Critical Reviews in Microbiology最新文献

The complex interaction between Aspergillus and Bacillus has been gaining attention with the evolution of their co-culture applications. Information reported on this interaction from different points of view including both synergistic and antagonistic mechanisms necessitates a review for better understanding. This review focuses on the interaction, biofilm formation, and the diverse biotechnological applications of Aspergillus and Bacillus, giving special attention to Aspergillus niger and Bacillus subtilis. The review demonstrates that co-cultivation of Aspergillus and Bacillus exhibits significant transcriptional changes, impacting metabolism and secondary metabolite production in both organisms. Signaling from living fungal hyphae, EPS production, TasA fibrils, and regulators like Spo0A are essential in forming biofilm communities. Nutrient availability and pH levels, species type, and mutations in EPS-producing genes may also influence whether Bacillus will act antagonistically or synergistically with Aspergillus. This dual-nature complex interaction activates silent genes synthesizing novel compounds mainly with antifungal and medicinal properties, showcasing its potential for diverse applications in various fields such as agriculture and crop protection, bioremediation, environmental biotechnology, food science and fermentation, industrial biotechnology, and medical biotechnology and health. The use of Aspergillus and Bacillus species has evolved from simple monoculture applications to more sophisticated co-cultures and has been trending toward their synergy and metabolic optimization.

Neurodegenerative diseases, such as Alzheimer's disease (AD), Parkinson's disease (PD), and multiple sclerosis (MS), affect millions of people worldwide. While considerable progress has been made to elucidate the pathogenesis of these diseases in recent years, their specific mechanisms remain largely unknown. Many research study results have proven a certain association between the oral microbiome and neurodegenerative diseases. This review focuses on the relationship between the oral microbiome and neurodegenerative diseases, with a particular focus on the mechanisms of neuroinflammation.

Dermatophytoses is a well-known name among dermatologists due to its high prevalence among various ages of humans. It is mainly caused by skin-infecting fungi called dermatophytes. From these dermatophytes, Trichophyton indotineae is a newly virulent species with high prevalence and multidrug properties. It was first described in the Indian subcontinent as a closely genetically related strain to Trichophyton interdigitale and Trichophyton mentagrophytes, and spread quickly worldwide. Terbinafine has been utilized for the treatment of dermatophytosis caused by T. indotineae owing to the development of resistance to azole in many of its strains. Wide use of terbinafine has also induced later the development of terbinafine-resistant strains of T. indotineae. Point mutations in the squalene epoxidase (SQLE) gene, which lead to single or multiple substitutions in amino acid positions in the encoded protein (SQLE), are the main reason for antifungal resistance in T. indotineae. This review aims to determine the background of terbinafine-resistant strains of T. indotineae and where they are currently located.

Vaccination plays a critical role in public health by reducing the incidence and prevalence of infectious diseases. The efficacy of a vaccine has numerous determinants, which include age, sex, genetics, environment, geographic location, nutritional status, maternal antibodies, and prior exposure to pathogens. However, little is known about the role of gut microbiome in vaccine efficacy and how it can be targeted through dietary interventions to improve immunological responses. Unveiling this link is imperative, particularly in the post-pandemic world, considering impaired COVID-19 vaccine response observed in dysbiotic individuals. Therefore, this article aims to comprehensively review how diet and probiotics can modulate gut microbiome composition, which is linked to vaccine efficacy. Dietary fiber and polyphenolic compounds derived from plant-based foods improve gut microbial diversity and vaccine efficacy by promoting the growth of short-chain fatty acids-producing microbes. On the other hand, animal-based foods have mixed effects - whey protein and fish oil promote gut eubiosis and vaccine efficacy. In contrast, lard and red meat have adverse effects. Studies further indicate that probiotic supplements exert varied effects, mostly strain and dosage-specific. Interlinking diet, microbiome, probiotics, and vaccines will reveal opportunities for newer research on diet-induced microbiome-manipulated precision vaccination strategies against infectious diseases.

The rise of antibiotic-resistant bacteria poses a grave threat to global health, with the ESKAPE pathogens, which comprise Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa and Enterobacter spp. being among the most notorious. The World Health Organization has reserved a group of last-resort antibiotics for treating multidrug-resistant bacterial infections, including those caused by ESKAPE pathogens. This situation calls for a comprehensive understanding of the resistance mechanisms as it threatens public health and hinder progress toward the Sustainable Development Goal (SDG) 3: Good Health and Well-being. The present article reviews resistance mechanisms, focusing on emerging resistance mutations in multidrug-resistant ESKAPE pathogens, particularly against last-resort antibiotics, and describes the role of biofilm formation in multidrug-resistant ESKAPE pathogens. It discusses the latest therapeutic advances, including the use of antimicrobial peptides and CRISPR-Cas systems, and the modulation of quorum sensing and iron homeostasis, which offer promising strategies for countering resistance. The integration of CRISPR-based tools and biofilm-targeted approaches provides a potential framework for managing ESKAPE infections. By highlighting the spread of current resistance mutations and biofilm-targeted approaches, the review aims to contribute significantly to advancing our understanding and strategies in combatting this pressing global health challenge.

Infections account for approximately 15% of human cancers worldwide. Viruses are the most predominant infectious agents and can infect and alter various types of human cells thereby leading to the development of various forms of cancer. Current studies have reported that Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C virus (HBC), human papillomavirus (HPV), Kaposi's sarcoma-associated herpesvirus (KSHV), human T-lymphotropic virus 1 (HTLV-1), Markel cell polyomavirus (MCPyV), and BK polyomavirus are the most important oncogenic viruses that are directly involved in the initiation and progression of cancer. Additionally, some recent studies have also reported that some non-oncogenic viruses, such as COVID-19 causing SARS-CoV-2, HIV and Dengue may potentially facilitate the onset of cancer. In this review, we outline the current knowledge of the molecular machinery of viral infection, and how viral oncogenic proteins play a specific role in cellular transformation as well as oncogenesis. Here, we have also discussed the available preventive and treatment approaches for viral infection and oncogenesis. This review will further help in the making of a roadmap for future research and the development of effective therapies such as precision medicine, gene therapies, vaccine development, and immunotherapy.

Human Ureaplasma species are being increasingly recognized as opportunistic pathogens in human genitourinary tract infections, infertility, adverse pregnancy, neonatal morbidities, and other adult invasive infections. Although some general reviews have focused on the detection and clinical manifestations of Ureaplasma spp., the molecular epidemiology, antimicrobial resistance, and pathogenesis of Ureaplasma spp. have not been adequately explained. The purpose of this review is to offer valuable insights into the current understanding and future research perspectives of the molecular epidemiology, antimicrobial resistance, and pathogenesis of human Ureaplasma infections. This review summarizes the conventional culture and detection methods and the latest molecular identification technologies for Ureaplasma spp. We also reviewed the global prevalence and mechanisms of antibiotic resistance for Ureaplasma spp. Aside from regular antibiotics, novel antibiotics with outstanding in vitro antimicrobial activity against Ureaplasma spp. are described. Furthermore, we discussed the pathogenic mechanisms of Ureaplasma spp., including adhesion, proinflammatory effects, cytotoxicity, and immune escape effects, from the perspectives of pathology, related molecules, and genetics.

The globe has recently seen several terrifying pandemics and outbreaks, underlining the ongoing danger presented by infectious microorganisms. This literature review aims to explore the wide range of infections that have the potential to lead to pandemics in the present and the future and pave the way to the conception of epidemic early warning systems. A systematic review was carried out to identify and compile data on infectious agents known to cause pandemics and those that pose future concerns. One hundred and fifteen articles were included in the review. They provided insights on 25 pathogens that could start or contribute to creating pandemic situations. Diagnostic procedures, clinical symptoms, and infection transmission routes were analyzed for each of these pathogens. Each infectious agent's potential is discussed, shedding light on the crucial aspects that render them potential threats to the future. This literature review provides insights for policymakers, healthcare professionals, and researchers in their quest to identify potential pandemic pathogens, and in their efforts to enhance pandemic preparedness through building early warning systems for continuous epidemiological monitoring.

Helicobacter pylori is a gram-negative bacterium that colonizes the stomach of approximately half of the worldwide population, with higher prevalence in densely populated areas like Asia, the Caribbean, Latin America, and Africa. H. pylori infections range from asymptomatic cases to potentially fatal diseases, including peptic ulcers, chronic gastritis, and stomach adenocarcinoma. The management of these conditions has become more difficult due to the rising prevalence of drug-resistant H. pylori infections, which ultimately lead to gastric cancer and mucosa-associated lymphoid tissue (MALT) lymphoma. In 1994, the International Agency for Research on Cancer (IARC) categorized H. pylori as a Group I carcinogen, contributing to approximately 780,000 cancer cases annually. Antibiotic resistance against drugs used to treat H. pylori infections ranges between 15% and 50% worldwide, with Asian countries having exceptionally high rates. This review systematically examines the impacts of H. pylori infection, the increasing prevalence of antibiotic resistance, and the urgent need for accurate diagnosis and precision treatment. The present status of precision treatment strategies and prospective approaches for eradicating infections caused by antibiotic-resistant H. pylori will also be evaluated.

Quorum sensing (QS) is a bacterial communication method closely linked with population density and regulates biofilm formation and the secretion of virulence factors through the release, recognition, and prompt response to small molecule signals. At low cell density, each bacterium produces a low concentration of QS signals that diffuse or are actively transported into the external environment. The accumulated QS signals in the external environment reach a threshold concentration when the bacterial population attains a certain density, enabling effective recognition and interaction of bacterial QS signals with their receptors. This leads to coordinated gene expression and various biological activities across the bacterial population. Targeting the QS system presents a promising strategy to hinder biofilm formation and virulence factor secretion, providing a potential approach to control bacterial growth and reproduction. This study aims to analyze the intercellular mechanisms of quorum quenching (QQ), which focuses on disrupting bacterial signal molecules to keep their concentration below the threshold and preventing the expression of specific pathogenic factors. The applications of QQ in different fields are also reviewed, underscoring its potential as a novel treatment for bacterial infections.