Pub Date : 2023-01-01DOI: 10.4103/ds.ds-d-22-00055
M. Odabaşı, Serkan Yazici, G. Ozkaya, E. Başkan, A. Oral
Background: Indoleamine 2,3-dioxygenase (IDO), an enzyme in the first step of tryptophan catabolism, plays a role in the pathogenesis of various malignancies and inflammatory diseases. Although its pathogenesis is unclear, vascular dysregulation and chronic inflammation are the most common culprits for rosacea. Objectives: The aim of this study is to evaluate the relationship between IDO and rosacea and whether there is a correlation with disease severity. Methods: Fifty-two patients with rosacea and 29 healthy volunteers were recruited. The patients were grouped according to severity stage, period, and subtype of the disease. Serum IDO levels were measured with enzyme-linked immunosorbent assay. Results: Serum IDO levels were significantly higher in the patients with rosacea compared to the healthy controls (P < 0.001) and were significantly higher in the patients in remission period and with papulopustular type rosacea compared to the controls (P = 0.002 and P = 0.001, respectively). The serum IDO levels of the female rosacea patients were higher than those of the healthy female controls (P < 0.001). When the diagnostic value of the parameter was investigated, it was observed that the serum IDO level has high sensitivity (83.3%) and specificity (76.1%), with a cutoff value of 47.1 ng/mL for female rosacea patients. Conclusion: IDO was found to increase in rosacea patients. With the high specificity and sensitivity observed, especially in female patients, IDO may be a supporting parameter in the diagnosis of rosacea.
{"title":"Serum indoleamine 2,3-dioxygenase level and diagnostic value in patients with rosacea","authors":"M. Odabaşı, Serkan Yazici, G. Ozkaya, E. Başkan, A. Oral","doi":"10.4103/ds.ds-d-22-00055","DOIUrl":"https://doi.org/10.4103/ds.ds-d-22-00055","url":null,"abstract":"Background: Indoleamine 2,3-dioxygenase (IDO), an enzyme in the first step of tryptophan catabolism, plays a role in the pathogenesis of various malignancies and inflammatory diseases. Although its pathogenesis is unclear, vascular dysregulation and chronic inflammation are the most common culprits for rosacea. Objectives: The aim of this study is to evaluate the relationship between IDO and rosacea and whether there is a correlation with disease severity. Methods: Fifty-two patients with rosacea and 29 healthy volunteers were recruited. The patients were grouped according to severity stage, period, and subtype of the disease. Serum IDO levels were measured with enzyme-linked immunosorbent assay. Results: Serum IDO levels were significantly higher in the patients with rosacea compared to the healthy controls (P < 0.001) and were significantly higher in the patients in remission period and with papulopustular type rosacea compared to the controls (P = 0.002 and P = 0.001, respectively). The serum IDO levels of the female rosacea patients were higher than those of the healthy female controls (P < 0.001). When the diagnostic value of the parameter was investigated, it was observed that the serum IDO level has high sensitivity (83.3%) and specificity (76.1%), with a cutoff value of 47.1 ng/mL for female rosacea patients. Conclusion: IDO was found to increase in rosacea patients. With the high specificity and sensitivity observed, especially in female patients, IDO may be a supporting parameter in the diagnosis of rosacea.","PeriodicalId":11107,"journal":{"name":"Dermatologica Sinica","volume":"3 6 1","pages":"25 - 30"},"PeriodicalIF":2.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79890372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.4103/ds.ds-d-22-00122
Wei-Ting Liu, Chao-Chun Yang
Dermatomyositis (DM) is a systemic autoimmune disease characterized by unique cutaneous manifestations and inflammatory myopathies. With the discovery of myositis-specific antibodies (MSAs), patients with DM, especially those with a higher risk of life-threatening complications, can be classified according to the MSA type. This retrospective study aimed to investigate the clinical significance of MSAs in patients with DM in Taiwan. A total of 33 patients with DM who underwent the MSA test, including 26 with classic DM and 7 with amyopathic DM, were included. There were 13 men and 20 women, with a mean age at diagnosis of 49.6 years. MSA was detected in 26 (78.8%) of 33 patients with DM. The most frequently detected MSA was anti-melanoma differentiation-associated protein 5 (MDA5) (10/33, 30.3%) followed by anti-transcription intermediary factor-1γ (TIF-1γ) (8/33, 24.2%). Dysphagia was present in 6 (18.2%) of the 33 patients and more frequently developed in patients with anti-TIF-1γ (+) (5/8, 62.5%) than those with anti-TIF-1γ (−) (1/25, 4.0%). Interstitial lung disease was noted in 15 patients (45.5%) and developed more frequently in patients with anti-MDA5 (+) (7/10, 70.0%) than those with anti-MDA5 (−) (8/23, 34.8%). Malignancies were detected in 4 (12.1%) patients, with one each of anti-Mi-2 (+), anti-TIF-1γ (+), anti-ARS (+), and MSA (−). Mortality occurred in 6 (18.2%) patients, of whom 4 were anti-MDA5 (+). Anti-MDA5 and anti-TIF-1γ were the two most commonly detected MSAs. The presence of specific MSAs is associated with a certain phenotype, and integrating MSAs while evaluating DM aids in accurate patient management.
{"title":"Myositis-specific antibodies in dermatomyositis: A single-center experience of 33 cases in Taiwan","authors":"Wei-Ting Liu, Chao-Chun Yang","doi":"10.4103/ds.ds-d-22-00122","DOIUrl":"https://doi.org/10.4103/ds.ds-d-22-00122","url":null,"abstract":"Dermatomyositis (DM) is a systemic autoimmune disease characterized by unique cutaneous manifestations and inflammatory myopathies. With the discovery of myositis-specific antibodies (MSAs), patients with DM, especially those with a higher risk of life-threatening complications, can be classified according to the MSA type. This retrospective study aimed to investigate the clinical significance of MSAs in patients with DM in Taiwan. A total of 33 patients with DM who underwent the MSA test, including 26 with classic DM and 7 with amyopathic DM, were included. There were 13 men and 20 women, with a mean age at diagnosis of 49.6 years. MSA was detected in 26 (78.8%) of 33 patients with DM. The most frequently detected MSA was anti-melanoma differentiation-associated protein 5 (MDA5) (10/33, 30.3%) followed by anti-transcription intermediary factor-1γ (TIF-1γ) (8/33, 24.2%). Dysphagia was present in 6 (18.2%) of the 33 patients and more frequently developed in patients with anti-TIF-1γ (+) (5/8, 62.5%) than those with anti-TIF-1γ (−) (1/25, 4.0%). Interstitial lung disease was noted in 15 patients (45.5%) and developed more frequently in patients with anti-MDA5 (+) (7/10, 70.0%) than those with anti-MDA5 (−) (8/23, 34.8%). Malignancies were detected in 4 (12.1%) patients, with one each of anti-Mi-2 (+), anti-TIF-1γ (+), anti-ARS (+), and MSA (−). Mortality occurred in 6 (18.2%) patients, of whom 4 were anti-MDA5 (+). Anti-MDA5 and anti-TIF-1γ were the two most commonly detected MSAs. The presence of specific MSAs is associated with a certain phenotype, and integrating MSAs while evaluating DM aids in accurate patient management.","PeriodicalId":11107,"journal":{"name":"Dermatologica Sinica","volume":"23 1","pages":"31 - 35"},"PeriodicalIF":2.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91227628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.4103/ds.ds-d-22-00031
Hsin-Yu Huang, Cheng-Ju Wu, Julia Yu‐Yun Lee, Yi-Chen Liao, C. Hsu
{"title":"Lymphocytic thrombophilic arteritis following mRNA-1273 severe acute respiratory syndrome coronavirus 2 vaccination: A case report and review of the literature","authors":"Hsin-Yu Huang, Cheng-Ju Wu, Julia Yu‐Yun Lee, Yi-Chen Liao, C. Hsu","doi":"10.4103/ds.ds-d-22-00031","DOIUrl":"https://doi.org/10.4103/ds.ds-d-22-00031","url":null,"abstract":"","PeriodicalId":11107,"journal":{"name":"Dermatologica Sinica","volume":"19 1","pages":"44 - 45"},"PeriodicalIF":2.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86998824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.4103/ds.ds-d-22-00096
Letizia Silocchi, G. Damiani
{"title":"Dermatological management in special population affected by psoriasis: A case report of an amputated transgender with psoriasis treated with apremilast","authors":"Letizia Silocchi, G. Damiani","doi":"10.4103/ds.ds-d-22-00096","DOIUrl":"https://doi.org/10.4103/ds.ds-d-22-00096","url":null,"abstract":"","PeriodicalId":11107,"journal":{"name":"Dermatologica Sinica","volume":"23 1","pages":"38 - 39"},"PeriodicalIF":2.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75755226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.4103/ds.ds-d-23-00064
Seungho Lee, W. Choi, Huiyoung Shin, Yujeong Park, J. Hong, AiYoung Lee
{"title":"Numerous osteoma cutis on the scalp caused by GNAS mutation","authors":"Seungho Lee, W. Choi, Huiyoung Shin, Yujeong Park, J. Hong, AiYoung Lee","doi":"10.4103/ds.ds-d-23-00064","DOIUrl":"https://doi.org/10.4103/ds.ds-d-23-00064","url":null,"abstract":"","PeriodicalId":11107,"journal":{"name":"Dermatologica Sinica","volume":"149 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75848778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.4103/ds.ds-d-22-00201
S. Pradhan, Jinghong Huang, X. Ran, Chaoliang Zhang, D. Tsuruta, H. Imanishi, Y. Ran
{"title":"Combination simple wet gauze technique placating children and calcofluor white staining microscopy enhances the diagnostic capability in kerion","authors":"S. Pradhan, Jinghong Huang, X. Ran, Chaoliang Zhang, D. Tsuruta, H. Imanishi, Y. Ran","doi":"10.4103/ds.ds-d-22-00201","DOIUrl":"https://doi.org/10.4103/ds.ds-d-22-00201","url":null,"abstract":"","PeriodicalId":11107,"journal":{"name":"Dermatologica Sinica","volume":"40 1","pages":"62 - 63"},"PeriodicalIF":2.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84885184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.4103/ds.ds-d-22-00154
S. Shao, Liang-Tseng Kuo, Yen-Ta Huang, P. Lai, Ching-Chi Chi
The Grading of Recommendations Assessment, Development, and Evaluation (GRADE) framework offers a structured approach to assess the certainty of evidence (CoE) in systematic reviews (SRs). The CoE for each outcome falls into one of the four categories: very low, low, moderate, or high. The judgment of CoE is based on five downgrading factors (including the risk of bias, indirectness, inconsistency, imprecision, and publication bias) and three upgrading factors (including large effect size, dose-response relationship, and opposing plausible residual bias and confounding). To improve the transparency of SRs, authors should indicate how they grade the CoE for each outcome and provide a rationale for downgrading or upgrading the CoE.
{"title":"Using Grading of Recommendations Assessment, Development, and Evaluation (GRADE) to rate the certainty of evidence of study outcomes from systematic reviews: A quick tutorial","authors":"S. Shao, Liang-Tseng Kuo, Yen-Ta Huang, P. Lai, Ching-Chi Chi","doi":"10.4103/ds.ds-d-22-00154","DOIUrl":"https://doi.org/10.4103/ds.ds-d-22-00154","url":null,"abstract":"The Grading of Recommendations Assessment, Development, and Evaluation (GRADE) framework offers a structured approach to assess the certainty of evidence (CoE) in systematic reviews (SRs). The CoE for each outcome falls into one of the four categories: very low, low, moderate, or high. The judgment of CoE is based on five downgrading factors (including the risk of bias, indirectness, inconsistency, imprecision, and publication bias) and three upgrading factors (including large effect size, dose-response relationship, and opposing plausible residual bias and confounding). To improve the transparency of SRs, authors should indicate how they grade the CoE for each outcome and provide a rationale for downgrading or upgrading the CoE.","PeriodicalId":11107,"journal":{"name":"Dermatologica Sinica","volume":"42 1","pages":"3 - 7"},"PeriodicalIF":2.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75818825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.4103/ds.v41-3-editorial
Shang-Hung Lin
The prolonged use of masks has been reported to cause adverse skin reactions in both health-care workers (HCWs) and the public. In this issue of Dermatol Sinica, Ku et al. conducted a narrative review to identify different adverse skin reactions and associated risk factors in HCW and the public with prolonged use of masks during the COVID-19 pandemic.[1] They reported that retroauricular dermatitis, cheilitis, rosacea, acne vulgaris, nasal bridge damage, itch, allergic contact dermatitis, and irritant contact dermatitis are common mask-related adverse skin reactions. In addition, the long duration of wearing masks, preexisting skin diseases, and being HCWs are highlighted as definite risk factors. This review summarized the mask-related dermatoses and the associated risk factors. Therefore, it helps HCWs and the public adopt appropriate preventative measures based on their individualized circumstances. Vitiligo is a chronic autoimmune depigmenting skin disorder resulting from the selective destruction of melanocytes. The pathogenesis of vitiligo is complex and the therapeutic choice for vitiligo was limited in the past. The wood’s light, dermoscopy, and clinical photography were traditionally used to diagnose vitiligo. Interestingly, several potential biomarkers and advanced noninvasive skin imaging such as reflectance confocal microscopy and optical coherence tomography have recently assisted in evaluating vitiligo disease activity and severity. The clinical management of vitiligo is aimed at halting disease progression and facilitating repigmentation. In this issue of Dermatol Sinica, Shen et al. update the pathogenesis of vitiligo, discuss emerging biomarkers for the assessment of vitiligo disease activity and severity, and summarize prospective targeted therapies in treating vitiligo.[2] Various scientific and technological breakthroughs have been achieved in the field of medicine, especially in the field of dermatology, improving the accuracy of disease diagnosis and treatment to a new stage, in which the application of Artificial Intelligence (AI) has played an indispensable role. However, a study in 2020 found that while 85% of dermatologists were aware that AI is an emerging technology conducive to the development of dermatology, only 24% had a better understanding of the field.[3] In this issue of Dermatol Sinica, Ye and Chen review the recent new development of AI in dermatology, to promote dermatologists in the better understanding and mastering of it.[4] In this issue of Dermatol Sinica, Song et al. reported that hypertrophic scar patients owned elevated HOX transcript antisense intergenic RNA (HOTAIR) and decreased miR-30a-5p.[5] HOTAIR knockdown can inhibit the proliferation, migration, and collagen synthesis of scar fibroblasts by negatively regulating the expression of miR-30a-5p. Ye et al. reported that dupilumab showed good efficacy and safety in patients with photodermatoses through light-induced type 2 inflammatory response.[6
{"title":"How to prevent mask-related adverse skin reactions","authors":"Shang-Hung Lin","doi":"10.4103/ds.v41-3-editorial","DOIUrl":"https://doi.org/10.4103/ds.v41-3-editorial","url":null,"abstract":"The prolonged use of masks has been reported to cause adverse skin reactions in both health-care workers (HCWs) and the public. In this issue of Dermatol Sinica, Ku et al. conducted a narrative review to identify different adverse skin reactions and associated risk factors in HCW and the public with prolonged use of masks during the COVID-19 pandemic.[1] They reported that retroauricular dermatitis, cheilitis, rosacea, acne vulgaris, nasal bridge damage, itch, allergic contact dermatitis, and irritant contact dermatitis are common mask-related adverse skin reactions. In addition, the long duration of wearing masks, preexisting skin diseases, and being HCWs are highlighted as definite risk factors. This review summarized the mask-related dermatoses and the associated risk factors. Therefore, it helps HCWs and the public adopt appropriate preventative measures based on their individualized circumstances. Vitiligo is a chronic autoimmune depigmenting skin disorder resulting from the selective destruction of melanocytes. The pathogenesis of vitiligo is complex and the therapeutic choice for vitiligo was limited in the past. The wood’s light, dermoscopy, and clinical photography were traditionally used to diagnose vitiligo. Interestingly, several potential biomarkers and advanced noninvasive skin imaging such as reflectance confocal microscopy and optical coherence tomography have recently assisted in evaluating vitiligo disease activity and severity. The clinical management of vitiligo is aimed at halting disease progression and facilitating repigmentation. In this issue of Dermatol Sinica, Shen et al. update the pathogenesis of vitiligo, discuss emerging biomarkers for the assessment of vitiligo disease activity and severity, and summarize prospective targeted therapies in treating vitiligo.[2] Various scientific and technological breakthroughs have been achieved in the field of medicine, especially in the field of dermatology, improving the accuracy of disease diagnosis and treatment to a new stage, in which the application of Artificial Intelligence (AI) has played an indispensable role. However, a study in 2020 found that while 85% of dermatologists were aware that AI is an emerging technology conducive to the development of dermatology, only 24% had a better understanding of the field.[3] In this issue of Dermatol Sinica, Ye and Chen review the recent new development of AI in dermatology, to promote dermatologists in the better understanding and mastering of it.[4] In this issue of Dermatol Sinica, Song et al. reported that hypertrophic scar patients owned elevated HOX transcript antisense intergenic RNA (HOTAIR) and decreased miR-30a-5p.[5] HOTAIR knockdown can inhibit the proliferation, migration, and collagen synthesis of scar fibroblasts by negatively regulating the expression of miR-30a-5p. Ye et al. reported that dupilumab showed good efficacy and safety in patients with photodermatoses through light-induced type 2 inflammatory response.[6","PeriodicalId":11107,"journal":{"name":"Dermatologica Sinica","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135913337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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