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Results of the osteopathic treatment of the temporomandibular joint dysfunction (meta-analysis) 骨科治疗颞下颌关节功能障碍的结果(荟萃分析)
Pub Date : 2023-03-25 DOI: 10.32885/2220-0975-2023-1-95-108
Yu. A. Milutka, Ya. Yu. Dyachkova, A. V. Evdokimova
Introduction. Dysfunction of the temporomandibular joint (TMJ), and especially such a symptom as facial pain, is one of the most common diseases in the modern world. Among the publications devoted to this problem, works about osteopathy as a method of TMJ treating have become increasingly common, and it allows us to summarize these works within the framework of a systematic review with using a meta-analysis.Aim: to study according to the literature the results of the osteopathic correction using for patients with TMJ dysfunctions, and to conduct a meta-analysis.Materials and methods. The selection of scientific papers from the available databases was carried out according to the following criteria. Inclusion criteria: availability of the article full text in Russian or English; patients aged from 18 to 65 years examined by a dentist and diagnosed with TMJ dysfunction; division of patients into 2 groups: receiving standard treatment in one group, and osteopathic and standard treatment in another group; the results of dental examination are described; the duration of observations from 3 to 6 months. Non-inclusion criteria: description of a single clinical case; the sample under study was less than 20 patients; studies on healthy volunteers; the presence of surgical and traumatological pathology in patients (the consequences of improperly fused fractures, orthognathic surgery, resorption of the condyles of the mandible). There was used R-studio program, including meta package, to perform meta-analysis. There was also used the Newcastle–Ottawa scale to assess the risk of systematic errors in the cohort studies.Results. The final analysis by the indicator of pain reduction in the head area according to the 10-point visualanalog scale (VAS) included 3 articles. The Newcastle scale′s results showed a low risk of systematic errors. The performed calculations support generally the assumption of the advantage of osteopathic correction inclusion in the therapy in terms of reducing the severity of pain syndrome, estimated in points according to VAS. When assessing the osteopathic status in all studies, the somatic dysfunctions of the head, neck region and local somatic TMJ dysfunctions were mainly detected in patients with TMJ dysfunctions.Conclusion. Based on the studied literature and the results of this meta-analysis, it can be concluded the advantage of osteopathic correction inclusion in the treatment of TMJ dysfunctions.
介绍。颞下颌关节(TMJ)功能障碍,尤其是面部疼痛,是当今世界最常见的疾病之一。在致力于这一问题的出版物中,将整骨疗法作为TMJ治疗方法的作品越来越普遍,这使我们能够在使用荟萃分析的系统回顾框架内总结这些作品。目的:根据文献研究骨科矫正治疗颞下颌关节功能障碍的效果,并进行meta分析。材料和方法。从现有数据库中选择科学论文是按照以下标准进行的。纳入标准:文章是否有俄文或英文全文;年龄在18至65岁,经牙医检查并诊断为颞下颌关节功能障碍的患者;将患者分为两组:一组接受标准治疗,另一组接受整骨疗法和标准治疗;描述牙科检查的结果;观察时间为3至6个月。未纳入标准:描述单一临床病例;研究的样本少于20名患者;健康志愿者研究;患者的外科和创伤病理学(不正确融合骨折的后果,正颌手术,下颌骨髁的吸收)。采用R-studio程序,包括meta包,进行meta分析。在队列研究中,还使用了纽卡斯尔-渥太华量表来评估系统错误的风险。根据10分视觉模拟评分法(VAS)对头部疼痛减轻指标进行最终分析,纳入3篇文章。纽卡斯尔量表的结果显示系统误差的风险很低。所进行的计算通常支持在治疗中纳入骨科矫正在减轻疼痛综合征严重程度方面的优势的假设,根据VAS评分进行估计。所有研究在评估成骨状态时,主要检测的是头颈部的躯体功能障碍和TMJ功能障碍患者的局部躯体功能障碍。根据所研究的文献和本meta分析的结果,可以得出骨科矫正纳入治疗TMJ功能障碍的优势。
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引用次数: 0
The influence of osteopathic correction on liquorodynamics in patients with tension-type headache 整骨矫正对紧张性头痛患者酒精动力学的影响
Pub Date : 2023-03-25 DOI: 10.32885/2220-0975-2023-1-45-56
V. Belash, V. A. Starostenko
Introduction. Tension-type headache (TTH) is known to be the most common type of headache in all age groups. The guidelines of the European Federation of Neurological Societies, the Italian Guidelines for Primary Headaches and the Italian Consensus Conference on Pain in Neurorehabilitation report that non-pharmacological therapies are valid adjunctive treatments for TTH. Previous studies have shown that the use of general osteopathic treatment in patients with TTH is accompanied by a significant decrease in the severity of pain syndrome and asthenic condition. We did not find any scientific publications devoted to the objectification of the results of osteopathic correction in TTH using magnetic resonance imaging (MRI).The aim of the study was to objectify the results of osteopathic correction by assessing changes in the liquor dynamics of the posterior cranial fossa in patients with tension-type headache.Materials and methods. The study was conducted from December 2020 to December 2021 at the clinic of the Center for New Medical Technologies, Novosibirsk. There were under the observation 10 patients with an established diagnosis of TTH aged from 18 to 55 years, 4 men, and 6 women. All patients before the start of treatment and after the course completion were assessed for their osteopathic status and underwent high-field MRI 3T of the brain with the calculation of the posterior cranial fossa restriction index (CFRI). CFRI reflects the state of liquorodynamics at the level of the skull base and shows the level of freedom in the relationship between fluid spaces and brain tissues. Study participants received a course of osteopathic correction, which included 3–4 procedures with an interval of 5–7 days. The observed patients did not receive any other therapy during the study period.Results. The examined patients were most characterized by regional biomechanical disorders (RBD): head (9); neck, structural component (5); thoracic, visceral component (5); dura mater region (9). In terms of severity, mild RBD prevailed (1 point). After treatment, patients have a decrease of the detection frequency of major regional somatic dysfunctions (SD). Statistically significant differences (p<0,05) were obtained in the SD incidence of head region; neck region, structural component; thoracic, visceral component; dura mater region. A statistically significant (p<0,05) increase in the mean CFRI from 30,22±0,63 to 31,78±0,73 % was found after the treatment.Conclusion. The results of the high-field MRI with the study of CFRI allow to quantitatively assess the changes of the cerebrospinal fluid dynamics in patients with tension-type headache, and it can be used as an objective criterion for the osteopathic correction results and the therapy clinical effectiveness. The study should be continued with a more representative sample.
介绍。紧张性头痛(TTH)是所有年龄组中最常见的头痛类型。欧洲神经学会联合会指南、意大利原发性头痛指南和意大利神经康复疼痛共识会议报告非药物治疗是TTH的有效辅助治疗。先前的研究表明,在TTH患者中使用一般整骨疗法可以显著降低疼痛综合征的严重程度和虚弱状态。我们没有发现任何科学出版物致力于利用磁共振成像(MRI)客观化TTH骨科矫正结果。本研究的目的是通过评估紧张性头痛患者后颅窝液体动力学的变化来客观化整骨矫正的结果。材料和方法。该研究于2020年12月至2021年12月在新西伯利亚新医疗技术中心的诊所进行。本组观察确诊TTH患者10例,年龄18 ~ 55岁,男4例,女6例。所有患者在治疗开始前和疗程结束后评估其骨病状态,并进行高场MRI 3T脑扫描,计算后颅窝限制指数(CFRI)。CFRI反映了颅底水平的酒精动力学状态,显示了液体空间与脑组织之间关系的自由程度。研究参与者接受了一个整骨矫正疗程,包括3-4次手术,间隔5-7天。观察患者在研究期间未接受任何其他治疗。检查的患者以区域生物力学障碍(RBD)为特征:头部(9);颈,结构部件(5);胸、内脏部分(5);在严重程度方面,轻度RBD占上风(1分)。经治疗后,患者的重大区域性躯体功能障碍(SD)检出率下降。头部区域SD发生率差异有统计学意义(p< 0.05);颈部区域,结构部件;胸、内脏成分;硬脑膜区域。治疗后平均CFRI由30.22±0.63上升至31.78±0.73%,差异有统计学意义(p< 0.05)。高场MRI结果结合CFRI的研究,可以定量评价紧张性头痛患者脑脊液动力学的变化,可作为骨科矫正效果和治疗临床效果的客观标准。该研究应以更具代表性的样本继续进行。
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引用次数: 0
Substantiation of the effectiveness of osteopathic correction in the treatment of patients suffering from post-puncture syndrome 证实骨科矫正治疗穿刺后综合征的有效性
Pub Date : 2023-03-25 DOI: 10.32885/2220-0975-2023-1-35-44
M. S. Krivenya, L. V. Gorobets
Introduction. Post-puncture syndrome (PPS) is a complex of symptoms that occurs 1–2 days after spinal anesthesia or lumbar puncture, and the headache is a leading symptom. Currently, there is no effective method of non-invasive treatment of PPS. Based on the possible role of dura mater damage in the PPS pathogenesis, it is reasonable to assume that the identification and osteopathic correction of somatic dysfunctions in the respective regions may be effective in the treatment of patients suffering from PPS.The aim of the study is to substantiate the possibility of using osteopathic correction in the treatment of patients suffering from post-puncture syndrome.Materials and methods. The study involved 40 patients with PPS syndrome aged 20 to 50 years who were hospitalized after surgery with spinal anesthesia using. Patients were randomized into two groups — control (20 patients) and main (20 patients). All study participants were prescribed bed and medium drinking (25–30 ml/kg body weight) regimen. Participants of the main group additionally received a single hour session of osteopathic correction on the first day after the operation. All patients were examined at the start of treatment and on the third day after the start of a treatment. The severity of pain was assessed using a visual analogue scale (VAS, from 0 to 10 points), the severity of PPS and the osteopathic status.Results. Patients suffering from PPS are characterized by the presence of intense pain syndrome (5–6 points according to VAS); they are characterized by a headache that worsens during taking a vertical position and is accompanied by dizziness and nausea. These patients are characterized by the presence of biomechanical disorders in the regions of the head, dura mater, lower extremities and neck (structural component). The use of osteopathic correction is accompanied by a statistically significant (p<0,05) decrease in the pain syndrome intensity, relief of PPS symptoms, and a decrease in the detection frequency of the most regional somatic dysfunctions.Conclusion. Based on the results obtained, it seems possible to recommend the inclusion of osteopathic correction in the complex of therapeutic measures for patients suffering from PPS.
介绍。穿刺后综合征(PPS)是脊髓麻醉或腰椎穿刺后1-2天出现的复杂症状,以头痛为主要症状。目前,还没有有效的非侵入性治疗PPS的方法。基于硬脑膜损伤在PPS发病机制中可能发挥的作用,我们有理由认为,对相应区域的躯体功能障碍进行识别和骨科矫正可能是治疗PPS患者的有效方法。该研究的目的是证实使用整骨矫正治疗患者穿刺后综合征的可能性。材料和方法。本研究涉及40例年龄在20 ~ 50岁的PPS综合征患者,他们在手术后使用脊髓麻醉住院。患者随机分为对照组(20例)和对照组(20例)。所有研究参与者都被规定卧床和中等饮酒(25-30毫升/公斤体重)方案。主组的参与者在术后第一天额外接受一小时的整骨矫正。所有患者在治疗开始时和治疗开始后第三天接受检查。采用视觉模拟评分(VAS, 0 - 10分)、PPS的严重程度和骨病状态评估疼痛的严重程度。PPS患者的特征是存在剧烈疼痛综合征(根据VAS评分为5-6分);他们的特点是在采取垂直姿势时头痛加重,并伴有头晕和恶心。这些患者的特征是在头部、硬脑膜、下肢和颈部(结构部分)区域存在生物力学障碍。采用整骨矫正后,疼痛综合征的强度、PPS症状的缓解以及大部分区域躯体功能障碍的检出率均有统计学意义(p< 0.05)的降低。根据所获得的结果,似乎有可能推荐将整骨矫正纳入PPS患者的综合治疗措施中。
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引用次数: 0
Goniometric effects of an osteopathic technique, active stretching with specific, fixation on the mobility of the Scapular Waist 一种骨科技术的角度效应,主动拉伸与特定的固定对肩胛骨腰部活动的影响
Pub Date : 2023-03-25 DOI: 10.32885/2220-0975-2023-1-120-128
M. A. Campillar
As observed during this investigation, the dysfunctions of the Scapular Waist are frequent musculoskeletal processes in the professional consultation, after cervicalgias and lumbalgias, therefore the study and the investigation on the possible causes is of great importance, and consequently the adequate therapeutics. The purpose of this research is the application of a soft tissue osteopathic technique, «streching with a specific fixation point», with certain maintenance times to achieve its effective flexibility. We worked with a total of 50 subjects, adults of both sexes. The participants were between 30 and 80 years of age. A goniometric measurement was made before and after the intervention. In conclusion, it was found that there are no statistically significant differences between the control group and the experimental group in the pre-intervention mobility levels, nor in the preand post-intervention mobility levels in the control group. It was observed that there are statistically significant differences in the pre and post intervention mobility levels in the experimental group and between the experimental group and the control in post intervention levels.
在本次调查中观察到,肩胛腰的功能障碍是继颈痛和腰痛之后在专业会诊中常见的肌肉骨骼过程,因此研究和调查其可能的原因,从而采取适当的治疗方法是非常重要的。本研究的目的是应用软组织整骨技术,“以特定的固定点拉伸”,在一定的维护时间内实现其有效的柔韧性。我们总共研究了50名受试者,男女皆有。参与者的年龄在30到80岁之间。在干预前后分别进行角度测量。综上所述,实验组与对照组在干预前活动能力水平上无统计学差异,对照组在干预前后活动能力水平上无统计学差异。观察发现,实验组干预前和干预后的活动能力水平以及干预后实验组和对照组之间的差异均有统计学意义。
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引用次数: 0
Osteopathic correction as part of the complex treatment of temporomandibular disorder 骨科矫正作为颞下颌紊乱复杂治疗的一部分
Pub Date : 2022-12-17 DOI: 10.32885/2220-0975-2022-4-103-115
A. Nesterov, E. E. Tsymbalov, M. A. Nikulina, A. N. Kantsepolsky
Described clinical case shows positive results of osteopathic correction in the complex treatment of syndrome of pain dysfunction of the temporomandibular joint (TMJ). Diagnosis and treatment of this syndrome attract attention because of the ambiguity of the etiology, pathogenesis and lack of effectiveness the treatment algorithm to achieve a stable result. We have developed and put in our practice own interdisciplinary algorithm which allows us to diagnose and resolve somatic dysfunctions before dental treatment. The purpose of that is increasing of adaptive functions of the body to changes in the dental system during the treatment. At the same time, dental treatment has to be with osteopathic support which levels increased load on adaptation mechanism which changes during dental bite correction. The interdisciplinary algorithm proposed by us allows us to evaluate the prognosis of the effectiveness of treatment of TMJ at the earliest diagnostic stages.
所描述的临床病例显示,在颞下颌关节(TMJ)疼痛功能障碍综合征的复杂治疗中,骨科矫正取得了积极的结果。该综合征的病因病机不明确,疗效不明显,治疗算法难以达到稳定的效果,引起了人们的关注。我们已经开发并实践了自己的跨学科算法,使我们能够在牙科治疗之前诊断和解决躯体功能障碍。这样做的目的是在治疗过程中增加身体对牙齿系统变化的适应功能。同时,牙科治疗必须采用整骨疗法,这增加了适应机制的负荷,而适应机制在牙咬矫正过程中发生了变化。我们提出的跨学科算法使我们能够在早期诊断阶段评估TMJ治疗有效性的预后。
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引用次数: 1
The use of autoimmunological parameters to evaluate the results of osteopathic correction: pilot study 使用自身免疫参数评价骨科矫正的结果:初步研究
Pub Date : 2022-12-17 DOI: 10.32885/2220-0975-2022-4-93-102
A. Ikhlef, Y. Potekhina, E. Tregubova, O. I. Kurbatov, A. Pukhalenko
Introduction. Osteopathic correction (OC) is aimed to eliminate somatic dysfunctions, which are reversible structural and functional disorders of tissue mobility. Adaptation mechanisms of the organism imply structural The aim of the study is to investigate the fundamental possibility of using functional (not nosological) autoimmunological indicators to evaluate the results of osteopathic correction.Materials and methods. The prospective study was conducted on the basis of the Department of Osteopathy of the Mechnikov NWSMU and the Institute of Osteopathy (Saint-Petersburg) in 2020–2021. 10 young and middle-aged people (20–52 years old) were examined. Patients underwent osteopathic correction in the amount of 2–3 sessions. Patients were examined according to the algorithms of osteopathic diagnostics; the ratio of antibody titers to 24 autoantigens of various body tissues and organs was evaluated using the ELI-Viscero-Test-24 method before and after the OC courses.Results. The relative content of autoantibodies to the main connective tissue protein collagen significantly (p=0,037) increased from a median value of 6 % (Q1–Q3 2–9 %) to 11 % (Q1–Q3 2–22 %). The other autoimmunological indicators varied in different directions.Conclusion. It is likely that OC triggers the processes of connective tissue restructuring, which are reflected in an increase in the indicators of auto-AT to collagen. Changes in other autoimmunological indicators require more detailed studies on a larger sample.
介绍。骨科矫正(OC)旨在消除躯体功能障碍,这是可逆的组织活动的结构和功能障碍。本研究的目的是探讨使用功能性(而非病原学)自身免疫指标来评估骨科矫正效果的基本可能性。材料和方法。这项前瞻性研究是在2020-2021年在梅奇尼科夫国立医科大学骨病科和圣彼得堡骨病研究所的基础上进行的。对10名20 ~ 52岁的中青年进行了调查。患者接受2-3次整骨矫正。根据骨科诊断算法对患者进行检查;采用elisa -脏器测试-24方法,测定小鼠在OC课程前后对24种自身抗原抗体滴度的比值。主要结缔组织蛋白胶原的自身抗体相对含量显著(p=0,037)从中位数6% (Q1-Q3 2 - 9%)增加到11% (Q1-Q3 2 - 22%)。其他自身免疫指标在不同方向上存在差异。OC可能触发了结缔组织的重组过程,这反映在胶原蛋白的auto-AT指标的增加。其他自身免疫指标的变化需要对更大样本进行更详细的研究。
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引用次数: 0
Effect of the clenching of teeth on the posture: differences between bruxer′s and unbruxer′s population 咬牙对姿势的影响:bruxer和unbruxer人群的差异
Pub Date : 2022-12-17 DOI: 10.32885/2220-0975-2022-4-145-155
M. Siffre, W. Bertucci, M. Soudain-Pineau
Objectives. Relying on the Thegosis theory, the purpose of this study is to analyze the effects of the clenching of teeth on the posture with a stabilometric platform.Method. Thirty-two subjects divided into two groups, Bruxism and Control using criteria from O. F. Molina and al., have passed two series of three stabilometric measures: unclenched teeth then clenched teeth. Posturological parameters analyzed in this study are: X-moyen, Y-moyen, Surface, LFS, VFY.Results. Statistical analysis of the data reveals significant differences for the X-moyen, the Surface and the VFY. Conclusion. This study shows that if unclenched teeth, bruxer subjects have a similar posture to the control subjects, clenched teeth have different postures and clenching of teeth tends to stabilize the bruxers and destabilize the control subjects.
目标。本研究以Thegosis理论为基础,利用稳定测量平台分析咬牙对体位的影响。根据o.f. Molina等人的标准,32名受试者被分为磨牙和控制两组,通过了两组三种稳定性测量:松开牙齿和紧咬牙齿。本研究分析的姿势参数有:X-moyen、Y-moyen、Surface、LFS、vfy。对数据进行统计分析,发现X-moyen、Surface和VFY之间存在显著差异。结论。本研究表明,当不咬牙时,磨牙者的姿势与对照组相似,而咬牙者的姿势不同,咬牙倾向于使磨牙稳定而使对照组不稳定。
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引用次数: 0
The possibilities of osteopathic correction using in adolescents with varicocele: a pilot study 青少年精索静脉曲张矫治的可能性:一项初步研究
Pub Date : 2022-12-17 DOI: 10.32885/2220-0975-2022-4-83-92
Yu. V. Kutsebo, E. A. Shchuchkina, N. Kozlova
Introduction. Currently, varicocele remains a largely unresolved problem in urology, and this makes it necessary to search for additional, including non-pharmacological, methods of treatment. In recent years, the effectiveness of osteopathic correction of patients with chronic venous insufficiency has been shown. However, at this moment, the use of osteopathic methods in the treatment of varicocele is not widely used, which makes it relevant to conduct research on this topic.The aim is to explore the possibility to use the osteopathic correction in adolescents with varicocele.Materials and methods. The study involved 40 participants aged 13–17 years. Two groups were formed: the main group (20 patients), whose participants received drug treatment and a course of osteopathic correction, and the control group (20 patients, data were collected retrospectively), whose participants received only drug therapy. For both groups, there were collected the parameters (before and after treatment) that characterize the state of the venous network of the spermatic cord (presence/absence of testicular hypotrophy, of cremaster reflex and of a positive Valsalva test; as well as the diameter of the cremaster veins and the value of the resistance index), and information on the presence/absence of pain syndrome.Results. In the control group, whose participants received only drug therapy, there was a significant (p<0,05) increase in the number of detected cases of pain syndrome and a positive Valsalva test, as well as a significant (p<0,05) increase in cremaster vein diameter at the end of treatment. Participants of the main group, who received osteopathic correction in addition to conservative therapy, were characterized by a significant (p<0,05) decrease in the diameter of the cremaster veins and an increase in the resistance index, the results differed significantly (p<0,05) from the corresponding values in the control group. Also, in the main group at the time of completion of treatment, there were recorded a statistically significantly (p<0,05) lower number of cases of pain syndrome, a positive Valsalva test, and the absence of a cremaster reflex in comparison with the control group.Conclusion. The results obtained in the framework of this pilot study allow us to positively assess the prospects for the use of osteopathic correction in the treatment of varicocele in adolescents. It is recommended to continue research in this direction over a longer period of time and on a larger sample size, with the obligatory formation of a parallel control.
介绍。目前,精索静脉曲张在泌尿外科仍然是一个很大程度上未解决的问题,这使得有必要寻找额外的,包括非药物的治疗方法。近年来,骨科矫正慢性静脉功能不全患者的有效性已得到证实。然而,目前使用整骨疗法治疗精索静脉曲张的应用并不广泛,这使得开展本课题的研究具有重要意义。目的是探讨使用整骨矫正青少年精索静脉曲张的可能性。材料和方法。这项研究涉及40名年龄在13-17岁之间的参与者。分为两组:主组(20例)接受药物治疗并进行一个疗程的整骨矫正;对照组(20例)仅接受药物治疗,资料回顾性收集。对于两组患者,收集了表征精索静脉网络状态的参数(治疗前后)(是否存在睾丸萎缩、cremaster反射和Valsalva试验阳性);以及脉径和阻力指数的值),以及有无疼痛综合征的信息。在只接受药物治疗的对照组中,疼痛综合征的检测病例和Valsalva试验阳性的数量显著(p< 0.05)增加,治疗结束时冠状静脉直径显著(p< 0.05)增加。主组患者在保守治疗的基础上进行整骨矫正,其特征是嵴静脉直径明显减小(p< 0.05),阻力指数明显升高(p< 0.05),结果与对照组的相应值有显著差异(p< 0.05)。治疗结束时,主组疼痛综合征、Valsalva试验阳性、无cremaster反射的发生率均低于对照组,差异有统计学意义(p< 0.05)。在这项初步研究的框架内获得的结果使我们能够积极评估在青少年精索静脉曲张治疗中使用整骨矫正的前景。建议在更长的时间和更大的样本量上继续在这个方向上进行研究,并必须形成平行对照。
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引用次数: 0
Fascial Distortion Model (FDM) by Stephen Typaldos from the modern research and therapeutic concepts point of view Stephen Typaldos从现代研究和治疗观念的角度阐述筋膜扭曲模型(FDM)
Pub Date : 2022-12-17 DOI: 10.32885/2220-0975-2022-4-116-125
A. Boldin, S. B. Sokolin, M. Tardov, E. Haimov, L. Agasarov
This article presents information regarding the original concept proposed by the American osteopath S. Typaldos — Fascial Distortion Model. This paper describes the diagnostic approach and the therapeutic techniques principles of the model. The article focuses on the theoretical substantiation of the model from the currently available modern data in the field of anatomy and physiology of the connective tissue (fascia) point of view. Also parallels are drawn between therapeutic FDM manipulations and therapeutic techniques of other manual methods known in Russia.
本文介绍了美国整骨医生S. Typaldos提出的最初概念-筋膜扭曲模型。本文介绍了该模型的诊断方法和治疗技术原理。本文着重从结缔组织(筋膜)解剖学和生理学领域现有的现代数据出发,对该模型进行理论论证。此外,在俄罗斯已知的治疗FDM操作和其他手工方法的治疗技术之间也有相似之处。
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引用次数: 0
Electron-donor and regulatory effects of superoxide anion radicals on the processes of osteogenesis and bone remodeling: literature review 电子供体和超氧阴离子自由基对成骨和骨重塑过程的调节作用:文献综述
Pub Date : 2022-12-17 DOI: 10.32885/2220-0975-2022-4-126-144
Y. Rakhmanin, A. D. Fesyun, A. Stekhin, G. Yakovleva
The analysis of scientific publications on the regulatory effect of peroxide anion radicals and electronic activation of the body on the function of osteogenesis and associated systems of the body is presented according to the following information sources: Scopus database, MEDLINE, Web of Science, eLibrary.ru, Google academy for the availability of peer-reviewed original and review publications on the key words: osteogenesis, musculoskeletal system, reoxygenation, hormonal regulators, electron-donor activity, associated water phase, rehabilitation, on the basis of which search phrases on the research topic were formed. Based on a number of evidencebased scientific studies on the regulatory effect of peroxide anion radicals and electronic activation on biological processes (changes in the functional state of the liver, hematological parameters, macro- and microelement composition of liquid media and animal organs, the course of reparative processes in damaged tissues), a biophysical mechanism of systemic homeostatic action of oxygen anion radicals is proposed. This mechanism consists in antihypoxic and detoxifying action during reoxygenation of ischemic tissues, in increasing proliferative activity and shifting osteogenesis regulators (sRANKL-OPG system) towards osteoprotegerin. At the same time, the processes of binding of intracellular free calcium and trace elements in osteoblasts, activation of the macrophage reaction, neoangiogenesis and restoration of myeloid tissue in the area of bone breakdown occur. It is shown that the use of micellar mechanoactivated calcium carbonate as a source of formation of peroxide anion radicals in an aqueous medium leads to a decrease in the redox state and stabilization of cell pH, activation of mitochondrial activity accompanied by intensification of metabolism, including the exchange of micro- and macroelements, improvement of the functions of the antioxidant defense system and nonspecific immunity of the body, stabilization of physiological and biochemical parameters and the functional state of internal organs. 
根据以下信息来源,对过氧化阴离子自由基和人体电子激活对成骨功能和身体相关系统功能的调节作用的科学出版物进行分析:Scopus数据库,MEDLINE, Web of Science, eLibrary.ru, Google academy提供同行评审的原创和评论出版物的关键词:成骨,肌肉骨骼系统,再氧化,激素调节,电子供体活性,相关水相,康复,在此基础上形成研究主题的搜索短语。基于对过氧化阴离子自由基和电子激活对生物过程(肝脏功能状态、血液学参数、液体介质和动物器官宏微量元素组成、损伤组织修复过程)的调节作用的多项循证科学研究,提出了氧阴离子自由基系统稳态作用的生物物理机制。这种机制包括缺血组织再氧化过程中的抗缺氧和解毒作用,增加增殖活性和将成骨调节因子(sRANKL-OPG系统)转向骨保护素。与此同时,成骨细胞内游离钙和微量元素的结合、巨噬细胞反应的激活、骨破裂区新生血管的生成和髓样组织的修复等过程也随之发生。研究表明,在水介质中使用胶束机械活化碳酸钙作为过氧化阴离子自由基形成的来源,导致氧化还原状态的降低和细胞pH的稳定,线粒体活性的激活伴随着代谢的增强,包括微量元素和大量元素的交换,抗氧化防御系统和身体非特异性免疫功能的改善。生理生化参数的稳定和内脏的功能状态。
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Russian Osteopathic Journal
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