Dermatologische Monatschrift最新文献

To the multigen family of cytokeratins belong 19 different polypeptides typical either for simple and glandular or for stratified squamous epithelia, and a special group of polypeptides characteristic for hair-forming cells. In regard to the current literature the specificities of their expression in the epidermis of the normal skin, in the sweat and sebaceous glands and in the hair roots are discussed.

The advancement of growth of albino guinea pig hair has been induced by sodium thiocyanate through oral application (32 mg/kg) and more distinctly through balneological use (0.3, 5 resp. 10 g/l). The density of the hair has been increased at 6-38%, the longitudinal growth advanced at 2-14% and the phases of follicle cycle have been changed on behalf of anagenic hair at 11-39%.

The effect of different urea concentrations on the skin penetration of hydrocortisone from topically applied vehicle was investigated. Therefore 14C-labeled urea and 3H-labeled hydrocortisone were determined simultaneously in different layers of human skin. It could be shown an increased penetration of hydrocortisone is dependent above all on penetrated urea amount into the horny layer and on the distribution of penetrated urea in the horny layer. Hence follows a strong vehicle dependence from penetration promotion of hydrocortisone as an example for glucocorticoids by urea can be deduced. For the using of the penetration promoting effect of urea at the development of glucocorticoid containing ointments the knowledge of the glucocorticoid and urea penetration in each vehicle is indispensable.

By means of monoclonal antibodies (mab) and alkaline phosphatase anti-alkaline-phosphatase (APAAP) technique, the distribution and characteristics of lymphocytic infiltrates were studied in biopsies from 15 patients with bullous pemphigoid (b.P.) and 5 patients with pemphigus vulgaris (P.v.). The biopsies were obtained from freshly developed blisters along with perilesional tissue. The lymphocytic infiltrates in b.P. as well as in P.v. were located in the area of the fresh lesions and consisted almost exclusively of T cells (CD3 positive lymphocytes). In b.P., the discrepancy between a decreased number of CD2 positive lymphocytes (10-20%) and markedly higher number of CD3 staining cells (50-60% of all infiltrate cells) was striking. The characterization of the T cell subpopulations in both dermatoses showed mainly T helper cell infiltrates (CD4), while only up to 10% of T suppressor cells (CD8) were detected. CD45R positive (CD4+/CD45R+: suppression inducing) as well as CD29-positive (CD4+CD29+: cells which provide help for antibody production) T-cell subpopulations were detected in both dermatoses particularly adjacent to blister in up to 10% of the cell infiltrates. Epidermal staining with CD29 mab in b.P. up to the stratum spinosum and in P.v. within intraepidermal blisters was detected. By means of CD19 and CD21 mab B lymphocytes were minimal. Perivascular individual cell staining occurred with CD7 CD16, CD56 and CD57 mab (K/NK cells) in b.P. as well as in P.v. patients. The predominance in T cell infiltrates, particularly T helper cells, suggests the role of cellular immune mechanism in the pathogenesis of these diseases, in b.P. the CD2 antigen (SE receptor) appears to be of particular importance.

22 patients suffering from exanthematic psoriasis were irradiated with the UV-lamps UVS 65-2 (Narva, Brand-Erbisdorf) or TL-01 (Philips Company, Eindhoven, Niederlande) respectively. The latter one emits a narrow-band UV-spectrum at 311 nm which seems to be most suitable for the treatment of psoriasis. On our condition the clearing rate was higher and the cumulative irradiation dose was significantly lower with the TL-01 lamp.

17 children suffering from neurodermatitis, aged 2 to 14 years, were treated with ketotifen at a dosage of 1 mg twice daily. In 7 children polyvalent therapy was given. Ketotifen therapy produced a pronounced alleviation of the itching within only two weeks and the patients became entirely itching free after 20 days on an average. The improvement of skin lesions appeared after two months of treatment. Patients became entirely skin lesions free between seven and nine months. In three patients the deterioration of skin lesions was triggered with infection. With regard to long-lasting of Ketotifen therapy, the side effects were not observed.

The authors describe the case of a male patient, 20 years old, with a rapidly developing picture of disseminated lichen ruber planus together with the formation of vesicles and blisters. Immunofluorescent examination demonstrated lichen ruber associated with bullous pemphigoid. A good therapeutic effect was obtained with a combination of Triamcinolon and Tigason.