Pub Date : 2024-06-26DOI: 10.2174/0115701794285586240523101245
Mohamad Hesam Shahrajabian, Wenli Sun
: Bitter melon (Momordica charantia L.) is a member of the Cucurbitaceae, which is also known as bitter squash, bitter gourd, karela, Goya melon and balsam pear. It is a rich source of different vitamins, potassium, zinc and other nutrients. The main pharmaceutical benefits of bitter melon are “antiinflammatory”, “antioxidant activity”, “antimicrobial characteristic”, “anticancer activity”, and “antihelmintic activity”, “antidiabetic effects”, “antiinflammation activity” and “treat skin conditions”. Its fruit is the main part of the plant which has been used for medicinal and food purposes. The primary metabolites in bitter gourd are common sugars, chlorophyll and proteins while secondary metabolites are carotenoids, alkaloids, phenolics, curcubitane triterpenoids, saponins, etc. The present review aims to study and survey on the nearly up-to-date results and findings regarding the pharmaceutical advantages and health benefits of bitter melon in an organic life.
{"title":"Multidimensional Uses of Bitter Melon (Momordica charantia L.) Considering the Important Functions of its Chemical Components","authors":"Mohamad Hesam Shahrajabian, Wenli Sun","doi":"10.2174/0115701794285586240523101245","DOIUrl":"https://doi.org/10.2174/0115701794285586240523101245","url":null,"abstract":": Bitter melon (Momordica charantia L.) is a member of the Cucurbitaceae, which is also known as bitter squash, bitter gourd, karela, Goya melon and balsam pear. It is a rich source of different vitamins, potassium, zinc and other nutrients. The main pharmaceutical benefits of bitter melon are “antiinflammatory”, “antioxidant activity”, “antimicrobial characteristic”, “anticancer activity”, and “antihelmintic activity”, “antidiabetic effects”, “antiinflammation activity” and “treat skin conditions”. Its fruit is the main part of the plant which has been used for medicinal and food purposes. The primary metabolites in bitter gourd are common sugars, chlorophyll and proteins while secondary metabolites are carotenoids, alkaloids, phenolics, curcubitane triterpenoids, saponins, etc. The present review aims to study and survey on the nearly up-to-date results and findings regarding the pharmaceutical advantages and health benefits of bitter melon in an organic life.","PeriodicalId":11101,"journal":{"name":"Current organic synthesis","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141502864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-24DOI: 10.2174/0115701794307025240521114902
Fatemeh Doraghi, Farzad Gilaninezhad, Somaye Karimian, Bagher Larijani, Mohammad Mahdavi
: Unsaturated pyrazolones can participate in organocatalytic reactions with various substrates to form spiro-cyclic pyrazolones, and fuzed-pyrazolone heterocycles. The present review describes progress since 2013 in the organocatalysis transformations of unsaturated pyrazolones. Pyrazolones are prevalent structural motifs in a wide variety of natural products and drug or drug-like molecules. A series of nitrogen-containing pyrazolones exhibits anti-cancer, antimicrobial, anti-inflammatory, anticonvulsant, antidepressant, antidiabetic, and an-tipyretic activities. Especially, chiral spiro-cyclic pyrazolones are recognized as targets in nat-ural products and clinical pharmaceuticals. Organocatalytic systems are powerful and reliable approaches that allow us to build structurally complex molecules in an enantioselectively and diastereoselectively manner. Avoiding the use of transition metal catalysts, readily available bifunctional organocatalysts, and the performance of the reaction at ambient temperature are other advantages of these catalytic systems. Despite considerable progress in this field, it is still one of the challenging goals for chemists to make new biologically active heterocyclic molecules.
{"title":"Developments in Organocatalysis Transformations of Unsaturated Pyrazolones","authors":"Fatemeh Doraghi, Farzad Gilaninezhad, Somaye Karimian, Bagher Larijani, Mohammad Mahdavi","doi":"10.2174/0115701794307025240521114902","DOIUrl":"https://doi.org/10.2174/0115701794307025240521114902","url":null,"abstract":": Unsaturated pyrazolones can participate in organocatalytic reactions with various substrates to form spiro-cyclic pyrazolones, and fuzed-pyrazolone heterocycles. The present review describes progress since 2013 in the organocatalysis transformations of unsaturated pyrazolones. Pyrazolones are prevalent structural motifs in a wide variety of natural products and drug or drug-like molecules. A series of nitrogen-containing pyrazolones exhibits anti-cancer, antimicrobial, anti-inflammatory, anticonvulsant, antidepressant, antidiabetic, and an-tipyretic activities. Especially, chiral spiro-cyclic pyrazolones are recognized as targets in nat-ural products and clinical pharmaceuticals. Organocatalytic systems are powerful and reliable approaches that allow us to build structurally complex molecules in an enantioselectively and diastereoselectively manner. Avoiding the use of transition metal catalysts, readily available bifunctional organocatalysts, and the performance of the reaction at ambient temperature are other advantages of these catalytic systems. Despite considerable progress in this field, it is still one of the challenging goals for chemists to make new biologically active heterocyclic molecules.","PeriodicalId":11101,"journal":{"name":"Current organic synthesis","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141502865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-06DOI: 10.2174/0115701794259226231023091306
Ashraf H F Abd El-Wahab
In this work, a series of novel 3-(halophenyl)-1-phenyl-1H-pyrazole moieties have been synthesized. Their structures were characterized by IR, NMR, and MS spectroscopy, and the corresponding antitumor properties were also studied.
Objectives: This study aimed to synthesize a series of new 3-(halophenyl)-1-phenyl-1Hpyrazole moieties and survey the antitumor properties of these compounds.
Materials and methods: 3-(halophenyl)-1-phenyl-1H-pyrazoles (4a-j) were prepared by reaction of phenyl hydrazine (3) with different halogen aromatic aldehydes (1a-j) and malononitrile (2) in C2H5OH and piperidine. The reaction took place under microwave irradiation settings for two minutes at140°C.
Results: Three human cancer cell lines were used as in vitro test subjects for compounds 4a - j. Three cell lines from mammals HeLa (a cell line for human cervical cancer), MCF-7 (a cell line for human breast cancer), and PC-3 (a cell line for human prostate cancer), all with 5- fluorouracil as the standard reference drug were used.
Conclusion: A series of novel 3-(halophenyl)-1-phenyl-1H-pyrazoles were synthesized in this work. All substances had their anticancer properties assessed.
{"title":"Synthesis and Antitumor Activities of Novel 5-amino-3-(halophenyl)- 1- phenyl-1H-pyrazole-4-carbonitriles.","authors":"Ashraf H F Abd El-Wahab","doi":"10.2174/0115701794259226231023091306","DOIUrl":"https://doi.org/10.2174/0115701794259226231023091306","url":null,"abstract":"<p><p>In this work, a series of novel 3-(halophenyl)-1-phenyl-1H-pyrazole moieties have been synthesized. Their structures were characterized by IR, NMR, and MS spectroscopy, and the corresponding antitumor properties were also studied.</p><p><strong>Objectives: </strong>This study aimed to synthesize a series of new 3-(halophenyl)-1-phenyl-1Hpyrazole moieties and survey the antitumor properties of these compounds.</p><p><strong>Materials and methods: </strong>3-(halophenyl)-1-phenyl-1H-pyrazoles (4a-j) were prepared by reaction of phenyl hydrazine (3) with different halogen aromatic aldehydes (1a-j) and malononitrile (2) in C2H5OH and piperidine. The reaction took place under microwave irradiation settings for two minutes at140°C.</p><p><strong>Results: </strong>Three human cancer cell lines were used as in vitro test subjects for compounds 4a - j. Three cell lines from mammals HeLa (a cell line for human cervical cancer), MCF-7 (a cell line for human breast cancer), and PC-3 (a cell line for human prostate cancer), all with 5- fluorouracil as the standard reference drug were used.</p><p><strong>Conclusion: </strong>A series of novel 3-(halophenyl)-1-phenyl-1H-pyrazoles were synthesized in this work. All substances had their anticancer properties assessed.</p>","PeriodicalId":11101,"journal":{"name":"Current organic synthesis","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140859693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-01DOI: 10.2174/157017942103240119181624
J. Liu, M. U. Rehman
{"title":"Combinatorial Study of Organic Structures","authors":"J. Liu, M. U. Rehman","doi":"10.2174/157017942103240119181624","DOIUrl":"https://doi.org/10.2174/157017942103240119181624","url":null,"abstract":"<jats:sec>\u0000<jats:title />\u0000<jats:p />\u0000</jats:sec>","PeriodicalId":11101,"journal":{"name":"Current organic synthesis","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141025297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-24DOI: 10.2174/1570179421999240422115539
Manoj K. Jaiswal, Abhishek Gupta, Faisal J. Ansari, Vinay K. Pandey, Vinod K. Tiwari
Two errors appeared in the text of the manuscript titled “Recent Progress on Synthesis of Functionalized 1,5- disubstituted Triazoles”, 2024; 21(4) : 513-558 [1]. We regret the errors and apologize to readers. The original article can be found online at: https://www.eurekaselect.com/article/131107
标题为 "Recent Progress on Synthesis of Functionalized 1,5- disubstituted Triazoles"（《官能化 1,5-二取代三唑合成的最新进展》）的手稿文本中出现两处错误，2024; 21(4) : 513-558 [1]。我们对这些错误表示遗憾，并向读者致歉。原文可在线查阅： https://www.eurekaselect.com/article/131107
{"title":"Corrigendum to: Recent Progress on Synthesis of Functionalized 1,5- disubstituted Triazoles","authors":"Manoj K. Jaiswal, Abhishek Gupta, Faisal J. Ansari, Vinay K. Pandey, Vinod K. Tiwari","doi":"10.2174/1570179421999240422115539","DOIUrl":"https://doi.org/10.2174/1570179421999240422115539","url":null,"abstract":"Two errors appeared in the text of the manuscript titled “Recent Progress on Synthesis of Functionalized 1,5- disubstituted Triazoles”, 2024; 21(4) : 513-558 [1]. We regret the errors and apologize to readers. The original article can be found online at: https://www.eurekaselect.com/article/131107","PeriodicalId":11101,"journal":{"name":"Current organic synthesis","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140799872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-19DOI: 10.2174/0115701794291133240327044308
Dania Altaher, Hiba Zalloum, Kamal Sweidan, Dima A. Sabbah, Husam AlSalamat, Mahmoud Sunjuk, Reem Isleem
Introduction: A new series of 4-hydroxy-8-methyl-2-oxo-1,2-dihydroquinoline-3-carboxamide derivatives has been synthesized in good yields, followed by complete characteri-zation using 1D-NMR, 2D-NMR, and IR techniques. Methods:: The final products contain amide, hydroxyl, and aromatic functional groups that usu-ally show significant bioactivity. The target products have been examined towards three cancer cell lines, namely colorectal cancer cell line (HCT116), breast cancer cell line (MCF-7), and leukemia cell line (K562) in addition to the fibroblast cells, that were used as a model for normal human tissue. Results:: The anticancer results signified that compound 6 showed the most activity in the series accomplished with IC50 values of 14.6, 5.3 and 12.8 μM, Conclusion:: Other compounds exhibited considerable activity, such as compounds 9 (IC50 3.5 and 19.0 μM), 10 (IC50 12.6 μM), and 11 (IC50 10.3 μM) against the three cancer cell lines HCT116, MCF-7 and K562, respectively.
{"title":"Synthesis, Characterization and Preliminary Screening of New N-Substi-tuted -8-Methyl-4-Hydroxy-2-Quinolone -3-Carboxamides as Potential An-ticancer Agents","authors":"Dania Altaher, Hiba Zalloum, Kamal Sweidan, Dima A. Sabbah, Husam AlSalamat, Mahmoud Sunjuk, Reem Isleem","doi":"10.2174/0115701794291133240327044308","DOIUrl":"https://doi.org/10.2174/0115701794291133240327044308","url":null,"abstract":"Introduction: A new series of 4-hydroxy-8-methyl-2-oxo-1,2-dihydroquinoline-3-carboxamide derivatives has been synthesized in good yields, followed by complete characteri-zation using 1D-NMR, 2D-NMR, and IR techniques. Methods:: The final products contain amide, hydroxyl, and aromatic functional groups that usu-ally show significant bioactivity. The target products have been examined towards three cancer cell lines, namely colorectal cancer cell line (HCT116), breast cancer cell line (MCF-7), and leukemia cell line (K562) in addition to the fibroblast cells, that were used as a model for normal human tissue. Results:: The anticancer results signified that compound 6 showed the most activity in the series accomplished with IC50 values of 14.6, 5.3 and 12.8 μM, Conclusion:: Other compounds exhibited considerable activity, such as compounds 9 (IC50 3.5 and 19.0 μM), 10 (IC50 12.6 μM), and 11 (IC50 10.3 μM) against the three cancer cell lines HCT116, MCF-7 and K562, respectively.","PeriodicalId":11101,"journal":{"name":"Current organic synthesis","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140629863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-19DOI: 10.2174/0115701794281945240327053046
M. Huilgol, Grace Divya D'Souza, I. N. Cangul
The degree sequence of a graph is the list of its vertex degrees arranged in usually increasing order. Many properties of the graphs realized from a degree sequence can be deduced by means of a recently introduced graph invariant called omega invariant. We used the definitions of the considered graph products together with the list of de-gree sequences of these graph products for some well-know graph classes. Naturally, the vertex degree and edge degree partitions are used. As the main theme of the paper is the omega invari-ant, we frequently used the definition and fundamental properties of this very new invariant for our calculations. Also, some algebraic properties of these products are deduced in line with some recent publications following the same fashion In this paper, we determine the degree sequences of strong and lexicographic products of two graphs and obtain the general form of the degree sequences of both products. We obtain a general formula for the omega invariant of strong and lexicographic products of two graphs. The algebraic structures of strong and lexicographic products are obtained. Moreover, we prove that strong and lexicographic products are not distributive over each other We have obtained the general expression for degree sequences of two important products of graphs and a general expression for omega invariants of strong and lexicographic products. Furthermore, we have obtained algebraic structures of strong and lexicographic prod-ucts in terms of their degree sequences. Also, it has been found that the disruptive property does not hold for strong and lexicographic products.
{"title":"Omega Indices of Strong and Lexicographic Products of Graphs","authors":"M. Huilgol, Grace Divya D'Souza, I. N. Cangul","doi":"10.2174/0115701794281945240327053046","DOIUrl":"https://doi.org/10.2174/0115701794281945240327053046","url":null,"abstract":"\u0000\u0000The degree sequence of a graph is the list of its vertex degrees arranged in usually increasing order. Many properties of the graphs realized from a degree sequence can be deduced by means of a recently introduced graph invariant called omega invariant.\u0000\u0000\u0000\u0000We used the definitions of the considered graph products together with the list of de-gree sequences of these graph products for some well-know graph classes. Naturally, the vertex degree and edge degree partitions are used. As the main theme of the paper is the omega invari-ant, we frequently used the definition and fundamental properties of this very new invariant for our calculations. Also, some algebraic properties of these products are deduced in line with some recent publications following the same fashion\u0000\u0000\u0000\u0000In this paper, we determine the degree sequences of strong and lexicographic products of two graphs and obtain the general form of the degree sequences of both products. We obtain a general formula for the omega invariant of strong and lexicographic products of two graphs. The algebraic structures of strong and lexicographic products are obtained. Moreover, we prove that strong and lexicographic products are not distributive over each other\u0000\u0000\u0000\u0000We have obtained the general expression for degree sequences of two important products of graphs and a general expression for omega invariants of strong and lexicographic products. Furthermore, we have obtained algebraic structures of strong and lexicographic prod-ucts in terms of their degree sequences. Also, it has been found that the disruptive property does not hold for strong and lexicographic products.\u0000","PeriodicalId":11101,"journal":{"name":"Current organic synthesis","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140685230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-16DOI: 10.2174/0115701794298435240324175513
Arman Seifallahi Teymourlouei, Seyed Morteza Naghib, M. R. Mozafari
:: Natural polysaccharide-based nanoparticles are known for their non-toxic nature and diverse medical applications. Graphene oxide (GO) nanoparticles show potential in cancer treat-ment due to their ability to target medication delivery and influence ROS generation. These nanocomposites are versatile in gene transport, therapy, and photodynamic therapy, especially when surface-modified. Proper dispersion and functionalization of GO in polymer matrices are crucial, with examples like hyaluronic acid-functionalized GO offering versatile platforms for cancer drug administration. The potential of graphene oxide extends to cancer phototherapy, electronic nanowires, hydrogels, antibacterial nanocomposites, and environmental applications. When activated by polysaccharides, graphene-based nanocomposites exhibit anti-inflammatory and anticancer properties, making them valuable across various industries, including water treat-ment.
{"title":"Stimuli-responsive Graphene-Polysaccharide Nanocomposites for Drug Delivery and Tissue Engineering","authors":"Arman Seifallahi Teymourlouei, Seyed Morteza Naghib, M. R. Mozafari","doi":"10.2174/0115701794298435240324175513","DOIUrl":"https://doi.org/10.2174/0115701794298435240324175513","url":null,"abstract":":: Natural polysaccharide-based nanoparticles are known for their non-toxic nature and diverse medical applications. Graphene oxide (GO) nanoparticles show potential in cancer treat-ment due to their ability to target medication delivery and influence ROS generation. These nanocomposites are versatile in gene transport, therapy, and photodynamic therapy, especially when surface-modified. Proper dispersion and functionalization of GO in polymer matrices are crucial, with examples like hyaluronic acid-functionalized GO offering versatile platforms for cancer drug administration. The potential of graphene oxide extends to cancer phototherapy, electronic nanowires, hydrogels, antibacterial nanocomposites, and environmental applications. When activated by polysaccharides, graphene-based nanocomposites exhibit anti-inflammatory and anticancer properties, making them valuable across various industries, including water treat-ment.","PeriodicalId":11101,"journal":{"name":"Current organic synthesis","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140570462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-15DOI: 10.2174/0115701794294862240322040633
Luana A. Machado, Cynthia L. M. Pereira, Ana Clara G. de Souza, Elivelton A. Ferreira, Flávia F. C. Marques, Ednilsom Orestes, Maria H. Araujo, Karen L. R. Paiva, Marina S. Mesquita, Sônia N. Báo, Leandro F. Pedrosa, Muhammad Jawad Nasim, Claus Jacob, Eufrânio N. da SilvaJúnior
Introduction: Lipid droplets (LDs) serve as primary storage sites for neutral lipids within cells and are crucial for lipid metabolism. Disorders affecting LDs can contribute to the pathogenesis of common metabolic diseases such as obesity and can-cer, highlighting the importance of comprehending LD biology in health and disease contexts. background: Several synthetic methods for the preparation of BODIPYs are reported in the literature, yet the exploration of the different applications of this exciting class of fluorescent compounds is less studied and, therefore, a wide avenue of possibilities remains to be discovered. Methods: Fluorescence assays are commonly used for the detection and quantification of lipids in biological samples or lipid-rich environments. In this study, BODIPYs were synthesized and analyzed for structural confirmation. objective: synthesis of BODIPYs and evaluation of their affinity for intracellular lipid droplets Results: These compounds were subsequently evaluated for photophysical, electro-chemical (cyclic voltammetry) and theoretical analysis, followed by live-cell imaging studies to confirm their affinity for intracellular lipid droplets. method: In this study, BODIPYs were synthesized and analyzed for structural confirmation. These compounds were subsequently evaluated for photophysical, electrochemical (cyclic voltammetry) and theoretical analysis followed by live-cell imaging studies to confirm their affinity for intracellular lipid droplets. Conclusion: BODIPYs have been identified as fluorogenic probes for live-cell imag-ing studies and found to serve as efficient and selective fluorescent compounds for intracellular lipid droplets. result: BODIPYs have been identified as fluorogenic probes for live-cell imaging studies and found to serve as efficient and selective fluorescent compounds for intracellular lipid droplets.
{"title":"BODIPYs as Fluorogenic Probes for Live-Cell Imaging of Lipid Droplets: Photophysical and Computational Studies","authors":"Luana A. Machado, Cynthia L. M. Pereira, Ana Clara G. de Souza, Elivelton A. Ferreira, Flávia F. C. Marques, Ednilsom Orestes, Maria H. Araujo, Karen L. R. Paiva, Marina S. Mesquita, Sônia N. Báo, Leandro F. Pedrosa, Muhammad Jawad Nasim, Claus Jacob, Eufrânio N. da SilvaJúnior","doi":"10.2174/0115701794294862240322040633","DOIUrl":"https://doi.org/10.2174/0115701794294862240322040633","url":null,"abstract":"Introduction: Lipid droplets (LDs) serve as primary storage sites for neutral lipids within cells and are crucial for lipid metabolism. Disorders affecting LDs can contribute to the pathogenesis of common metabolic diseases such as obesity and can-cer, highlighting the importance of comprehending LD biology in health and disease contexts. background: Several synthetic methods for the preparation of BODIPYs are reported in the literature, yet the exploration of the different applications of this exciting class of fluorescent compounds is less studied and, therefore, a wide avenue of possibilities remains to be discovered. Methods: Fluorescence assays are commonly used for the detection and quantification of lipids in biological samples or lipid-rich environments. In this study, BODIPYs were synthesized and analyzed for structural confirmation. objective: synthesis of BODIPYs and evaluation of their affinity for intracellular lipid droplets Results: These compounds were subsequently evaluated for photophysical, electro-chemical (cyclic voltammetry) and theoretical analysis, followed by live-cell imaging studies to confirm their affinity for intracellular lipid droplets. method: In this study, BODIPYs were synthesized and analyzed for structural confirmation. These compounds were subsequently evaluated for photophysical, electrochemical (cyclic voltammetry) and theoretical analysis followed by live-cell imaging studies to confirm their affinity for intracellular lipid droplets. Conclusion: BODIPYs have been identified as fluorogenic probes for live-cell imag-ing studies and found to serve as efficient and selective fluorescent compounds for intracellular lipid droplets. result: BODIPYs have been identified as fluorogenic probes for live-cell imaging studies and found to serve as efficient and selective fluorescent compounds for intracellular lipid droplets.","PeriodicalId":11101,"journal":{"name":"Current organic synthesis","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140570464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: The effect of power and duration of ultrasonic irradiation on the syn-thesis of thiazoles via the Hantzsch reaction was investigated. Methods: The reaction of phenacyl bromides with thioamides under ultrasonic irradiation af-forded the target thiazoles in good yields. Results: The results showed that high power and long irradiation time cause the decomposition of the reaction materials, and for this reaction, the irradiation power of 720 watts and a total duration of 4 minutes, wherein a pulsing function was performed in 50% of each second, were considered the most suitable irradiation properties for the synthesis of thiazoles through the Hantzsch reaction. Conclusion: The use of mild conditions, short time frame, high yields, simple separation of the reaction product, and no use of the base for neutralization are the advantages of the present method.
{"title":"Investigation of the Effect of Power and Duration of Ultrasonic Irradiation on the Synthesis of Thiazoles","authors":"Eghlima Ehsani, Afshin Sarvary, Setareh Habibzadeh","doi":"10.2174/0115701794287558240220115823","DOIUrl":"https://doi.org/10.2174/0115701794287558240220115823","url":null,"abstract":"Introduction: The effect of power and duration of ultrasonic irradiation on the syn-thesis of thiazoles via the Hantzsch reaction was investigated. Methods: The reaction of phenacyl bromides with thioamides under ultrasonic irradiation af-forded the target thiazoles in good yields. Results: The results showed that high power and long irradiation time cause the decomposition of the reaction materials, and for this reaction, the irradiation power of 720 watts and a total duration of 4 minutes, wherein a pulsing function was performed in 50% of each second, were considered the most suitable irradiation properties for the synthesis of thiazoles through the Hantzsch reaction. Conclusion: The use of mild conditions, short time frame, high yields, simple separation of the reaction product, and no use of the base for neutralization are the advantages of the present method.","PeriodicalId":11101,"journal":{"name":"Current organic synthesis","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140570378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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