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Effect of Sleep on Epileptic Discharges in Patients with Idiopathic Generalized Epilepsy. 睡眠对特发性全身性癫痫患者癫痫放电的影响。
IF 2 4区 医学 Q2 Medicine Pub Date : 2023-09-01 DOI: 10.1177/15500594221083256
Mustafa Emir Tavşanlı, Demet Kınay

Background. It is known that sleep and sleep deprivation affect the EEG findings, onset, frequency and semiology of the seizures. Generalized spike and wave discharges were found more common in drowsiness and sleep states, especially in childhood and juvenile absence epilepsy syndromes. Aim. In this study we aimed to show the effects of short sleep on the interictal and ictal discharges of the patients with genetic generalized epileptic seizures and to show the effects of treatment on the discharges during awake and sleep states. Method. 37 patients (29 females and 8 males) with a diagnosis of genetic generalized epilepsy syndrome were included. All the patients were investigated with video-EEG recording during awake, sleep and post sleep states. Epileptic discharges were counted manually. Discharge numbers and their relation with triggers were analyzed to see the difference between different vigilance states. Results. Number of ictal discharges is found to be increased after sleep. There was no difference in the control EEGs, which were taken under treatment. Conclusion. Sleep is a trigger of epileptic discharges in ictal nature, but an effective antiepileptic treatment prevents this effect.

背景。众所周知,睡眠和睡眠剥夺会影响脑电图结果、发作、频率和癫痫发作的符号学。广泛性尖峰和波放电在困倦和睡眠状态下更为常见,特别是在儿童和青少年无癫痫综合征中。的目标。本研究旨在探讨短睡眠对遗传性广泛性癫痫发作患者发作间期和发作初期放电的影响,以及治疗对清醒和睡眠状态下放电的影响。方法:37例确诊为遗传性全身性癫痫综合征的患者,其中女性29例,男性8例。对所有患者进行清醒、睡眠和睡眠后状态的视频脑电图记录。手工统计癫痫放电。分析放电次数及其与触发因素的关系,观察不同警戒状态之间的差异。结果。睡眠后,脑电波放电次数增加。对照组的脑电图在治疗过程中没有差异。结论。睡眠是癫痫放电的触发因素,但有效的抗癫痫治疗可以防止这种影响。
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引用次数: 3
Acceptability by End-users of a Standardized Structured Format for Reporting EEG. 最终用户对EEG报告的标准化结构化格式的可接受性。
IF 2 4区 医学 Q2 Medicine Pub Date : 2023-09-01 DOI: 10.1177/15500594221091527
Alioth Guerrero-Aranda, Henry Friman-Guillen, Andrés Antonio González-Garrido

The report of the electroencephalogram (EEG) results has traditionally been made using free-text formats with a huge variation in descriptions due to several factors. Recently, the International Federation of Clinical Neurophysiology (IFCN) endorsed the use of the Standardized Computer-based Organized Reporting of EEG (SCORE). This system has many advantages, but only some concerns have been investigated so far. This study aimed to assess the end-users acceptability of this proposed EEG report format. A 16-item electronic survey was sent to physicians who use EEG services of a medical diagnosis clinic. Physicians had been receiving the EEG reports in free-text formats from the same three board-certified electroencephalographers for the past three years. In January 2019, the report changed to the SCORE format. The survey assessed five main topics: physician information and historical use of EEG; personal preferences; comparative aspects of the formats; impact of the new format on clinical decision-making; and satisfaction. Thirty-two of 52 have responded to the survey (61%). On average, 81% of the responders have received enough reports with the new format to reliably complete the survey. Every responder prefers the standardized compared to the free-text format. Twenty-five responders like the inclusion of the head model, and interestingly, five suggest including another legend to differentiate "slow activity" from "other abnormal activity". Virtually all responders would recommend the new format, but one-third read only the conclusion. Our findings suggest high acceptability of this standardized report format. Despite the limitations of this study, we hope these findings contribute to the improvement and expansion of standardized EEG reporting systems.

脑电图(EEG)结果的报告传统上使用自由文本格式,由于多种因素,其描述差异很大。最近,国际临床神经生理学联合会(IFCN)赞同使用基于计算机的EEG标准化组织报告(SCORE)。该系统有许多优点,但目前只研究了一些问题。本研究旨在评估最终用户对这种提议的脑电图报告格式的接受程度。一份包含16个项目的电子调查被发送给使用EEG服务的医疗诊断诊所的医生。在过去的三年里,医生们一直从同样的三个委员会认证的脑电图学家那里收到自由文本格式的脑电图报告。2019年1月,该报告改为SCORE格式。该调查评估了五个主要主题:医生信息和脑电图的历史使用;个人喜好;格式的比较方面;新格式对临床决策的影响;和满意度。52人中有32人(61%)回应了调查。平均而言,81%的应答者收到了足够的新格式报告,以可靠地完成调查。与自由文本格式相比,每个回答者都更喜欢标准化格式。25名回应者喜欢包括头部模型,有趣的是,5人建议包括另一个图例来区分“缓慢活动”和“其他异常活动”。几乎所有的回复者都会推荐新的格式,但三分之一的人只阅读结论。我们的研究结果表明这种标准化报告格式的可接受性很高。尽管本研究存在局限性,但我们希望这些发现有助于改进和扩展标准化的脑电图报告系统。
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引用次数: 2
Exploratory Study on the Clinical use of EEG for the People with Chronic Stroke and Their Correlation with the Neuropsychological Outcome. 慢性脑卒中患者脑电图的临床应用及其与神经心理学结果相关性的探索性研究。
IF 2 4区 医学 Q2 Medicine Pub Date : 2023-09-01 Epub Date: 2022-01-24 DOI: 10.1177/15500594221074858
Marko Ka Leung Chan, Winnie Ka Yee Yeung, Jason King Pong Yu, Serena Sin Wah Ng, Raymond Kai Yu Tong

Objective. To measure the EEG signals of the people with chronic stroke in eyes-closed and eyes-open condition and study their relationship with the cognitive function and mental wellbeing. Methods. The investigators would conduct cognitive and mental wellbeing tests on recruited subjects. Their EEG signal was acquired by the 16-channel EEG system. The absolute power under different frequency bands and EEG indices (delta alpha ratio and pairwise derived brain symmetry index) in different eye conditions was calculated. Pearson's correlation was conducted to investigate the association between the clinical tests and the EEG index. Results. 32 subjects were recruited for the study. There was a significant correlation between the pairwise derived brain symmetry index (pdBSI) in eyes-open condition with the Stroop Test (p = .002), Paced Auditory Serial Addition Test-3 s (p = .008)/2 s (p = .002) and WHO-5 well-being scale (p = .023). Conclusions. There is a significant correlation between the brain symmetry index and the cognitive and wellbeing assessment. Brain symmetry index over the delta frequency has been found to be the most useful parameter relating to the clinical score.Significance:It is recommended to use EEG as an adjunctive neuropsychological assessment in clinics for people with chronic stroke, especially for clients who could not undertake conventional assessments (eg aphasia, attention problem).Highlights: There is a significant correlation between the EEG index and the clinical neuropsychological assessmentPairwise Derived Brain Symmetry index in delta frequency range correlated with most of the neuropsychological outcome.It is feasible for us to adopt EEG as an adjunctive assessment in clinical settings.

客观的测量慢性脑卒中患者在闭眼和睁眼状态下的脑电信号,研究其和认知功能和心理健康的关系。方法。研究人员将对招募的受试者进行认知和心理健康测试。他们的脑电信号由16通道脑电系统采集。计算了不同频带下的绝对功率和不同眼睛条件下的EEG指数(delta-alpha比率和成对导出的大脑对称性指数)。采用Pearson相关性研究临床测试与脑电图指数之间的相关性。后果研究招募了32名受试者。在睁眼条件下,成对衍生的脑对称指数(pdBSI)与Stroop测试之间存在显著相关性(p = .002),起搏听觉序列加法测试-3 s(p = .008)/2秒(p = .002)和WHO-5幸福感量表(p = .023)。结论。大脑对称性指数与认知和幸福感评估之间存在显著相关性。德尔塔频率上的大脑对称性指数已被发现是与临床评分相关的最有用的参数。意义:建议在临床上使用脑电图作为慢性脑卒中患者的辅助神经心理学评估,特别是对于无法进行常规评估的客户(如失语症、注意力问题)。亮点:脑电图指数与临床神经心理学评估之间存在显著相关性。delta频率范围内的成对衍生脑对称性指数与大多数神经心理学结果相关。我们在临床环境中采用脑电图作为辅助评估是可行的。
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引用次数: 2
Spectrum of EEG Findings in Patients with Leptomeningeal Carcinomatosis and Seizures: Correlation with Neurodiagnostic Results and Outcome. 脑膜轻脑膜癌和癫痫患者的脑电图频谱:与神经诊断结果和预后的相关性。
IF 2 4区 医学 Q2 Medicine Pub Date : 2023-09-01 DOI: 10.1177/15500594221112643
Cansu Ayvacioglu Cagan, Ezgi Demirel Ozbek, Nese Dericioglu

Purpose: Leptomeningeal carcinomatosis (LC) is a devastating condition in patients with systemic malignancies or primary brain tumors. Although much is known about neuro-radiologic investigations, there is very little information about EEG findings in these patients. Whether EEG is correlated with cranial magnetic resonance imaging (MRI) results and survival has not been investigated. Methods: Medical records of 2340 adult patients with the diagnosis of brain tumor, either metastatic (Group 1) or primary (Group 2), between 2000-2021 were reviewed for the presence of LC and seizures. Demographic and clinical features, laboratory results and Karnofsky performance scores of included patients were noted. Available routine EEG recordings were re-evaluated. Any possible correlation between EEG findings-MRI and EEG findings-survival were investigated statistically. Results: Sixty-six patients with LC and seizures were identified. The most common malignancies were lung cancer and glioblastoma multiforme. Twenty-six EEG recordings of 17 patients in Group 1, and 13 EEGs of 9 patients in Group 2 were available for final analysis. The most common EEG characteristic was background slowing (73%). The most frequent findings were rhythmic periodic patterns or spike wave activity (27%). Sporadic epileptiform discharges (8%) or ictal recordings (4%) were very rare. None of the EEG features correlated with MRI results or survival. Conclusion: There are various EEG patterns in patients with LC and seizures. The most common findings are related to background activity, with rhythmic periodic patterns or spike wave activity being observed less commonly. EEG characteristics do not predict MRI findings or survival.

目的:脑膜轻脑膜癌(LC)是系统性恶性肿瘤或原发性脑肿瘤患者的一种破坏性疾病。虽然我们对神经影像学检查了解很多,但对这些患者的脑电图检查却知之甚少。脑电图是否与颅磁共振成像(MRI)结果和生存率相关尚未研究。方法:回顾2000-2021年间2340例诊断为脑肿瘤的成人患者的医疗记录,包括转移性(1组)或原发性(2组),以确定LC和癫痫的存在。记录纳入患者的人口学和临床特征、实验室结果和Karnofsky表现评分。重新评估可用的常规脑电图记录。对脑电图结果(mri)与脑电图结果(生存率)之间可能存在的相关性进行统计学调查。结果:66例LC合并癫痫发作。最常见的恶性肿瘤是肺癌和多形性胶质母细胞瘤。组1有17例患者的26条脑电图记录,组2有9例患者的13条脑电图记录可供最终分析。最常见的EEG特征是背景减慢(73%)。最常见的发现是有节奏的周期模式或尖峰波活动(27%)。散发的癫痫样放电(8%)或发作记录(4%)非常罕见。脑电图特征与MRI结果或生存率均无相关性。结论:LC伴癫痫发作患者的脑电图模式多种多样。最常见的发现与背景活动有关,有节奏的周期模式或尖峰波活动不太常见。脑电图特征不能预测MRI结果或生存率。
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引用次数: 1
Continuous Spikes and Waves During Sleep (CSWS), Severe Epileptic Encephalopathy, and Choreoathetosis due to Mutations in FRRS1L. FRRS1L基因突变引起的睡眠期间连续尖峰和波、严重癫痫性脑病和舞蹈病
IF 2 4区 医学 Q2 Medicine Pub Date : 2023-09-01 DOI: 10.1177/15500594221112508
Ali Mir, Fawzia Amer, Mona Ali, Wajd Alotaibi, Manar Alotaibi, Abdullah Hedaithy, Fatimah Aldurayhim, Fatimah Hussain, Shahid Bashir, Yousef Housawi

Background. Biallelic pathogenic variants in the FRRS1L gene are now known to cause developmental and epileptic encephalopathy-37 (DEE37). It can also be associated with chorea and continuous spikes and waves during sleep (CSWS). CSWS is a rare age-related epileptic encephalopathy syndrome of childhood that is characterized by seizures, neurocognitive regression and electrical status epilepticus during sleep (ESES) on electroencephalogram (EEG) that evolves in four stages. Seizures start during the prodromal phase but the ESES on EEG appears only during acute stage and this is the stage when the diagnosis of CSWS can be made. Methods. We present two patients with FRRS1L mutation causing DEE37 with CSWS. We also review twenty-nine cases of DEE37 described in the literature before and discuss its association with CSWS in the total cohort of thirty-one cases. Results. Developmental regression was found in 80% of the patients, mean age of seizure onset was 18 months, ESES or slow spike and wave on the EEG were reported mostly in the older patients (median age of 11 years) and hypsarrhythmia was reported in younger patients (median age of 4 years). This could suggest that if the younger patients were followed longer their EEG would have evolved into ESES during the acute stage of this syndrome and a diagnosis of CSWS could be made. Conclusion. Recognizing ESES and the natural evolution of CSWS is important in diagnosis and proper management of these patients. More detailed report of EEG findings and the evolution of epilepsy and development are needed to further characterize this syndrome.

背景。目前已知FRRS1L基因的双等位致病变异可引起发育性和癫痫性脑病-37 (DEE37)。它也可能与舞蹈病和睡眠期间的连续尖峰和波(CSWS)有关。CSWS是一种罕见的儿童期与年龄相关的癫痫性脑病综合征,其特征为癫痫发作、神经认知衰退和睡眠期间癫痫持续电状态(ESES),其发展分为四个阶段。癫痫发作始于前驱期,但脑电图上的ESES仅在急性期出现,这是可以诊断CSWS的阶段。方法。我们报告了两例FRRS1L突变导致DEE37合并CSWS的患者。我们还回顾了之前文献中描述的29例DEE37病例,并在31例队列中讨论其与CSWS的关系。结果。80%的患者出现发育倒退,癫痫发作平均年龄为18个月,ESES或脑电图慢峰慢波多见于老年患者(中位年龄为11岁),低心律失常多见于年轻患者(中位年龄为4岁)。这可能表明,如果对年轻患者进行更长时间的随访,他们的脑电图将在该综合征的急性期演变为ESES,从而可以做出CSWS的诊断。结论。认识ESES和CSWS的自然演变对CSWS患者的诊断和适当治疗具有重要意义。需要更详细的脑电图结果和癫痫的演变和发展报告,以进一步表征该综合征。
{"title":"Continuous Spikes and Waves During Sleep (CSWS), Severe Epileptic Encephalopathy, and Choreoathetosis due to Mutations in <i>FRRS1L</i>.","authors":"Ali Mir,&nbsp;Fawzia Amer,&nbsp;Mona Ali,&nbsp;Wajd Alotaibi,&nbsp;Manar Alotaibi,&nbsp;Abdullah Hedaithy,&nbsp;Fatimah Aldurayhim,&nbsp;Fatimah Hussain,&nbsp;Shahid Bashir,&nbsp;Yousef Housawi","doi":"10.1177/15500594221112508","DOIUrl":"https://doi.org/10.1177/15500594221112508","url":null,"abstract":"<p><p><i>Background.</i> Biallelic pathogenic variants in the <i>FRRS1L</i> gene are now known to cause developmental and epileptic encephalopathy-37 (DEE37). It can also be associated with chorea and continuous spikes and waves during sleep (CSWS). CSWS is a rare age-related epileptic encephalopathy syndrome of childhood that is characterized by seizures, neurocognitive regression and electrical status epilepticus during sleep (ESES) on electroencephalogram (EEG) that evolves in four stages. Seizures start during the prodromal phase but the ESES on EEG appears only during acute stage and this is the stage when the diagnosis of CSWS can be made. <i>Methods.</i> We present two patients with <i>FRRS1L</i> mutation causing DEE37 with CSWS. We also review twenty-nine cases of DEE37 described in the literature before and discuss its association with CSWS in the total cohort of thirty-one cases. <i>Results.</i> Developmental regression was found in 80% of the patients, mean age of seizure onset was 18 months, ESES or slow spike and wave on the EEG were reported mostly in the older patients (median age of 11 years) and hypsarrhythmia was reported in younger patients (median age of 4 years). This could suggest that if the younger patients were followed longer their EEG would have evolved into ESES during the acute stage of this syndrome and a diagnosis of CSWS could be made. <i>Conclusion.</i> Recognizing ESES and the natural evolution of CSWS is important in diagnosis and proper management of these patients. More detailed report of EEG findings and the evolution of epilepsy and development are needed to further characterize this syndrome.</p>","PeriodicalId":10682,"journal":{"name":"Clinical EEG and Neuroscience","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10312667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Emotional Modulation of Response Inhibition in Adolescents During Acute Suicidal Crisis: Event-Related Potentials in an Emotional Go/NoGo Task. 青少年急性自杀危机反应抑制的情绪调节:情绪去/不去任务中的事件相关电位。
IF 2 4区 医学 Q2 Medicine Pub Date : 2023-09-01 DOI: 10.1177/15500594211063311
Meggan Porteous, Paniz Tavakoli, Kenneth Campbell, Allyson Dale, Addo Boafo, Rebecca Robillard

Objectives. Suicide is the second leading cause of adolescent deaths and may be linked to difficulties with inhibitory and emotional processing. This study assessed the neural correlates of cognitive inhibition during emotional processing in adolescents hospitalized for a suicidal crisis. Methods. Event-related potentials were recorded during an emotional Go/NoGo task in 12 adolescents who attempted suicide and 12 age- and sex-matched healthy controls. Results. Compared to the control group, the suicidal group showed significantly reduced positivity at the time of the P3d (difference waveform reflecting NoGo minus Go trials) in response to happy and neutral, but not sad stimuli. For happy stimuli, this group difference was restricted to the right hemisphere. Further analyses indicated that the suicidal group had a reversed pattern of P3 amplitude in response to inhibition, with lower amplitudes in the NoGo compared to the Go conditions. Suicidal symptoms severity strongly correlated with lower amplitude of the P3d in response to neutral faces. Conclusions. These findings provide more insight into inhibition difficulties in adolescents with acute suicidal risk. Interactions between emotional and inhibition processing should be considered when treating acutely suicidal youths.

目标。自杀是青少年死亡的第二大原因,可能与抑制和情绪处理困难有关。本研究评估了因自杀危机住院的青少年情绪处理过程中认知抑制的神经相关。方法。在12名企图自杀的青少年和12名年龄和性别匹配的健康对照者的情绪Go/NoGo任务中记录事件相关电位。结果。与对照组相比,自杀组在P3d(反映NoGo - Go试验的差异波形)时对快乐和中性刺激的积极性显著降低,但对悲伤刺激没有反应。对于快乐刺激,这种组间差异仅限于右半球。进一步的分析表明,自杀组的P3波幅对抑制的反应是相反的,与Go条件相比,NoGo条件下的波幅更低。自杀症状的严重程度与对中性面孔反应的P3d振幅较低密切相关。结论。这些发现对有急性自杀风险的青少年的抑制困难提供了更多的见解。在治疗急性自杀青少年时,应考虑情绪和抑制加工之间的相互作用。
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引用次数: 2
The Value of Concurrent Electrocardiography When Performing an Electroencephalograph. 进行脑电图时并发心电图的价值。
IF 2 4区 医学 Q2 Medicine Pub Date : 2023-09-01 DOI: 10.1177/15500594221129434
Nimalan Harinesan, Dennis Cordato, Roy G Beran

Introduction. The use of concurrent, single lead electrocardiograph (ECG) recording, when performing a routine electroencephalograph (EEG), has been standard practice for many years. Previous studies have reported on the usefulness of concurrent EEG in assessing syncope and the detection of newly identified cardiac dysrhythmia but have relied on specialist cardiologist interpretation of the ECG trace. This study expands the understanding of concurrent ECG and provides demographic information regarding the incidence, nature of ECG changes and diagnostic utility of ECG interpretation, during routine EEGs, as evaluated by neurologists. Methods. A single center, retrospective study of routine concurrent EEG and ECG recordings was performed. All routine EEGs, performed within a 12 month period were analysed. Demographic data, underlying comorbidities, reasons for referral and ECG changes were assessed. Results. ECG abnormalities were identified in 147 (13.5%) of concurrent ECG/EEG routine recordings. The presence of ECG abnormalities was significantly associated with the reason for referral, namely being assessed for the evaluation of seizure activity and with increasing patient age. Thirty-eight patients (3.5%) had newly identified ECG abnormalities, of which atrial fibrillation (AF) (12 patients) and sinus bradycardia (9 patients) were the most common. Five patients (0.5%) had a change in their management consequent to the identified ECG changes. Conclusions. These findings support the value of neurologists' interpretation and need for ongoing concurrent ECGs, during routine EEG recordings. The study raises concern about the requesting clinician's response to the identification of newly diagnosed cardiac dysrhythmias.

介绍。在进行常规脑电图(EEG)时,使用并发单导联心电图(ECG)记录已成为多年来的标准做法。先前的研究报道了并发脑电图在评估晕厥和检测新发现的心律失常方面的有用性,但依赖于专科心脏病专家对心电图痕迹的解释。这项研究扩大了对并发心电图的理解,并提供了关于发生率、ECG变化的性质和心电图解释的诊断效用的人口统计信息,在常规脑电图中,由神经科医生评估。方法。采用单中心回顾性研究,同时进行常规脑电图和心电图记录。分析12个月内所有常规脑电图。评估了人口统计数据、潜在合并症、转诊原因和心电图变化。结果。心电图异常147例(13.5%)。心电图异常的存在与转诊的原因显著相关,即评估癫痫活动和患者年龄的增加。38例(3.5%)患者新发现心电图异常,其中房颤(AF) 12例、窦性心动过缓(9例)最为常见。5名患者(0.5%)因心电图改变而改变了治疗方法。结论。这些发现支持了神经科医生的解释的价值,以及在常规脑电图记录期间持续并发心电图的必要性。这项研究引起了人们对临床医生对新诊断的心律失常的反应的关注。
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引用次数: 0
Abnormal Cross Frequency Coupling of Brain Electroencephalographic Oscillations Related to Visual Oddball Task in Parkinson's Disease with Mild Cognitive Impairment. 帕金森病伴轻度认知障碍患者与视觉怪球任务相关的脑电图振荡异常交叉频率耦合
IF 2 4区 医学 Q2 Medicine Pub Date : 2023-07-01 DOI: 10.1177/15500594221128713
Zübeyir Bayraktaroğlu, Tuba Aktürk, Görsev Yener, Tom A de Graaf, Lütfü Hanoğlu, Ebru Yıldırım, Duygu Hünerli Gündüz, İlayda Kıyı, Alexander T Sack, Claudio Babiloni, Bahar Güntekin

Parkinson's disease (PD) is a movement disorder caused by degeneration in dopaminergic neurons. During the disease course, most of PD patients develop mild cognitive impairment (PDMCI) and dementia, especially affecting frontal executive functions. In this study, we tested the hypothesis that PDMCI patients may be characterized by abnormal neurophysiological oscillatory mechanisms coupling frontal and posterior cortical areas during cognitive information processing. To test this hypothesis, event-related EEG oscillations (EROs) during counting visual target (rare) stimuli in an oddball task were recorded in healthy controls (HC; N = 51), cognitively unimpaired PD patients (N = 48), and PDMCI patients (N = 53). Hilbert transform served to estimate instantaneous phase and amplitude of EROs from delta to gamma frequency bands, while modulation index computed ERO phase-amplitude coupling (PAC) at electrode pairs. As compared to the HC and PD groups, the PDMCI group was characterized by (1) more posterior topography of the delta-theta PAC and (2) reversed delta-low frequency alpha PAC direction, ie, posterior-to-anterior rather than anterior-to-posterior. These results suggest that during cognitive demands, PDMCI patients are characterized by abnormal neurophysiological oscillatory mechanisms mainly led by delta frequencies underpinning functional connectivity from frontal to parietal cortical areas.

帕金森病(PD)是一种由多巴胺能神经元变性引起的运动障碍。在病程中,大多数PD患者出现轻度认知障碍(PDMCI)和痴呆,尤其是影响额叶执行功能。在本研究中,我们验证了PDMCI患者在认知信息加工过程中可能存在与额、后皮质区耦合的异常神经生理振荡机制的假设。为了验证这一假设,我们记录了健康对照组在奇数任务中计数视觉目标(罕见)刺激时的事件相关脑电图振荡(EROs)。N = 51),认知未受损PD患者(N = 48)和PDMCI患者(N = 53)。希尔伯特变换用于估计从δ到γ频段的EROs的瞬时相位和幅度,而调制指数计算电极对上的ERO相幅耦合(PAC)。与HC和PD组相比,PDMCI组的特点是(1)δ - θ PAC的后侧地形更多,(2)δ -低频α PAC方向相反,即从后向前而不是从前向后。这些结果表明,在认知需求期间,PDMCI患者的特征是异常的神经生理振荡机制,主要是由支撑额叶到顶叶皮质区功能连接的δ频率引起的。
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引用次数: 2
Aperiodic Neural Activity is a Better Predictor of Schizophrenia than Neural Oscillations. 非周期性神经活动比神经振荡更能预测精神分裂症。
IF 2 4区 医学 Q2 Medicine Pub Date : 2023-07-01 DOI: 10.1177/15500594231165589
Erik J Peterson, Burke Q Rosen, Aysenil Belger, Bradley Voytek, Alana M Campbell

Diagnosis and symptom severity in schizophrenia are associated with irregularities across neural oscillatory frequency bands, including theta, alpha, beta, and gamma. However, electroencephalographic signals consist of both periodic and aperiodic activity characterized by the (1/fX) shape in the power spectrum. In this paper, we investigated oscillatory and aperiodic activity differences between patients with schizophrenia and healthy controls during a target detection task. Separation into periodic and aperiodic components revealed that the steepness of the power spectrum better-predicted group status than traditional band-limited oscillatory power in classification analysis. Aperiodic activity also outperformed the predictions made using participants' behavioral responses. Additionally, the differences in aperiodic activity were highly consistent across all electrodes. In sum, compared to oscillations the aperiodic activity appears to be a more accurate and more robust way to differentiate patients with schizophrenia from healthy controls.

精神分裂症的诊断和症状严重程度与神经振荡频带的不规则性有关,包括θ、α、β和γ。然而,脑电图信号包括周期性和非周期性活动,其特征是功率谱中的(1/fX)形状。在本文中,我们研究了精神分裂症患者和健康对照者在目标检测任务中振荡和非周期活动的差异。周期和非周期分量的分离表明,在分类分析中,功率谱的陡峭度比传统的带限振荡功率更能预测群体状态。非周期性活动的表现也优于根据参与者的行为反应做出的预测。此外,非周期活性的差异在所有电极上都是高度一致的。总之,与振荡相比,非周期活动似乎是区分精神分裂症患者与健康对照的更准确和更可靠的方法。
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引用次数: 20
Event-related Oscillations to Emotional Faces are Related to a History of Internalizing Disorders. 情绪面孔的事件相关振荡与内化障碍史有关。
IF 1.6 4区 医学 Q3 CLINICAL NEUROLOGY Pub Date : 2023-07-01 Epub Date: 2022-04-04 DOI: 10.1177/15500594221088258
Cindy L Ehlers, Derek Wills, Katherine J Karriker-Jaffe, Evelyn Phillips, Corrine Kim, David A Gilder

Event-related oscillations (EROs) may represent sensitive biomarkers or endophenotypes for disorders that underlie risk behaviors such as suicidal thoughts and actions. In this study, young adults of American Indian (AI) (n = 821) and Mexican American (MA) (n = 721) ancestry (age 18-30 yrs) were clinically assessed for internalizing and externalizing disorders, and an internalizing scale was generated by extracting core diagnostic items from 6 lifetime DSM5-compatible diagnoses (social phobia, panic disorder, agoraphobia, obsessive compulsive disorder, post-traumatic stress disorder, major depressive episode) and symptoms of suicidality. EROs were generated to sad, happy and neutral faces, and energy and phase locking of delta ERO oscillations were assessed in frontal areas. An increase in delta ERO energy was found in the frontal lead (FZ) following presentation of the sad facial expressions in those with a history of 10 or more internalizing symptoms compared to those with no symptoms. Increases in delta ERO energy in FZ were also associated with a diagnosis of major depressive disorder (MDD), but not with anxiety disorders or antisocial personality disorder/conduct disorders (ASP). Major depression was also associated with increases in cross-cortical phase-locking (FZ-PZ). A decrease in the percentage of correctly identified neutral faces also was seen among those with 10 or more internalizing symptoms compared to those without internalizing symptoms, and in those with anxiety disorders, but not in those with ASP or MDD as compared to their controls. These findings suggest ERO measures may represent important potential biomarkers of depressive disorders as well as risk indicators for suicidal behaviors.

事件相关振荡(EROs)可能是导致自杀想法和行为等危险行为的敏感生物标记或内表型。在这项研究中,对美国印第安人(AI)(n = 821)和墨西哥裔美国人(MA)(n = 721)血统的年轻成年人(18-30 岁)进行了内化和外化障碍的临床评估,并从 6 个与 DSM5 兼容的终生诊断(社交恐惧症、恐慌症、广场恐惧症、强迫症、创伤后应激障碍、重度抑郁发作)和自杀症状中提取核心诊断项目,生成了内化量表。对悲伤、快乐和中性面孔产生ERO,并对额叶区δERO振荡的能量和锁相进行评估。与无症状的人相比,有10个或更多内化症状的人在呈现悲伤表情后,额叶前导(FZ)的δERO能量会增加。FZ中δERO能量的增加还与重度抑郁症(MDD)的诊断有关,但与焦虑症或反社会人格障碍/行为障碍(ASP)无关。重度抑郁症还与跨皮层锁相(FZ-PZ)的增加有关。与无内化症状者和焦虑症患者相比,有 10 个或更多内化症状者正确识别中性面孔的百分比也有所下降,但与对照组相比,反社会人格障碍或多重抑郁症患者的这一百分比则没有下降。这些研究结果表明,ERO 测量可能是抑郁障碍的重要潜在生物标志物,也是自杀行为的风险指标。
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Clinical EEG and Neuroscience
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