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P300 Following Four Voluntarily Regulated Yoga Breathing Practices and Breath Awareness. P300遵循四个自愿调节的瑜伽呼吸练习和呼吸意识。
IF 2 4区 医学 Q3 CLINICAL NEUROLOGY Pub Date : 2023-03-01 DOI: 10.1177/15500594221089369
Niranjan Kala, Shirley Telles, Sachin Kumar Sharma, Acharya Balkrishna

Attention was influenced by yoga breathing in previously published research. Each yoga breathing practice uniquely modifies specific breath characteristics. Differences in the study designs, assessment methods and interventions resulted in difficulty in comparing effects between yoga breathing practices. This study aimed (i) to compare four yoga breathing practices on attention using an auditory oddball task and (ii) to determine cardiac autonomic activity associated with attention using heart rate variability. P300 event related potential was recorded simultaneously with heart rate variability before and after 18-minute periods each of (i) high frequency yoga breathing (with increased breath frequency), (ii) bellows yoga breathing (with increased depth of respiration), (iii) alternate nostril yoga breathing (with alternate nostril patency), (iv) bumblebee yoga breathing (with prolonged exhale), (v) breath awareness (with attention to the breath) and (vi) quiet seated rest as control in 38 yoga experienced males (average age ± SD; 24.08 ± 4.01 years). The six sessions were on separate, randomly allocated days. The P300 peak amplitude recorded at Pz was significantly increased after four yoga breathing practices (Bonferroni adjusted post-hoc tests, repeated measures ANOVA). No significant changes were noted in heart rate variability following yoga breathing or control sessions. These findings suggest that the four yoga breathing practices increase the attentional neural resources engaged for this auditory oddball task, irrespective of the characteristic of breath uniquely regulated in the four yoga breathing practices.

在先前发表的研究中,注意力受到瑜伽呼吸的影响。每个瑜伽呼吸练习都独特地修改特定的呼吸特征。研究设计、评估方法和干预措施的差异导致很难比较瑜伽呼吸练习的效果。本研究的目的是(i)比较四种瑜伽呼吸练习对注意力的影响,使用听觉怪球任务;(ii)使用心率变异性来确定与注意力相关的心脏自主神经活动。同时记录P300事件相关电位与心率变异性分别在(i)高频瑜伽呼吸(呼吸频率增加),(ii)风箱瑜伽呼吸(呼吸深度增加),(iii)交替鼻孔瑜伽呼吸(交替鼻孔开放),(iv)大黄蜂瑜伽呼吸(呼气时间延长),(v)呼吸意识(注意呼吸)和(vi)安静坐着休息作为对照,38名有瑜伽经验的男性(平均年龄±SD;(24.08±4.01年)。这六次会议分别在随机分配的日期进行。四次瑜伽呼吸练习后,P300在Pz记录的峰值幅度显著增加(Bonferroni调整后的事后检验,重复测量方差分析)。在瑜伽呼吸或控制课程后,心率变异性没有明显变化。这些发现表明,四种瑜伽呼吸练习增加了参与这种听觉怪异任务的注意力神经资源,而不考虑四种瑜伽呼吸练习中独特调节的呼吸特征。
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引用次数: 2
A Class Activation Map-Based Interpretable Transfer Learning Model for Automated Detection of ADHD from fMRI Data. 基于类激活图的可解释迁移学习模型用于fMRI数据的ADHD自动检测。
IF 2 4区 医学 Q3 CLINICAL NEUROLOGY Pub Date : 2023-03-01 DOI: 10.1177/15500594221122699
Caglar Uyulan, Turker Tekin Erguzel, Omer Turk, Shams Farhad, Baris Metin, Nevzat Tarhan

Automatic detection of Attention Deficit Hyperactivity Disorder (ADHD) based on the functional Magnetic Resonance Imaging (fMRI) through Deep Learning (DL) is becoming a quite useful methodology due to the curse of-dimensionality problem of the data is solved. Also, this method proposes an invasive and robust solution to the variances in data acquisition and class distribution imbalances. In this paper, a transfer learning approach, specifically ResNet-50 type pre-trained 2D-Convolutional Neural Network (CNN) was used to automatically classify ADHD and healthy children. The results demonstrated that ResNet-50 architecture with 10-k cross-validation (CV) achieves an overall classification accuracy of 93.45%. The interpretation of the results was done via the Class Activation Map (CAM) analysis which showed that children with ADHD differed from controls in a wide range of brain areas including frontal, parietal and temporal lobes.

由于解决了数据的维数诅咒问题,基于功能磁共振成像(fMRI)的深度学习自动检测注意缺陷多动障碍(ADHD)已成为一种非常有用的方法。此外,该方法还提供了一种侵入性和鲁棒性的解决方案,以解决数据采集的差异和类分布的不平衡。本文采用迁移学习方法,即ResNet-50型预训练2d -卷积神经网络(CNN)对ADHD儿童和健康儿童进行自动分类。结果表明,采用10-k交叉验证(CV)的ResNet-50架构,总体分类准确率达到93.45%。对结果的解释是通过班级激活图(CAM)分析完成的,该分析显示多动症儿童在包括额叶、顶叶和颞叶在内的广泛的大脑区域与对照组不同。
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引用次数: 2
When to Choose Paroxetine Treatment in Skin-Picking Disorder: A Case Report. 何时选择帕罗西汀治疗抠皮障碍:一例报告。
IF 2 4区 医学 Q3 CLINICAL NEUROLOGY Pub Date : 2023-03-01 DOI: 10.1177/15500594211073390
Mehmet K Arıkan, Muazzez Ç Oba, Reyhan İlhan, Mehmet C Mat

Skin picking disorder (SPD) characterized by repetitive compulsive scratching in the absence of a primary skin disease is strongly associated with psychiatric comorbidities, including obsessive-compulsive disorder (OCD) and depression (MDD). Selective serotonin reuptake inhibitors (SSRIs) have been used in the treatment of SPD with variable success. Nevertheless, the optimum treatment choice for SPD is an issue for clinicians. This case report presents a 32-year-old female SPD patient treated with four-week paroxetine monotherapy. Based upon the clinical interview and standardized questionnaires, the patient was diagnosed with OCD with depressive features and Skin Picking Disorder. In addition to symptom severity scales, quantitative electroencephalography (qEEG) was also applied. Paroxetine treatment was started (titrated from 5 to 40 mg/day) and doubled each week. After four-week paroxetine monotherapy, OCD symptoms were diminished, and skin lesions were completely regressed leaving solely post inflammatory hyperpigmentation. Post-treatment qEEG assessment also showed a normalization of frontal alpha power and amplitude asymmetry. It can be concluded that if OCD includes SPD with abnormal EEG patterns; then the treatment success using paroxetine will be very high.

在没有原发性皮肤病的情况下,以重复性强迫性抓挠为特征的抠皮障碍(SPD)与精神合并症(包括强迫症(OCD)和抑郁症(MDD))密切相关。选择性5 -羟色胺再摄取抑制剂(SSRIs)已被用于治疗SPD的不同的成功。然而,SPD的最佳治疗选择对临床医生来说是一个问题。本病例报告为一32岁女性SPD患者,接受四周的帕罗西汀单药治疗。根据临床访谈和标准化问卷,诊断为强迫症伴抑郁特征和采摘皮肤障碍。除症状严重程度量表外,还应用定量脑电图(qEEG)。开始帕罗西汀治疗(从5毫克/天滴定至40毫克/天),每周加倍。帕罗西汀单药治疗4周后,强迫症症状减轻,皮肤病变完全消退,仅留下炎症性色素沉着。治疗后的qEEG评估也显示额叶α功率归一化和幅度不对称。结论:如果强迫症包括SPD伴异常脑电图;那么使用帕罗西汀治疗的成功率会很高。
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引用次数: 0
EEG - Imaging Evolution of the MV2 Subtype of Sporadic Creutzfeldt-Jakob Disease During the two-Year Course of the Disease. 散发性克雅病MV2亚型在2年病程中的脑电图成像演变
IF 2 4区 医学 Q3 CLINICAL NEUROLOGY Pub Date : 2023-03-01 DOI: 10.1177/15500594221101628
Afrantou Theodora, Syntila Styliani-Aggeliki, Ioannidis Panagiotis, Sklaviadis Theodoros, Boziki Marina, Grigoriadis Nikolaos

Sporadic Creutzfeldt-Jakob disease (sCJD) is a rare transmissible disease. According to molecular classification, six clinical phenotypes of sCJD have been described: MM1, MM2, MV1, MV2, VV1 and VV2. MV2 subtype comprises 9% of sCJD cases. Atypical clinical course has been reported to be the main caveat for the diagnosis of the MV2 subtype. We hereby present a rare case of MV2 subtype of sCJD, highlighting the evolution of clinical, EEG and imaging attributes over a two-year period, thus underlining the atypical course of the disease.

散发克雅氏病(sCJD)是一种罕见的传染性疾病。根据分子分类,sCJD有六种临床表型:MM1、MM2、MV1、MV2、VV1和VV2。MV2亚型占sCJD病例的9%。据报道,非典型临床病程是诊断MV2亚型的主要警告。我们在此报告一例罕见的MV2亚型sCJD,突出了两年期间临床,脑电图和影像学属性的演变,从而强调了该疾病的非典型病程。
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引用次数: 0
Reflection of the Ictal Electrocorticographic Discharges Confined to the Medial Temporal Lobe to the Scalp-Recorded Electroencephalogram. 局限于内侧颞叶的颅皮质电图放电在头皮记录脑电图上的反映。
IF 2 4区 医学 Q3 CLINICAL NEUROLOGY Pub Date : 2023-03-01 DOI: 10.1177/15500594211062702
Nobutaka Mukae, Takafumi Shimogawa, Ayumi Sakata, Taira Uehara, Hiroshi Shigeto, Koji Yoshimoto, Takato Morioka

Objective: Previous reports on the simultaneous recording of electroencephalography (EEG) and electrocorticography (ECoG) have demonstrated that, in patients with temporal lobe epilepsy (TLE), ictal ECoG discharges with an amplitude as high as 1000 μV originating from the medial temporal lobe could not be recorded on EEG. In contrast, ictal EEG discharges were recorded after ictal ECoG discharges propagated to the lateral temporal lobe. Here, we report a case of TLE in which the ictal EEG discharges, corresponding to ictal ECoG discharges confined to the medial temporal lobe, were recorded. Case report: In the present case, ictal EEG discharges were hardly recognized when the amplitude of the ECoG discharges was less than 1500 μV. During the evolution and burst suppression phase, corresponding to highly synchronized ECoG discharges with amplitudes greater than 1500 to 2000 μV, rhythmic negative waves with the same frequency were clearly recorded both on the lateral temporal lobe and scalp. The amplitude of the lateral temporal ECoG was approximately one-tenth of that of the medial temporal ECoG. The amplitude of the scalp EEG was approximately one-tenth of that of the lateral temporal ECoG. Conclusions: Highly synchronized ictal ECoG discharges with high amplitude of greater than 1500 to 2000 μV in the medial temporal lobe could be recorded on the scalp as ictal EEG discharges via volume conduction.

目的:以往关于同时记录脑电图(EEG)和皮质电图(ECoG)的报道表明,在颞叶癫痫(TLE)患者中,脑电图上无法记录到来自内侧颞叶的振幅高达1000 μV的脑电图放电。相反,在脑电图放电传播到外侧颞叶后,记录脑电图的初始放电。在这里,我们报告了一例TLE病例,其中记录了与局限于内侧颞叶的颅侧脑电图相对应的颅侧脑电图。病例报告:本病例中,当脑电图放电幅度小于1500 μV时,脑电图初期放电难以识别。在演化和爆发抑制阶段,对应于脑电图高度同步放电,振幅大于1500 ~ 2000 μV,颞外侧叶和头皮均明显记录到相同频率的节律性负波。外侧颞叶ECoG的振幅约为内侧颞叶ECoG的十分之一。头皮脑电图的振幅约为外侧颞叶脑电图的十分之一。结论:脑内颞叶高度同步且振幅大于1500 ~ 2000 μV的脑电图放电可作为脑容量传导的脑电图放电记录在头皮上。
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引用次数: 1
Special Issue: Mild Cognitive Impairment. 特刊:轻度认知障碍。
IF 2 4区 医学 Q3 CLINICAL NEUROLOGY Pub Date : 2023-01-01 DOI: 10.1177/15500594221132662
Norman C Moore
Mild Cognitive Impairment (MCI) is found in Alzheimer ’ s disease (ADMCI), Parkinson ’ s disease (PDMCI), Lewy body dementia, cerebrovascular disease (Brad fi eld 1 ), sleep apnea and insomnia (Gilley 2 ). Studies have shown that monoclonal antibody treatment removes amyloid plaques from the AD brain. However, this did not result in clinical improvement in moderate and severe AD. One explanation was that the brain cells were already too damaged. Subsequent studies of mild AD and ADMCI suggested some bene fi t by reducing amyloid before the brain was too damaged. In June 2021, this led to the FDA approval of the monoclonal antibody, aducanumab, for the treatment of mild AD and ADMCI. This MCI Special Issue is timely, because the FDA approval of aducanumab has led to increased interest in ADMCI.
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引用次数: 0
Unusual EEG Artifact in Patients with DBS. DBS患者异常的脑电图伪影。
IF 2 4区 医学 Q3 CLINICAL NEUROLOGY Pub Date : 2022-11-01 Epub Date: 2021-12-03 DOI: 10.1177/15500594211063710
Maria Baldwin, Sydney Palka, Donna Leppla, Bethany Hollis, Anne C Van Cott, James F Castellano
Use of deep brain stimulation (DBS) technology has expanded over the past decade and is currently employed for treatment of various movement disorders such as Parkinson disease, tremors, dystonia, and epilepsy. A high frequency artifact has been well described on electroencephalograms (EEGs) of patients with DBS and is considered a result of the electrical nature of the stimulation. We present 3 cases of an unusually slow frequency and rhythmic artifact in DBS patients. This unfamiliar artifact could be mistaken for an ictal pattern, especially in patients with altered sensorium. Recognition of this novel artifact will minimize misinterpretation and potential unnecessary treatment.
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引用次数: 1
Erratum to Association Study Between White Matter Microstructure and Intelligence Decline in Schizophrenia. 精神分裂症患者脑白质微结构与智力下降相关性研究的勘误
IF 2 4区 医学 Q3 CLINICAL NEUROLOGY Pub Date : 2022-11-01 Epub Date: 2022-04-04 DOI: 10.1177/15500594221084258
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引用次数: 0
Treating Severe Traumatic Brain Injury: Combining Neurofeedback and Hyperbaric Oxygen Therapy in a Single Case Study. 治疗严重创伤性脑损伤:结合神经反馈和高压氧治疗在一个案例研究。
IF 2 4区 医学 Q3 CLINICAL NEUROLOGY Pub Date : 2022-11-01 Epub Date: 2021-12-21 DOI: 10.1177/15500594211068255
Rebecca D White, Robert P Turner, Noah Arnold, Annie Bernica, Brigitte N Lewis, Ronald J Swatzyna

In 2014, a 26-year-old male was involved in a motor vehicle accident resulting in a severe traumatic brain injury (TBI). The patient sustained a closed-head left temporal injury with coup contrecoup impact to the frontal region. The patient underwent a left side craniotomy and was comatose for 26 days. After gaining consciousness, he was discharged to a brain injury treatment center that worked with physical, speech, and occupational issues. He was discharged after eight months with significant speech, ambulation, spasticity, and cognitive issues as well as the onset of posttraumatic epilepsy. His parents sought hyperbaric oxygen treatment (HBOT) from a doctor in Louisiana. After 165 dives, the HBOT doctor recommended an addition of neurofeedback (NFB) therapy. In March 2019 the patient started NFB therapy intermixed with HBOT. The combination of NFB and HBOT improved plasticity and functionality in the areas of injury and the correlated symptoms including short-term memory, personality, language, and executive function, as well as significantly reducing the incidence of seizures. Severe brain injuries often leave lasting deficits with little hope for major recovery and there is a need for further research into long-term, effective neurological treatments for severe brain injuries. These results suggest that HBOT combined with NFB may be a viable option in treating severe brain injuries and should be investigated.

2014年,一名26岁的男性在一场机动车事故中导致严重的创伤性脑损伤(TBI)。患者头部左侧颞叶闭合性损伤,额叶区域有偶发撞击。患者接受左侧开颅手术,昏迷26天。在恢复意识后,他被送往脑损伤治疗中心,该中心处理身体、语言和职业问题。8个月后出院,伴有明显的言语、行走、痉挛和认知问题,以及创伤后癫痫的发作。他的父母向路易斯安那州的医生寻求高压氧治疗(HBOT)。165次潜水后,HBOT医生建议增加神经反馈(NFB)疗法。2019年3月,患者开始了NFB混合HBOT治疗。NFB和HBOT的结合改善了损伤区域的可塑性和功能,以及包括短期记忆、人格、语言和执行功能在内的相关症状,并显著降低了癫痫发作的发生率。严重的脑损伤通常会留下持久的缺陷,几乎没有恢复的希望,因此需要进一步研究对严重脑损伤进行长期有效的神经学治疗。这些结果表明HBOT联合NFB可能是治疗严重脑损伤的可行选择,值得研究。
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引用次数: 2
QEEG Biomarkers for ECT Treatment Response in Schizophrenia. 精神分裂症ECT治疗反应的QEEG生物标志物。
IF 2 4区 医学 Q3 CLINICAL NEUROLOGY Pub Date : 2022-11-01 Epub Date: 2021-11-18 DOI: 10.1177/15500594211058260
Jiayue Cheng, Yanyan Ren, Qiumeng Gu, Yongguang He, Zhen Wang

Background: Electroconvulsive therapy (ECT) is a clinically effective treatment for schizophrenia (SZD). However, studies have shown that only about 50 to 80% of patients show response to ECT. To identify the most suitable patients for ECT, developing biomarkers predicting ECT response remains an important goal. This study aimed to explore the quantitative electroencephalography (QEEG) biomarkers to predict ECT efficacy. Methods: Thirty patients who met DSM-5 criteria for SZD and had been assigned to ECT were recruited. 32-lead Resting-EEG recordings were collected one hour before the initial ECT treatment. Positive and negative symptoms scale (PANSS) was assessed at baseline and after the eighth ECT session. EEG data were analyzed using mutual information. Results: In the brain network density threshold range of 0.05 to 0.2, the assortativity of the right temporal, right parietal, and right occipital cortex in the response group was significantly higher than that in the non-response group (p<.05) in the beta band. In the theta band, the left frontal, parietal, right occipital cortex, and central area assortativity were higher in the response group than in the non-response group (p<.05). Conclusions: QEEG might be a useful approach to identify the candidate biomarker for ECT in clinical practice.

背景:电痉挛治疗(ECT)是一种临床有效的治疗精神分裂症(SZD)的方法。然而,研究表明,只有大约50%到80%的患者对ECT有反应。为了确定最适合ECT的患者,开发预测ECT反应的生物标志物仍然是一个重要的目标。本研究旨在探讨定量脑电图(QEEG)生物标志物预测ECT疗效。方法:招募30例符合DSM-5标准的SZD患者,并分配电痉挛治疗。32导联静息脑电图记录采集于ECT治疗前1小时。在基线和第八次电痉挛治疗后评估阳性和阴性症状量表(PANSS)。利用互信息分析脑电数据。结果:在0.05 ~ 0.2的脑网络密度阈值范围内,反应组的右颞叶、右顶叶和右枕叶皮质在β波段的匹配性显著高于非反应组(p . 0.05)。在θ波段,反应组的左额叶、顶叶、右枕叶皮层和中央区域的协调性高于无反应组(p . 0.05)。结论:在临床实践中,QEEG可能是确定ECT候选生物标志物的有效方法。
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引用次数: 0
期刊
Clinical EEG and Neuroscience
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