首页 > 最新文献

Current Cardiology Reviews最新文献

英文 中文
Coronary Artery Aneurysms as a Cause of Acute Coronary Syndrome Presentation - A Focused Review. 冠状动脉瘤作为急性冠状动脉综合征的病因——一篇重点综述。
IF 2.4 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2023-01-01 DOI: 10.2174/1573403X19666230331103508
Azka Latif, Amy Tran, Junaid Ahsan, Noman Lateef, Waiel Abusina, Vikas Kapoor, Zoraiz Ahsan, Soban Ahmad, Mohsin Mirza

Coronary artery aneurysms (CAA) are defined as a dilation of a coronary vessel greater than 1.5 times the diameter of a local reference vessel. While CAAs tend to be incidental findings on imaging, they result in complications, such as thrombosis, embolization, ischemia, arrhythmias, and heart failure. Among symptomatic cases, chest pain has been the most common manifestation of CAAs. This necessitates an understanding of CAAs as a cause of acute coronary syndrome (ACS) presentation. However, due to the unclear pathophysiology of CAAs and their variable presentation complicated by similar ACS conditions, there is no clear strategy for CAA management. In this article, we will discuss the contribution of CAAs to ACS presentations and review the current management options for CAAs.

冠状动脉瘤(CAA)是指冠状血管的扩张大于局部参考血管直径的1.5倍。虽然CAA往往是影像学上的偶然发现,但它们会导致并发症,如血栓形成、栓塞、缺血、心律失常和心力衰竭。在有症状的病例中,胸痛是CAA最常见的表现。这就需要了解CAA作为急性冠状动脉综合征(ACS)表现的原因。然而,由于CAA的病理生理学尚不清楚,其可变表现因类似的ACS条件而复杂,因此没有明确的CAA管理策略。在本文中,我们将讨论CAA对ACS演示的贡献,并回顾CAA的当前管理选项。
{"title":"Coronary Artery Aneurysms as a Cause of Acute Coronary Syndrome Presentation - A Focused Review.","authors":"Azka Latif, Amy Tran, Junaid Ahsan, Noman Lateef, Waiel Abusina, Vikas Kapoor, Zoraiz Ahsan, Soban Ahmad, Mohsin Mirza","doi":"10.2174/1573403X19666230331103508","DOIUrl":"10.2174/1573403X19666230331103508","url":null,"abstract":"<p><p>Coronary artery aneurysms (CAA) are defined as a dilation of a coronary vessel greater than 1.5 times the diameter of a local reference vessel. While CAAs tend to be incidental findings on imaging, they result in complications, such as thrombosis, embolization, ischemia, arrhythmias, and heart failure. Among symptomatic cases, chest pain has been the most common manifestation of CAAs. This necessitates an understanding of CAAs as a cause of acute coronary syndrome (ACS) presentation. However, due to the unclear pathophysiology of CAAs and their variable presentation complicated by similar ACS conditions, there is no clear strategy for CAA management. In this article, we will discuss the contribution of CAAs to ACS presentations and review the current management options for CAAs.</p>","PeriodicalId":10832,"journal":{"name":"Current Cardiology Reviews","volume":"19 5","pages":"68-72"},"PeriodicalIF":2.4,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10518882/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9880417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Acute Right Ventricular Failure: Pathophysiology, Diagnostic Approach with Emphasis on the Role of Echocardiography. 急性右心室衰竭:病理生理学,超声心动图作用的诊断方法。
IF 2.4 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2023-01-01 DOI: 10.2174/1573403X19666230206115611
Han Naung Tun, Abdallah Almaghraby, Vladyslav Kavalerchyk, Denisa Muraru, Hatem Soliman-Aboumarie, Mahmoud Abdelnabi

Right ventricular function is one of the important predictors of survival in heart failure patients. In the past, there has been only limited knowledge regarding right-sided heart failure when compared to left-sided failure. However, there are more emerging data in recent years, and several studies have emphasized the unique features of the right ventricle regarding its anatomy, pathophysiology, clinical consequences, diagnostic modalities, and treatment options. Despite that, management of acute right ventricular failure is still challenging. This article summarizes an overview of acute right heart failure including pathophysiology, causes, clinical features, and diagnostic work-up with emphasis on the role of echocardiography.

右心室功能是心力衰竭患者生存的重要预测因素之一。在过去,与左侧心力衰竭相比,关于右侧心力衰竭的知识有限。然而,近年来有更多的新数据,一些研究强调了右心室在解剖学、病理生理学、临床后果、诊断模式和治疗选择方面的独特特征。尽管如此,急性右心室衰竭的治疗仍然具有挑战性。本文综述了急性右心衰竭的病理生理学、病因、临床特征和诊断检查,并强调了超声心动图的作用。
{"title":"Acute Right Ventricular Failure: Pathophysiology, Diagnostic Approach with Emphasis on the Role of Echocardiography.","authors":"Han Naung Tun, Abdallah Almaghraby, Vladyslav Kavalerchyk, Denisa Muraru, Hatem Soliman-Aboumarie, Mahmoud Abdelnabi","doi":"10.2174/1573403X19666230206115611","DOIUrl":"10.2174/1573403X19666230206115611","url":null,"abstract":"<p><p>Right ventricular function is one of the important predictors of survival in heart failure patients. In the past, there has been only limited knowledge regarding right-sided heart failure when compared to left-sided failure. However, there are more emerging data in recent years, and several studies have emphasized the unique features of the right ventricle regarding its anatomy, pathophysiology, clinical consequences, diagnostic modalities, and treatment options. Despite that, management of acute right ventricular failure is still challenging. This article summarizes an overview of acute right heart failure including pathophysiology, causes, clinical features, and diagnostic work-up with emphasis on the role of echocardiography.</p>","PeriodicalId":10832,"journal":{"name":"Current Cardiology Reviews","volume":"19 4","pages":"e060223213452"},"PeriodicalIF":2.4,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10494269/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9884665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Machine-learning Algorithms for Ischemic Heart Disease Prediction: A Systematic Review. 缺血性心脏病预测的机器学习算法:系统综述。
IF 1.9 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2023-01-01 DOI: 10.2174/1573403X18666220609123053
Salam H Bani Hani, Muayyad M Ahmad

Purpose: This review aims to summarize and evaluate the most accurate machinelearning algorithm used to predict ischemic heart disease.

Methods: This systematic review was performed following PRISMA guidelines. A comprehensive search was carried out using multiple databases such as Science Direct, PubMed MEDLINE, CINAHL, and IEEE explore.

Results: Thirteen articles published between 2017 to 2021 were eligible for inclusion. Three themes were extracted: the commonly used algorithm to predict ischemic heart disease, the accuracy of algorithms to predict ischemic heart disease, and the clinical outcomes to improve the quality of care. All methods have utilized supervised and unsupervised machine-learning.

Conclusion: Applying machine-learning is expected to assist clinicians in interpreting patients' data and implementing optimal algorithms for their datasets. Furthermore, machine-learning can build evidence-based that supports health care providers to manage individual situations who need invasive procedures such as catheterizations.

目的:本综述旨在总结和评估用于预测缺血性心脏病的最准确的机器学习算法。方法:根据PRISMA指南进行系统回顾。使用Science Direct、PubMedMEDLINE、CINAHL和IEEE explore等多个数据库进行了全面搜索。结果:2017年至2021年间发表的13篇文章符合入选条件。提取了三个主题:预测缺血性心脏病的常用算法,预测缺血性心脏疾病的算法的准确性,以及提高护理质量的临床结果。所有方法都使用了有监督和无监督的机器学习。结论:应用机器学习有望帮助临床医生解释患者的数据并为其数据集实现最佳算法。此外,机器学习可以建立基于证据的基础,支持医疗保健提供者管理需要导管等侵入性程序的个人情况。
{"title":"Machine-learning Algorithms for Ischemic Heart Disease Prediction: A Systematic Review.","authors":"Salam H Bani Hani, Muayyad M Ahmad","doi":"10.2174/1573403X18666220609123053","DOIUrl":"10.2174/1573403X18666220609123053","url":null,"abstract":"<p><strong>Purpose: </strong>This review aims to summarize and evaluate the most accurate machinelearning algorithm used to predict ischemic heart disease.</p><p><strong>Methods: </strong>This systematic review was performed following PRISMA guidelines. A comprehensive search was carried out using multiple databases such as Science Direct, PubMed MEDLINE, CINAHL, and IEEE explore.</p><p><strong>Results: </strong>Thirteen articles published between 2017 to 2021 were eligible for inclusion. Three themes were extracted: the commonly used algorithm to predict ischemic heart disease, the accuracy of algorithms to predict ischemic heart disease, and the clinical outcomes to improve the quality of care. All methods have utilized supervised and unsupervised machine-learning.</p><p><strong>Conclusion: </strong>Applying machine-learning is expected to assist clinicians in interpreting patients' data and implementing optimal algorithms for their datasets. Furthermore, machine-learning can build evidence-based that supports health care providers to manage individual situations who need invasive procedures such as catheterizations.</p>","PeriodicalId":10832,"journal":{"name":"Current Cardiology Reviews","volume":"19 1","pages":"e090622205797"},"PeriodicalIF":1.9,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10201879/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10665781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Incidence, Current Guidelines and Management of Gastrointestinal Bleeding after Transcatheter Aortic Valve Replacement: A Systematic Review. 经导管主动脉瓣置换术后胃肠道出血的发生率、当前指南和管理:一项系统综述。
IF 1.9 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2023-01-01 DOI: 10.2174/1573403X18666220623150830
Devina Adalja, Harshvardhan Zala, Varun Victor, Aakash Sheth, Charles Willyard, Emi Suzuki, Harsh P Patel, Monil Majmundar, Saraschandra Vallabhajosyula, Rajkumar Doshi

Background: There is a significant increase in morbidity and mortality in patients complicated by major bleeding following transcatheter aortic valve replacement (TAVR). It has become more challenging to manage such complications when the patient needs to be on anticoagulation or antiplatelet agent post-procedure to prevent thrombotic/embolic complications.

Methods: We systematically reviewed all available randomized controlled trials and observational studies to identify incidence rates of gastrointestinal bleeding post-procedure. After performing a systematic search, a total of 8731 patients from 15 studies (5 RCTs and 10 non-RCTs) were included in this review.

Results: The average rate of gastrointestinal bleeding during follow-up was 3.0% in randomized controlled trials and 1.9% among observational studies.

Conclusion: Gastrointestinal bleeding has been noted to be higher in the RCTs as compared to observational studies. This review expands knowledge of current guidelines and possible management of patients undergoing TAVR.

背景:经导管主动脉瓣置换术(TAVR)后并发大出血的患者的发病率和死亡率显著增加。当患者在术后需要服用抗凝剂或抗血小板药物以预防血栓/栓塞并发症时,处理此类并发症变得更具挑战性。方法:我们系统地回顾了所有可用的随机对照试验和观察性研究,以确定术后胃肠道出血的发生率。在进行系统搜索后,来自15项研究(5项随机对照试验和10项非随机对照试验)的8731名患者被纳入本综述。结果:在随机对照试验中,随访期间胃肠道出血的平均发生率为3.0%,在观察性研究中为1.9%。结论:与观察性研究相比,随机对照试验中的胃肠道出血率更高。这篇综述扩展了对接受TAVR的患者的当前指南和可能的管理的了解。
{"title":"Incidence, Current Guidelines and Management of Gastrointestinal Bleeding after Transcatheter Aortic Valve Replacement: A Systematic Review.","authors":"Devina Adalja, Harshvardhan Zala, Varun Victor, Aakash Sheth, Charles Willyard, Emi Suzuki, Harsh P Patel, Monil Majmundar, Saraschandra Vallabhajosyula, Rajkumar Doshi","doi":"10.2174/1573403X18666220623150830","DOIUrl":"10.2174/1573403X18666220623150830","url":null,"abstract":"<p><strong>Background: </strong>There is a significant increase in morbidity and mortality in patients complicated by major bleeding following transcatheter aortic valve replacement (TAVR). It has become more challenging to manage such complications when the patient needs to be on anticoagulation or antiplatelet agent post-procedure to prevent thrombotic/embolic complications.</p><p><strong>Methods: </strong>We systematically reviewed all available randomized controlled trials and observational studies to identify incidence rates of gastrointestinal bleeding post-procedure. After performing a systematic search, a total of 8731 patients from 15 studies (5 RCTs and 10 non-RCTs) were included in this review.</p><p><strong>Results: </strong>The average rate of gastrointestinal bleeding during follow-up was 3.0% in randomized controlled trials and 1.9% among observational studies.</p><p><strong>Conclusion: </strong>Gastrointestinal bleeding has been noted to be higher in the RCTs as compared to observational studies. This review expands knowledge of current guidelines and possible management of patients undergoing TAVR.</p>","PeriodicalId":10832,"journal":{"name":"Current Cardiology Reviews","volume":"19 1","pages":"e230622206351"},"PeriodicalIF":1.9,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10201885/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9233750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Vertebral Artery Interventions: A Comprehensive Updated Review. 椎动脉介入治疗:一篇全面更新的综述。
IF 1.9 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2023-01-01 DOI: 10.2174/1573403X18666220317093131
Oscar Maitas, Tamunoinemi Bob-Manuel, Justin Price, Abdullah Noor, Koyenum Obi, Nelson Okoh, Kiran Garikapati, Jeong Kim, Sanjida Jahan, James S Jenkins

Patients with posterior circulation ischemia due to vertebral artery stenosis account for 20 to 25% of ischemic strokes and have an increased risk of recurrent stroke. In patients treated with medical therapy alone, the risk of recurrence is particularly increased in the first few weeks after symptoms occur, with an annual stroke rate of 10 to 15%. Additionally, obstructive disease of the vertebrobasilar system carries a worse prognosis, with a 30% mortality at 2-years if managed medically without additional surgical or endovascular intervention. Percutaneous transluminal angioplasty and stenting of symptomatic vertebral artery stenosis are promising options widely used in clinical practice with good technical results; however, the improved clinical outcome has been examined in various clinical trials without a sufficient sample size to conclusively determine whether stenting is better than medical therapy. Surgical revascularization is an alternative approach for the treatment of symptomatic vertebral artery stenosis that carries a 10-20% mortality rate. Despite the advances in medical therapy and endovascular and surgical options, symptomatic vertebral artery stenosis continues to impose a high risk of stroke recurrence with associated high morbidity and mortality. This review aims to provide a focused update on the percutaneous treatment of vertebral artery stenosis, its appropriate diagnostic approach, and advances in medical therapies.

由于椎动脉狭窄导致后循环缺血的患者占缺血性中风的20%至25%,并且复发性中风的风险增加。在单独接受药物治疗的患者中,在症状出现后的最初几周,复发的风险尤其增加,每年的中风率为10%至15%。此外,椎基底动脉系统阻塞性疾病的预后更差,如果在没有额外手术或血管内干预的情况下进行医学治疗,2年时死亡率为30%。症状性椎动脉狭窄的经皮腔内血管成形术和支架置入术是临床上广泛应用的有前景的选择,具有良好的技术效果;然而,在没有足够的样本量来最终确定支架置入术是否优于药物治疗的情况下,各种临床试验都对改善的临床结果进行了检查。手术血运重建是治疗症状性椎动脉狭窄的一种替代方法,死亡率为10-20%。尽管在药物治疗、血管内和手术选择方面取得了进展,但有症状的椎动脉狭窄仍然会带来中风复发的高风险,并伴有高发病率和高死亡率。这篇综述旨在对经皮治疗椎动脉狭窄、其适当的诊断方法和医学治疗进展进行重点更新。
{"title":"Vertebral Artery Interventions: A Comprehensive Updated Review.","authors":"Oscar Maitas, Tamunoinemi Bob-Manuel, Justin Price, Abdullah Noor, Koyenum Obi, Nelson Okoh, Kiran Garikapati, Jeong Kim, Sanjida Jahan, James S Jenkins","doi":"10.2174/1573403X18666220317093131","DOIUrl":"10.2174/1573403X18666220317093131","url":null,"abstract":"<p><p>Patients with posterior circulation ischemia due to vertebral artery stenosis account for 20 to 25% of ischemic strokes and have an increased risk of recurrent stroke. In patients treated with medical therapy alone, the risk of recurrence is particularly increased in the first few weeks after symptoms occur, with an annual stroke rate of 10 to 15%. Additionally, obstructive disease of the vertebrobasilar system carries a worse prognosis, with a 30% mortality at 2-years if managed medically without additional surgical or endovascular intervention. Percutaneous transluminal angioplasty and stenting of symptomatic vertebral artery stenosis are promising options widely used in clinical practice with good technical results; however, the improved clinical outcome has been examined in various clinical trials without a sufficient sample size to conclusively determine whether stenting is better than medical therapy. Surgical revascularization is an alternative approach for the treatment of symptomatic vertebral artery stenosis that carries a 10-20% mortality rate. Despite the advances in medical therapy and endovascular and surgical options, symptomatic vertebral artery stenosis continues to impose a high risk of stroke recurrence with associated high morbidity and mortality. This review aims to provide a focused update on the percutaneous treatment of vertebral artery stenosis, its appropriate diagnostic approach, and advances in medical therapies.</p>","PeriodicalId":10832,"journal":{"name":"Current Cardiology Reviews","volume":"19 1","pages":"e170322202296"},"PeriodicalIF":1.9,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10201878/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9233244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Takotsubo Cardiomyopathy and COVID-19: A Case Report and Literature Review. Takotsubo型心肌病与新冠肺炎:病例报告和文献回顾。
IF 1.9 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2023-01-01 DOI: 10.2174/1573403X18666220818155039
Solís Gabriel José, Edgar Francisco Carrizales-Sepúlveda, Raymundo Vera-Pineda, Eliu Jefte Morales-Rendón, José de Jesús Ortiz-Corona, Ramiro Flores-Ramírez

Background: Takotsubo cardiomyopathy is characterized by transient regional ventricular abnormalities in the absence of coronary artery disease and is reported as a complication of COVID-19.

Case presentation: It can have a diverse clinical presentation, occasionally resembling an acute coronary syndrome, and progress to acute heart failure and cardiogenic shock, adversely affecting patients' prognosis. A high index of suspicion and a thorough diagnostic approach supported by ancillary studies like echocardiography and coronary angiography is key for an accurate diagnosis and correct medical treatment. Herein, we report a patient with severe COVID-19 who developed Takotsubo cardiomyopathy.

Conclusion: We also present a detailed literature review regarding the relationship between COVID-19 and Takotsubo cardiomyopathy.

背景:Takotsubo心肌病的特征是在没有冠状动脉疾病的情况下出现短暂的区域性心室异常,并被报道为COVID-19的并发症。病例表现:它可以有不同的临床表现,偶尔类似于急性冠状动脉综合征,并发展为急性心力衰竭和心源性休克,对患者的预后产生不利影响。高怀疑指数和由超声心动图和冠状动脉造影等辅助研究支持的彻底诊断方法是准确诊断和正确治疗的关键。在此,我们报告了一名患有严重新冠肺炎并发展为Takotsubo心肌病的患者。结论:我们还对新冠肺炎与Takotsubo心肌病之间的关系进行了详细的文献综述。
{"title":"Takotsubo Cardiomyopathy and COVID-19: A Case Report and Literature Review.","authors":"Solís Gabriel José, Edgar Francisco Carrizales-Sepúlveda, Raymundo Vera-Pineda, Eliu Jefte Morales-Rendón, José de Jesús Ortiz-Corona, Ramiro Flores-Ramírez","doi":"10.2174/1573403X18666220818155039","DOIUrl":"10.2174/1573403X18666220818155039","url":null,"abstract":"<p><strong>Background: </strong>Takotsubo cardiomyopathy is characterized by transient regional ventricular abnormalities in the absence of coronary artery disease and is reported as a complication of COVID-19.</p><p><strong>Case presentation: </strong>It can have a diverse clinical presentation, occasionally resembling an acute coronary syndrome, and progress to acute heart failure and cardiogenic shock, adversely affecting patients' prognosis. A high index of suspicion and a thorough diagnostic approach supported by ancillary studies like echocardiography and coronary angiography is key for an accurate diagnosis and correct medical treatment. Herein, we report a patient with severe COVID-19 who developed Takotsubo cardiomyopathy.</p><p><strong>Conclusion: </strong>We also present a detailed literature review regarding the relationship between COVID-19 and Takotsubo cardiomyopathy.</p>","PeriodicalId":10832,"journal":{"name":"Current Cardiology Reviews","volume":"19 2","pages":"e180822207660"},"PeriodicalIF":1.9,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10201897/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9830703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cardio-Metabolic Health and HRT in Menopause: Novel Insights in Mitochondrial Biogenesis and RAAS. 更年期的心脏代谢健康和激素替代疗法:线粒体生物发生和RAAS的新见解。
IF 2.4 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2023-01-01 DOI: 10.2174/1573403X19666230206130205
Guilherme Renke, Elaine Kemen, Priscila Scalabrin, Cleibe Braz, Thomaz Baesso, Marcela Batista Pereira

Recent evidence shows the cardiometabolic effects of estrogen administration in postmenopausal women. Women have a cardiometabolic advantage during their reproductive years, which is lost at menopause due to declining estradiol (E2). E2, also known as 17-beta-estradiol, has diverse effects in its target tissues, including the cardiovascular (CV) system, through genomic and non-genomic signaling. Metabolic changes characteristic of menopause include a worsening lipid profile, changes in body fat distribution, epicardial and pericardial fat deposition, increased susceptibility to weight gain, and increased blood pressure, resulting in an increased risk of accelerated cardiovascular disease (CVD) development. E2 mediates its cardioprotective actions by increasing mitochondrial biogenesis, angiogenesis, and vasodilation, decreasing reactive oxygen species (ROS) and oxidative stress, and modulating the renin-angiotensin-aldosterone system (RAAS). In this review, we assess whether it is prudent to develop an approach to managing postmenopausal women based on modifying the patient's CV risk that includes human-identical hormone replacement therapy (HRT), modulation of RAAS, and stimulating mitochondrial biogenesis. Further research is needed to assess the safety and benefit of HRT to reduce cardiometabolic risk.

最近的证据表明,雌激素对绝经后妇女的心脏代谢有影响。女性在生育期具有心脏代谢优势,而在更年期由于雌二醇(E2)的下降而失去了这一优势。E2,也称为17β-雌二醇,通过基因组和非基因组信号传导在其靶组织中具有不同的作用,包括心血管系统。更年期特有的代谢变化包括脂质状况恶化、体脂分布变化、心外膜和心包脂肪沉积、体重增加易感性增加和血压升高,导致心血管疾病(CVD)发展加速的风险增加。E2通过增加线粒体生物发生、血管生成和血管舒张、减少活性氧(ROS)和氧化应激以及调节肾素-血管紧张素-醛固酮系统(RAAS)来介导其心脏保护作用。在这篇综述中,我们评估了在改变患者CV风险的基础上开发一种管理绝经后妇女的方法是否谨慎,包括人类相同激素替代疗法(HRT)、调节RAAS和刺激线粒体生物发生。需要进一步的研究来评估激素替代疗法的安全性和益处,以降低心脏代谢风险。
{"title":"Cardio-Metabolic Health and HRT in Menopause: Novel Insights in Mitochondrial Biogenesis and RAAS.","authors":"Guilherme Renke, Elaine Kemen, Priscila Scalabrin, Cleibe Braz, Thomaz Baesso, Marcela Batista Pereira","doi":"10.2174/1573403X19666230206130205","DOIUrl":"10.2174/1573403X19666230206130205","url":null,"abstract":"<p><p>Recent evidence shows the cardiometabolic effects of estrogen administration in postmenopausal women. Women have a cardiometabolic advantage during their reproductive years, which is lost at menopause due to declining estradiol (E2). E2, also known as 17-beta-estradiol, has diverse effects in its target tissues, including the cardiovascular (CV) system, through genomic and non-genomic signaling. Metabolic changes characteristic of menopause include a worsening lipid profile, changes in body fat distribution, epicardial and pericardial fat deposition, increased susceptibility to weight gain, and increased blood pressure, resulting in an increased risk of accelerated cardiovascular disease (CVD) development. E2 mediates its cardioprotective actions by increasing mitochondrial biogenesis, angiogenesis, and vasodilation, decreasing reactive oxygen species (ROS) and oxidative stress, and modulating the renin-angiotensin-aldosterone system (RAAS). In this review, we assess whether it is prudent to develop an approach to managing postmenopausal women based on modifying the patient's CV risk that includes human-identical hormone replacement therapy (HRT), modulation of RAAS, and stimulating mitochondrial biogenesis. Further research is needed to assess the safety and benefit of HRT to reduce cardiometabolic risk.</p>","PeriodicalId":10832,"journal":{"name":"Current Cardiology Reviews","volume":"19 4","pages":"e060223213459"},"PeriodicalIF":2.4,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10494270/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9842654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Case Report: Culture-negative Prosthetic Valve Endocarditis. 病例报告:培养阴性人工瓣膜心内膜炎。
IF 2.4 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2023-01-01 DOI: 10.2174/1573403X19666230411151214
Ignacio D Velazquez, Kenneth K Woo, Mohammed Siddiqui, Sion K Roy

Background: Prosthetic valve endocarditis can be difficult to diagnose and cause significant morbidity and mortality, especially when no culture data are available to guide therapy. Transthoracic and transesophageal echocardiograms, the studies of choice for initial endocarditis evaluation, can be less reliable due to artifact and post-surgical changes. Some less common forms of endocarditis may be difficult to culture and, due to their fastidious nature, may delay the identification of causative organisms. Given the lack of directed antimicrobial treatment, culturenegative prosthetic valve endocarditis is specifically difficult. A wide differential diagnosis is critical to make a timely diagnosis and initiate treatment.

Case presentation: We present a case of a patient presenting with dyspnea which was found to have culture-negative endocarditis requiring mitral and aortic valve replacement that ultimately was complicated with culture-negative prosthetic valve endocarditis. Identifying a culprit organism made appropriate and timely antimicrobial treatment difficult, ultimately resulting in the patient dying from endocarditis complications.

Conclusion: A high index of suspicion is needed when managing infective endocarditis, especially when prosthetic valves are involved. Diagnostic accuracy of cultures and echocardiography may be reduced when dealing with prosthetic valve endocarditis; thus, alternative methods of diagnosis may be required to make a timely diagnosis of causative organisms.

背景:人工瓣膜心内膜炎可能很难诊断,并导致显著的发病率和死亡率,尤其是当没有可用的培养数据来指导治疗时。经胸超声心动图和经食道超声心动图是评估心内膜炎的首选研究,但由于伪影和术后变化,其可靠性可能较低。一些不太常见的心内膜炎可能很难培养,而且由于其挑剔的性质,可能会延迟病原体的鉴定。由于缺乏直接的抗菌治疗,培养阴性人工瓣膜心内膜炎特别困难。广泛的鉴别诊断对于及时诊断和开始治疗至关重要。病例介绍:我们报告了一例患者出现呼吸困难,发现其患有培养阴性心内膜炎,需要更换二尖瓣和主动脉瓣,最终并发培养阴性人工瓣膜心内膜炎。识别罪魁祸首使适当及时的抗菌治疗变得困难,最终导致患者死于心内膜炎并发症。结论:在处理感染性心内膜炎时,尤其是涉及人工瓣膜时,需要高度怀疑。在处理人工瓣膜心内膜炎时,培养物和超声心动图的诊断准确性可能会降低;因此,可能需要其他诊断方法来及时诊断病原体。
{"title":"Case Report: Culture-negative Prosthetic Valve Endocarditis.","authors":"Ignacio D Velazquez, Kenneth K Woo, Mohammed Siddiqui, Sion K Roy","doi":"10.2174/1573403X19666230411151214","DOIUrl":"10.2174/1573403X19666230411151214","url":null,"abstract":"<p><strong>Background: </strong>Prosthetic valve endocarditis can be difficult to diagnose and cause significant morbidity and mortality, especially when no culture data are available to guide therapy. Transthoracic and transesophageal echocardiograms, the studies of choice for initial endocarditis evaluation, can be less reliable due to artifact and post-surgical changes. Some less common forms of endocarditis may be difficult to culture and, due to their fastidious nature, may delay the identification of causative organisms. Given the lack of directed antimicrobial treatment, culturenegative prosthetic valve endocarditis is specifically difficult. A wide differential diagnosis is critical to make a timely diagnosis and initiate treatment.</p><p><strong>Case presentation: </strong>We present a case of a patient presenting with dyspnea which was found to have culture-negative endocarditis requiring mitral and aortic valve replacement that ultimately was complicated with culture-negative prosthetic valve endocarditis. Identifying a culprit organism made appropriate and timely antimicrobial treatment difficult, ultimately resulting in the patient dying from endocarditis complications.</p><p><strong>Conclusion: </strong>A high index of suspicion is needed when managing infective endocarditis, especially when prosthetic valves are involved. Diagnostic accuracy of cultures and echocardiography may be reduced when dealing with prosthetic valve endocarditis; thus, alternative methods of diagnosis may be required to make a timely diagnosis of causative organisms.</p>","PeriodicalId":10832,"journal":{"name":"Current Cardiology Reviews","volume":" ","pages":"5-8"},"PeriodicalIF":2.4,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10636796/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9513673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
CHARGE-AF: A Useful Score For Atrial Fibrillation Prediction? CHARGE-AF:预测心房颤动的有用分数?
IF 1.9 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2023-01-01 DOI: 10.2174/1573403X18666220901102557
Christos Goudis, Stylianos Daios, Fotios Dimitriadis, Tong Liu

Atrial fibrillation (AF) is the commonest arrhythmia in clinical practice and is associated with increased morbidity and mortality. Various predictive scores for new-onset AF have been proposed, but so far, none have been widely used in clinical practice. CHARGE-AF score was developed from a pooled diverse population from three large cohorts (Atherosclerosis Risk in Communities study, Cardiovascular Health Study and Framingham Heart Study). A simple 5-year predictive model includes the variables of age, race, height, weight, systolic and diastolic blood pressure, current smoking, use of antihypertensive medication, diabetes mellitus, history of myocardial infarction and heart failure. Recent studies report that the CHARGE-AF score has good discrimination for incident AF and seems to be a promising prediction model for this arrhythmia. New screening tools (smartphone apps, smartwatches) are rapidly developing for AF detection. Therefore, the wide application of the CHARGE-AF score in clinical practice and the upcoming usage of mobile health technologies and smartwatches may result in better AF prediction and adequate stroke prevention, especially in high-risk patients.

心房颤动(AF)是临床上最常见的心律失常,与发病率和死亡率的增加有关。新发性房颤的各种预测评分已经被提出,但到目前为止,还没有一种在临床实践中得到广泛应用。CHARGE-AF评分是从三个大队列(社区动脉粥样硬化风险研究、心血管健康研究和弗雷明汉心脏研究)的不同人群中得出的。一个简单的5年预测模型包括年龄、种族、身高、体重、收缩压和舒张压、当前吸烟、抗高血压药物的使用、糖尿病、心肌梗死和心力衰竭史等变量。最近的研究报告称,CHARGE-AF评分对发生的房颤有很好的辨别力,似乎是这种心律失常的一个很有前途的预测模型。新的AF检测筛查工具(智能手机应用程序、智能手表)正在迅速发展。因此,CHARGE-AF评分在临床实践中的广泛应用,以及移动健康技术和智能手表的即将使用,可能会带来更好的AF预测和充分的中风预防,尤其是在高危患者中。
{"title":"CHARGE-AF: A Useful Score For Atrial Fibrillation Prediction?","authors":"Christos Goudis, Stylianos Daios, Fotios Dimitriadis, Tong Liu","doi":"10.2174/1573403X18666220901102557","DOIUrl":"10.2174/1573403X18666220901102557","url":null,"abstract":"<p><p>Atrial fibrillation (AF) is the commonest arrhythmia in clinical practice and is associated with increased morbidity and mortality. Various predictive scores for new-onset AF have been proposed, but so far, none have been widely used in clinical practice. CHARGE-AF score was developed from a pooled diverse population from three large cohorts (Atherosclerosis Risk in Communities study, Cardiovascular Health Study and Framingham Heart Study). A simple 5-year predictive model includes the variables of age, race, height, weight, systolic and diastolic blood pressure, current smoking, use of antihypertensive medication, diabetes mellitus, history of myocardial infarction and heart failure. Recent studies report that the CHARGE-AF score has good discrimination for incident AF and seems to be a promising prediction model for this arrhythmia. New screening tools (smartphone apps, smartwatches) are rapidly developing for AF detection. Therefore, the wide application of the CHARGE-AF score in clinical practice and the upcoming usage of mobile health technologies and smartwatches may result in better AF prediction and adequate stroke prevention, especially in high-risk patients.</p>","PeriodicalId":10832,"journal":{"name":"Current Cardiology Reviews","volume":"19 2","pages":"e010922208402"},"PeriodicalIF":1.9,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10201902/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9771911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pseudocoarctation of the Arch and the Abdominal Aorta: A Review. 主动脉弓和腹主动脉假性缩窄:综述。
IF 2.4 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2023-01-01 DOI: 10.2174/1573403X19666230329135028
Manjappa Mahadevappa, Prashanth Kulkarni, Lakshay Attri, Nidhi Basavaraj

Pseudocoarctaion of the aorta is a rare congenital anomaly occurring in isolation or with other congenital heart diseases. The anatomical basis of the condition is linked to an elongated, redundant aorta which may affect the arch, or the abdominal aorta rarely giving rise to kink and buckling without causing any significant functional stenosis. It should be carefully differentiated from the common true coarctation of the aorta. No clinical features are specific to pseudo coarctation and are often diagnosed incidentally. Although asymptomatic in the majority, few patients can have nonspecific symptoms and complications due to aneurysm formation, dissection, or rupture of the aorta. Hence Pseudocoarctaion should be closely followed for the onset of symptoms or possible complications. Without recommendations, no specific therapy is indicated in asymptomatic patients, although symptoms and complications warrant definitive treatment. As the natural history of the disease is unknown, the condition, when diagnosed, should be closely followed up for the occurrence of any complications. This article reports a pseudo aortic coarctation involving the arch and a brief literature review of this rare congenital anomaly.

主动脉假性缩窄是一种罕见的先天性异常,单独发生或与其他先天性心脏病一起发生。这种情况的解剖学基础与细长、多余的主动脉有关,这可能会影响主动脉弓,或者腹主动脉很少会出现扭结和屈曲,而不会导致任何显著的功能性狭窄。应该小心地将其与常见的真正的主动脉缩窄区分开来。伪缩窄没有特定的临床特征,通常是偶然诊断出来的。尽管大多数患者没有症状,但很少有患者会因动脉瘤形成、夹层或主动脉破裂而出现非特异性症状和并发症。因此,假性缩窄应密切关注症状的出现或可能的并发症。在没有建议的情况下,无症状患者没有特定的治疗方法,尽管症状和并发症需要明确的治疗。由于该疾病的自然病史尚不清楚,因此在诊断时,应密切随访是否出现任何并发症。本文报告了一例涉及主动脉弓的假性主动脉缩窄,并对这种罕见的先天性异常进行了简要的文献回顾。
{"title":"Pseudocoarctation of the Arch and the Abdominal Aorta: A Review.","authors":"Manjappa Mahadevappa, Prashanth Kulkarni, Lakshay Attri, Nidhi Basavaraj","doi":"10.2174/1573403X19666230329135028","DOIUrl":"10.2174/1573403X19666230329135028","url":null,"abstract":"<p><p>Pseudocoarctaion of the aorta is a rare congenital anomaly occurring in isolation or with other congenital heart diseases. The anatomical basis of the condition is linked to an elongated, redundant aorta which may affect the arch, or the abdominal aorta rarely giving rise to kink and buckling without causing any significant functional stenosis. It should be carefully differentiated from the common true coarctation of the aorta. No clinical features are specific to pseudo coarctation and are often diagnosed incidentally. Although asymptomatic in the majority, few patients can have nonspecific symptoms and complications due to aneurysm formation, dissection, or rupture of the aorta. Hence Pseudocoarctaion should be closely followed for the onset of symptoms or possible complications. Without recommendations, no specific therapy is indicated in asymptomatic patients, although symptoms and complications warrant definitive treatment. As the natural history of the disease is unknown, the condition, when diagnosed, should be closely followed up for the occurrence of any complications. This article reports a pseudo aortic coarctation involving the arch and a brief literature review of this rare congenital anomaly.</p>","PeriodicalId":10832,"journal":{"name":"Current Cardiology Reviews","volume":"19 5","pages":"73-82"},"PeriodicalIF":2.4,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10518887/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9880413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Current Cardiology Reviews
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1