A secondary bacterial infection of the influenza virus in the lungs is a key cause of exacerbation and death. The pathogenesis is characterized by complex interactions between co-infecting pathogens and the host, leading to the destruction of the physical barrier of the airways and the dysregulation of the immune response. This article will review the progress of the mechanism of secondary bacterial infection of influenza virus and provide strategies for preventing the co-infection of influenza virus and bacteria.
{"title":"Research progress on the mechanism of secondary bacterial infection of influenza virus","authors":"Liu Lin, Xiangyan Zhang","doi":"10.4103/cai.cai_3_20","DOIUrl":"https://doi.org/10.4103/cai.cai_3_20","url":null,"abstract":"A secondary bacterial infection of the influenza virus in the lungs is a key cause of exacerbation and death. The pathogenesis is characterized by complex interactions between co-infecting pathogens and the host, leading to the destruction of the physical barrier of the airways and the dysregulation of the immune response. This article will review the progress of the mechanism of secondary bacterial infection of influenza virus and provide strategies for preventing the co-infection of influenza virus and bacteria.","PeriodicalId":107566,"journal":{"name":"Community Acquired Infection","volume":"56 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123476836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
H1N1 pneumonia is one of the most common causes of community-acquired pneumonia in India. It occurs throughout the year without any seasonal variation. The clinical presentation of the disease varies in severity each year and complications associated with it are most unusual. We recently reported a case of recurrent pneumomediastinum associated with H1N1. Here, we want to report another patient who was diagnosed with severe H1N1 pneumonia complicated by a cardiac tamponade. Cardiac tamponade is a life threatening complication of viral pneumonia and needs to addressed immediately. Ours is the first case report with cardiac tamponade associated with H1N1 pneumonia.
{"title":"Swine flu: Common disease with a rare complication","authors":"Bhavna P Singh","doi":"10.4103/cai.cai_2_19","DOIUrl":"https://doi.org/10.4103/cai.cai_2_19","url":null,"abstract":"H1N1 pneumonia is one of the most common causes of community-acquired pneumonia in India. It occurs throughout the year without any seasonal variation. The clinical presentation of the disease varies in severity each year and complications associated with it are most unusual. We recently reported a case of recurrent pneumomediastinum associated with H1N1. Here, we want to report another patient who was diagnosed with severe H1N1 pneumonia complicated by a cardiac tamponade. Cardiac tamponade is a life threatening complication of viral pneumonia and needs to addressed immediately. Ours is the first case report with cardiac tamponade associated with H1N1 pneumonia.","PeriodicalId":107566,"journal":{"name":"Community Acquired Infection","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115406112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mohit Kamthania, R. Kumari, Sirajuddin Ali, A. Hussain, A. Jha
H9N2 avian influenza viruses cause worldwide infections in animals including humans and show a threat as a pandemic infection. Since 1998 more than 59 cases including one death due to H9N2 infection had been reported worldwide and the majority of confirmed cases were young children. Due to the large host variety, tolerance to both poultry and mammals and widespread gene reassortment, H9N2 viruses played a crucial role in worldwide infection. In this review, we discuss the current worldwide infection of H9N2 avian influenza viruses as well as their host range, pathogenesis, epidemiology, diagnosis, control, and its pandemic potential.
{"title":"Current information of H9N2 virus zoonotic infection and its emerging pandemic potential: A review","authors":"Mohit Kamthania, R. Kumari, Sirajuddin Ali, A. Hussain, A. Jha","doi":"10.4103/cai.cai_2_20","DOIUrl":"https://doi.org/10.4103/cai.cai_2_20","url":null,"abstract":"H9N2 avian influenza viruses cause worldwide infections in animals including humans and show a threat as a pandemic infection. Since 1998 more than 59 cases including one death due to H9N2 infection had been reported worldwide and the majority of confirmed cases were young children. Due to the large host variety, tolerance to both poultry and mammals and widespread gene reassortment, H9N2 viruses played a crucial role in worldwide infection. In this review, we discuss the current worldwide infection of H9N2 avian influenza viruses as well as their host range, pathogenesis, epidemiology, diagnosis, control, and its pandemic potential.","PeriodicalId":107566,"journal":{"name":"Community Acquired Infection","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121913466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Olaniyan, T. Ojediran, Ferdinand Uwaifo, Mufutau Azeez
Background: Mono-infections of Plasmodium spp., hepatitis B virus (HBV), and Mycobacterium tuberculosis could elicit activation of complements for innate immunity leading to inflammatory responses. Objective: This work was designed to determine host immune responses to mono-infections of Plasmodium spp., HBV, and M. tuberculosis in blood complement 3 (C3), complement 5 (C5), tumor necrosis factor-alpha (TNF-α), and interleukin 10 (IL-10). Materials and Methods: Of 200 volunteers 66 Plasmodium spp., mono-infected, 28 HBV mono-infected, 12 M. tuberculosis mono-infected and 62 noninfected volunteers were studied as test and controls. ELISA was used to determine HBV, hepatitis C virus (HCV), HIV, plasma C3, C5, IL-10, and TNF-α while Plasmodium spp., was identified by Geimsha thick-film microscopy and M. tuberculosis by immunofluorescence microscopy. Results: The results obtained in the 200 volunteers showed. 69% (138) were infected with one or more of Plasmodium, HBV, HCV, HIV, and M. tuberculosis; 31% (62) were not infected; 16% (32) had co-infections of at least two of Plasmodium, HBV, HCV, HIV, and M. tuberculosis; 33% (66) were Plasmodium spp., mono-infected 14% (28) were HBV mono-infected while 6% (12) were M. tuberculosis. mono-infected. There was a significant increase in the plasma C3 in M. tuberculosis mono-infection compared with Plasmodium mono-infection; HBV mono-infection and control (P < 0.05). There was a significant increase in the plasma C3 in Plasmodium mono-infection compared with HBV mono-infection and control (P < 0.05) There was a significant decrease in the plasma C3 in the results obtained in HBV mono-infection compared with the control (P < 0.05). There was a significant increase in the plasma C5 in M. tuberculosis mono-infection compared with Plasmodium mono-infection; HBV mono-infection and control (P < 0.05). There was a significant increase in the plasma C5 in Plasmodium mono-infection compared with HBV mono-infection (P < 0.05). There was a significant decrease in plasma IL-10 and increased plasma TNF-α in Plasmodium, M. tuberculosis, and HBV mono-infections compared with the control (P < 0.05). There was also a significant increase in plasma TNF-α in M. tuberculosis mono-infection compared with Plasmodium mono-infection (P < 0.05). Conclusion: There was an evidence of host immune responses as evidenced by a significant increase in plasma C3, C5, and TNF-α including a decrease in IL-10 in mono-infections of Plasmodium spp., HBV and M. tuberculosis.
{"title":"Host immune responses to mono-infections of Plasmodium spp., hepatitis B virus, and Mycobacterium tuberculosis as evidenced by blood complement 3, complement 5, tumor necrosis factor-α and interleukin-10","authors":"M. Olaniyan, T. Ojediran, Ferdinand Uwaifo, Mufutau Azeez","doi":"10.4103/cai.cai_4_19","DOIUrl":"https://doi.org/10.4103/cai.cai_4_19","url":null,"abstract":"Background: Mono-infections of Plasmodium spp., hepatitis B virus (HBV), and Mycobacterium tuberculosis could elicit activation of complements for innate immunity leading to inflammatory responses. Objective: This work was designed to determine host immune responses to mono-infections of Plasmodium spp., HBV, and M. tuberculosis in blood complement 3 (C3), complement 5 (C5), tumor necrosis factor-alpha (TNF-α), and interleukin 10 (IL-10). Materials and Methods: Of 200 volunteers 66 Plasmodium spp., mono-infected, 28 HBV mono-infected, 12 M. tuberculosis mono-infected and 62 noninfected volunteers were studied as test and controls. ELISA was used to determine HBV, hepatitis C virus (HCV), HIV, plasma C3, C5, IL-10, and TNF-α while Plasmodium spp., was identified by Geimsha thick-film microscopy and M. tuberculosis by immunofluorescence microscopy. Results: The results obtained in the 200 volunteers showed. 69% (138) were infected with one or more of Plasmodium, HBV, HCV, HIV, and M. tuberculosis; 31% (62) were not infected; 16% (32) had co-infections of at least two of Plasmodium, HBV, HCV, HIV, and M. tuberculosis; 33% (66) were Plasmodium spp., mono-infected 14% (28) were HBV mono-infected while 6% (12) were M. tuberculosis. mono-infected. There was a significant increase in the plasma C3 in M. tuberculosis mono-infection compared with Plasmodium mono-infection; HBV mono-infection and control (P < 0.05). There was a significant increase in the plasma C3 in Plasmodium mono-infection compared with HBV mono-infection and control (P < 0.05) There was a significant decrease in the plasma C3 in the results obtained in HBV mono-infection compared with the control (P < 0.05). There was a significant increase in the plasma C5 in M. tuberculosis mono-infection compared with Plasmodium mono-infection; HBV mono-infection and control (P < 0.05). There was a significant increase in the plasma C5 in Plasmodium mono-infection compared with HBV mono-infection (P < 0.05). There was a significant decrease in plasma IL-10 and increased plasma TNF-α in Plasmodium, M. tuberculosis, and HBV mono-infections compared with the control (P < 0.05). There was also a significant increase in plasma TNF-α in M. tuberculosis mono-infection compared with Plasmodium mono-infection (P < 0.05). Conclusion: There was an evidence of host immune responses as evidenced by a significant increase in plasma C3, C5, and TNF-α including a decrease in IL-10 in mono-infections of Plasmodium spp., HBV and M. tuberculosis.","PeriodicalId":107566,"journal":{"name":"Community Acquired Infection","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132145769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-09-25DOI: 10.4103/2225-6482.141744
A. Torres
of antibiotics in the 1950’s.[26,27] In particular, the mortality rates of hospitalized CAP patients in Europe are 5-15% rising to 40% in intensive care unit admitted patients.[2] Moreover, in hospitalized CAP patients mortality increases dramatically in the presence of determined risk factors (comorbidities, immunosuppression, increasing age) up to 20-40%.[28,29] Indeed, it is known that 25-50% of all deaths from pneumonia are reported within the first 30 days after diagnosis with a large proportion of deaths being related to co-morbidities rather than directed due to pneumonia. After 30-day, mortality is still increased in patients with CAP with the majority of deaths being the result of co-morbidities and particularly cardiovascular co-morbidities.[27,30-32]
{"title":"Community-acquired pneumonia: Changing paradigms about mortality","authors":"A. Torres","doi":"10.4103/2225-6482.141744","DOIUrl":"https://doi.org/10.4103/2225-6482.141744","url":null,"abstract":"of antibiotics in the 1950’s.[26,27] In particular, the mortality rates of hospitalized CAP patients in Europe are 5-15% rising to 40% in intensive care unit admitted patients.[2] Moreover, in hospitalized CAP patients mortality increases dramatically in the presence of determined risk factors (comorbidities, immunosuppression, increasing age) up to 20-40%.[28,29] Indeed, it is known that 25-50% of all deaths from pneumonia are reported within the first 30 days after diagnosis with a large proportion of deaths being related to co-morbidities rather than directed due to pneumonia. After 30-day, mortality is still increased in patients with CAP with the majority of deaths being the result of co-morbidities and particularly cardiovascular co-morbidities.[27,30-32]","PeriodicalId":107566,"journal":{"name":"Community Acquired Infection","volume":"70 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132782929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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