疗方法。虽然特征模式在目视检查中很明显,但使用qEEG技术有可能提供治疗效果的定量证据。我们首先评估了从AS儿童收集的基线脑电图记录的频谱功率,并将其与年龄匹配的神经典型对照进行比较,这证实了先前报道的发现,即AS儿童的δ功率升高导致总功率增加。然后,我们回顾性分析了在评估米诺环素(3mg /kg/d)的安全性和耐受性的临床试验中收集的数据,以比较治疗结束时AS儿童(4-12岁)的脑电图活动记录和洗净后的脑电图频谱功率和癫痫样事件。在基线和米诺环素治疗期间,AS受试者表现出增加的δ功率;然而,在米诺环素治疗后,AS受试者的脑电图频谱功率和癫痫样活动显著降低。我们的研究结果支持qEEG分析在评估AS中的应用,并表明该技术可能有助于评估AS的治疗效果。因此,脑电图功率正常化可能成为筛选治疗方法以衡量整体疗效的重要指标。随着治疗方法从临床前研究过渡到临床研究,建立能够定量评估具有独特脑电图模式的As和神经系统疾病的推定治疗方法的结果测量是至关重要的。
{"title":"Quantitative EEG Analysis in Angelman Syndrome: Candidate Method for Assessing Therapeutics.","authors":"Luis A Martinez,&nbsp;Heather A Born,&nbsp;Sarah Harris,&nbsp;Angelique Regnier-Golanov,&nbsp;Joseph C Grieco,&nbsp;Edwin J Weeber,&nbsp;Anne E Anderson","doi":"10.1177/1550059420973095","DOIUrl":"https://doi.org/10.1177/1550059420973095","url":null,"abstract":"<p><p>The goal of these studies was to use quantitative (q)EEG techniques on data from children with Angelman syndrome (AS) using spectral power analysis, and to evaluate this as a potential biomarker and quantitative method to evaluate therapeutics. Although characteristic patterns are evident in visual inspection, using qEEG techniques has the potential to provide quantitative evidence of treatment efficacy. We first assessed spectral power from baseline EEG recordings collected from children with AS compared to age-matched neurotypical controls, which corroborated the previously reported finding of increased total power driven by elevated delta power in children with AS. We then retrospectively analyzed data collected during a clinical trial evaluating the safety and tolerability of minocycline (3 mg/kg/d) to compare pretreatment recordings from children with AS (4-12 years of age) to EEG activity at the end of treatment and following washout for EEG spectral power and epileptiform events. At baseline and during minocycline treatment, the AS subjects demonstrated increased delta power; however, following washout from minocycline treatment the AS subjects had significantly reduced EEG spectral power and epileptiform activity. Our findings support the use of qEEG analysis in evaluating AS and suggest that this technique may be useful to evaluate therapeutic efficacy in AS. Normalizing EEG power in AS therefore may become an important metric in screening therapeutics to gauge overall efficacy. As therapeutics transition from preclinical to clinical studies, it is vital to establish outcome measures that can quantitatively evaluate putative treatments for AS and neurological disorders with distinctive EEG patterns.</p>","PeriodicalId":10682,"journal":{"name":"Clinical EEG and Neuroscience","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1550059420973095","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10550569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 10
Cerebral cortex Functional Networks of Transdermal Electrical Stimulation at Daling (PC7) Acupoint. 大陵穴经皮电刺激的大脑皮层功能网络。
IF 2 4区 医学 Q2 Medicine Pub Date : 2023-03-01 DOI: 10.1177/15500594221123692
Haili Wang, Ning Yin, Aoxiang Wang, Guizhi Xu

The cerebral cortex functional network of Electroencephalogram (EEG) signals during transcutaneous electrical acupoint stimulation (TEAS) on 21 healthy subjects was constructed by using three modules: standard low-resolution brain electromagnetic tomography (sLORETA), phase-locking value (PLV), and complex network. We investigated the brain functional network triggered by PC7 stimulation by comparing with resting state and non-acupoint stimulation. The results showed that the PC7 stimulation mainly activated frontal lobe and temporal lobe including prefrontal cortex (BA10), insular lobe (BA13), temporal gyrus (BA22), anterior cingulate cortex (BA32), temporal pole (BA38), dorsolateral prefrontal cortex (BA46), and inferior frontal cortex (BA47), which are all closely linked to cognition, spirit, and emotion in brain. Furthermore, the degrees of node in frontal, temporal, and whole brain are increased significantly or extreme significantly with p < 0.05, p < 0.05, and p < 0.01, respectively; clustering coefficient in frontal, temporal, and whole brain are all statistically significant (p < 0.05). The information transmission efficiency of cerebral cortex has been greatly improved. During PC7 stimulation, the topological changes in the activation of cerebral regions and cortical functional networks are consistent with the therapeutic effect, which may provide theoretical support for acupoint stimulation to regulate nerve function.

采用标准低分辨率脑电断层扫描(sLORETA)、锁相值(PLV)和复杂网络3个模块,构建21例健康人经皮穴位电刺激(TEAS)时脑电信号的大脑皮层功能网络。通过比较静息状态和非穴位刺激对PC7刺激触发的脑功能网络的影响。结果表明,PC7刺激主要激活额叶和颞叶,包括前额叶皮质(BA10)、岛叶(BA13)、颞回(BA22)、前扣带皮质(BA32)、颞极(BA38)、背外侧前额叶皮质(BA46)和下额叶皮质(BA47),这些区域与大脑的认知、精神和情感密切相关。此外,随着p p p p的增加,额叶、颞叶和全脑的结度显著或极显著增加
{"title":"Cerebral cortex Functional Networks of Transdermal Electrical Stimulation at Daling (PC7) Acupoint.","authors":"Haili Wang,&nbsp;Ning Yin,&nbsp;Aoxiang Wang,&nbsp;Guizhi Xu","doi":"10.1177/15500594221123692","DOIUrl":"https://doi.org/10.1177/15500594221123692","url":null,"abstract":"<p><p>The cerebral cortex functional network of Electroencephalogram (EEG) signals during transcutaneous electrical acupoint stimulation (TEAS) on 21 healthy subjects was constructed by using three modules: standard low-resolution brain electromagnetic tomography (sLORETA), phase-locking value (<i>PLV</i>), and complex network. We investigated the brain functional network triggered by PC7 stimulation by comparing with resting state and non-acupoint stimulation. The results showed that the PC7 stimulation mainly activated frontal lobe and temporal lobe including prefrontal cortex (BA10), insular lobe (BA13), temporal gyrus (BA22), anterior cingulate cortex (BA32), temporal pole (BA38), dorsolateral prefrontal cortex (BA46), and inferior frontal cortex (BA47), which are all closely linked to cognition, spirit, and emotion in brain. Furthermore, the degrees of node in frontal, temporal, and whole brain are increased significantly or extreme significantly with <i>p</i> < 0.05, <i>p</i> < 0.05, and <i>p</i> < 0.01, respectively; clustering coefficient in frontal, temporal, and whole brain are all statistically significant (<i>p</i> < 0.05). The information transmission efficiency of cerebral cortex has been greatly improved. During PC7 stimulation, the topological changes in the activation of cerebral regions and cortical functional networks are consistent with the therapeutic effect, which may provide theoretical support for acupoint stimulation to regulate nerve function.</p>","PeriodicalId":10682,"journal":{"name":"Clinical EEG and Neuroscience","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10551063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Religious Experience and Clinical-EEG Aspects in Adult People with Epilepsy. 成人癫痫患者的宗教体验与临床-脑电图。
IF 2 4区 医学 Q2 Medicine Pub Date : 2023-03-01 DOI: 10.1177/15500594211050493
Gloria M A S Tedrus, Letícia M Vargas, Karen G Rodrigues

Spirituality and religiosity are complex cognitive phenomena; however, the relationship between spiritual experiences and epilepsy continues to be debated. Methods. Data from the daily spiritual experience scale (DSES) were related to EEG data and clinical variables of 100 adult people with epilepsy (PWEs). DSES scores were compared to 51 normal individuals (control group [CG]), with a significance level of P < .05. Results. The total score in the DSES was 36.1 ± 14 and 37.6 ± 13.2, respectively, in the PWEs and in the CG. In the PWEs, there was a correlation between DSES and age (Pearson's correlation; -0.22; P = .027) and educational level (0.207; P = .039). PWEs with ≥one seizure/month have a lower frequency of daily spiritual experiences than those with better controlled seizures (T-test; 39.2 ± 16.2 vs 31.7 ± 7.6; P = .038). EEG epileptiform activity (EA) in the right hemisphere was associated with a higher frequency of spiritual experiences than those with left-hemisphere EA (29.8 ± 9.0 vs 38.5 ± 17.5; P = .010). Conclusion. Demographic aspects, EA in the right hemisphere, and lower seizure frequency are associated with daily spiritual experiences in epilepsy, suggesting an association between aspects of spirituality, epilepsy, and neurobiological correlates.

精神性和宗教性是复杂的认知现象;然而,精神体验和癫痫之间的关系仍在争论中。方法。将100例成人癫痫患者的日常精神体验量表(DSES)数据与脑电图数据及临床变量进行关联分析。与51例正常人(对照组[CG])进行DSES评分比较,差异有统计学意义(P)。DSES总分为36.1±14分,pwe总分为37.6±13.2分,CG总分为37.6±13.2分。在pwe中,DSES与年龄之间存在相关性(Pearson’s correlation;-0.22;P = 0.027)和教育水平(0.207;p = .039)。癫痫发作≥1次/月的pwe患者每日精神体验频率低于癫痫发作控制较好的患者(t检验;39.2±16.2 vs 31.7±7.6;p = .038)。右半球脑电图癫痫样活动(EA)与精神体验频率的相关性高于左半球脑电图癫痫样活动(29.8±9.0 vs 38.5±17.5;p = .010)。结论。人口统计学方面、右半球EA和较低的癫痫发作频率与癫痫患者的日常精神体验有关,表明精神、癫痫和神经生物学相关方面之间存在关联。
{"title":"Religious Experience and Clinical-EEG Aspects in Adult People with Epilepsy.","authors":"Gloria M A S Tedrus,&nbsp;Letícia M Vargas,&nbsp;Karen G Rodrigues","doi":"10.1177/15500594211050493","DOIUrl":"https://doi.org/10.1177/15500594211050493","url":null,"abstract":"<p><p>Spirituality and religiosity are complex cognitive phenomena; however, the relationship between spiritual experiences and epilepsy continues to be debated. <i>Methods</i>. Data from the daily spiritual experience scale (DSES) were related to EEG data and clinical variables of 100 adult people with epilepsy (PWEs). DSES scores were compared to 51 normal individuals (control group [CG]), with a significance level of <i>P</i> < .05. <i>Results</i>. The total score in the DSES was 36.1 ± 14 and 37.6 ± 13.2, respectively, in the PWEs and in the CG. In the PWEs, there was a correlation between DSES and age (Pearson's correlation; -0.22; <i>P</i> = .027) and educational level (0.207; <i>P</i> = .039). PWEs with ≥one seizure/month have a lower frequency of daily spiritual experiences than those with better controlled seizures (<i>T</i>-test; 39.2 ± 16.2 vs 31.7 ± 7.6; <i>P</i> = .038). EEG epileptiform activity (EA) in the right hemisphere was associated with a higher frequency of spiritual experiences than those with left-hemisphere EA (29.8 ± 9.0 vs 38.5 ± 17.5; <i>P</i> = .010). <i>Conclusion</i>. Demographic aspects, EA in the right hemisphere, and lower seizure frequency are associated with daily spiritual experiences in epilepsy, suggesting an association between aspects of spirituality, epilepsy, and neurobiological correlates.</p>","PeriodicalId":10682,"journal":{"name":"Clinical EEG and Neuroscience","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10493876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Effects of Concentrative Meditation on the Electroencephalogram in Novice Meditators. 集中冥想对初学冥想者脑电图的影响。
IF 2 4区 医学 Q2 Medicine Pub Date : 2023-03-01 DOI: 10.1177/15500594211065897
Alexander T Duda, Adam R Clarke, Frances M De Blasio, Thomas W Rout, Robert J Barry

Following investigations into the benefits of meditation on psychological health and well-being, research is now seeking to understand the mechanisms underlying these outcomes. This study aimed to identify natural alpha and theta frequency components during eyes-closed resting and concentrative meditation states and examined their differences within and between two testing sessions. Novice meditators had their EEG recorded during eyes-closed resting and concentrative meditation conditions, before and after engaging in a brief daily concentrative meditation practice for approximately one-month. Separate frequency Principal Components Analyses (f-PCA) yielded four spectral components of interest, congruent between both conditions and sessions: Delta-Theta-Alpha, Low Alpha, High Alpha, and Alpha-Beta. While all four components showed some increase in the meditation condition at the second session, only Low Alpha (∼9.5-10.0 Hz) showed similar increases while resting. These findings support the use of f-PCA as a novel method of data analysis in the investigation of psychophysiological states in meditation.

在调查了冥想对心理健康和幸福的好处之后,现在的研究正在寻求理解这些结果背后的机制。本研究旨在确定闭眼休息和集中冥想状态下的自然α和θ频率成分,并检查它们在两个测试阶段内和之间的差异。研究人员记录了冥想新手在闭眼休息和集中冥想状态下的脑电图,在进行为期大约一个月的简短的日常集中冥想练习之前和之后。独立频率主成分分析(f-PCA)产生了四个感兴趣的频谱成分,在两个条件和会话之间是一致的:Delta-Theta-Alpha, Low -Alpha, High -Alpha和Alpha- beta。虽然在第二阶段的冥想条件下,所有四个成分都显示出一些增加,但只有低α (~ 9.5-10.0 Hz)在休息时显示出类似的增加。这些发现支持使用f-PCA作为一种新的数据分析方法来研究冥想中的心理生理状态。
{"title":"The Effects of Concentrative Meditation on the Electroencephalogram in Novice Meditators.","authors":"Alexander T Duda,&nbsp;Adam R Clarke,&nbsp;Frances M De Blasio,&nbsp;Thomas W Rout,&nbsp;Robert J Barry","doi":"10.1177/15500594211065897","DOIUrl":"https://doi.org/10.1177/15500594211065897","url":null,"abstract":"<p><p>Following investigations into the benefits of meditation on psychological health and well-being, research is now seeking to understand the mechanisms underlying these outcomes. This study aimed to identify natural alpha and theta frequency components during eyes-closed resting and concentrative meditation states and examined their differences within and between two testing sessions. Novice meditators had their EEG recorded during eyes-closed resting and concentrative meditation conditions, before and after engaging in a brief daily concentrative meditation practice for approximately one-month. Separate frequency Principal Components Analyses (f-PCA) yielded four spectral components of interest, congruent between both conditions and sessions: Delta-Theta-Alpha, Low Alpha, High Alpha, and Alpha-Beta. While all four components showed some increase in the meditation condition at the second session, only Low Alpha (∼9.5-10.0 Hz) showed similar increases while resting. These findings support the use of f-PCA as a novel method of data analysis in the investigation of psychophysiological states in meditation.</p>","PeriodicalId":10682,"journal":{"name":"Clinical EEG and Neuroscience","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10495226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
The Effect of dry Needling in Chronic Stroke with a complex Network Approach: A Case Study. 干针治疗慢性脑卒中的复杂网络效应:个案研究。
IF 2 4区 医学 Q2 Medicine Pub Date : 2023-03-01 DOI: 10.1177/15500594221120136
Borhan Asadi, Kheirollah Rahsepar Fard, Noureddin Nakhostin Ansari, Álvaro Marco, Sandra Calvo, Pablo Herrero

Background: Dry Needling (DN) has been demonstrated to be effective in improving sensorimotor function and spasticity in patients with chronic stroke. Electroencephalogram (EEG) has been used to analyze if DN has effects on the central nervous system of patients with stroke. There are no studies on how DN works in patients with chronic stroke based on EEG analysis using complex networks. Objective: The aim of this study was to assess how DN works when it is applied in a patient with stroke, using the graph theory. Methods: One session of DN was applied to the spastic brachialis muscle of a 62-year-old man with right hemiplegia after stroke. EEG was used to analyze the effects of DN following metrics that measure the topological configuration: 1) network density, 2) clustering coefficient, 3) average shortest path length, 4) betweenness centrality, and 5) small-worldness. Measurements were taken before and during DN. Results: An improvement of the brain activity was observed in this patient with stroke after the application of DN, which led to variations of local parameters of the brain network in the delta, theta and alpha bands, and inclined towards those of the healthy control bands. Conclusions: This case study showed the positive effects of DN on brain network of a patient with chronic stroke.

背景:干针(DN)已被证明对改善慢性脑卒中患者的感觉运动功能和痉挛是有效的。脑电图(EEG)已被用于分析DN是否对脑卒中患者的中枢神经系统有影响。目前还没有基于复杂网络的脑电图分析来研究DN在慢性脑卒中患者中的作用。目的:本研究的目的是评估如何工作时,DN应用于中风患者,使用图论。方法:对62岁右偏瘫脑卒中后痉挛性肱肌进行一期DN治疗。采用EEG分析DN对拓扑结构的影响:1)网络密度,2)聚类系数,3)平均最短路径长度,4)中间性中心性,5)小世界性。在DN之前和DN期间进行测量。结果:该脑卒中患者应用DN后脑活动有所改善,导致delta、theta和alpha波段脑网络局部参数发生变化,向健康对照带倾斜。结论:本病例研究显示DN对慢性脑卒中患者脑网络的积极作用。
{"title":"The Effect of dry Needling in Chronic Stroke with a complex Network Approach: A Case Study.","authors":"Borhan Asadi,&nbsp;Kheirollah Rahsepar Fard,&nbsp;Noureddin Nakhostin Ansari,&nbsp;Álvaro Marco,&nbsp;Sandra Calvo,&nbsp;Pablo Herrero","doi":"10.1177/15500594221120136","DOIUrl":"https://doi.org/10.1177/15500594221120136","url":null,"abstract":"<p><p><i>Background:</i> Dry Needling (DN) has been demonstrated to be effective in improving sensorimotor function and spasticity in patients with chronic stroke. Electroencephalogram (EEG) has been used to analyze if DN has effects on the central nervous system of patients with stroke. There are no studies on how DN works in patients with chronic stroke based on EEG analysis using complex networks. <i>Objective</i>: The aim of this study was to assess how DN works when it is applied in a patient with stroke, using the graph theory. <i>Methods:</i> One session of DN was applied to the spastic brachialis muscle of a 62-year-old man with right hemiplegia after stroke. EEG was used to analyze the effects of DN following metrics that measure the topological configuration: 1) network density, 2) clustering coefficient, 3) average shortest path length, 4) betweenness centrality, and 5) small-worldness. Measurements were taken before and during DN. <i>Results:</i> An improvement of the brain activity was observed in this patient with stroke after the application of DN, which led to variations of local parameters of the brain network in the delta, theta and alpha bands, and inclined towards those of the healthy control bands. <i>Conclusions:</i> This case study showed the positive effects of DN on brain network of a patient with chronic stroke.</p>","PeriodicalId":10682,"journal":{"name":"Clinical EEG and Neuroscience","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10861623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Towards Robust, Reproducible, and Clinically Actionable EEG Biomarkers: Large Open Access EEG Database for Discovery and Out-of-sample Validation. 迈向稳健、可重复和临床可操作的脑电图生物标志物:用于发现和样本外验证的大型开放访问脑电图数据库。
IF 2 4区 医学 Q2 Medicine Pub Date : 2023-03-01 DOI: 10.1177/15500594221120516
Hanneke van Dijk, Mark Koppenberg, Martijn Arns
Recently, one of the most impactful neuroscience findings that forms a fundament of the amyloid hypothesis of Alzheimer was called into question after evidence was presented about image tampering of Western Blots (see for full overview). A 2006 Nature paper which reported that Aβ clumps, also known as plaques, in brain tissue are the primary cause of Azheimer’s symptoms, formed a key piece of evidence of this well-known amyloid hypothesis. The image tampering was not only found in the 2006 study, follow-up investigations uncovered 100’s of doctored images, including at least 70 from the original group, calling much of the evidence behind the amyloid hypothesis into question. This means that research on Alzheimer’s has been misdirected for >16 years, billions of research dollars mis-spent and probably a multitude of that amount spent by the pharmacological industry on development of drugs targeting plaques, for which recently many failed clinical trials were reported. But above all, it led to a lack of progress in improvement of treatments for those patients who need it most. This shocking discovery calls for action and a change in the way we evaluate biomarkers in general, but also within the field of psychophysiology and EEG biomarkers, where many biomarker-studies suffer from small sample sizes as well as a lack of (out-of-sample) validation, rendering them statistically underpowered and the biomarkers unapplicable in practice. As for our own EEG-examples, we now know that various meta-analyses have failed to confirm some of the most wellknown diagnostic EEG biomarkers, such as theta-beta ratio (TBR) in ADHD and frontal alpha asymmetry (FAA) in MDD. This latter meta-analysis indicated earlier conclusions on FAA were driven by underpowered studies, and that only sample sizes of >200 yielded biologically plausible effects. Therefore, large datasets are necessary for meaningful biomarker discovery. Unfortunately, we’ve experienced not being able to replicate our own research ourselves as well. In 2012, we reported on three biomarkers that predicted non-response to rTMS in depression: high fronto-central theta, a low individual alpha peak frequency (iAPF), and a large P300 amplitude at site Pz. Our sample comprised 90 MDD patients, however, in a new sample of 106 patients, replication failed for all three biomarkers. This disappointing experience prompted us to only publish on biomarkers when we conduct out-of-sample validation and replication. The most recent example was Brainmarker-I as a treatment stratification biomarker in ADHD, that included a total of 4249 EEG’s to develop the biomarker, two datasets (N = 472) to investigate its predictive value, and three independent datasets (N = 336) for blinded-out-of-sample validation where predictions of the biomarker are confirmed by an external researcher not involved in the data-analysis. In addition, together with a group of EEG research colleagues, we established the International Consortium on Ne
{"title":"Towards Robust, Reproducible, and Clinically Actionable EEG Biomarkers: Large Open Access EEG Database for Discovery and Out-of-sample Validation.","authors":"Hanneke van Dijk,&nbsp;Mark Koppenberg,&nbsp;Martijn Arns","doi":"10.1177/15500594221120516","DOIUrl":"https://doi.org/10.1177/15500594221120516","url":null,"abstract":"Recently, one of the most impactful neuroscience findings that forms a fundament of the amyloid hypothesis of Alzheimer was called into question after evidence was presented about image tampering of Western Blots (see for full overview). A 2006 Nature paper which reported that Aβ clumps, also known as plaques, in brain tissue are the primary cause of Azheimer’s symptoms, formed a key piece of evidence of this well-known amyloid hypothesis. The image tampering was not only found in the 2006 study, follow-up investigations uncovered 100’s of doctored images, including at least 70 from the original group, calling much of the evidence behind the amyloid hypothesis into question. This means that research on Alzheimer’s has been misdirected for >16 years, billions of research dollars mis-spent and probably a multitude of that amount spent by the pharmacological industry on development of drugs targeting plaques, for which recently many failed clinical trials were reported. But above all, it led to a lack of progress in improvement of treatments for those patients who need it most. This shocking discovery calls for action and a change in the way we evaluate biomarkers in general, but also within the field of psychophysiology and EEG biomarkers, where many biomarker-studies suffer from small sample sizes as well as a lack of (out-of-sample) validation, rendering them statistically underpowered and the biomarkers unapplicable in practice. As for our own EEG-examples, we now know that various meta-analyses have failed to confirm some of the most wellknown diagnostic EEG biomarkers, such as theta-beta ratio (TBR) in ADHD and frontal alpha asymmetry (FAA) in MDD. This latter meta-analysis indicated earlier conclusions on FAA were driven by underpowered studies, and that only sample sizes of >200 yielded biologically plausible effects. Therefore, large datasets are necessary for meaningful biomarker discovery. Unfortunately, we’ve experienced not being able to replicate our own research ourselves as well. In 2012, we reported on three biomarkers that predicted non-response to rTMS in depression: high fronto-central theta, a low individual alpha peak frequency (iAPF), and a large P300 amplitude at site Pz. Our sample comprised 90 MDD patients, however, in a new sample of 106 patients, replication failed for all three biomarkers. This disappointing experience prompted us to only publish on biomarkers when we conduct out-of-sample validation and replication. The most recent example was Brainmarker-I as a treatment stratification biomarker in ADHD, that included a total of 4249 EEG’s to develop the biomarker, two datasets (N = 472) to investigate its predictive value, and three independent datasets (N = 336) for blinded-out-of-sample validation where predictions of the biomarker are confirmed by an external researcher not involved in the data-analysis. In addition, together with a group of EEG research colleagues, we established the International Consortium on Ne","PeriodicalId":10682,"journal":{"name":"Clinical EEG and Neuroscience","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10699791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
期刊
Clinical EEG and Neuroscience
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1