Pub Date : 2023-11-10DOI: 10.4103/ds.ds-d-23-00041
I-Heng Chiu, Tsen-Fang Tsai
{"title":"Use of cyclosporine in the treatment of patients with possible neurogenic rosacea presenting as persistent facial edema with burning sensation: A case series","authors":"I-Heng Chiu, Tsen-Fang Tsai","doi":"10.4103/ds.ds-d-23-00041","DOIUrl":"https://doi.org/10.4103/ds.ds-d-23-00041","url":null,"abstract":"","PeriodicalId":11107,"journal":{"name":"Dermatologica Sinica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135186557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-10DOI: 10.4103/ds.ds-d-23-00065
Wei-En Wang, Chung-Hsing Chang
Dear Editor, A 56-year-old woman presented with chronic pain in her digits. She had worked in the seafood frozen-packaging line of a food factory for many years. Physical examination revealed ulcerations on the pulps and knuckles of her digits, with hyperkeratosis and fissures [Figure 1a-d]. No similar lesions on toes were found. The lesions were worsened by exposure to a cold environment. Raynaud’s phenomenon and sclerodactyly were not observed. In addition, a patch of cicatricial alopecia was observed on the vertex of the scalp [Figure 1e]. Discoid lupus erythematosus was confirmed by skin biopsy.Figure 1: (a-d) Erythematous plaques with fissures and ulceration on the fingers and pulps of the digits. (e) A patch of cicatricial alopecia on the vertex of the scalp. (f and g) Bilateral hand magnetic resonance angiography showed patent distal radial arteries, ulnar to interdigital arteries, and postcontrast enhancement of soft tissue swelling over the 1st to 5th digits.Blood tests revealed high titers of anti-Ro/SSA antibodies (50.1 EliA U/mL) and low C4 levels (18.2 mg/dL). However, she tested negative for antinuclear antibodies (ANA), anticardiolipin antibodies, anti-Scl-70 antibodies, and anti-double-stranded DNA antibodies. The cryoglobulin and cold agglutinin tests were negative. A diagnosis of systemic lupus erythematosus (SLE) was not fulfilled. Bilateral hand magnetic resonance angiography showed patent distal radial arteries, ulnar to interdigital arteries, and postcontrast enhancement of soft-tissue swelling over the 1st to 5th digits [Figure 1f and g]. Based on her clinical symptoms and laboratory results, she was diagnosed with chilblain lupus erythematosus (CHLE). The proposed CHLE diagnostic criteria have not yet been validated, although the Mayo Clinic diagnostic criteria proposed by Su et al. include clinical presentation, laboratory findings, and histopathology.[1] She was treated with oral pentoxifylline and nifedipine for 5 months; however, only mild improvement was seen. We further administrated a 10-day regimen of intravenous alprostadil at a dose of 60 µg/day. Significant improvement in the digital ulcers was observed within 2 weeks [Figure 2a]. Laser Doppler flowmetry revealed increased microvascular perfusion in the digits of the left hand at 30°C and 44°C during the 8-week follow-up [Figure 2b].Figure 2: (a) The digital ulcers showed significant improvement within 2 weeks (left hand). (b) Laser Doppler flowmetry revealed an increase in microvascular perfusion in the middle digit of the left hand both at 30°C and 44°C after alprostadil treatment during an 8-week follow-up.CHLE is a rare form of cutaneous lupus erythematosus; based on previous studies, it coexists with SLE in 33%–88% of patients.[2,3] Moreover, SLE developed in these patients before or after the onset of CHLE.[2,3] CHLE lesions initially present as violaceous-erythematous papules and plaques on the toes, fingers, or face, and they worsen during exposure to co
{"title":"Efficacy of alprostadil in chilblain lupus erythematosus","authors":"Wei-En Wang, Chung-Hsing Chang","doi":"10.4103/ds.ds-d-23-00065","DOIUrl":"https://doi.org/10.4103/ds.ds-d-23-00065","url":null,"abstract":"Dear Editor, A 56-year-old woman presented with chronic pain in her digits. She had worked in the seafood frozen-packaging line of a food factory for many years. Physical examination revealed ulcerations on the pulps and knuckles of her digits, with hyperkeratosis and fissures [Figure 1a-d]. No similar lesions on toes were found. The lesions were worsened by exposure to a cold environment. Raynaud’s phenomenon and sclerodactyly were not observed. In addition, a patch of cicatricial alopecia was observed on the vertex of the scalp [Figure 1e]. Discoid lupus erythematosus was confirmed by skin biopsy.Figure 1: (a-d) Erythematous plaques with fissures and ulceration on the fingers and pulps of the digits. (e) A patch of cicatricial alopecia on the vertex of the scalp. (f and g) Bilateral hand magnetic resonance angiography showed patent distal radial arteries, ulnar to interdigital arteries, and postcontrast enhancement of soft tissue swelling over the 1st to 5th digits.Blood tests revealed high titers of anti-Ro/SSA antibodies (50.1 EliA U/mL) and low C4 levels (18.2 mg/dL). However, she tested negative for antinuclear antibodies (ANA), anticardiolipin antibodies, anti-Scl-70 antibodies, and anti-double-stranded DNA antibodies. The cryoglobulin and cold agglutinin tests were negative. A diagnosis of systemic lupus erythematosus (SLE) was not fulfilled. Bilateral hand magnetic resonance angiography showed patent distal radial arteries, ulnar to interdigital arteries, and postcontrast enhancement of soft-tissue swelling over the 1st to 5th digits [Figure 1f and g]. Based on her clinical symptoms and laboratory results, she was diagnosed with chilblain lupus erythematosus (CHLE). The proposed CHLE diagnostic criteria have not yet been validated, although the Mayo Clinic diagnostic criteria proposed by Su et al. include clinical presentation, laboratory findings, and histopathology.[1] She was treated with oral pentoxifylline and nifedipine for 5 months; however, only mild improvement was seen. We further administrated a 10-day regimen of intravenous alprostadil at a dose of 60 µg/day. Significant improvement in the digital ulcers was observed within 2 weeks [Figure 2a]. Laser Doppler flowmetry revealed increased microvascular perfusion in the digits of the left hand at 30°C and 44°C during the 8-week follow-up [Figure 2b].Figure 2: (a) The digital ulcers showed significant improvement within 2 weeks (left hand). (b) Laser Doppler flowmetry revealed an increase in microvascular perfusion in the middle digit of the left hand both at 30°C and 44°C after alprostadil treatment during an 8-week follow-up.CHLE is a rare form of cutaneous lupus erythematosus; based on previous studies, it coexists with SLE in 33%–88% of patients.[2,3] Moreover, SLE developed in these patients before or after the onset of CHLE.[2,3] CHLE lesions initially present as violaceous-erythematous papules and plaques on the toes, fingers, or face, and they worsen during exposure to co","PeriodicalId":11107,"journal":{"name":"Dermatologica Sinica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135136490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-03DOI: 10.4103/ds.ds-d-23-00109
Tzu-Yu Liu, Feng-Ling Lin
Dear Editor, Cutaneous nocardiosis is a type of skin and soft-tissue infection caused by Nocardia species, a kind of bacteria isolated from the environment. Sulfamethoxazole is the priority choice of oral medication,[1] but impaired renal function is a concern. Herein, we present a case successfully treated with oral cefixime as an alternative. An 87-year-old man with diabetes mellitus, congestive heart failure, and stage 4 chronic kidney disease (estimated glomerular filtration rate: 28.5 mL/min/1.73 m²) suffered from painful lesions on the face after falling to the ground. Abrasion wound and ecchymosis developed initially, so he was brought to local clinic for management. The patient did not receive systemic immunosuppressant or glucocorticoids, nor was he diagnosed with malignancy or an autoimmune disease. Topical antibiotic was given, and his wound gradually healed. However, pustular eruptions at the trauma site developed 1 week later. Cellulitis was impressed first, so topical fusidic acid cream and oral doxycycline were applied after obtaining the wound culture. The primary wound culture yielded coagulase-negative Staphylococcus epidermidis, which indicated colonization or contamination of the specimen. His symptoms also did not improve after 1-week oral antibiotic treatment. He then came to the dermatology clinic. Physical examination revealed erythematous firm nodules and pustules with erythematous-based patches on the left cheek [Figure 1a]. The patient was afebrile then.Figure 1: Clinical presentation: (a) before treatment: erythematous nodules and pustules on left cheek; (b) after treatment: erythema and pustules on left cheek resolved.Differential diagnoses included bacterial cellulitis, atypical infection (e.g. sporotrichosis, nocardiosis, tuberculosis, nontuberculous mycobacterium, or leishmaniasis), or Majocchi granuloma. He then received skin biopsy with tissue culture. Pathology report revealed suppurative microabscesses with aggregation of histiocytes [Figure 2a]. Immunohistochemistry stain showed negative for Gram’s stain [Figure 2b], periodic acid–Schiff stain [Figure 2c], or acid-fast stain [Figure 2d]. The tissue culture yielded Nocardiabrasiliensis, so cutaneous nocardiosis was diagnosed. The chest X-ray only showed enlarged heart size without increased infiltration or nodule at the lung field. Considering the impaired renal function of the patient, sulfamethoxazole was not given. We prescribed alternative treatment with oral cefixime 100 mg twice a day. After 4-week treatment, the skin lesion of the patient almost resolved [Figure 1b].Figure 2: Histopathological investigation: (a) Histopathology stain of the skin biopsy revealed suppurative microabscesses with aggregation of histiocytes (H and E, ×200); immunohistochemical stain of skin biopsy revealed negative for (b) Gram’s stain (×200), (c) periodic acid–Schiff stain (×200), and (d) acid-fast stain (×200).Cutaneous nocardiosis is skin and soft-tissue infection from a ki
{"title":"A case of cutaneous nocardiosis successfully treated with third-generation cephalosporin","authors":"Tzu-Yu Liu, Feng-Ling Lin","doi":"10.4103/ds.ds-d-23-00109","DOIUrl":"https://doi.org/10.4103/ds.ds-d-23-00109","url":null,"abstract":"Dear Editor, Cutaneous nocardiosis is a type of skin and soft-tissue infection caused by Nocardia species, a kind of bacteria isolated from the environment. Sulfamethoxazole is the priority choice of oral medication,[1] but impaired renal function is a concern. Herein, we present a case successfully treated with oral cefixime as an alternative. An 87-year-old man with diabetes mellitus, congestive heart failure, and stage 4 chronic kidney disease (estimated glomerular filtration rate: 28.5 mL/min/1.73 m²) suffered from painful lesions on the face after falling to the ground. Abrasion wound and ecchymosis developed initially, so he was brought to local clinic for management. The patient did not receive systemic immunosuppressant or glucocorticoids, nor was he diagnosed with malignancy or an autoimmune disease. Topical antibiotic was given, and his wound gradually healed. However, pustular eruptions at the trauma site developed 1 week later. Cellulitis was impressed first, so topical fusidic acid cream and oral doxycycline were applied after obtaining the wound culture. The primary wound culture yielded coagulase-negative Staphylococcus epidermidis, which indicated colonization or contamination of the specimen. His symptoms also did not improve after 1-week oral antibiotic treatment. He then came to the dermatology clinic. Physical examination revealed erythematous firm nodules and pustules with erythematous-based patches on the left cheek [Figure 1a]. The patient was afebrile then.Figure 1: Clinical presentation: (a) before treatment: erythematous nodules and pustules on left cheek; (b) after treatment: erythema and pustules on left cheek resolved.Differential diagnoses included bacterial cellulitis, atypical infection (e.g. sporotrichosis, nocardiosis, tuberculosis, nontuberculous mycobacterium, or leishmaniasis), or Majocchi granuloma. He then received skin biopsy with tissue culture. Pathology report revealed suppurative microabscesses with aggregation of histiocytes [Figure 2a]. Immunohistochemistry stain showed negative for Gram’s stain [Figure 2b], periodic acid–Schiff stain [Figure 2c], or acid-fast stain [Figure 2d]. The tissue culture yielded Nocardiabrasiliensis, so cutaneous nocardiosis was diagnosed. The chest X-ray only showed enlarged heart size without increased infiltration or nodule at the lung field. Considering the impaired renal function of the patient, sulfamethoxazole was not given. We prescribed alternative treatment with oral cefixime 100 mg twice a day. After 4-week treatment, the skin lesion of the patient almost resolved [Figure 1b].Figure 2: Histopathological investigation: (a) Histopathology stain of the skin biopsy revealed suppurative microabscesses with aggregation of histiocytes (H and E, ×200); immunohistochemical stain of skin biopsy revealed negative for (b) Gram’s stain (×200), (c) periodic acid–Schiff stain (×200), and (d) acid-fast stain (×200).Cutaneous nocardiosis is skin and soft-tissue infection from a ki","PeriodicalId":11107,"journal":{"name":"Dermatologica Sinica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135869199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-01DOI: 10.4103/ds.ds-d-22-00172
Rui-Xian Ye, X. Tian, Jingyao Liang, Rujun Xue, Qiongxiao Huang, Yimin Liang, YuMei Liu
Photoaggravated dermatoses (PD) are diseases that occur without ultraviolet (UV) radiation but are sometimes or frequently exacerbated by UV radiation. The clinical manifestations of PD are varied, some patients may present with pruritic nodular lesions at the site of light exposure, which possibly through a light-induced type 2 inflammatory response. Some cases may be difficult to treat, safe and effective treatment methods are constantly being explored. Here, we reported five patients with moderate to severe PD with skin nodules as main manifestations successfully treated with dupilumab, who were previously resistant to conventional treatment. After the 16-week treatment period, dupilumab showed good efficacy and safety in PD mainly characterized by nodules.
{"title":"Dupilumab for patients with photoaggravated dermatoses with skin nodules as main manifestations: A case series","authors":"Rui-Xian Ye, X. Tian, Jingyao Liang, Rujun Xue, Qiongxiao Huang, Yimin Liang, YuMei Liu","doi":"10.4103/ds.ds-d-22-00172","DOIUrl":"https://doi.org/10.4103/ds.ds-d-22-00172","url":null,"abstract":"Photoaggravated dermatoses (PD) are diseases that occur without ultraviolet (UV) radiation but are sometimes or frequently exacerbated by UV radiation. The clinical manifestations of PD are varied, some patients may present with pruritic nodular lesions at the site of light exposure, which possibly through a light-induced type 2 inflammatory response. Some cases may be difficult to treat, safe and effective treatment methods are constantly being explored. Here, we reported five patients with moderate to severe PD with skin nodules as main manifestations successfully treated with dupilumab, who were previously resistant to conventional treatment. After the 16-week treatment period, dupilumab showed good efficacy and safety in PD mainly characterized by nodules.","PeriodicalId":11107,"journal":{"name":"Dermatologica Sinica","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76087574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-01DOI: 10.4103/ds.ds-d-22-00210
Yu-Hua Lee, Nai-Wen Kang, P. Cheng
{"title":"Paraneoplastic bullous pemphigoid presented with figurate erythema: A case report and review of literature","authors":"Yu-Hua Lee, Nai-Wen Kang, P. Cheng","doi":"10.4103/ds.ds-d-22-00210","DOIUrl":"https://doi.org/10.4103/ds.ds-d-22-00210","url":null,"abstract":"","PeriodicalId":11107,"journal":{"name":"Dermatologica Sinica","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85998076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-01DOI: 10.4103//DS.V41-1_Editorial
C. Hsu
{"title":"Scoring systems for pemphigus","authors":"C. Hsu","doi":"10.4103//DS.V41-1_Editorial","DOIUrl":"https://doi.org/10.4103//DS.V41-1_Editorial","url":null,"abstract":"","PeriodicalId":11107,"journal":{"name":"Dermatologica Sinica","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79983013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-01DOI: 10.4103/ds.ds-d-22-00205
Yusuf Kelleci, F. Aydın, Gokhan Sahin, E. Yuksel
Background: Alopecia areata (AA) is a disease of unknown etiology which is thought to be autoimmune, that presents challenges in terms of treatment. Platelet-rich plasma (PRP) can induce the development of new hair follicles through various growth factors it contains. PRP could be a treatment option for patients with AA. Objectives: We aim to evaluate the effectiveness and safety of PRP treatment in patients with patch-type AA. Methods: The study included 17 patients diagnosed with patch-type AA who received PRP treatment at least 3 sessions every 4 weeks. Treatment response was evaluated by calculating the severity of alopecia tool (SALT) scores. Results: The mean age of patients was 29.70 ± 10.09, and the mean disease duration was 18.17 ± 39.46 months. The mean SALT score of 17 patients was 6.82 ± 4.96 and 4.35 ± 4.58 before treatment and at the end of the 3rd month, respectively. The reduction in SALT scores was statistically significant (P = 0.01). At the end of the 3rd month, six patients (35.3%) had an excellent response, one patient (5.9%) had a good response, one patient (5.9%) had a partial response, and nine patients (52.9%) showed no response. The mean SALT scores of four patients who received six sessions of PRP of treatment were 6.00 ± 2.94 and 1.75 ± 2.06 at the end of the 6th month. No serious side effects were noted. Relapse was observed in one patient within 1 year of follow-up. Conclusion: As a result of our study, PRP treatment was found to be an effective and reliable treatment method in patients with mild AA.
{"title":"Platelet-rich plasma in the treatment of alopecia areata: A retrospective evaluation of 17 patients","authors":"Yusuf Kelleci, F. Aydın, Gokhan Sahin, E. Yuksel","doi":"10.4103/ds.ds-d-22-00205","DOIUrl":"https://doi.org/10.4103/ds.ds-d-22-00205","url":null,"abstract":"Background: Alopecia areata (AA) is a disease of unknown etiology which is thought to be autoimmune, that presents challenges in terms of treatment. Platelet-rich plasma (PRP) can induce the development of new hair follicles through various growth factors it contains. PRP could be a treatment option for patients with AA. Objectives: We aim to evaluate the effectiveness and safety of PRP treatment in patients with patch-type AA. Methods: The study included 17 patients diagnosed with patch-type AA who received PRP treatment at least 3 sessions every 4 weeks. Treatment response was evaluated by calculating the severity of alopecia tool (SALT) scores. Results: The mean age of patients was 29.70 ± 10.09, and the mean disease duration was 18.17 ± 39.46 months. The mean SALT score of 17 patients was 6.82 ± 4.96 and 4.35 ± 4.58 before treatment and at the end of the 3rd month, respectively. The reduction in SALT scores was statistically significant (P = 0.01). At the end of the 3rd month, six patients (35.3%) had an excellent response, one patient (5.9%) had a good response, one patient (5.9%) had a partial response, and nine patients (52.9%) showed no response. The mean SALT scores of four patients who received six sessions of PRP of treatment were 6.00 ± 2.94 and 1.75 ± 2.06 at the end of the 6th month. No serious side effects were noted. Relapse was observed in one patient within 1 year of follow-up. Conclusion: As a result of our study, PRP treatment was found to be an effective and reliable treatment method in patients with mild AA.","PeriodicalId":11107,"journal":{"name":"Dermatologica Sinica","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77850899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-01DOI: 10.4103/ds.ds-d-22-00141
Yuan Zheng, Pingdong Jiang, Liyin Zhang
Background: Malignant melanoma is a typical type of cancer that feature the obesity paradox. Objectives: We aim to evaluate the role of acyl-CoA synthetase medium-chain 3 (ACSM3) in obesity paradox in malignant melanoma (MM). Methods: With reproduction of the Cancer Genome Atlas (TCGA) MM dataset and validation using immunohistochemistry, we evaluated correlations of ACSM3 expression with body mass index (BMI), gender, and androgen receptor (AR) expression. Results: ACSM family genes were downregulated in MM and in normal skin exposed to ultraviolet. Higher expression of ACSM3 was associated with improved overall survival in men but not in women. Subgroup analysis showed the best survival outcome in obese patients with high ACSM3 expression. ACSM3 expression was significantly lower in cases with ulceration. NET-GE-based gene enrichment analysis of ACSM-overexpressed cases showed significant enrichment in lipid metabolism and butanoate metabolism. AR stood as the top possible transcription factor of ACSM3 using multiple algorithms. Expressions of ACSM3 and AR were positively correlated in obese men and overweight women. ACSM3 expression was positively correlated with BMI in men and overweight women. Conclusion: ACSM3 expression is associated with obesity in MM patients and correlates with AR. Functional analysis linking the findings to the obesity paradox warrants further study.
{"title":"Expression of acyl-CoA synthetase medium-chain 3 is associated with obesity in melanoma patients and correlates with androgen receptor","authors":"Yuan Zheng, Pingdong Jiang, Liyin Zhang","doi":"10.4103/ds.ds-d-22-00141","DOIUrl":"https://doi.org/10.4103/ds.ds-d-22-00141","url":null,"abstract":"Background: Malignant melanoma is a typical type of cancer that feature the obesity paradox. Objectives: We aim to evaluate the role of acyl-CoA synthetase medium-chain 3 (ACSM3) in obesity paradox in malignant melanoma (MM). Methods: With reproduction of the Cancer Genome Atlas (TCGA) MM dataset and validation using immunohistochemistry, we evaluated correlations of ACSM3 expression with body mass index (BMI), gender, and androgen receptor (AR) expression. Results: ACSM family genes were downregulated in MM and in normal skin exposed to ultraviolet. Higher expression of ACSM3 was associated with improved overall survival in men but not in women. Subgroup analysis showed the best survival outcome in obese patients with high ACSM3 expression. ACSM3 expression was significantly lower in cases with ulceration. NET-GE-based gene enrichment analysis of ACSM-overexpressed cases showed significant enrichment in lipid metabolism and butanoate metabolism. AR stood as the top possible transcription factor of ACSM3 using multiple algorithms. Expressions of ACSM3 and AR were positively correlated in obese men and overweight women. ACSM3 expression was positively correlated with BMI in men and overweight women. Conclusion: ACSM3 expression is associated with obesity in MM patients and correlates with AR. Functional analysis linking the findings to the obesity paradox warrants further study.","PeriodicalId":11107,"journal":{"name":"Dermatologica Sinica","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76551356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-01DOI: 10.4103/ds.ds-d-23-00001
W. Nho, Junyoung Kim, S. Kee, Dong-Jin Kim, K. Yoon
{"title":"Giant perforating pilomatricoma: A case report","authors":"W. Nho, Junyoung Kim, S. Kee, Dong-Jin Kim, K. Yoon","doi":"10.4103/ds.ds-d-23-00001","DOIUrl":"https://doi.org/10.4103/ds.ds-d-23-00001","url":null,"abstract":"","PeriodicalId":11107,"journal":{"name":"Dermatologica Sinica","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73605088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：