Many people in the general population battle intense chronic pain daily and it disrupts their quality of life. Current OTC therapies provide mixed results and have profound limitations. However, the Hydroglide Body and Facial Lotion is a patent-pending product that delivers consistently positive outcomes. It’s a dual-fighting agent for dermatological issues and is useful for general body aches as well as for debilitating and excruciating pain.
{"title":"New Class of Derma-Pharmaceutical used to Alleviate Pain, Neuropathy and Increase Wound Healing","authors":"Milton D. Moore","doi":"10.33425/2690-537x.1013","DOIUrl":"https://doi.org/10.33425/2690-537x.1013","url":null,"abstract":"Many people in the general population battle intense chronic pain daily and it disrupts their quality of life. Current OTC therapies provide mixed results and have profound limitations. However, the Hydroglide Body and Facial Lotion is a patent-pending product that delivers consistently positive outcomes. It’s a dual-fighting agent for dermatological issues and is useful for general body aches as well as for debilitating and excruciating pain.","PeriodicalId":11152,"journal":{"name":"Dermatology Research","volume":"41 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79063692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
I. Alfonso-Trujillo, Yetter Cruz-Leon, Melissa Johana Espitia-Cordero, Eduardo Jesús Núñez-Jordán, Yaquelin Luciana Morales Novo, Jesus Lazaro Diego-De la Campa, Angela Rosa Gutierrez-Rojas, Julio Antonio López-Silva, Daymi Serpa-Almaguer
Introduction: The rejuvenation of the perioral region has a certain degree of difficulty. The search for painless and minimally invasive alternatives is a challenge in the field of aesthetic medicine. Objective: To evaluate the efficacy and safety of intradermal microinjection of autologous platelet concentrate (APC) in the treatment of perioral skin aging signs. Method: An observational, analytical and longitudinal study was carried out in 60 patients from the Hospital Clínico Quirúrgico: “Hermanos Ameijeiras”, in the period between March 1, 2017 and March 31, 2020. The treatment was applied monthly. For 1 year. The final evaluation was carried out 3 months after the end of the treatment. Results: 60 women with an average age of 45 ± 4.3 years were treated. After treatment, there were significant changes in the Glogau Photo Damage Scale (P = 0.028), in the Global Aesthetic Improvement Scale (P <0.032) and in the Evaluative Scale of the severity range of the nasolabial fold (P = 0.031). The adverse events found were pain, inflammation and ecchymosis. The degree of satisfaction reported by the patients was good (16.7%) and very good (83.8%) (P <0.038). Conclusions: The autologous platelet concentrate proved to be effective and safe to reduce the signs of perioral skin aging, associated with a high degree of patient satisfaction.
{"title":"Efficacy and Safety of Autologous Platelets Concentrated in the Treatment of Perioral Skin Aging.","authors":"I. Alfonso-Trujillo, Yetter Cruz-Leon, Melissa Johana Espitia-Cordero, Eduardo Jesús Núñez-Jordán, Yaquelin Luciana Morales Novo, Jesus Lazaro Diego-De la Campa, Angela Rosa Gutierrez-Rojas, Julio Antonio López-Silva, Daymi Serpa-Almaguer","doi":"10.33425/2690-537x.1015","DOIUrl":"https://doi.org/10.33425/2690-537x.1015","url":null,"abstract":"Introduction: The rejuvenation of the perioral region has a certain degree of difficulty. The search for painless and minimally invasive alternatives is a challenge in the field of aesthetic medicine. Objective: To evaluate the efficacy and safety of intradermal microinjection of autologous platelet concentrate (APC) in the treatment of perioral skin aging signs. Method: An observational, analytical and longitudinal study was carried out in 60 patients from the Hospital Clínico Quirúrgico: “Hermanos Ameijeiras”, in the period between March 1, 2017 and March 31, 2020. The treatment was applied monthly. For 1 year. The final evaluation was carried out 3 months after the end of the treatment. Results: 60 women with an average age of 45 ± 4.3 years were treated. After treatment, there were significant changes in the Glogau Photo Damage Scale (P = 0.028), in the Global Aesthetic Improvement Scale (P <0.032) and in the Evaluative Scale of the severity range of the nasolabial fold (P = 0.031). The adverse events found were pain, inflammation and ecchymosis. The degree of satisfaction reported by the patients was good (16.7%) and very good (83.8%) (P <0.038). Conclusions: The autologous platelet concentrate proved to be effective and safe to reduce the signs of perioral skin aging, associated with a high degree of patient satisfaction.","PeriodicalId":11152,"journal":{"name":"Dermatology Research","volume":"227 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80153237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
I. Trujillo, Yetter Cruz León, Mariana Sarao Pineda, Nora Rosales Hernández, Yaquelin Luciana Morales Novo, Jesus Lazaro Diego De la Campa, Ángela Rosa Gutiérrez Rojas, J. L. López Silva, Daymi Serpa Almaguer
Introduction: Platelet rich plasma (PRP) is an autologous serum that contains high concentrations of platelets and growth factors. It is currently a versatile therapy in dermatology; however, few studies objectively evaluate its efficacy. Objective: To evaluate the efficacy and safety of intradermal microinjection of autologous platelet concentrate (APC) in the treatment of crow's feet rejuvenation. Method: An observational, analytical and longitudinal study was carried out in 60 patients from the Hospital Clínico Quirúrgico: “Hermanos Ameijeiras”, in the period between March 1, 2017 and March 31, 2020. The treatment was applied monthly. for 1 year. The final evaluation was carried out 3 months after the end of the treatment. Results: 60 women with an average age of 45 ± 4.3 years were treated. After treatment, there were significant changes in the Glogau Photo Damage Scale (P = 0.0022), in the Photonumeric Scale to assess the severity of crow's feet (P = 0.0111) and in the Global Aesthetic Improvement Scale. (P = 0.0033). The adverse events found were pain, inflammation and ecchymosis. The degree of satisfaction reported by the patients was good (16.6%) and very good (83.3%) (P = 0.0021). Conclusions: The autologous platelet concentrate proved to be effective and safe in reducing the signs of cutaneous aging of crow's feet, associated with a high degree of patient satisfaction.
{"title":"Efficacy and Safety of Autologous Platelets Concentrate in the Treatment of Crow's Feet Photo Aging","authors":"I. Trujillo, Yetter Cruz León, Mariana Sarao Pineda, Nora Rosales Hernández, Yaquelin Luciana Morales Novo, Jesus Lazaro Diego De la Campa, Ángela Rosa Gutiérrez Rojas, J. L. López Silva, Daymi Serpa Almaguer","doi":"10.33425/2690-537x.1016","DOIUrl":"https://doi.org/10.33425/2690-537x.1016","url":null,"abstract":"Introduction: Platelet rich plasma (PRP) is an autologous serum that contains high concentrations of platelets and growth factors. It is currently a versatile therapy in dermatology; however, few studies objectively evaluate its efficacy. Objective: To evaluate the efficacy and safety of intradermal microinjection of autologous platelet concentrate (APC) in the treatment of crow's feet rejuvenation. Method: An observational, analytical and longitudinal study was carried out in 60 patients from the Hospital Clínico Quirúrgico: “Hermanos Ameijeiras”, in the period between March 1, 2017 and March 31, 2020. The treatment was applied monthly. for 1 year. The final evaluation was carried out 3 months after the end of the treatment. Results: 60 women with an average age of 45 ± 4.3 years were treated. After treatment, there were significant changes in the Glogau Photo Damage Scale (P = 0.0022), in the Photonumeric Scale to assess the severity of crow's feet (P = 0.0111) and in the Global Aesthetic Improvement Scale. (P = 0.0033). The adverse events found were pain, inflammation and ecchymosis. The degree of satisfaction reported by the patients was good (16.6%) and very good (83.3%) (P = 0.0021). Conclusions: The autologous platelet concentrate proved to be effective and safe in reducing the signs of cutaneous aging of crow's feet, associated with a high degree of patient satisfaction.","PeriodicalId":11152,"journal":{"name":"Dermatology Research","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82780841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tony Tang Yuqi, Wang Feng, Ling Fangzhou, Tang Yuqiu
The challenge in the second degree thermal burn wound healing is the risk of infection and Hypertrophic scarring. We administered herbal formulated HLQ ointment on second degree. Burn wound, it produced zero pain of daily dressing changes and achieved complete re epithelialization in 7-14 days.
{"title":"Second Degree Burn Healed in 10 Days with Herbal Formulated HLQ Ointment","authors":"Tony Tang Yuqi, Wang Feng, Ling Fangzhou, Tang Yuqiu","doi":"10.33425/2690-537x.1012","DOIUrl":"https://doi.org/10.33425/2690-537x.1012","url":null,"abstract":"The challenge in the second degree thermal burn wound healing is the risk of infection and Hypertrophic scarring. We administered herbal formulated HLQ ointment on second degree. Burn wound, it produced zero pain of daily dressing changes and achieved complete re epithelialization in 7-14 days.","PeriodicalId":11152,"journal":{"name":"Dermatology Research","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89322778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Expanding the Frontiers of Dermatology: Skin Leucocytes Collected for Different Types of Studies in Immune deficient Subjects","authors":"Nuwayri Salti N, Knio K","doi":"10.33425/2690-537x.1011","DOIUrl":"https://doi.org/10.33425/2690-537x.1011","url":null,"abstract":"","PeriodicalId":11152,"journal":{"name":"Dermatology Research","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74761492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
On February 26, 2019, the Food & Drug Administration (FDA) published an update to the Sunscreen Drug Products for Overthe-Counter Human Use in the Federal Register [1], requesting additional information on 12 petroleum-based sunscreen actives (cinoxate, dioxybenzone, ensulizole, homosalate, meradimate, octinoxate, octisalate, octocrylene, padimate O, sulisobenzone, oxybenzone and avobenzone). This is because the public record does not currently contain sufficient data to support that these drugs are Generally Recognized as Safe and Effective (GRASE). The FDA went on to conduct and publish a small clinical trail [2] to determine whether four of these drugs (avobenzone, oxybenzone, octocrylene, and ecamsule) absorb into the systemic circulation and whether they would exceed the FDA level for toxicological concern (0.5 ng/mL). The data collected demonstrated that all four sunscreen drugs absorbed through the skin and into the blood, and accumulated above the 0.5 ng/mL level within the first day (4 applications) of the study. Oxybenzone exceeded the level of concern after the first application demonstrating an overall maximum plasma concentration between 169.3 and 209.6 ng/mL for concentrations ranging from 4% to 6% in products, respectively.
{"title":"Why Evaluate the Sunscreen Active Oxybenzone (Benzophenone-3) for Carcinogenicity and Reproductive Toxicology or Consider it Unsafe for Human Use?","authors":"DiNardo Jc, Downs Ca","doi":"10.33425/2690-537x.1005","DOIUrl":"https://doi.org/10.33425/2690-537x.1005","url":null,"abstract":"On February 26, 2019, the Food & Drug Administration (FDA) published an update to the Sunscreen Drug Products for Overthe-Counter Human Use in the Federal Register [1], requesting additional information on 12 petroleum-based sunscreen actives (cinoxate, dioxybenzone, ensulizole, homosalate, meradimate, octinoxate, octisalate, octocrylene, padimate O, sulisobenzone, oxybenzone and avobenzone). This is because the public record does not currently contain sufficient data to support that these drugs are Generally Recognized as Safe and Effective (GRASE). The FDA went on to conduct and publish a small clinical trail [2] to determine whether four of these drugs (avobenzone, oxybenzone, octocrylene, and ecamsule) absorb into the systemic circulation and whether they would exceed the FDA level for toxicological concern (0.5 ng/mL). The data collected demonstrated that all four sunscreen drugs absorbed through the skin and into the blood, and accumulated above the 0.5 ng/mL level within the first day (4 applications) of the study. Oxybenzone exceeded the level of concern after the first application demonstrating an overall maximum plasma concentration between 169.3 and 209.6 ng/mL for concentrations ranging from 4% to 6% in products, respectively.","PeriodicalId":11152,"journal":{"name":"Dermatology Research","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75993697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lips and perioral area are fundamental in youthful appearance. The perioral region is the most dynamic anatomic area of the face and is subject to complex and dramatic changes during aging. The ideal and effective treatment for perioral rejuvenation and, above all, smoker's lines, has yet to be identified. All proposed techniques and previous studies reported only subjective results. The propose of this study is to evaluate the treatment of the upper lips and the smoker’s lines with a superficial disepithelization with a non-ablative multifrequency electrosurgery and a peeling based on mandelic acid. Patients with upper lip wrinkles were inserted into the protocol. After a light scrub, we proceeded to make a superficial dermabrasion using a multifrequency electrosurgery able to create a voltaic arc. Once the superficial corneal layer of the skin was removed, we made a peeling consisting of mandelic acid combined with lactoferrin until a white Frost was obtained. We treated 25 women with an average age of 60 (Range 52/73). A marked improvement, from 70% to 90%, was observed in 18 patients with class I II wrinkles. Instead a moderate improvement was observed in 7 cases with class II III wrinkles, with percentages ranging from 40% to 60%. Dermabrasion controlled by a voltaic arc, combined with peeling with MA and LF, has proved effective for the marked reduction of perioral wrinkles. The arc acts without coming into contact with the tissues, creating a delicate coagulation. To reduce any side effects related to the use of the voltaic arc and to have a homogeneous skin regeneration without dyschromia or scars, we used a mandelic acid which was able to act without inducing erythema, to accelerate the repairing of the skin, to moisturize the skin and give it a tensor effect.
{"title":"Dermabrasion with Non-Ablative Electrosurgery and Peeling with Mandelic Acid and Lactoferrin In the Treatment of Perioral Wrinkles","authors":"Guarino Enrico, F. Lucia, Pelliccia Roberto","doi":"10.33425/2690-537x.1003","DOIUrl":"https://doi.org/10.33425/2690-537x.1003","url":null,"abstract":"Lips and perioral area are fundamental in youthful appearance. The perioral region is the most dynamic anatomic area of the face and is subject to complex and dramatic changes during aging. The ideal and effective treatment for perioral rejuvenation and, above all, smoker's lines, has yet to be identified. All proposed techniques and previous studies reported only subjective results. The propose of this study is to evaluate the treatment of the upper lips and the smoker’s lines with a superficial disepithelization with a non-ablative multifrequency electrosurgery and a peeling based on mandelic acid. Patients with upper lip wrinkles were inserted into the protocol. After a light scrub, we proceeded to make a superficial dermabrasion using a multifrequency electrosurgery able to create a voltaic arc. Once the superficial corneal layer of the skin was removed, we made a peeling consisting of mandelic acid combined with lactoferrin until a white Frost was obtained. We treated 25 women with an average age of 60 (Range 52/73). A marked improvement, from 70% to 90%, was observed in 18 patients with class I II wrinkles. Instead a moderate improvement was observed in 7 cases with class II III wrinkles, with percentages ranging from 40% to 60%. Dermabrasion controlled by a voltaic arc, combined with peeling with MA and LF, has proved effective for the marked reduction of perioral wrinkles. The arc acts without coming into contact with the tissues, creating a delicate coagulation. To reduce any side effects related to the use of the voltaic arc and to have a homogeneous skin regeneration without dyschromia or scars, we used a mandelic acid which was able to act without inducing erythema, to accelerate the repairing of the skin, to moisturize the skin and give it a tensor effect.","PeriodicalId":11152,"journal":{"name":"Dermatology Research","volume":"118 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77384580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
I. Trujillo, Tomás Alejandro Tabilo Bocic, Ángela Rosa Gutiérrez Rojas, Hugo Nodarse Cuní, María Elena Flores Andrade, María del Carmen Toledo García
Background: The continuous recurrence of condyloma acuminata makes the constant search for necessary therapeutic alternatives. Patients and method: To evaluate the therapeutic efficacy and safety of pegylated interferon, alone or adjuvant for cryosurgery, in the condyloma acuminata an open clinical trial was carried out on 30 patients of the "Hermanos Ameijeiras" hospital, who were randomized to receive for 6 weeks (group A) only fortnightly cryosurgery, (group B) subcutaneous pegylated interferon, once a week, associated with fortnightly cryosurgery application or (group C) only subcutaneous pegylated interferon, once a week. The main variable was the percentage of recurrence at one year of follow-up, evaluated quarterly. There was also a rigorous control of adverse events. Results: At the end of the treatment 8/10 (80%) patients from group A, 10/10 (100%) from group B and 9/10 (90%) from group C were left without injuries. During the follow-up, none of the patients who received pegylated interferon, alone or adjuvant to cryosurgery, had recurrences; while 100% of patients who received cryosurgery as exclusive treatment relapsed (p <0.000). The most frequent events were local burning (100%) due to cryosurgery and fever (6.6%), headache (6.6%), myalgia (3.3%) and malaise (3.3%) due to interferon. Conclusion: Pegylated interferon alone or adjuvant to cryosurgery provides benefits for the quality of life of patients, with absolute and relative reduction of a 100% of the risk of recurrence.
{"title":"Therapy with Pegylated Interferon or Combined with Cryosurgery in Condyloma Acuminata. Phase iii Clinical Trial","authors":"I. Trujillo, Tomás Alejandro Tabilo Bocic, Ángela Rosa Gutiérrez Rojas, Hugo Nodarse Cuní, María Elena Flores Andrade, María del Carmen Toledo García","doi":"10.33425/2690-537x.1001","DOIUrl":"https://doi.org/10.33425/2690-537x.1001","url":null,"abstract":"Background: The continuous recurrence of condyloma acuminata makes the constant search for necessary therapeutic alternatives. Patients and method: To evaluate the therapeutic efficacy and safety of pegylated interferon, alone or adjuvant for cryosurgery, in the condyloma acuminata an open clinical trial was carried out on 30 patients of the \"Hermanos Ameijeiras\" hospital, who were randomized to receive for 6 weeks (group A) only fortnightly cryosurgery, (group B) subcutaneous pegylated interferon, once a week, associated with fortnightly cryosurgery application or (group C) only subcutaneous pegylated interferon, once a week. The main variable was the percentage of recurrence at one year of follow-up, evaluated quarterly. There was also a rigorous control of adverse events. Results: At the end of the treatment 8/10 (80%) patients from group A, 10/10 (100%) from group B and 9/10 (90%) from group C were left without injuries. During the follow-up, none of the patients who received pegylated interferon, alone or adjuvant to cryosurgery, had recurrences; while 100% of patients who received cryosurgery as exclusive treatment relapsed (p <0.000). The most frequent events were local burning (100%) due to cryosurgery and fever (6.6%), headache (6.6%), myalgia (3.3%) and malaise (3.3%) due to interferon. Conclusion: Pegylated interferon alone or adjuvant to cryosurgery provides benefits for the quality of life of patients, with absolute and relative reduction of a 100% of the risk of recurrence.","PeriodicalId":11152,"journal":{"name":"Dermatology Research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84137423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lopez-Gaydon Amandine, Baillif Vincent, B. Cindy, Van Goethem Emeline, Demarne Frédéric, Dubourdeau Marc, B. Nicolas
To the Editor, Bioactive lipid mediators derived from polyunsaturated fatty acids (PUFA) contribute to skin health through a fine and a spatiotemporal control of inflammation and immune response [1]. Arachidonic acid (AA; 20:4n-6), eicosapentaenoic acid (EPA; 20:5n-3) and docosahexaenoic acid (DHA; 22:6n-3) are the most predominant essential fatty acids in human skin [2]. They are precursors for synthesis of mediators that are pro-inflammatory or that actively end this process and named for this specific effect, specialized proresolving lipid mediators (SPMs). Upon induction of inflammation resolution, cells that initially triggered inflammation undergo a biochemical paradigm shift, known as “lipid mediator class switch”, during which they stop producing classical proinflammatory mediators and start to actively synthesize SPMs. These include AA-derived lipoxins (LXA4 and LXB4), EPA-derived resolvins and DHA-derived resolvins, protectins and maresins [3].
{"title":"Differential Profile of Proinflammatory/Proresolving Lipid Mediators in Acute Inflammation Model using Young and Old Skin Biopsies","authors":"Lopez-Gaydon Amandine, Baillif Vincent, B. Cindy, Van Goethem Emeline, Demarne Frédéric, Dubourdeau Marc, B. Nicolas","doi":"10.33425/2690-537x.1002","DOIUrl":"https://doi.org/10.33425/2690-537x.1002","url":null,"abstract":"To the Editor, Bioactive lipid mediators derived from polyunsaturated fatty acids (PUFA) contribute to skin health through a fine and a spatiotemporal control of inflammation and immune response [1]. Arachidonic acid (AA; 20:4n-6), eicosapentaenoic acid (EPA; 20:5n-3) and docosahexaenoic acid (DHA; 22:6n-3) are the most predominant essential fatty acids in human skin [2]. They are precursors for synthesis of mediators that are pro-inflammatory or that actively end this process and named for this specific effect, specialized proresolving lipid mediators (SPMs). Upon induction of inflammation resolution, cells that initially triggered inflammation undergo a biochemical paradigm shift, known as “lipid mediator class switch”, during which they stop producing classical proinflammatory mediators and start to actively synthesize SPMs. These include AA-derived lipoxins (LXA4 and LXB4), EPA-derived resolvins and DHA-derived resolvins, protectins and maresins [3].","PeriodicalId":11152,"journal":{"name":"Dermatology Research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76843363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. K., Hattori T, Kitukawa Y, Aotsuka A, W. T, Kubosawa H, I. S
Many patients with atopic dermatitis have not only skin but also multiple organ disorders such as intestinal tract and cervical spine. As the cause, the involvement of a toxin (called superantigen) produced by Staphylococcus aureus, which is detected from the skin of atopic dermatitis, is presumed. As a measure against Staphylococcus aureus, the use of Povidone-iodine was listed as adjuvant therapy in the Japanese Guidelines for Atopic Dermatitis Treatment 2018. In the future, we would like to treat atopic dermatitis as a superantigen disease and propose that Povidone-iodine solution be used in combination with general treatment as a measure against Staphylococcus aureus.
{"title":"Antiseptic Treatment of Povidone-Iodine Solution as a Countermeasure against Staphylococcus Aureus in Atopic Dermatitis","authors":"S. K., Hattori T, Kitukawa Y, Aotsuka A, W. T, Kubosawa H, I. S","doi":"10.33425/2690-537x.1004","DOIUrl":"https://doi.org/10.33425/2690-537x.1004","url":null,"abstract":"Many patients with atopic dermatitis have not only skin but also multiple organ disorders such as intestinal tract and cervical spine. As the cause, the involvement of a toxin (called superantigen) produced by Staphylococcus aureus, which is detected from the skin of atopic dermatitis, is presumed. As a measure against Staphylococcus aureus, the use of Povidone-iodine was listed as adjuvant therapy in the Japanese Guidelines for Atopic Dermatitis Treatment 2018. In the future, we would like to treat atopic dermatitis as a superantigen disease and propose that Povidone-iodine solution be used in combination with general treatment as a measure against Staphylococcus aureus.","PeriodicalId":11152,"journal":{"name":"Dermatology Research","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86407174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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