{"title":"HOXB2 is a prognostic biomarker and correlated with immune infiltration in colorectal cancer and glioma.","authors":"Zhenrui Liu, Puqiao Wen, Yuxuan Liao, Dawei Zhou, Hongyi Wang, Ruofan Xu, Zhen Zhang","doi":"10.1007/s12672-026-04650-9","DOIUrl":"https://doi.org/10.1007/s12672-026-04650-9","url":null,"abstract":"","PeriodicalId":11148,"journal":{"name":"Discover. Oncology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146178214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Synovial sarcoma (SS) is a rare and aggressive soft tissue malignancy, typically occurring in the extremities, but extremely rare as a primary tumor of the breast. We present a case of a 53-year-old Nigerian female with a recurrent breast lesion previously misdiagnosed as metaplastic carcinoma. Imaging revealed a large, multifocal mass with aggressive features. Histopathologic and immunohistochemical evaluation following modified radical mastectomy supported a diagnosis of poorly differentiated synovial sarcoma. Due to the aggressive nature and rarity of this tumor in the breast, this case highlights the diagnostic challenges and importance of molecular and immunohistochemical studies. The patient was advised to pursue chemotherapy and radiotherapy but opted to continue treatment in her home country.
{"title":"Diagnostic challenges in poorly differentiated primary synovial sarcoma of the breast.","authors":"Burak Kankaya, Zeynep Tatar, Yusuf Emre Altundal, Suleyman Buyukasik, Selin Kapan","doi":"10.1007/s12672-026-04634-9","DOIUrl":"https://doi.org/10.1007/s12672-026-04634-9","url":null,"abstract":"<p><p>Synovial sarcoma (SS) is a rare and aggressive soft tissue malignancy, typically occurring in the extremities, but extremely rare as a primary tumor of the breast. We present a case of a 53-year-old Nigerian female with a recurrent breast lesion previously misdiagnosed as metaplastic carcinoma. Imaging revealed a large, multifocal mass with aggressive features. Histopathologic and immunohistochemical evaluation following modified radical mastectomy supported a diagnosis of poorly differentiated synovial sarcoma. Due to the aggressive nature and rarity of this tumor in the breast, this case highlights the diagnostic challenges and importance of molecular and immunohistochemical studies. The patient was advised to pursue chemotherapy and radiotherapy but opted to continue treatment in her home country.</p>","PeriodicalId":11148,"journal":{"name":"Discover. Oncology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146164565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-12DOI: 10.1007/s12672-026-04485-4
Xikong Pan, Tingbo Ye, Jianjun Liu, Xucai Zheng
Glutamine metabolism plays a key role in cancer initiation and progression. This study aims to explore the independent and interactive roles of glutamine metabolism-related genes and immune characteristic in head and neck squamous cell carcinoma (HNSCC). Clinical and gene expression data from HNSCC patients were downloaded from the Gene Expression Omnibus (GEO) database and The Cancer Genome Atlas (TCGA). A comprehensive evaluation of 21 glutamine metabolism-related genes in HNSCC tissues was conducted. A risk model based on glutamine metabolism-related genes was constructed using Cox regression and least absolute shrinkage and selection operator (LASSO) regression analyses. The association between glutamine metabolism-related genes and immune infiltration was assessed using the Estimation of STromal and Immune cells in MAlignant Tumors using Expression data (ESTIMATE) method. The expression levels of the hub gene were verified in vitro models. Four glutamine metabolism-related genes (GOT2, FAH, LAT, and SLC7A11) were identified for constructing a risk score model for HNSCC patients. High expression levels of GOT2 were identified as a poor prognostic factor in HNSCC, as demonstrated by Kaplan-Meier analysis (HR:1.006, p < 0.001). Patients with a low-risk score exhibited higher ESTIMATE scores and Immune Scores compared to those with a high-risk score. GOT2 emerged as a hub gene associated with the survival of HNSCC patients. In vitro functional experiments demonstrated that downregulation of GOT2 expression suppresses proliferation, invasion, and metastasis. In conclusions, we developed and validated a prognostic risk scoring system based on four glutamine metabolism-associated genes, which demonstrated robust predictive capacity for clinical outcomes and immune infiltration patterns in HNSCC. Mechanistically, GOT2 emerged as a central regulator interfacing with the immunosuppressive tumor microenvironment, potentially driving oncogenesis through dual metabolic-immune reprogramming. These findings highlight GOT2 as a novel therapeutic target, offering a promising strategy to overcome immunotherapy resistance in HNSCC.
谷氨酰胺代谢在癌症的发生和发展中起着关键作用。本研究旨在探讨谷氨酰胺代谢相关基因与头颈部鳞状细胞癌（HNSCC）免疫特性在头颈部鳞状细胞癌（HNSCC）中的独立和相互作用。从基因表达综合数据库（gene expression Omnibus， GEO）和癌症基因组图谱（the Cancer Genome Atlas， TCGA）下载HNSCC患者的临床和基因表达数据。对HNSCC组织中21个谷氨酰胺代谢相关基因进行了综合评价。采用Cox回归和最小绝对收缩和选择算子（LASSO）回归分析，构建基于谷氨酰胺代谢相关基因的风险模型。利用表达数据（ESTIMATE）方法评估谷氨酰胺代谢相关基因与免疫浸润之间的关系。hub基因的表达水平在体外模型中得到验证。筛选谷氨酰胺代谢相关基因（GOT2、FAH、LAT和SLC7A11），构建HNSCC患者风险评分模型。Kaplan-Meier分析显示，高表达水平的GOT2被认为是HNSCC的一个不良预后因素(HR:1.006, p
{"title":"Integrated analysis of glutamine metabolism and immune microenvironment identifies GOT2 as a prognostic gene in head and neck squamous cell carcinoma.","authors":"Xikong Pan, Tingbo Ye, Jianjun Liu, Xucai Zheng","doi":"10.1007/s12672-026-04485-4","DOIUrl":"https://doi.org/10.1007/s12672-026-04485-4","url":null,"abstract":"<p><p>Glutamine metabolism plays a key role in cancer initiation and progression. This study aims to explore the independent and interactive roles of glutamine metabolism-related genes and immune characteristic in head and neck squamous cell carcinoma (HNSCC). Clinical and gene expression data from HNSCC patients were downloaded from the Gene Expression Omnibus (GEO) database and The Cancer Genome Atlas (TCGA). A comprehensive evaluation of 21 glutamine metabolism-related genes in HNSCC tissues was conducted. A risk model based on glutamine metabolism-related genes was constructed using Cox regression and least absolute shrinkage and selection operator (LASSO) regression analyses. The association between glutamine metabolism-related genes and immune infiltration was assessed using the Estimation of STromal and Immune cells in MAlignant Tumors using Expression data (ESTIMATE) method. The expression levels of the hub gene were verified in vitro models. Four glutamine metabolism-related genes (GOT2, FAH, LAT, and SLC7A11) were identified for constructing a risk score model for HNSCC patients. High expression levels of GOT2 were identified as a poor prognostic factor in HNSCC, as demonstrated by Kaplan-Meier analysis (HR:1.006, p < 0.001). Patients with a low-risk score exhibited higher ESTIMATE scores and Immune Scores compared to those with a high-risk score. GOT2 emerged as a hub gene associated with the survival of HNSCC patients. In vitro functional experiments demonstrated that downregulation of GOT2 expression suppresses proliferation, invasion, and metastasis. In conclusions, we developed and validated a prognostic risk scoring system based on four glutamine metabolism-associated genes, which demonstrated robust predictive capacity for clinical outcomes and immune infiltration patterns in HNSCC. Mechanistically, GOT2 emerged as a central regulator interfacing with the immunosuppressive tumor microenvironment, potentially driving oncogenesis through dual metabolic-immune reprogramming. These findings highlight GOT2 as a novel therapeutic target, offering a promising strategy to overcome immunotherapy resistance in HNSCC.</p>","PeriodicalId":11148,"journal":{"name":"Discover. Oncology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146164599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Analysis of prognostic factors related to pulmonary metastasectomy for hepatocellular carcinoma following liver resection.","authors":"Yingying Bao, Ze Yang, Yixiao Yang, Jianhui Zhao, Wen Chen, Liang Wen, Tingbo Liang","doi":"10.1007/s12672-026-04606-z","DOIUrl":"https://doi.org/10.1007/s12672-026-04606-z","url":null,"abstract":"","PeriodicalId":11148,"journal":{"name":"Discover. Oncology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146164623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-12DOI: 10.1007/s12672-026-04599-9
Linrui Cai, Erqi Tang, Huilian Zhang, Yujie Wang, Yihuang Cai
{"title":"Establishment and validation of a prognostic model for oral squamous cell carcinoma based on ribosomal and apoptosis-related gene expression.","authors":"Linrui Cai, Erqi Tang, Huilian Zhang, Yujie Wang, Yihuang Cai","doi":"10.1007/s12672-026-04599-9","DOIUrl":"https://doi.org/10.1007/s12672-026-04599-9","url":null,"abstract":"","PeriodicalId":11148,"journal":{"name":"Discover. Oncology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146164631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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