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Comprehensive analysis of PANoptosis-related molecular subtypes and prognostic model development of clear cell renal cell carcinoma. 透明细胞肾细胞癌panoposis相关分子亚型及预后模型发展的综合分析。
IF 2.9 4区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2026-02-06 DOI: 10.1007/s12672-026-04561-9
Peng Zhou, Zhen Xu, Weidong Gan, Xin Jin

Background: Clear cell renal cell carcinoma (ccRCC) exhibits strong heterogeneity and variable therapeutic responses. PANoptosis, an integrated form of inflammatory programmed cell death, may influence tumor immunity and prognosis, yet its role in ccRCC remains unclear.

Methods: Multi-omics data from TCGA database were analyzed to characterize PANoptosis-related genes (PRG), define molecular and gene subtypes, and construct a prognostic PRG score using Cox and LASSO regression. Immune infiltration, drug sensitivity, and predicted immunotherapy response were evaluated. Single-cell RNA sequencing analysis was used to map PRG expression across cell populations. In vitro experiments were performed to validate RBCK1 function in ccRCC.

Results: 14 PRG showed marked CNV alterations and differential expression. Three PRG molecular subtypes displayed distinct survival outcomes and immune landscapes. A three-gene PRG score (RIPK1, PYCARD, RBCK1) independently stratified prognosis and correlated with immune infiltration, mutation burden, and therapy sensitivity. Lower scores predicted better immunotherapy response and higher drug sensitivity. Single-cell analysis revealed broad PRG expression across macrophages, epithelial cells, endothelial cells, and stem-like cells. RBCK1 was significantly upregulated in ccRCC and promoted proliferation and migration, while its knockdown inhibited tumor cell growth.

Conclusions: We delineated the PANoptosis landscape in ccRCC and developed a robust PRG score with strong prognostic and immunological relevance. RBCK1 functions as a key oncogenic regulator and potential therapeutic target. These findings offer a valuable framework for precision risk assessment and treatment optimization in ccRCC.

背景:透明细胞肾细胞癌(ccRCC)表现出很强的异质性和不同的治疗反应。PANoptosis是炎症性程序性细胞死亡的一种综合形式,可能影响肿瘤免疫和预后,但其在ccRCC中的作用尚不清楚。方法:分析来自TCGA数据库的多组学数据,对panoptosis相关基因(PRG)进行表征,定义分子和基因亚型,并采用Cox和LASSO回归构建预后PRG评分。评估免疫浸润、药物敏感性和预测免疫治疗反应。单细胞RNA测序分析用于绘制PRG在细胞群中的表达图谱。通过体外实验验证RBCK1在ccRCC中的作用。结果:14个PRG出现了明显的CNV改变和差异表达。三种PRG分子亚型表现出不同的生存结果和免疫景观。三基因PRG评分(RIPK1, PYCARD, RBCK1)独立分层预后,并与免疫浸润,突变负担和治疗敏感性相关。较低的分数预示着更好的免疫治疗反应和更高的药物敏感性。单细胞分析显示PRG在巨噬细胞、上皮细胞、内皮细胞和干细胞样细胞中广泛表达。RBCK1在ccRCC中显著上调,促进肿瘤细胞的增殖和迁移,而RBCK1的下调抑制肿瘤细胞的生长。结论:我们描绘了ccRCC的PANoptosis景观,并开发了一个强大的PRG评分,具有很强的预后和免疫学相关性。RBCK1是一个关键的致癌调节因子和潜在的治疗靶点。这些发现为ccRCC的精确风险评估和治疗优化提供了有价值的框架。
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引用次数: 0
Gonadal and growth impairment in childhood cancer survivors' cohort. 儿童癌症幸存者队列中的性腺和生长障碍。
IF 2.9 4区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2026-02-06 DOI: 10.1007/s12672-026-04590-4
Chanchal Biswas, Neha Goel, Prashant Prabhakar, Rani Gera, Amitabh Singh, Neha Kawatra Madan
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引用次数: 0
Exosomal miR-484 from lung adenocarcinoma promotes osteoclastogenesis and osteolytic bone metastasis by targeting PECAM1. 肺腺癌外泌体miR-484通过靶向PECAM1促进破骨细胞发生和溶骨转移。
IF 2.9 4区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2026-02-06 DOI: 10.1007/s12672-026-04511-5
Zhongkai Tong, Xiaoxiao Zhu, Mengqing Hu, Cenli Wang, Xiaofei Liang, Chunli Wu, Zhenyan Li, Lin He, Jian Li, Zhenyue Ye, Zhaoxing Dong, Yong Zhou
{"title":"Exosomal miR-484 from lung adenocarcinoma promotes osteoclastogenesis and osteolytic bone metastasis by targeting PECAM1.","authors":"Zhongkai Tong, Xiaoxiao Zhu, Mengqing Hu, Cenli Wang, Xiaofei Liang, Chunli Wu, Zhenyan Li, Lin He, Jian Li, Zhenyue Ye, Zhaoxing Dong, Yong Zhou","doi":"10.1007/s12672-026-04511-5","DOIUrl":"https://doi.org/10.1007/s12672-026-04511-5","url":null,"abstract":"","PeriodicalId":11148,"journal":{"name":"Discover. Oncology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146131491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A novel ferroptosis- and endoplasmic reticulum stress-related gene signature for predicting prognosis, immune features and drug sensitivity in gastric cancer. 一种新的预测胃癌预后、免疫特征和药物敏感性的铁下垂和内质网应激相关基因标记。
IF 2.9 4区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2026-02-06 DOI: 10.1007/s12672-026-04562-8
Hongyu Chen, Zhilei Chen, Ke Cao, Zhenjun Wang
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引用次数: 0
miR-27b-3p directly targets PPARG to regulate pancreatic cancer progression. miR-27b-3p直接靶向PPARG调控胰腺癌进展。
IF 2.9 4区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2026-02-05 DOI: 10.1007/s12672-026-04509-z
Lijun Zhu, Cuiping Long, Yaxin Tang, Chenxi Wu, Linxi Wei, Tao Ye, Jun Chen
{"title":"miR-27b-3p directly targets PPARG to regulate pancreatic cancer progression.","authors":"Lijun Zhu, Cuiping Long, Yaxin Tang, Chenxi Wu, Linxi Wei, Tao Ye, Jun Chen","doi":"10.1007/s12672-026-04509-z","DOIUrl":"https://doi.org/10.1007/s12672-026-04509-z","url":null,"abstract":"","PeriodicalId":11148,"journal":{"name":"Discover. Oncology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146123989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bioinformatic analysis and cellular functional assays uncover the role of NXPH4 in breast cancer. 生物信息学分析和细胞功能分析揭示了NXPH4在乳腺癌中的作用。
IF 2.9 4区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2026-02-05 DOI: 10.1007/s12672-026-04519-x
Dong Dong Yang, Ze Kuan Xue, Sheng Qiu Jia, Cheng Hao Liu, Rui Yang, Chun Ling Chen, Yong Zhou Huang, Xin Chun Zhao, Gui Lin Huang, Ji Xue Hou
{"title":"Bioinformatic analysis and cellular functional assays uncover the role of NXPH4 in breast cancer.","authors":"Dong Dong Yang, Ze Kuan Xue, Sheng Qiu Jia, Cheng Hao Liu, Rui Yang, Chun Ling Chen, Yong Zhou Huang, Xin Chun Zhao, Gui Lin Huang, Ji Xue Hou","doi":"10.1007/s12672-026-04519-x","DOIUrl":"https://doi.org/10.1007/s12672-026-04519-x","url":null,"abstract":"","PeriodicalId":11148,"journal":{"name":"Discover. Oncology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146123999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Circ_0041150 inhibits proliferation of pancreatic adenocarcinoma cells by regulating triglyceride accumulation via the miR-1178-3p/AADAC axis. Circ_0041150通过miR-1178-3p/AADAC轴调节甘油三酯积累抑制胰腺腺癌细胞增殖。
IF 2.9 4区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2026-02-05 DOI: 10.1007/s12672-026-04577-1
Jing-Jing Zhao, Na-Ya Hu, Hui-Ru Wang, Cui-Juan Qian, Jun Yao
{"title":"Circ_0041150 inhibits proliferation of pancreatic adenocarcinoma cells by regulating triglyceride accumulation via the miR-1178-3p/AADAC axis.","authors":"Jing-Jing Zhao, Na-Ya Hu, Hui-Ru Wang, Cui-Juan Qian, Jun Yao","doi":"10.1007/s12672-026-04577-1","DOIUrl":"https://doi.org/10.1007/s12672-026-04577-1","url":null,"abstract":"","PeriodicalId":11148,"journal":{"name":"Discover. Oncology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146124037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Role of SERPINA1 in the tumor immune microenvironment of breast cancer and construction of a prognostic model. SERPINA1在乳腺癌肿瘤免疫微环境中的作用及预后模型的构建
IF 2.9 4区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2026-02-05 DOI: 10.1007/s12672-026-04555-7
Xiaolin Xia, Jiaqi Liu, Jine Liu, Shuai Chen, Zhou Chen
{"title":"Role of SERPINA1 in the tumor immune microenvironment of breast cancer and construction of a prognostic model.","authors":"Xiaolin Xia, Jiaqi Liu, Jine Liu, Shuai Chen, Zhou Chen","doi":"10.1007/s12672-026-04555-7","DOIUrl":"https://doi.org/10.1007/s12672-026-04555-7","url":null,"abstract":"","PeriodicalId":11148,"journal":{"name":"Discover. Oncology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146124119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
WGCNA-derived lncRNA MAP3K4-AS1 regulates apoptosis and cell cycle in TNBC MDA-MB-231 cells validated by siRNA knockdown. wgna来源的lncRNA MAP3K4-AS1调节TNBC MDA-MB-231细胞的凋亡和细胞周期,siRNA敲低证实。
IF 2.9 4区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2026-02-05 DOI: 10.1007/s12672-026-04568-2
Pegah Khaaki, Amirhosein Yari, Saba Abedimanesh, Seyedeh Zahra Bahojb Mahdavi, Omid Pourbagherian, Habib MotieGhader, Amir Ali Mokhtarzadeh
{"title":"WGCNA-derived lncRNA MAP3K4-AS1 regulates apoptosis and cell cycle in TNBC MDA-MB-231 cells validated by siRNA knockdown.","authors":"Pegah Khaaki, Amirhosein Yari, Saba Abedimanesh, Seyedeh Zahra Bahojb Mahdavi, Omid Pourbagherian, Habib MotieGhader, Amir Ali Mokhtarzadeh","doi":"10.1007/s12672-026-04568-2","DOIUrl":"https://doi.org/10.1007/s12672-026-04568-2","url":null,"abstract":"","PeriodicalId":11148,"journal":{"name":"Discover. Oncology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146124147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
CCL19 and CCR6 as diagnostic biomarkers for differentiating phyllodes tumors from breast fibroadenomas: a machine learning-driven approach integrating EMT biology. CCL19和CCR6作为区分乳腺纤维腺瘤和叶状瘤的诊断性生物标志物:一种整合EMT生物学的机器学习驱动方法。
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{"title":"CCL19 and CCR6 as diagnostic biomarkers for differentiating phyllodes tumors from breast fibroadenomas: a machine learning-driven approach integrating EMT biology.","authors":"Hui Gao, YanDan Lan, LiQiong Lv, Hui Liu","doi":"10.1007/s12672-026-04451-0","DOIUrl":"https://doi.org/10.1007/s12672-026-04451-0","url":null,"abstract":"","PeriodicalId":11148,"journal":{"name":"Discover. Oncology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146118095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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Discover. Oncology
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