Pub Date : 2021-01-11DOI: 10.2174/2213346108999210111224631
D. Kundu, A. Roy, A. Singha, Subir Panja
In recent times, Nickel has become a powerful alternative transition metal catalyst for performing cross-coupling reactions due to its low cost and better sustainability. Thus, a sustainable Nicatalyzed C-Se cross coupling has been developed in the presence of catalytic amount of copper iodide as co-catalyst. A wide range of substituted diaryl selenides has been synthesized by this Ni-Cu dual catalyzed C-Se cross coupling. The reaction is following an oxidative addition and reductive elimination pathway where Cu is playing an important role in transmetalation. The mechanism of the reaction was established by several experimental techniques.
{"title":"Nickel-copper Co-catalyzed Sustainable Synthesis of Diaryl-chalcogenides","authors":"D. Kundu, A. Roy, A. Singha, Subir Panja","doi":"10.2174/2213346108999210111224631","DOIUrl":"https://doi.org/10.2174/2213346108999210111224631","url":null,"abstract":"\u0000\u0000In recent times, Nickel has become a powerful alternative transition metal catalyst for performing\u0000cross-coupling reactions due to its low cost and better sustainability. Thus, a sustainable Nicatalyzed\u0000C-Se cross coupling has been developed in the presence of catalytic amount of copper iodide\u0000as co-catalyst. A wide range of substituted diaryl selenides has been synthesized by this Ni-Cu dual\u0000catalyzed C-Se cross coupling. The reaction is following an oxidative addition and reductive elimination\u0000pathway where Cu is playing an important role in transmetalation. The mechanism of the reaction\u0000was established by several experimental techniques.\u0000","PeriodicalId":10856,"journal":{"name":"Current Green Chemistry","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2021-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49217924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.2174/2213347xmtewpoti12
Avik K.Bagdi
{"title":"Rhodamines as Photocatalyst in Organic Synthesis","authors":"Avik K.Bagdi","doi":"10.2174/2213347xmtewpoti12","DOIUrl":"https://doi.org/10.2174/2213347xmtewpoti12","url":null,"abstract":"","PeriodicalId":10856,"journal":{"name":"Current Green Chemistry","volume":"134 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68187563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-12-24DOI: 10.2174/2213346107999201224110618
N. Patel, R. Parmar, Hetal I. Soni
Microwave irradiated facile and efficient process for one pot Ugi multicomponent reaction of a novel series of fluoroquinolone scaffolds is described here. On the basis of this approach, a new route to synthesize this privileged scaffolds was designed with higher yields, a clean procedure, time efficient and simple work-up. Our aim is to develop a biologically active fluoroquinolone scaffolds by microwave induced one pot Ugi multicomponent reaction. All the synthesized molecules were characterized by IR, 1H NMR, 13C NMR, and Mass spectra. The antimicrobial activity of the synthesized compounds was screened against two Gram-negative bacteria (Escherichia coli, Pseudomonas aeruginosa), two Gram-positive bacteria (Staphylococcus aureus, Streptococcus pyogenes), and three fungi (Candida albicans, Aspergillus niger, Aspergillus clavatus) utilizing the MIC (Minimal Inhibitory Concentration) method and antitubercular activity H37Rv utilizing L. J. Slope method. Some of these novel derivatives demonstrate moderate to good in vitro antibacterial, antifungal and antitubercular activities.
{"title":"Microwave Induced One Pot Ugi Multicomponent Reaction of Fluoroquino Lone Scaffolds: Their Biological Evaluation","authors":"N. Patel, R. Parmar, Hetal I. Soni","doi":"10.2174/2213346107999201224110618","DOIUrl":"https://doi.org/10.2174/2213346107999201224110618","url":null,"abstract":"\u0000\u0000Microwave irradiated facile and efficient process for one pot Ugi multicomponent reaction\u0000of a novel series of fluoroquinolone scaffolds is described here. On the basis of this approach,\u0000a new route to synthesize this privileged scaffolds was designed with higher yields, a\u0000clean procedure, time efficient and simple work-up. Our aim is to develop a biologically active\u0000fluoroquinolone scaffolds by microwave induced one pot Ugi multicomponent reaction. All the\u0000synthesized molecules were characterized by IR, 1H NMR, 13C NMR, and Mass spectra. The antimicrobial\u0000activity of the synthesized compounds was screened against two Gram-negative bacteria\u0000(Escherichia coli, Pseudomonas aeruginosa), two Gram-positive bacteria (Staphylococcus\u0000aureus, Streptococcus pyogenes), and three fungi (Candida albicans, Aspergillus niger, Aspergillus\u0000clavatus) utilizing the MIC (Minimal Inhibitory Concentration) method and antitubercular activity\u0000H37Rv utilizing L. J. Slope method. Some of these novel derivatives demonstrate moderate\u0000to good in vitro antibacterial, antifungal and antitubercular activities.\u0000","PeriodicalId":10856,"journal":{"name":"Current Green Chemistry","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2020-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44247068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-12-08DOI: 10.2174/2213346107999201208214038
A. K. Pathan, Pravinkumar Patil, A. Shinde, S. Zangade
Iodination of organic substrate is an important reaction for synthesis of pharmacological active molecules. In view of these concerns, we reported the convenient procedure for synthesis of iodo compounds using iodine and iodic acid in PEG-400.We have reported the eco-friendly procedure for preparation of aromatic iodo compounds using iodine and iodic acid in green reaction media as polyethylene glycol (PEG-400). The iodination of some aromatic compounds such as benzaldehydes, acetophenones, phenols, amines and heterocyclic compounds carried out using iodine, iodic acid and PEG-400. The synthesized substituted aromatic iodo compounds were confirmed based on spectral characterization and mixed melting points. The method comprises several advantages such as simple reaction procedure, easy isolation, quantitative yields, and purity of iodo products.
{"title":"Eco-friendly and Green Procedure for Iodination of Reactive Aromatics Using PEG 400-I2/HIO3 Combination","authors":"A. K. Pathan, Pravinkumar Patil, A. Shinde, S. Zangade","doi":"10.2174/2213346107999201208214038","DOIUrl":"https://doi.org/10.2174/2213346107999201208214038","url":null,"abstract":"\u0000\u0000Iodination of organic substrate is an important reaction for synthesis of pharmacological active\u0000molecules.\u0000\u0000\u0000\u0000In view of these concerns, we reported the convenient procedure for synthesis of iodo compounds using iodine\u0000and iodic acid in PEG-400.We have reported the eco-friendly procedure for preparation of aromatic iodo compounds using\u0000iodine and iodic acid in green reaction media as polyethylene glycol (PEG-400).\u0000\u0000\u0000\u0000The iodination of some aromatic compounds such as benzaldehydes, acetophenones, phenols, amines and\u0000heterocyclic compounds carried out using iodine, iodic acid and PEG-400. The synthesized substituted aromatic iodo\u0000compounds were confirmed based on spectral characterization and mixed melting points.\u0000\u0000\u0000\u0000The method comprises several advantages such as simple reaction procedure, easy isolation, quantitative\u0000yields, and purity of iodo products.\u0000","PeriodicalId":10856,"journal":{"name":"Current Green Chemistry","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2020-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47916323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-11-11DOI: 10.2174/2213346107999201111201105
Fatemeh Molaei Yielzoleh, Kobra Nikoofar
In this review, we focused on the six- and pseudo-six-component transformations in organic syntheses as a class of important and applicable MCRs. Although the MCRs usage in recent years is enhanced the reports for more than five-component MCRs are still rare. In some cases, these kinds of MCRs are the combination of some tandem named reactions that generated a union MCR. Preparation of multi-functionalized heterocycles, prevention of intermediate separation, reaction progressing in a one-pot continuous manner, elevated total yield, high atom economy, and preparation of potent bioactive multi-cycles hetero-organics via the construction of several new bonds are some highlighted features of MCRs. In this article, we classified the mentioned sixcomponent reactions based on reaction media. Another subdivision is applied based on thermal energy usage or ambient temperature. In fact, two aspects of the green chemistry rules have been discussed.
{"title":"An Outlook to Six- and Pseudo Six-component Reactions in Organic Synthesis with a Glance at Some Aspects of Green Chemistry","authors":"Fatemeh Molaei Yielzoleh, Kobra Nikoofar","doi":"10.2174/2213346107999201111201105","DOIUrl":"https://doi.org/10.2174/2213346107999201111201105","url":null,"abstract":"\u0000\u0000In this review, we focused on the six- and pseudo-six-component transformations in organic\u0000syntheses as a class of important and applicable MCRs. Although the MCRs usage in recent\u0000years is enhanced the reports for more than five-component MCRs are still rare. In some cases,\u0000these kinds of MCRs are the combination of some tandem named reactions that generated a union\u0000MCR. Preparation of multi-functionalized heterocycles, prevention of intermediate separation, reaction\u0000progressing in a one-pot continuous manner, elevated total yield, high atom economy, and\u0000preparation of potent bioactive multi-cycles hetero-organics via the construction of several new\u0000bonds are some highlighted features of MCRs. In this article, we classified the mentioned sixcomponent\u0000reactions based on reaction media. Another subdivision is applied based on thermal\u0000energy usage or ambient temperature. In fact, two aspects of the green chemistry rules have been\u0000discussed.\u0000","PeriodicalId":10856,"journal":{"name":"Current Green Chemistry","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2020-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43958284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-10-26DOI: 10.2174/2213346107999201026201232
A. K. Bagdi, P. Sikdar
Organic synthesis, under environment-friendly conditions, has a great impact on sustainable development. In this context, visible light photocatalysis has emerged as a green model, as this offers an energy-efficient pathway towards the organic transformation. Different transition-metal catalysts (Ir-, Ru-, Cu- etc.) and organic dyes (eosin Y, rose bengal, methylene blue, etc.) are wellknown photocatalysts in organic synthesis. Apart from the well-known organophotoredox catalysts, rhodamines (Rhodamine B and Rhodamine 6G) have also been employed as efficient photocatalysts for different organic transformations. In this review, we will focus on the photocatalysis by rhodamines in organic synthesis. The mechanistic pathway of the methodologies will also be discussed. We believe this review will stimulate the employment of rhodamines in the visible light photocatalysis for efficient organic transformations in the future.
{"title":"Rhodamines as Photocatalyst in Organic Synthesis","authors":"A. K. Bagdi, P. Sikdar","doi":"10.2174/2213346107999201026201232","DOIUrl":"https://doi.org/10.2174/2213346107999201026201232","url":null,"abstract":"\u0000\u0000Organic synthesis, under environment-friendly conditions, has a great impact on sustainable\u0000development. In this context, visible light photocatalysis has emerged as a green model, as this\u0000offers an energy-efficient pathway towards the organic transformation. Different transition-metal\u0000catalysts (Ir-, Ru-, Cu- etc.) and organic dyes (eosin Y, rose bengal, methylene blue, etc.) are wellknown\u0000photocatalysts in organic synthesis. Apart from the well-known organophotoredox catalysts,\u0000rhodamines (Rhodamine B and Rhodamine 6G) have also been employed as efficient photocatalysts\u0000for different organic transformations. In this review, we will focus on the photocatalysis by rhodamines\u0000in organic synthesis. The mechanistic pathway of the methodologies will also be discussed.\u0000We believe this review will stimulate the employment of rhodamines in the visible light\u0000photocatalysis for efficient organic transformations in the future.\u0000","PeriodicalId":10856,"journal":{"name":"Current Green Chemistry","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2020-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49442444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-09-21DOI: 10.2174/2213346107999200616110434
Daniela Hartwig, J. Nascimento, Luana Bettanin, Thalita B. Aquino, R. Jacob, E. Lenardão
Deep Eutectic Solvent (DES) as a “green solvent” has been used as an alternative to replace Volatile Organic Compounds (VOCs) and traditional Ionic Liquids (ILs). In recent years, DES has gained much attention due to its excellent properties such as low cost, easy preparation, high viscosity, low vapor pressure, low volatility, high thermal stability, biodegradability and non-toxicity, among others. Other classes of compounds with increased interest are organosulfur compounds due to their applicability as synthetic intermediates in organic reactions and their high importance in pharmaceutical and agrochemical industries. This review describes the recent advances in the preparation of organosulfur compounds using DES as an alternative solvent, focusing on several types of organic reactions, including aromatic substitution reactions (SNAr), condensation, cyclocondensation, cyclization, ring-opening, thia-Michael addition, one-pot reactions and heterocyclodehydrations.
{"title":"Deep Eutectic Solvents: An Alternative Medium for the Preparation of Organosulfur Compounds","authors":"Daniela Hartwig, J. Nascimento, Luana Bettanin, Thalita B. Aquino, R. Jacob, E. Lenardão","doi":"10.2174/2213346107999200616110434","DOIUrl":"https://doi.org/10.2174/2213346107999200616110434","url":null,"abstract":"\u0000\u0000Deep Eutectic Solvent (DES) as a “green solvent” has been used as an alternative to replace\u0000Volatile Organic Compounds (VOCs) and traditional Ionic Liquids (ILs). In recent years, DES has\u0000gained much attention due to its excellent properties such as low cost, easy preparation, high viscosity,\u0000low vapor pressure, low volatility, high thermal stability, biodegradability and non-toxicity, among\u0000others. Other classes of compounds with increased interest are organosulfur compounds due to their\u0000applicability as synthetic intermediates in organic reactions and their high importance in pharmaceutical\u0000and agrochemical industries. This review describes the recent advances in the preparation of organosulfur\u0000compounds using DES as an alternative solvent, focusing on several types of organic reactions,\u0000including aromatic substitution reactions (SNAr), condensation, cyclocondensation, cyclization,\u0000ring-opening, thia-Michael addition, one-pot reactions and heterocyclodehydrations.\u0000","PeriodicalId":10856,"journal":{"name":"Current Green Chemistry","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2020-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43137751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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