Pub Date : 2023-01-01DOI: 10.4103/ds.ds-d-22-00055
M. Odabaşı, Serkan Yazici, G. Ozkaya, E. Başkan, A. Oral
Background: Indoleamine 2,3-dioxygenase (IDO), an enzyme in the first step of tryptophan catabolism, plays a role in the pathogenesis of various malignancies and inflammatory diseases. Although its pathogenesis is unclear, vascular dysregulation and chronic inflammation are the most common culprits for rosacea. Objectives: The aim of this study is to evaluate the relationship between IDO and rosacea and whether there is a correlation with disease severity. Methods: Fifty-two patients with rosacea and 29 healthy volunteers were recruited. The patients were grouped according to severity stage, period, and subtype of the disease. Serum IDO levels were measured with enzyme-linked immunosorbent assay. Results: Serum IDO levels were significantly higher in the patients with rosacea compared to the healthy controls (P < 0.001) and were significantly higher in the patients in remission period and with papulopustular type rosacea compared to the controls (P = 0.002 and P = 0.001, respectively). The serum IDO levels of the female rosacea patients were higher than those of the healthy female controls (P < 0.001). When the diagnostic value of the parameter was investigated, it was observed that the serum IDO level has high sensitivity (83.3%) and specificity (76.1%), with a cutoff value of 47.1 ng/mL for female rosacea patients. Conclusion: IDO was found to increase in rosacea patients. With the high specificity and sensitivity observed, especially in female patients, IDO may be a supporting parameter in the diagnosis of rosacea.
{"title":"Serum indoleamine 2,3-dioxygenase level and diagnostic value in patients with rosacea","authors":"M. Odabaşı, Serkan Yazici, G. Ozkaya, E. Başkan, A. Oral","doi":"10.4103/ds.ds-d-22-00055","DOIUrl":"https://doi.org/10.4103/ds.ds-d-22-00055","url":null,"abstract":"Background: Indoleamine 2,3-dioxygenase (IDO), an enzyme in the first step of tryptophan catabolism, plays a role in the pathogenesis of various malignancies and inflammatory diseases. Although its pathogenesis is unclear, vascular dysregulation and chronic inflammation are the most common culprits for rosacea. Objectives: The aim of this study is to evaluate the relationship between IDO and rosacea and whether there is a correlation with disease severity. Methods: Fifty-two patients with rosacea and 29 healthy volunteers were recruited. The patients were grouped according to severity stage, period, and subtype of the disease. Serum IDO levels were measured with enzyme-linked immunosorbent assay. Results: Serum IDO levels were significantly higher in the patients with rosacea compared to the healthy controls (P < 0.001) and were significantly higher in the patients in remission period and with papulopustular type rosacea compared to the controls (P = 0.002 and P = 0.001, respectively). The serum IDO levels of the female rosacea patients were higher than those of the healthy female controls (P < 0.001). When the diagnostic value of the parameter was investigated, it was observed that the serum IDO level has high sensitivity (83.3%) and specificity (76.1%), with a cutoff value of 47.1 ng/mL for female rosacea patients. Conclusion: IDO was found to increase in rosacea patients. With the high specificity and sensitivity observed, especially in female patients, IDO may be a supporting parameter in the diagnosis of rosacea.","PeriodicalId":11107,"journal":{"name":"Dermatologica Sinica","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79890372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.4103/1027-8117.363837
Hsuan-An Su, Y. Tsai
{"title":"Verrucous inverse psoriasis: A novel variant of psoriasis","authors":"Hsuan-An Su, Y. Tsai","doi":"10.4103/1027-8117.363837","DOIUrl":"https://doi.org/10.4103/1027-8117.363837","url":null,"abstract":"","PeriodicalId":11107,"journal":{"name":"Dermatologica Sinica","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86570733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.4103/ds.ds-d-23-00137
Yng Sun, Wei-Yao Wang, Kuan-Yu Chu, Cheng-CheE Lan, StephenChu-Sung Hu
Dear Editor, Mpox (formerly known as monkeypox), a zoonotic disease caused by the monkeypox virus, has caused recent global outbreaks.[1,2] The initial clinical presentation of mpox may manifest with nonspecific symptoms, which may result in delayed diagnosis. Herein, we report a case of mpox with an atypical clinical presentation and the “rising sun” sign observed on dermoscopy. A 44-year-old Taiwanese man, who has sex with men (MSM), presented with a 1-week history of fever, headache, sore throat, and left neck pain and a 4-day history of itchy rash on the limbs. His medical history includes human immunodeficiency virus (HIV) infection, which is being managed with emtricitabine/rilpivirine/tenofovir/alafenamide. He had recently received a diagnosis of acute tonsillitis at the otolaryngology clinic and was treated with amoxicillin/clavulanic acid. However, the symptoms did not improve, and a few vesiculopustular lesions developed on the distal parts of the limbs, starting from the left palm and progressing to the left forearm and legs. Physical examination showed exudative and swollen left tonsil, tender left cervical lymphadenopathy, and asynchronous skin lesions comprising crusted lesions on the left palm and forearm and pustules with perilesional erythema on the left hand and legs [Figure 1a-f]. Polarized dermoscopic examination revealed homogeneous brownish coloration for the left palm-crusted lesion, brown-to-red central crust with peripheral erythema for the left forearm-crusted lesion, and central homogeneous yellow area surrounded by bright erythematous halo (resembling “rising sun”) for pustules on the left hand and legs [Figure 2a-f]. The torso and anogenital region were spared.Figure 1: Clinical images. (a) Swollen left tonsil with whitish-yellow exudate was noted on examination of the oral cavity. (b and c) Crusted lesions on the left palm and forearm. (d-f) Pustules with perilesional erythema on the left hand, ankle, and bilateral knees.Figure 2: Polarized dermoscopic images. (a) Homogeneous brownish coloration for the left palm-crusted lesion. (b) Brown-to-red central crust with peripheral erythema for the left forearm-crusted lesion. (c-e) Central homogeneous yellow area surrounded by bright erythematous halo for pustules, resembling “rising sun,” on the left hand, ankle, and knee. (f) Homogeneous yellow coloration with a central crust and mild peripheral erythema for the pustule on the right knee.Travel and contact history revealed that the patient had not traveled abroad recently but had engaged in unprotected oral sex with another man 2 weeks before the onset of the symptoms. Laboratory analysis revealed leukocytosis (13610/ul), elevated C-reactive protein level (15.49 mg/L), and a normal CD4 cell count (1003 cells/mm3). The HIV viral load was undetectable. Serological tests for herpes simplex virus (HSV), varicella-zoster virus, and syphilis were negative. Due to suspicion of mpox based on clinical features and epidemiologic c
{"title":"Mpox (Monkeypox) with atypical clinical presentation and distinctive dermoscopic findings","authors":"Yng Sun, Wei-Yao Wang, Kuan-Yu Chu, Cheng-CheE Lan, StephenChu-Sung Hu","doi":"10.4103/ds.ds-d-23-00137","DOIUrl":"https://doi.org/10.4103/ds.ds-d-23-00137","url":null,"abstract":"Dear Editor, Mpox (formerly known as monkeypox), a zoonotic disease caused by the monkeypox virus, has caused recent global outbreaks.[1,2] The initial clinical presentation of mpox may manifest with nonspecific symptoms, which may result in delayed diagnosis. Herein, we report a case of mpox with an atypical clinical presentation and the “rising sun” sign observed on dermoscopy. A 44-year-old Taiwanese man, who has sex with men (MSM), presented with a 1-week history of fever, headache, sore throat, and left neck pain and a 4-day history of itchy rash on the limbs. His medical history includes human immunodeficiency virus (HIV) infection, which is being managed with emtricitabine/rilpivirine/tenofovir/alafenamide. He had recently received a diagnosis of acute tonsillitis at the otolaryngology clinic and was treated with amoxicillin/clavulanic acid. However, the symptoms did not improve, and a few vesiculopustular lesions developed on the distal parts of the limbs, starting from the left palm and progressing to the left forearm and legs. Physical examination showed exudative and swollen left tonsil, tender left cervical lymphadenopathy, and asynchronous skin lesions comprising crusted lesions on the left palm and forearm and pustules with perilesional erythema on the left hand and legs [Figure 1a-f]. Polarized dermoscopic examination revealed homogeneous brownish coloration for the left palm-crusted lesion, brown-to-red central crust with peripheral erythema for the left forearm-crusted lesion, and central homogeneous yellow area surrounded by bright erythematous halo (resembling “rising sun”) for pustules on the left hand and legs [Figure 2a-f]. The torso and anogenital region were spared.Figure 1: Clinical images. (a) Swollen left tonsil with whitish-yellow exudate was noted on examination of the oral cavity. (b and c) Crusted lesions on the left palm and forearm. (d-f) Pustules with perilesional erythema on the left hand, ankle, and bilateral knees.Figure 2: Polarized dermoscopic images. (a) Homogeneous brownish coloration for the left palm-crusted lesion. (b) Brown-to-red central crust with peripheral erythema for the left forearm-crusted lesion. (c-e) Central homogeneous yellow area surrounded by bright erythematous halo for pustules, resembling “rising sun,” on the left hand, ankle, and knee. (f) Homogeneous yellow coloration with a central crust and mild peripheral erythema for the pustule on the right knee.Travel and contact history revealed that the patient had not traveled abroad recently but had engaged in unprotected oral sex with another man 2 weeks before the onset of the symptoms. Laboratory analysis revealed leukocytosis (13610/ul), elevated C-reactive protein level (15.49 mg/L), and a normal CD4 cell count (1003 cells/mm3). The HIV viral load was undetectable. Serological tests for herpes simplex virus (HSV), varicella-zoster virus, and syphilis were negative. Due to suspicion of mpox based on clinical features and epidemiologic c","PeriodicalId":11107,"journal":{"name":"Dermatologica Sinica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135913570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.4103/ds.ds-d-22-00096
Letizia Silocchi, G. Damiani
{"title":"Dermatological management in special population affected by psoriasis: A case report of an amputated transgender with psoriasis treated with apremilast","authors":"Letizia Silocchi, G. Damiani","doi":"10.4103/ds.ds-d-22-00096","DOIUrl":"https://doi.org/10.4103/ds.ds-d-22-00096","url":null,"abstract":"","PeriodicalId":11107,"journal":{"name":"Dermatologica Sinica","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75755226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.4103/ds.ds-d-22-00201
S. Pradhan, Jinghong Huang, X. Ran, Chaoliang Zhang, D. Tsuruta, H. Imanishi, Y. Ran
{"title":"Combination simple wet gauze technique placating children and calcofluor white staining microscopy enhances the diagnostic capability in kerion","authors":"S. Pradhan, Jinghong Huang, X. Ran, Chaoliang Zhang, D. Tsuruta, H. Imanishi, Y. Ran","doi":"10.4103/ds.ds-d-22-00201","DOIUrl":"https://doi.org/10.4103/ds.ds-d-22-00201","url":null,"abstract":"","PeriodicalId":11107,"journal":{"name":"Dermatologica Sinica","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84885184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.4103/ds.ds-d-23-00064
Seungho Lee, W. Choi, Huiyoung Shin, Yujeong Park, J. Hong, AiYoung Lee
{"title":"Numerous osteoma cutis on the scalp caused by GNAS mutation","authors":"Seungho Lee, W. Choi, Huiyoung Shin, Yujeong Park, J. Hong, AiYoung Lee","doi":"10.4103/ds.ds-d-23-00064","DOIUrl":"https://doi.org/10.4103/ds.ds-d-23-00064","url":null,"abstract":"","PeriodicalId":11107,"journal":{"name":"Dermatologica Sinica","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75848778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.4103/ds.ds-d-22-00031
Hsin-Yu Huang, Cheng-Ju Wu, Julia Yu‐Yun Lee, Yi-Chen Liao, C. Hsu
{"title":"Lymphocytic thrombophilic arteritis following mRNA-1273 severe acute respiratory syndrome coronavirus 2 vaccination: A case report and review of the literature","authors":"Hsin-Yu Huang, Cheng-Ju Wu, Julia Yu‐Yun Lee, Yi-Chen Liao, C. Hsu","doi":"10.4103/ds.ds-d-22-00031","DOIUrl":"https://doi.org/10.4103/ds.ds-d-22-00031","url":null,"abstract":"","PeriodicalId":11107,"journal":{"name":"Dermatologica Sinica","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86998824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.4103/ds.ds-d-22-00068
Meng-Han Shen, Shih-Jyun Yang, Ya-Ching Chang, Y. Chuang
{"title":"Dermatomyositis with insidious advanced renal cell carcinoma: A case report","authors":"Meng-Han Shen, Shih-Jyun Yang, Ya-Ching Chang, Y. Chuang","doi":"10.4103/ds.ds-d-22-00068","DOIUrl":"https://doi.org/10.4103/ds.ds-d-22-00068","url":null,"abstract":"","PeriodicalId":11107,"journal":{"name":"Dermatologica Sinica","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85733467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.4103/ds.ds-d-22-00122
Wei-Ting Liu, Chao-Chun Yang
Dermatomyositis (DM) is a systemic autoimmune disease characterized by unique cutaneous manifestations and inflammatory myopathies. With the discovery of myositis-specific antibodies (MSAs), patients with DM, especially those with a higher risk of life-threatening complications, can be classified according to the MSA type. This retrospective study aimed to investigate the clinical significance of MSAs in patients with DM in Taiwan. A total of 33 patients with DM who underwent the MSA test, including 26 with classic DM and 7 with amyopathic DM, were included. There were 13 men and 20 women, with a mean age at diagnosis of 49.6 years. MSA was detected in 26 (78.8%) of 33 patients with DM. The most frequently detected MSA was anti-melanoma differentiation-associated protein 5 (MDA5) (10/33, 30.3%) followed by anti-transcription intermediary factor-1γ (TIF-1γ) (8/33, 24.2%). Dysphagia was present in 6 (18.2%) of the 33 patients and more frequently developed in patients with anti-TIF-1γ (+) (5/8, 62.5%) than those with anti-TIF-1γ (−) (1/25, 4.0%). Interstitial lung disease was noted in 15 patients (45.5%) and developed more frequently in patients with anti-MDA5 (+) (7/10, 70.0%) than those with anti-MDA5 (−) (8/23, 34.8%). Malignancies were detected in 4 (12.1%) patients, with one each of anti-Mi-2 (+), anti-TIF-1γ (+), anti-ARS (+), and MSA (−). Mortality occurred in 6 (18.2%) patients, of whom 4 were anti-MDA5 (+). Anti-MDA5 and anti-TIF-1γ were the two most commonly detected MSAs. The presence of specific MSAs is associated with a certain phenotype, and integrating MSAs while evaluating DM aids in accurate patient management.
{"title":"Myositis-specific antibodies in dermatomyositis: A single-center experience of 33 cases in Taiwan","authors":"Wei-Ting Liu, Chao-Chun Yang","doi":"10.4103/ds.ds-d-22-00122","DOIUrl":"https://doi.org/10.4103/ds.ds-d-22-00122","url":null,"abstract":"Dermatomyositis (DM) is a systemic autoimmune disease characterized by unique cutaneous manifestations and inflammatory myopathies. With the discovery of myositis-specific antibodies (MSAs), patients with DM, especially those with a higher risk of life-threatening complications, can be classified according to the MSA type. This retrospective study aimed to investigate the clinical significance of MSAs in patients with DM in Taiwan. A total of 33 patients with DM who underwent the MSA test, including 26 with classic DM and 7 with amyopathic DM, were included. There were 13 men and 20 women, with a mean age at diagnosis of 49.6 years. MSA was detected in 26 (78.8%) of 33 patients with DM. The most frequently detected MSA was anti-melanoma differentiation-associated protein 5 (MDA5) (10/33, 30.3%) followed by anti-transcription intermediary factor-1γ (TIF-1γ) (8/33, 24.2%). Dysphagia was present in 6 (18.2%) of the 33 patients and more frequently developed in patients with anti-TIF-1γ (+) (5/8, 62.5%) than those with anti-TIF-1γ (−) (1/25, 4.0%). Interstitial lung disease was noted in 15 patients (45.5%) and developed more frequently in patients with anti-MDA5 (+) (7/10, 70.0%) than those with anti-MDA5 (−) (8/23, 34.8%). Malignancies were detected in 4 (12.1%) patients, with one each of anti-Mi-2 (+), anti-TIF-1γ (+), anti-ARS (+), and MSA (−). Mortality occurred in 6 (18.2%) patients, of whom 4 were anti-MDA5 (+). Anti-MDA5 and anti-TIF-1γ were the two most commonly detected MSAs. The presence of specific MSAs is associated with a certain phenotype, and integrating MSAs while evaluating DM aids in accurate patient management.","PeriodicalId":11107,"journal":{"name":"Dermatologica Sinica","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91227628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.4103/ds.ds-d-22-00118
Jenny Chiang, R. Lin, Meng-Sui Lee
{"title":"Two cases with dermatomyositis-like skin rash and myopathy following COVID-19 vaccination","authors":"Jenny Chiang, R. Lin, Meng-Sui Lee","doi":"10.4103/ds.ds-d-22-00118","DOIUrl":"https://doi.org/10.4103/ds.ds-d-22-00118","url":null,"abstract":"","PeriodicalId":11107,"journal":{"name":"Dermatologica Sinica","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80503617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：