The article is devoted to the history of pediatrics in Transbaikal Region and Anna Nikolaevna Bek role in children healthcare development. The topicality of Anna Nikolaevna and Evgeniy Vladimirovich Bek works in studying of Urov disease is discussed. The little-known facts about the first kindergartens implementation in Chita are presented.
{"title":"Anna Nikolaevna Bek is the First Pediatrician in Eastern Transbaikal Region","authors":"V. Shcherbak","doi":"10.15690/vsp.v21i4.2423","DOIUrl":"https://doi.org/10.15690/vsp.v21i4.2423","url":null,"abstract":"The article is devoted to the history of pediatrics in Transbaikal Region and Anna Nikolaevna Bek role in children healthcare development. The topicality of Anna Nikolaevna and Evgeniy Vladimirovich Bek works in studying of Urov disease is discussed. The little-known facts about the first kindergartens implementation in Chita are presented.","PeriodicalId":10867,"journal":{"name":"Current pediatrics","volume":"205 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86829956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
R. Matveev, V. Y. Albitskiy, T. Denisova, S. A. Sher, Melsik S. Denisov, Ludmila L. Kozyreva
This article presents the results of historical and medical study reflecting the state of child health care system in Chuvash Autonomous Soviet Socialist Republic during the Great Patriotic War of 1941–1945. The aim of the study is to analyze the situation regarding children’s health care during the most crucial period for our country. We have studied published and unpublished documents from the State Archive of Russian Federation, archives of Chuvash Republic, newspapers, journals, collections of scientific articles, and monographs to cover this issue. Local health authorities have significantly reorganized their work during the war years and set new tasks for protection of local and evacuated children’s health and lives. People’s Commissariat of Public Health of Chuvash Autonomous Soviet Socialist Republic has managed to prevent the reduction in the number of pediatric medical and preventive institutions, implemented their adequate staffing level, increase the efficacy of therapeutic and preventive measures, and resist infectious diseases outbreaks even under the evacuation measures, insufficient funding, and lack of qualified specialists. The child health care system created before the war in the whole USSR (Chuvashia included) and the medical and preventive work that was carried out during the war gave positive results. Child mortality decreased by 1.7 times compared to the pre-war 1940. Thus, children’s health care in Chuvashia withstood this difficult test and proved its efficacy during the Great Patriotic War.
{"title":"Children’s Health Care in Chuvashia Region During the Great Patriotic War of 1941–1945","authors":"R. Matveev, V. Y. Albitskiy, T. Denisova, S. A. Sher, Melsik S. Denisov, Ludmila L. Kozyreva","doi":"10.15690/vsp.v21i4.2432","DOIUrl":"https://doi.org/10.15690/vsp.v21i4.2432","url":null,"abstract":"This article presents the results of historical and medical study reflecting the state of child health care system in Chuvash Autonomous Soviet Socialist Republic during the Great Patriotic War of 1941–1945. The aim of the study is to analyze the situation regarding children’s health care during the most crucial period for our country. We have studied published and unpublished documents from the State Archive of Russian Federation, archives of Chuvash Republic, newspapers, journals, collections of scientific articles, and monographs to cover this issue. Local health authorities have significantly reorganized their work during the war years and set new tasks for protection of local and evacuated children’s health and lives. People’s Commissariat of Public Health of Chuvash Autonomous Soviet Socialist Republic has managed to prevent the reduction in the number of pediatric medical and preventive institutions, implemented their adequate staffing level, increase the efficacy of therapeutic and preventive measures, and resist infectious diseases outbreaks even under the evacuation measures, insufficient funding, and lack of qualified specialists. The child health care system created before the war in the whole USSR (Chuvashia included) and the medical and preventive work that was carried out during the war gave positive results. Child mortality decreased by 1.7 times compared to the pre-war 1940. Thus, children’s health care in Chuvashia withstood this difficult test and proved its efficacy during the Great Patriotic War.","PeriodicalId":10867,"journal":{"name":"Current pediatrics","volume":"40 1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75865373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The article is devoted to the end of the final (according to the authors) period in the development of classic medicine in Russia, that was based on principles dating back to the Hippocratic oath. Authors have concluded that the main paradigm has been changed from humanistic to market one after discussion of all the patterns and features of Russian medicine during XIX–XX centuries on the therapeutic and pediatric clinics models.
{"title":"Requiem on Hippocratic Medicine or 20th Century Clinic as the Final Stage of Classic Medicine in Russia (Therapeutic and Pediatric Clinics Models)","authors":"V. Borodulin, V. Albitsky","doi":"10.15690/vsp.v21i4.2424","DOIUrl":"https://doi.org/10.15690/vsp.v21i4.2424","url":null,"abstract":"The article is devoted to the end of the final (according to the authors) period in the development of classic medicine in Russia, that was based on principles dating back to the Hippocratic oath. Authors have concluded that the main paradigm has been changed from humanistic to market one after discussion of all the patterns and features of Russian medicine during XIX–XX centuries on the therapeutic and pediatric clinics models.","PeriodicalId":10867,"journal":{"name":"Current pediatrics","volume":"2013 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86466335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
N. A. Daikhes, K. Diab, D. Kondratchikov, O. Pashchinina, Liudmila V. Balakina
Ear deformities occur in 5–50% of newborns [1, 2]. Usually ear deformities minimally affect hearing, however, they can lead to psychological disorders, anxiety, social isolation, and behavioral problems. Ear deformities can spontaneously self-correct without any treatment in about 30% of cases. Surgical or non-surgical correction of ears’ shape is the only alternative for the rest of the patients. Molding is an effective method for non-surgical correction of ear deformations. It is possible to achieve better treatment results if you start the procedure during the first days of life due to sufficient plasticity of ear cartilage in newborns. Otherwise, otoplasty would be necessary at the age of 3–6 years.
{"title":"Ear Deformities in Children","authors":"N. A. Daikhes, K. Diab, D. Kondratchikov, O. Pashchinina, Liudmila V. Balakina","doi":"10.15690/vsp.v21i4.2434","DOIUrl":"https://doi.org/10.15690/vsp.v21i4.2434","url":null,"abstract":"Ear deformities occur in 5–50% of newborns [1, 2]. Usually ear deformities minimally affect hearing, however, they can lead to psychological disorders, anxiety, social isolation, and behavioral problems. Ear deformities can spontaneously self-correct without any treatment in about 30% of cases. Surgical or non-surgical correction of ears’ shape is the only alternative for the rest of the patients. Molding is an effective method for non-surgical correction of ear deformations. It is possible to achieve better treatment results if you start the procedure during the first days of life due to sufficient plasticity of ear cartilage in newborns. Otherwise, otoplasty would be necessary at the age of 3–6 years.","PeriodicalId":10867,"journal":{"name":"Current pediatrics","volume":"28 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87626590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tatiana S. Kashinskaya, N. Shakhova, Yrij F. Lobanov, E. M. Kamaltynova
Various conclusive evidence on the role of vitamin D in the pathogenesis of atopic dermatitis (AD) has been obtained in recent decades. Many studies have shown that patients with AD have low concentration of 25(OH)D in blood associated with high concentration of allergen specific IgE (according to several reports). The analysis of low 25(OH)D concentration prevalence, association of vitamin D deficiency with AD severity and sensitization to allergens, and association of vitamin D disorders with risk of AD development is presented.
{"title":"Prevalence of Vitamin D Insufficiency/Deficiency and Their Role in Atopic Dermatitis Development and Course in Children","authors":"Tatiana S. Kashinskaya, N. Shakhova, Yrij F. Lobanov, E. M. Kamaltynova","doi":"10.15690/vsp.v21i4.2435","DOIUrl":"https://doi.org/10.15690/vsp.v21i4.2435","url":null,"abstract":"Various conclusive evidence on the role of vitamin D in the pathogenesis of atopic dermatitis (AD) has been obtained in recent decades. Many studies have shown that patients with AD have low concentration of 25(OH)D in blood associated with high concentration of allergen specific IgE (according to several reports). The analysis of low 25(OH)D concentration prevalence, association of vitamin D deficiency with AD severity and sensitization to allergens, and association of vitamin D disorders with risk of AD development is presented.","PeriodicalId":10867,"journal":{"name":"Current pediatrics","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87894288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The prevalence of childhood obesity in the world is significant and it is topical issue due to the high risk of chronic non-communicable diseases development. This article presents the analysis of pathogenetic role of visceral obesity, describes modern methods for measuring visceral adipose tissue, discusses major terminology on obesity. The current data on inflammation induced by excess of visceral adipose tissue and inflammasome’s role in this process are summed up. All the findings are crucial for the development of tools for prevention any obesity associated adverse effects in children.
{"title":"Visceral Obesity: Terminology, Measurement, and Its Correlation with Inflammation","authors":"A. A. Tarabrina, L. M. Ogorodova, O. Fedorova","doi":"10.15690/vsp.v21i4.2433","DOIUrl":"https://doi.org/10.15690/vsp.v21i4.2433","url":null,"abstract":"The prevalence of childhood obesity in the world is significant and it is topical issue due to the high risk of chronic non-communicable diseases development. This article presents the analysis of pathogenetic role of visceral obesity, describes modern methods for measuring visceral adipose tissue, discusses major terminology on obesity. The current data on inflammation induced by excess of visceral adipose tissue and inflammasome’s role in this process are summed up. All the findings are crucial for the development of tools for prevention any obesity associated adverse effects in children.","PeriodicalId":10867,"journal":{"name":"Current pediatrics","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89944621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
E. V. Shestak, O. Kovtun, O. Ksenofontova, D. Dodrov
Background. Nowadays there is no consensus on the tactics and optimal protocol for Continuous Positive Airway Pressure (СРАР) at transient tachypnea of newborns (TTN) in delivery room. Objective. The aim of the study is to examine the efficacy and safety of standardized protocol of CPAP therapy for newborns with TTN in delivery room. Methods. The clinical study (implementation of standardized CPAP protocol) included full-term infants (gestational age — 37–41 weeks) with diagnosed TTN and CPAP therapy during first 60 minutes of life. Similar inclusion criteria were applied for the historical control group (born within previous year for whom CPAP was implemented according to “usual” protocol). Initiation of mononasal CPAP in main group was carried out when respiratory disorders were assessed according to Downes scale ≥ 3 points with control points at 20–40–60 minutes via the same scale, in control group at ≥ 4 points — for all cases, and according to the doctor's decision at 1–3 points. Mean airway pressure was maintained at 8 and 5–10 cm H2O, CPAP duration was 20–60 and 5–30 min, respectively. The major endpoints: the frequency of patient transfer from delivery room to intensive care unit or hospitalization to the neonatal pathology department, as well as total period of hospitalization. Moreover, frequency of invasive manipulations (intravenous catheterization, parenteral feeding), antibacterial therapy, cerebral injuries (cerebral ischemia, intracerebral hemorrhage), nasal passages injuries, pneumothorax (in the first 24 hours of life) were recorded during the entire hospitalization period. Results. 140 newborns with TTN were included in the clinical study, 30 were excluded from the study, specifically 13 due to violation of the CPAP protocol. The historical control group included 165 newborns. This groups were comparable for most baseline (before the start of CPAP) indicators except for maternal COVID-19 frequency during pregnancy and twin newborns frequency. This groups were comparable for most baseline (before the start of CPAP) indicators except for the frequency of maternal COVID-19 cases during pregnancy and the frequency of twin newborns. Hospitalization rate in intensive care units (18.2 versus 70.3%; p < 0.001) and neonatal pathology departments (31.8 versus 80.0%; p < 0.001), as well as total period of hospitalization (3 versus 10 days; p < 0.001) were lower in the standardized CPAP therapy group. Lower frequency of invasive manipulations, antibacterial therapy, and cerebral ischemia was recorded in this group. The safety of СРАР administration in delivery room was confirmed by the absence of nasal passages injuries in both groups, as well as comparable frequency of pneumothorax. Conclusion. The use of standardized CPAP protocol in delivery room for full-term newborns with TTN had higher rate of favorable hospitalization outcomes. Study limitations require validation of all the findings in independent studies.
背景。目前对产房新生儿短暂性呼吸急促(TTN)持续气道正压通气(СРАР)的策略和最佳方案尚无共识。目标。本研究旨在探讨产房CPAP治疗新生儿TTN的标准化方案的有效性和安全性。方法。临床研究(实施标准化CPAP方案)包括在出生后60分钟内诊断为TTN并接受CPAP治疗的足月婴儿(胎龄- 37-41周)。历史对照组(前一年内出生，按“常规”方案实施CPAP)采用类似的纳入标准。当呼吸障碍按Downes量表≥3分进行评估时，主组开始单鼻CPAP，对照组所有病例均按≥4分进行评估，控制点为20-40-60分钟，1-3分根据医生决定。平均气道压力维持在8和5-10 cm H2O, CPAP持续时间分别为20-60和5-30 min。主要终点:患者从产房转至重症监护病房或住院至新生儿病理科的频率，以及总住院时间。此外，记录整个住院期间有创操作(静脉置管、肠外喂养)、抗菌治疗、脑损伤(脑缺血、脑出血)、鼻道损伤、气胸(出生后24小时)的发生频率。结果:140名患有TTN的新生儿纳入临床研究，30名因违反CPAP协议而被排除在研究之外，其中13名因违反CPAP协议而被排除。历史对照组包括165名新生儿。这两组在大多数基线(CPAP开始前)指标上具有可比性，但妊娠期间孕产妇COVID-19频率和双胞胎新生儿频率除外。除了妊娠期间孕产妇COVID-19病例的频率和双胞胎新生儿的频率外，这两组在大多数基线(CPAP开始前)指标上具有可比性。重症监护病房的住院率(18.2比70.3%;P < 0.001)和新生儿病理科(31.8% vs 80.0%;P < 0.001)，以及总住院时间(3天vs 10天;p < 0.001)，标准化CPAP治疗组较低。有创手法、抗菌药物治疗及脑缺血发生率均较低。两组患者均无鼻道损伤，气胸发生率相当，证实了产房中СРАР给药的安全性。结论。在产房采用标准化CPAP方案治疗TTN足月新生儿的住院预后良好率较高。研究的局限性需要对独立研究中的所有发现进行验证。
{"title":"Efficacy and Safety of Standardized Protocol of CPAP Therapy for Full-Term Newborns in Delivery Room at Transient Tachypnea: Clinical Trial with Historical Control","authors":"E. V. Shestak, O. Kovtun, O. Ksenofontova, D. Dodrov","doi":"10.15690/vsp.v21i4.2445","DOIUrl":"https://doi.org/10.15690/vsp.v21i4.2445","url":null,"abstract":"Background. Nowadays there is no consensus on the tactics and optimal protocol for Continuous Positive Airway Pressure (СРАР) at transient tachypnea of newborns (TTN) in delivery room. Objective. The aim of the study is to examine the efficacy and safety of standardized protocol of CPAP therapy for newborns with TTN in delivery room. Methods. The clinical study (implementation of standardized CPAP protocol) included full-term infants (gestational age — 37–41 weeks) with diagnosed TTN and CPAP therapy during first 60 minutes of life. Similar inclusion criteria were applied for the historical control group (born within previous year for whom CPAP was implemented according to “usual” protocol). Initiation of mononasal CPAP in main group was carried out when respiratory disorders were assessed according to Downes scale ≥ 3 points with control points at 20–40–60 minutes via the same scale, in control group at ≥ 4 points — for all cases, and according to the doctor's decision at 1–3 points. Mean airway pressure was maintained at 8 and 5–10 cm H2O, CPAP duration was 20–60 and 5–30 min, respectively. The major endpoints: the frequency of patient transfer from delivery room to intensive care unit or hospitalization to the neonatal pathology department, as well as total period of hospitalization. Moreover, frequency of invasive manipulations (intravenous catheterization, parenteral feeding), antibacterial therapy, cerebral injuries (cerebral ischemia, intracerebral hemorrhage), nasal passages injuries, pneumothorax (in the first 24 hours of life) were recorded during the entire hospitalization period. Results. 140 newborns with TTN were included in the clinical study, 30 were excluded from the study, specifically 13 due to violation of the CPAP protocol. The historical control group included 165 newborns. This groups were comparable for most baseline (before the start of CPAP) indicators except for maternal COVID-19 frequency during pregnancy and twin newborns frequency. This groups were comparable for most baseline (before the start of CPAP) indicators except for the frequency of maternal COVID-19 cases during pregnancy and the frequency of twin newborns. Hospitalization rate in intensive care units (18.2 versus 70.3%; p < 0.001) and neonatal pathology departments (31.8 versus 80.0%; p < 0.001), as well as total period of hospitalization (3 versus 10 days; p < 0.001) were lower in the standardized CPAP therapy group. Lower frequency of invasive manipulations, antibacterial therapy, and cerebral ischemia was recorded in this group. The safety of СРАР administration in delivery room was confirmed by the absence of nasal passages injuries in both groups, as well as comparable frequency of pneumothorax. Conclusion. The use of standardized CPAP protocol in delivery room for full-term newborns with TTN had higher rate of favorable hospitalization outcomes. Study limitations require validation of all the findings in independent studies.","PeriodicalId":10867,"journal":{"name":"Current pediatrics","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73004379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Basova, M. Bebchuk, N. Ustinova, L. Namazova-Baranova, Kamilla E. Efendiyeva, E. Vishneva
Background. Child and adolescent suicides remain one of the most painful public issues. The COVID-19 pandemic has aggravated this topic as the number of suicides among children population has increased in this period. Research and practice guidelines identify the leading role of primary care physicians in the prevention, identification, and routing of patients with suicidal behavior. At the same time, there were no studies on pediatricians’ competence in the field of suicides.Objective. The aim of the study is to study pediatricians’ competence in prevention, risk determination or and detection of suicidal behavior.Methods. Cross-sectional study was conducted with the usage of original electronic questionnaire aimed on identifying the level of pediatricians’ competence in evaluating suicidal behavior in children. Questionnaire included 18 questions.Results. We have received 208 electronic questionnaires. 97.1% of specialists have confirmed that they evaluate emotional status of their patients during admission. During admission: 86.1% of specialists have considered the characteristics of children appearance, facial expression, voice intonation, 65.4% — have asked questions about mood, 62.5% — have interviewed parents. 98.6% of specialists pay attention to the presence of self-inflicted injuries marks, 88.4% — ask about the origin of these injuries. Only 36.1% of respondents ask patients about suicidal thoughts, intentions, or actions. Only 69.3% of specialists are ready to refer their patients to psychologist, and 51.7% — to psychiatrist.Conclusion. Even though most surveyed pediatricians notice signs of suicidal intent (low mood, self-inflicted injuries), they avoid discussing the topic of suicide during admission. Increasing the competence of pediatricians should be aimed on destigmatisation in the field of mental health, increasing the knowledge level, and developing practical skills in working with children with suicidal behavior.
{"title":"Pediatricians’ Competence in Prevention, Risk Determination or Detection of Suicidal Behavior in Children: Cross-Sectional Survey Study","authors":"A. Basova, M. Bebchuk, N. Ustinova, L. Namazova-Baranova, Kamilla E. Efendiyeva, E. Vishneva","doi":"10.15690/vsp.v21i3.2430","DOIUrl":"https://doi.org/10.15690/vsp.v21i3.2430","url":null,"abstract":"Background. Child and adolescent suicides remain one of the most painful public issues. The COVID-19 pandemic has aggravated this topic as the number of suicides among children population has increased in this period. Research and practice guidelines identify the leading role of primary care physicians in the prevention, identification, and routing of patients with suicidal behavior. At the same time, there were no studies on pediatricians’ competence in the field of suicides.Objective. The aim of the study is to study pediatricians’ competence in prevention, risk determination or and detection of suicidal behavior.Methods. Cross-sectional study was conducted with the usage of original electronic questionnaire aimed on identifying the level of pediatricians’ competence in evaluating suicidal behavior in children. Questionnaire included 18 questions.Results. We have received 208 electronic questionnaires. 97.1% of specialists have confirmed that they evaluate emotional status of their patients during admission. During admission: 86.1% of specialists have considered the characteristics of children appearance, facial expression, voice intonation, 65.4% — have asked questions about mood, 62.5% — have interviewed parents. 98.6% of specialists pay attention to the presence of self-inflicted injuries marks, 88.4% — ask about the origin of these injuries. Only 36.1% of respondents ask patients about suicidal thoughts, intentions, or actions. Only 69.3% of specialists are ready to refer their patients to psychologist, and 51.7% — to psychiatrist.Conclusion. Even though most surveyed pediatricians notice signs of suicidal intent (low mood, self-inflicted injuries), they avoid discussing the topic of suicide during admission. Increasing the competence of pediatricians should be aimed on destigmatisation in the field of mental health, increasing the knowledge level, and developing practical skills in working with children with suicidal behavior.","PeriodicalId":10867,"journal":{"name":"Current pediatrics","volume":"80 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72788161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
N. Buchinskaya, Aida Zh. Akhenbekova, Aliya A. Bugybay, M. Kostik
Progeria, or Hutchinson-Gilford Syndrome is a rare disease from the group of laminopathies characterized by premature aging with skin, bones and cardiovascular system lesions. Pathogenesis is based on pathogenic variants in the LMNA gene leading to anomalies in the nuclear membrane morphology, gene expression disruption, chromatin structure changes, mitochondrial dysfunction, DNA repair and alternative splicing defects, and telomere shortening acceleration. Major manifestations of the disease are: skin lesions (scleroderma-like syndrome and pigmented lesions), lipodystrophy, late teeth cutting, teeth crowding, alopecia, nail dystrophy, osteolysis of distal phalanges, hip joints valgus deformation, joints contractures, atherosclerosis, hearing loss, early heart attacks and strokes. Scleroderma-like skin changes, osteoporosis, flexion contractures of hands’ interphalangeal joints, and hip joints osteoarthritis require differential diagnosis with rheumatic diseases. The basic strategy in management of patients with progeria is the prevention and treatment of its cardiovascular manifestations (early strokes and heart attacks, arterial hypertension, and atherosclerosis), as well as the increase of patients’ quality of life and daily activity. The efficacy of therapy in patients with progeria via the use of farnesyltransferase inhibitors (monotherapy; combination with bisphosphonates or statins), retinoids, and 1,25(OH)2 — vitamin D3 is studied. This literature review is updated with clinical case description of a girl with progeria. The diagnosis was confirmed by sequencing of the LMNA gene (Sanger), and previously described pathogenic variant in exon 11 (c.1824C>T, rs58596362) in the heterozygous state (p.Gly608Gly, NM_170707.3) was revealed.
{"title":"Progeria (Hutchinson-Gilford Syndrome): Literature Review and Clinical Case","authors":"N. Buchinskaya, Aida Zh. Akhenbekova, Aliya A. Bugybay, M. Kostik","doi":"10.15690/vsp.v21i3.2431","DOIUrl":"https://doi.org/10.15690/vsp.v21i3.2431","url":null,"abstract":"Progeria, or Hutchinson-Gilford Syndrome is a rare disease from the group of laminopathies characterized by premature aging with skin, bones and cardiovascular system lesions. Pathogenesis is based on pathogenic variants in the LMNA gene leading to anomalies in the nuclear membrane morphology, gene expression disruption, chromatin structure changes, mitochondrial dysfunction, DNA repair and alternative splicing defects, and telomere shortening acceleration. Major manifestations of the disease are: skin lesions (scleroderma-like syndrome and pigmented lesions), lipodystrophy, late teeth cutting, teeth crowding, alopecia, nail dystrophy, osteolysis of distal phalanges, hip joints valgus deformation, joints contractures, atherosclerosis, hearing loss, early heart attacks and strokes. Scleroderma-like skin changes, osteoporosis, flexion contractures of hands’ interphalangeal joints, and hip joints osteoarthritis require differential diagnosis with rheumatic diseases. The basic strategy in management of patients with progeria is the prevention and treatment of its cardiovascular manifestations (early strokes and heart attacks, arterial hypertension, and atherosclerosis), as well as the increase of patients’ quality of life and daily activity. The efficacy of therapy in patients with progeria via the use of farnesyltransferase inhibitors (monotherapy; combination with bisphosphonates or statins), retinoids, and 1,25(OH)2 — vitamin D3 is studied. This literature review is updated with clinical case description of a girl with progeria. The diagnosis was confirmed by sequencing of the LMNA gene (Sanger), and previously described pathogenic variant in exon 11 (c.1824C>T, rs58596362) in the heterozygous state (p.Gly608Gly, NM_170707.3) was revealed.","PeriodicalId":10867,"journal":{"name":"Current pediatrics","volume":"68 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89608564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This article presents a narrative that reveals the state of life and health of children in the first months of the Great Patriotic War. Special place goes to the analysis of archival documents indicating the distressful situation of evacuated children, faced unsanitary conditions, lack of food, and difficulties with settling in new places of residence. The activity of the Council of People's Commissars of the USSR, the People's Commissariat of Health of the USSR and the RSFSR on carrying out measures of social support for minors in the first period of the Great Patriotic War is presented. The maximum possible conditions for the protection of minors’ health were implemented as consequence of the execution of orders on places. Difficulties with the implementation of measures for the arrangement of evacuated children in various regions of the country are described depending on local resources and taken measures efficacy (Tula, Ryazan, Yaroslavl, Kuibyshev regions). The ongoing activities are clearly illustrated by the example of the work of the Middle Volga Institute for the Protection of Motherhood and Infancy.
{"title":"Social Support for Minors in the First Period of Great Patriotic War","authors":"R. S. Serebryaniy, D. V. Kamelskikh, O. Yaremchuk","doi":"10.15690/vsp.v21i3.2425","DOIUrl":"https://doi.org/10.15690/vsp.v21i3.2425","url":null,"abstract":"This article presents a narrative that reveals the state of life and health of children in the first months of the Great Patriotic War. Special place goes to the analysis of archival documents indicating the distressful situation of evacuated children, faced unsanitary conditions, lack of food, and difficulties with settling in new places of residence. The activity of the Council of People's Commissars of the USSR, the People's Commissariat of Health of the USSR and the RSFSR on carrying out measures of social support for minors in the first period of the Great Patriotic War is presented. The maximum possible conditions for the protection of minors’ health were implemented as consequence of the execution of orders on places. Difficulties with the implementation of measures for the arrangement of evacuated children in various regions of the country are described depending on local resources and taken measures efficacy (Tula, Ryazan, Yaroslavl, Kuibyshev regions). The ongoing activities are clearly illustrated by the example of the work of the Middle Volga Institute for the Protection of Motherhood and Infancy.","PeriodicalId":10867,"journal":{"name":"Current pediatrics","volume":"43 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85857996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：