{"title":"Synthesis, Characterization, Biological Activity of 4-Oxo-imidazolidin-2-thione Derivatives","authors":"Amal Mahmoud Yo","doi":"10.3923/CRC.2017.1.13","DOIUrl":"https://doi.org/10.3923/CRC.2017.1.13","url":null,"abstract":"","PeriodicalId":10941,"journal":{"name":"Current Research in Chemistry","volume":"3 1","pages":"1-13"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84050671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
O. Ajani, J. D. Udonne, C. Ehi-Eromosele, J. Olugbuyiro, D. Aderohunmu, C. O. Ajanaku, O. Audu
Background and Objective: Sulfonamides are known to represent a class of medicinally important compounds and chemical intermediates, which are extensively used in drug development. The aim of this present study is to synthesize a series of arylsulfonamide-based dialkylated amide motifs. Materials and Methods: In this study, the design and development of arylsulfonamide pharmacophore bearing N,N-diethyl substituted amide moieties 2a-k was achieved in improved yields using non-conventional amidation of p-tolylsulfonamide precursors 1a-k. The structures of the compounds were substantiated based on the results of elemental analysis and spectroscopic data namely, FT-IR, 1H-NMR, 13C-NMR and mass spectra. Results: The series of targeted compounds were synthesized in good to excellent yields and subsequently purified by column chromatography where necessary. Conclusion: The synthesis of arylsulfonamide-based dialkylated amide motifs was successfully achieved. These compounds may serve as versatile intermediates that pave ways toward achieving diverse bioactive heterocyclic compounds for future drug discovery and development.
{"title":"Synthesis and spectral study of N,N-diethyl-2-methyl-1-tosylpyrrolidine-2-carboxamide and functionalized sulfonamide scaffolds.","authors":"O. Ajani, J. D. Udonne, C. Ehi-Eromosele, J. Olugbuyiro, D. Aderohunmu, C. O. Ajanaku, O. Audu","doi":"10.3923/CRC.2016.10.20","DOIUrl":"https://doi.org/10.3923/CRC.2016.10.20","url":null,"abstract":"Background and Objective: Sulfonamides are known to represent a class of medicinally important compounds and chemical \u0000intermediates, which are extensively used in drug development. The aim of this present study is to synthesize a series of \u0000arylsulfonamide-based dialkylated amide motifs. Materials and Methods: In this study, the design and development of arylsulfonamide \u0000pharmacophore bearing N,N-diethyl substituted amide moieties 2a-k was achieved in improved yields using non-conventional amidation \u0000of p-tolylsulfonamide precursors 1a-k. The structures of the compounds were substantiated based on the results of elemental analysis \u0000and spectroscopic data namely, FT-IR, 1H-NMR, 13C-NMR and mass spectra. Results: The series of targeted compounds were synthesized \u0000in good to excellent yields and subsequently purified by column chromatography where necessary. Conclusion: The synthesis of \u0000arylsulfonamide-based dialkylated amide motifs was successfully achieved. These compounds may serve as versatile intermediates that \u0000pave ways toward achieving diverse bioactive heterocyclic compounds for future drug discovery and development.","PeriodicalId":10941,"journal":{"name":"Current Research in Chemistry","volume":"12 1","pages":"10-20"},"PeriodicalIF":0.0,"publicationDate":"2016-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78658217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
1-Phenylazo-2-naphthol (PAN) was subjected to electrocoagulation using a 0.3 A d.c electrolytic cell in various solvents including ethanol, acetone, benzene and n-hexane. The extent of decolourization of PAN in the solvents has been determined. The highest decolourization was achieved in ethanol with colour removal efficiency of 63% within the first 15 min and 79% after 120 min of electrocoagulation. The decolourization of PAN in the solvents is observed to follow the order: Ethanol>n-hexane>benzene>acetone. The electrocoagulation data has also been interpreted based on adsorption kinetic models. Electrocoagulation of PAN in all the solvents obeyed the pseudo-second order kinetic model and Elovich kinetic model.
{"title":"Electrocoagulation of Azo-2-Naphthol Dye Using Aluminium Electrodes: Effect of Solvent and Kinetics of Adsorption","authors":"V. Mkpenie, O. Abakedi","doi":"10.3923/CRC.2015.34.43","DOIUrl":"https://doi.org/10.3923/CRC.2015.34.43","url":null,"abstract":"1-Phenylazo-2-naphthol (PAN) was subjected to electrocoagulation using a 0.3 A d.c electrolytic cell in various solvents including ethanol, acetone, benzene and n-hexane. The extent of decolourization of PAN in the solvents has been determined. The highest decolourization was achieved in ethanol with colour removal efficiency of 63% within the first 15 min and 79% after 120 min of electrocoagulation. The decolourization of PAN in the solvents is observed to follow the order: Ethanol>n-hexane>benzene>acetone. The electrocoagulation data has also been interpreted based on adsorption kinetic models. Electrocoagulation of PAN in all the solvents obeyed the pseudo-second order kinetic model and Elovich kinetic model.","PeriodicalId":10941,"journal":{"name":"Current Research in Chemistry","volume":"30 1","pages":"34-43"},"PeriodicalIF":0.0,"publicationDate":"2015-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90268310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Kawsar, S. Uddin, S. Nishat, M. A. Manchur, Y. Ozeki
A novel regioselective benzenesulphonylation and N-acetylsulfanilylation series of methyl α-D-glucopyranoside derivative (1) has been carried out by direct method and afforded the 6-O-benzenesulfonyl derivative (2) and 6-O-N-acetylsulfanilyl derivative (7) in an excellent yields. In order to obtain newer products, the 6-O-glucopyranoside derivative was further transformed to a series of 2,3,4-tri-O-acyl derivatives (3-6 and 8-11) containing a wide variety of functionalities in a single molecular framework. The structures of the newly synthesized compounds were elucidated with the aid of FTIR, H-NMR spectroscopy and elemental analysis. All the synthesized compounds were also tested for their antibacterial activity against some human pathogenic bacterial microorganisms. For comparative studies, antibacterial activity of standard antibiotics, ampicillin was also carried out against these microorganisms. The study revealed that the acylated products exhibit moderate to good antimicrobial activities. It was interesting to observe that the selected compounds were more sensitive against gram-negative bacteria than that of the gram-positive bacterial strains. We carried out the antibacterial activities of the tested chemicals in vitro. In vivo screening studies of the tested compounds showing promising results will be the subject of our future investigation.
采用直接法对甲基α- d -吡喃葡萄糖苷衍生物(1)进行了新的区域选择性苯磺酰化和n -乙酰磺酰化系列反应，得到了收率较高的6- o -苯磺酰衍生物(2)和6- o - n -乙酰磺酰衍生物(7)。为了获得更新的产品，6- o -葡萄糖吡喃苷衍生物进一步转化为一系列2,3,4-三- o -酰基衍生物(3-6和8-11)，在单一分子框架中含有多种功能。通过FTIR、H-NMR和元素分析对新合成化合物的结构进行了表征。并对合成的化合物进行了抑菌活性测试。为了比较研究标准抗生素氨苄西林对这些微生物的抑菌活性。研究表明，酰基化产物具有中等至良好的抗菌活性。有趣的是，所选化合物对革兰氏阴性菌比革兰氏阳性菌更敏感。我们在体外进行了被试化学物质的抗菌活性。在体内筛选研究的测试化合物显示有希望的结果将是我们未来的研究主题。
{"title":"Synthesis, Characterization and Antibacterial Susceptibility of some Benzenesulfonyl and N-Acetylsulfanilyl Derivatives of Methyl α-D-Glucopyranoside","authors":"S. Kawsar, S. Uddin, S. Nishat, M. A. Manchur, Y. Ozeki","doi":"10.3923/CRC.2015.21.33","DOIUrl":"https://doi.org/10.3923/CRC.2015.21.33","url":null,"abstract":"A novel regioselective benzenesulphonylation and N-acetylsulfanilylation series of methyl α-D-glucopyranoside derivative (1) has been carried out by direct method and afforded the 6-O-benzenesulfonyl derivative (2) and 6-O-N-acetylsulfanilyl derivative (7) in an excellent yields. In order to obtain newer products, the 6-O-glucopyranoside derivative was further transformed to a series of 2,3,4-tri-O-acyl derivatives (3-6 and 8-11) containing a wide variety of functionalities in a single molecular framework. The structures of the newly synthesized compounds were elucidated with the aid of FTIR, H-NMR spectroscopy and elemental analysis. All the synthesized compounds were also tested for their antibacterial activity against some human pathogenic bacterial microorganisms. For comparative studies, antibacterial activity of standard antibiotics, ampicillin was also carried out against these microorganisms. The study revealed that the acylated products exhibit moderate to good antimicrobial activities. It was interesting to observe that the selected compounds were more sensitive against gram-negative bacteria than that of the gram-positive bacterial strains. We carried out the antibacterial activities of the tested chemicals in vitro. In vivo screening studies of the tested compounds showing promising results will be the subject of our future investigation.","PeriodicalId":10941,"journal":{"name":"Current Research in Chemistry","volume":"140 1","pages":"21-33"},"PeriodicalIF":0.0,"publicationDate":"2015-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79965020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
D. Chandra, G. Kohli, K. Prasad, G. Bisht, Vinay Deep Punetha, K. S. Khetwal, Manoj Kumar Devrani, H. Pandey
{"title":"Phytochemical and Ethnomedicinal Uses of Family Gentianaceae","authors":"D. Chandra, G. Kohli, K. Prasad, G. Bisht, Vinay Deep Punetha, K. S. Khetwal, Manoj Kumar Devrani, H. Pandey","doi":"10.3923/CRC.2015.44.52","DOIUrl":"https://doi.org/10.3923/CRC.2015.44.52","url":null,"abstract":"","PeriodicalId":10941,"journal":{"name":"Current Research in Chemistry","volume":"54 1","pages":"44-52"},"PeriodicalIF":0.0,"publicationDate":"2015-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87518430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
C. Chukwu, O. C. Okafor, F. Nwabue, J. Afiukwa, A. Uwakwe
{"title":"GC-MS Determination of Bioactive Components of Napoleona imperalis P. Beauv","authors":"C. Chukwu, O. C. Okafor, F. Nwabue, J. Afiukwa, A. Uwakwe","doi":"10.3923/CRC.2015.9.13","DOIUrl":"https://doi.org/10.3923/CRC.2015.9.13","url":null,"abstract":"","PeriodicalId":10941,"journal":{"name":"Current Research in Chemistry","volume":"46 1","pages":"9-13"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87309930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A new series of hydroquinolines derivatives (1, 2) have been achieved by the cyclo condensation of 2 (4-methoxybenzylidenemalonitrile), aniline and dimedone in the presence of piperidene. Cyclization of 5,6,7,8-tetrahydro-4-(4-methoxyphenyl)-7,7-dimethyl-5-oxo-2-(phenylamino) quinoline-3-carbonitrile (2) sulphuric acid at room temperature afforded 7,8-dihydro-4-(4methoxyphenyl)-7,7-dimethylquinolin-5(6H)-one[2,3-b]2,3-dihydroquinolin-4 (1H)-one (3). Several substituted pyrimido[4,5-b]quinoline derivatives (4, 5, 6 and 7) were synthesized from 2-amino-1,4,5,6,7,8-hexahydro-4-(4-methoxphenyl)-7,7,-dimethyl-5-oxo-1-phenylquinoline-3carbonitrile (1) via cyclization with thiourea, chloroacetyl chloride, phenyl isothiocynate and formamide, respectively. The condensation of dimedone, with 4-methoxybenzylidene malononitrile in the presence of trimethylamine afforded 11-amino-3,4,8,9-tetrahydro-12-(4-methoxyphenyl)3,3,8,8-tetramethyl-2H-chromeno[2,3-b]quinoline-1, 10(7H,12H)-dione (8) but in ammonium acetate afforded 7,8-dihydro-4-(4-methoxyphenyl)-7,7-dimethylquinolin-5(1H,4H,6H)-one[2,3-b]4-amino-7,8dihydro-7,7-dimethylquinolin-5(6H)-one (9). The structures of the synthesized compounds were elucidated by elemental analyses and spectral data.
{"title":"Synthesis of Some New Hydroquinoline and Pyrimido[4,5-b] Quinoline Derivatives","authors":"A. Ghoneim, M. Assy","doi":"10.3923/CRC.2015.14.20","DOIUrl":"https://doi.org/10.3923/CRC.2015.14.20","url":null,"abstract":"A new series of hydroquinolines derivatives (1, 2) have been achieved by the cyclo condensation of 2 (4-methoxybenzylidenemalonitrile), aniline and dimedone in the presence of piperidene. Cyclization of 5,6,7,8-tetrahydro-4-(4-methoxyphenyl)-7,7-dimethyl-5-oxo-2-(phenylamino) quinoline-3-carbonitrile (2) sulphuric acid at room temperature afforded 7,8-dihydro-4-(4methoxyphenyl)-7,7-dimethylquinolin-5(6H)-one[2,3-b]2,3-dihydroquinolin-4 (1H)-one (3). Several substituted pyrimido[4,5-b]quinoline derivatives (4, 5, 6 and 7) were synthesized from 2-amino-1,4,5,6,7,8-hexahydro-4-(4-methoxphenyl)-7,7,-dimethyl-5-oxo-1-phenylquinoline-3carbonitrile (1) via cyclization with thiourea, chloroacetyl chloride, phenyl isothiocynate and formamide, respectively. The condensation of dimedone, with 4-methoxybenzylidene malononitrile in the presence of trimethylamine afforded 11-amino-3,4,8,9-tetrahydro-12-(4-methoxyphenyl)3,3,8,8-tetramethyl-2H-chromeno[2,3-b]quinoline-1, 10(7H,12H)-dione (8) but in ammonium acetate afforded 7,8-dihydro-4-(4-methoxyphenyl)-7,7-dimethylquinolin-5(1H,4H,6H)-one[2,3-b]4-amino-7,8dihydro-7,7-dimethylquinolin-5(6H)-one (9). The structures of the synthesized compounds were elucidated by elemental analyses and spectral data.","PeriodicalId":10941,"journal":{"name":"Current Research in Chemistry","volume":"112 1","pages":"14-20"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90767000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
K. Satyavani, S. Gurudeeban, V. Manigandan, E. Rajamanick, T. Ramanathan
{"title":"Chemical Compositions of Medicinal Mangrove Species Acanthus ilicifolius, Excoecaria agallocha, Rhizophora apiculata and Rhizophora mucronata","authors":"K. Satyavani, S. Gurudeeban, V. Manigandan, E. Rajamanick, T. Ramanathan","doi":"10.3923/CRC.2015.1.8","DOIUrl":"https://doi.org/10.3923/CRC.2015.1.8","url":null,"abstract":"","PeriodicalId":10941,"journal":{"name":"Current Research in Chemistry","volume":"20 1","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84766354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ramit Kapoor, R. Arora, Ravinesh Mishra, Manu Arora, Pooja Mittal
{"title":"Synthesis of Novel Mannich Bases of Pioglitazone","authors":"Ramit Kapoor, R. Arora, Ravinesh Mishra, Manu Arora, Pooja Mittal","doi":"10.3923/CRC.2014.10.15","DOIUrl":"https://doi.org/10.3923/CRC.2014.10.15","url":null,"abstract":"","PeriodicalId":10941,"journal":{"name":"Current Research in Chemistry","volume":"12 1","pages":"10-15"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88360383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Synthesis and Application of Disazo Dyes Derived from 2-amino-5-mercapto-1,3, 4-thiadiazole and 2-chloroaniline on Acrylic Fabric and Nylon 66 Fabric","authors":"J. Otutu, E. M. Efurhievwe, S. U. Ameru","doi":"10.3923/CRC.2014.1.9","DOIUrl":"https://doi.org/10.3923/CRC.2014.1.9","url":null,"abstract":"","PeriodicalId":10941,"journal":{"name":"Current Research in Chemistry","volume":"25 1","pages":"1-9"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78985221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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