Pub Date : 2025-01-01Epub Date: 2024-12-05DOI: 10.1007/s40495-024-00388-6
Ahmad Shannar, Pochung Jordan Chou, Rebecca Peter, Parv Dushyant Dave, Komal Patel, Yuxin Pan, Jiawei Xu, Md Shahid Sarwar, Ah-Ng Kong
Purpose of review: Dietary phytochemicals, bioactive compounds derived from plants, have gained increasing attention for their potential role in cancer prevention. Among these, NRF2 (nuclear factor erythroid 2-related factor 2) activating dietary phytochemicals such as curcumin, sulforaphane, ursolic acid, and cyanidin have demonstrated significant antioxidant and anti-inflammatory properties, making them promising agents in chemoprevention. This review examines the pharmacokinetic (PK) and pharmacodynamic (PD) profiles of these dietary phytochemicals, with a focus on their NRF2-mediated effects in cancer prevention.
Recent findings: Preclinical studies have highlighted the potential of these dietary phytochemicals to modulate oxidative stress and inflammation, key drivers of carcinogenesis. We explore the complexity of their PK/PD properties, influenced by factors such as bioavailability, metabolism, and drug interactions. While most of these phytochemicals follow two compartmental PK, their anti-oxidant and anti-inflammatory effects follow the indirect response (IDR) model. Furthermore, we discuss the application of physiologically based pharmacokinetic (PBPK) modeling to simulate the behavior of these compounds in humans, providing insights for clinical translation.
Summary: The integration of PK-PD analysis into the development of dietary phytochemical-based therapies offers a pathway to optimize dosing strategies, enhance therapeutic efficacy, and improve safety. This review underscores the importance of these compounds as part of cancer interception strategies, particularly in the early stages of cancer development, where they may offer a natural, less toxic alternative to conventional therapies.
{"title":"Pharmacodynamics (PD), Pharmacokinetics (PK) and PK-PD Modeling of NRF2 Activating Dietary Phytochemicals in Cancer Prevention and in Health.","authors":"Ahmad Shannar, Pochung Jordan Chou, Rebecca Peter, Parv Dushyant Dave, Komal Patel, Yuxin Pan, Jiawei Xu, Md Shahid Sarwar, Ah-Ng Kong","doi":"10.1007/s40495-024-00388-6","DOIUrl":"10.1007/s40495-024-00388-6","url":null,"abstract":"<p><strong>Purpose of review: </strong>Dietary phytochemicals, bioactive compounds derived from plants, have gained increasing attention for their potential role in cancer prevention. Among these, NRF2 (nuclear factor erythroid 2-related factor 2) activating dietary phytochemicals such as curcumin, sulforaphane, ursolic acid, and cyanidin have demonstrated significant antioxidant and anti-inflammatory properties, making them promising agents in chemoprevention. This review examines the pharmacokinetic (PK) and pharmacodynamic (PD) profiles of these dietary phytochemicals, with a focus on their NRF2-mediated effects in cancer prevention.</p><p><strong>Recent findings: </strong>Preclinical studies have highlighted the potential of these dietary phytochemicals to modulate oxidative stress and inflammation, key drivers of carcinogenesis. We explore the complexity of their PK/PD properties, influenced by factors such as bioavailability, metabolism, and drug interactions. While most of these phytochemicals follow two compartmental PK, their anti-oxidant and anti-inflammatory effects follow the indirect response (IDR) model. Furthermore, we discuss the application of physiologically based pharmacokinetic (PBPK) modeling to simulate the behavior of these compounds in humans, providing insights for clinical translation.</p><p><strong>Summary: </strong>The integration of PK-PD analysis into the development of dietary phytochemical-based therapies offers a pathway to optimize dosing strategies, enhance therapeutic efficacy, and improve safety. This review underscores the importance of these compounds as part of cancer interception strategies, particularly in the early stages of cancer development, where they may offer a natural, less toxic alternative to conventional therapies.</p><p><strong>Graphical abstract: </strong></p>","PeriodicalId":11139,"journal":{"name":"Current Pharmacology Reports","volume":"11 1","pages":"6"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11618211/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142794002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Mental Health and the Microbiome: A Review of Psychological Impacts of Gut Microflora","authors":"Ananya Gupt, Sonal Naudiyal, Anju Rani, Sunil Kumar","doi":"10.1007/s40495-024-00357-z","DOIUrl":"https://doi.org/10.1007/s40495-024-00357-z","url":null,"abstract":"","PeriodicalId":11139,"journal":{"name":"Current Pharmacology Reports","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141235065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-26DOI: 10.1007/s40495-024-00353-3
N. Sahakyan, M. J. Nasim, Claus Jacob
{"title":"Redoxification (of the Organism) Through Diet and Supplementation with a Focus on Natural Polymeric Redox Modulators","authors":"N. Sahakyan, M. J. Nasim, Claus Jacob","doi":"10.1007/s40495-024-00353-3","DOIUrl":"https://doi.org/10.1007/s40495-024-00353-3","url":null,"abstract":"","PeriodicalId":11139,"journal":{"name":"Current Pharmacology Reports","volume":"34 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140378202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-18DOI: 10.1007/s40495-024-00354-2
Janvi Parekh, Himani Shende, Ajay Kumar, H. Tuli, Ginpreet Kaur
{"title":"Assessing the Clinical Correlation between Alzheimer's disease and Type-2 Diabetes Mellitus: Current Strategies and Emerging Perspectives","authors":"Janvi Parekh, Himani Shende, Ajay Kumar, H. Tuli, Ginpreet Kaur","doi":"10.1007/s40495-024-00354-2","DOIUrl":"https://doi.org/10.1007/s40495-024-00354-2","url":null,"abstract":"","PeriodicalId":11139,"journal":{"name":"Current Pharmacology Reports","volume":"74 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140234143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-30DOI: 10.1007/s40495-024-00351-5
P. K. Goyal, Kavita Sangwan
{"title":"Pharmacological Profile of FDA-Approved Orphan Drugs in the Year 2022","authors":"P. K. Goyal, Kavita Sangwan","doi":"10.1007/s40495-024-00351-5","DOIUrl":"https://doi.org/10.1007/s40495-024-00351-5","url":null,"abstract":"","PeriodicalId":11139,"journal":{"name":"Current Pharmacology Reports","volume":"286 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140480666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-13DOI: 10.1007/s40495-023-00350-y
Eleni Paschalidou, Philippos Tasioudis, Georgios N. Katsaras, Thomas Papoulakis, Dorothea Kapoukranidou, T. Papamitsou
{"title":"Efficacy and Safety of Topical Sirolimus for the Treatment of Angiofibromas in Tuberous Sclerosis: a Systematic Review and Meta-analysis","authors":"Eleni Paschalidou, Philippos Tasioudis, Georgios N. Katsaras, Thomas Papoulakis, Dorothea Kapoukranidou, T. Papamitsou","doi":"10.1007/s40495-023-00350-y","DOIUrl":"https://doi.org/10.1007/s40495-023-00350-y","url":null,"abstract":"","PeriodicalId":11139,"journal":{"name":"Current Pharmacology Reports","volume":"117 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139003512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-13DOI: 10.1007/s40495-023-00349-5
V. A. Afrose Farzana, Sekar Kumaran, A. Pandurangan
{"title":"A Comprehensive Review on the Effect of Natural Products on Colorectal Cancer","authors":"V. A. Afrose Farzana, Sekar Kumaran, A. Pandurangan","doi":"10.1007/s40495-023-00349-5","DOIUrl":"https://doi.org/10.1007/s40495-023-00349-5","url":null,"abstract":"","PeriodicalId":11139,"journal":{"name":"Current Pharmacology Reports","volume":"83 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139004384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-06DOI: 10.1007/s40495-023-00348-6
Saranya Udayakumar, A. Girigoswami, K. Girigoswami
{"title":"Biological Activities of Carrageenan from Red Algae: a Mini Review","authors":"Saranya Udayakumar, A. Girigoswami, K. Girigoswami","doi":"10.1007/s40495-023-00348-6","DOIUrl":"https://doi.org/10.1007/s40495-023-00348-6","url":null,"abstract":"","PeriodicalId":11139,"journal":{"name":"Current Pharmacology Reports","volume":"51 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138597440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-02DOI: 10.1007/s40495-023-00347-7
Rashmi Gupta, Anand K. Chaudhary, Rohit Sharma
{"title":"Analgesic and Anti-inflammatory Potential of Ricinus communis Linn.: Evidence from Pharmacology to Clinical Studies","authors":"Rashmi Gupta, Anand K. Chaudhary, Rohit Sharma","doi":"10.1007/s40495-023-00347-7","DOIUrl":"https://doi.org/10.1007/s40495-023-00347-7","url":null,"abstract":"","PeriodicalId":11139,"journal":{"name":"Current Pharmacology Reports","volume":"36 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138606768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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