Pub Date : 2025-11-22DOI: 10.1007/s00125-025-06600-6
Adam G. Maynard, Raghav Bhardwaj, Thouis R. Jones, Melina Claussnitzer
{"title":"Bridging the variant-to-function gap in type 2 diabetes: advances and challenges","authors":"Adam G. Maynard, Raghav Bhardwaj, Thouis R. Jones, Melina Claussnitzer","doi":"10.1007/s00125-025-06600-6","DOIUrl":"https://doi.org/10.1007/s00125-025-06600-6","url":null,"abstract":"","PeriodicalId":11164,"journal":{"name":"Diabetologia","volume":"104 1","pages":""},"PeriodicalIF":8.2,"publicationDate":"2025-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145567095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-21DOI: 10.1007/s00125-025-06610-4
Jørn Nerup,Åke Lernmark
{"title":"The rise and fall of a paradigm and conceiving a new hypothesis for type 1 diabetes.","authors":"Jørn Nerup,Åke Lernmark","doi":"10.1007/s00125-025-06610-4","DOIUrl":"https://doi.org/10.1007/s00125-025-06610-4","url":null,"abstract":"","PeriodicalId":11164,"journal":{"name":"Diabetologia","volume":"79 1","pages":""},"PeriodicalIF":8.2,"publicationDate":"2025-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145559045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-20DOI: 10.1007/s00125-025-06604-2
Amber Wouters, Pierre Lemaitre, Laure Degroote, Marijke Viaene, Marc Packbier, Nick Geukens, Chantal Mathieu, Conny Gysemans
{"title":"Redosing of anti-CD3 antibodies in NOD mice with new-onset diabetes does not alter the effect of a single treatment course","authors":"Amber Wouters, Pierre Lemaitre, Laure Degroote, Marijke Viaene, Marc Packbier, Nick Geukens, Chantal Mathieu, Conny Gysemans","doi":"10.1007/s00125-025-06604-2","DOIUrl":"https://doi.org/10.1007/s00125-025-06604-2","url":null,"abstract":"","PeriodicalId":11164,"journal":{"name":"Diabetologia","volume":"159 1","pages":""},"PeriodicalIF":8.2,"publicationDate":"2025-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145553278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-20DOI: 10.1007/s00125-025-06611-3
Peter Stenvinkel, Peter Kotanko, Johanna Painer-Gigler, Paul G. Shiels, Pieter Evenepoel, Leon Schurgers, Barbara Natterson-Horowitz, Szilvia Kalogeropoulu, Joshua Schiffman, Richard J. Johnson
This review explores the remarkable metabolic adaptations of species that thrive in extreme environments, providing insights into their resilience, flexibility and disease resistance. Species such as hibernating brown bears, migratory birds, cavefish, Greenland sharks and naked mole rats exhibit unique metabolic traits that challenge conventional paradigms of metabolic regulation. These adaptations, including resistance to hypoxia and metabolic ageing, offer potential solutions to human metabolic disorders, including obesity, type 2 diabetes and CVD. Insights from comparative physiology, particularly the mechanisms by which animals cope with food scarcity, extreme temperatures and hypoxia, could help identify novel therapeutic targets for advancing human health. For example, hibernation can serve as a model for understanding metabolic diseases, providing insights into reversible insulin resistance and energy homeostasis. This review also highlights the impact of environmental stressors, including climate change, on these species, which may jeopardise their survival despite their resilience. Accelerating anthropogenic environmental change threatens even the most resilient animal species. We call for a holistic approach to conservation and environmental protection to preserve these species and the valuable lessons they offer for managing our metabolic health. Graphical
{"title":"Comparative physiology and biomimetics in metabolic and environmental health: what can we learn from extreme animal phenotypes?","authors":"Peter Stenvinkel, Peter Kotanko, Johanna Painer-Gigler, Paul G. Shiels, Pieter Evenepoel, Leon Schurgers, Barbara Natterson-Horowitz, Szilvia Kalogeropoulu, Joshua Schiffman, Richard J. Johnson","doi":"10.1007/s00125-025-06611-3","DOIUrl":"https://doi.org/10.1007/s00125-025-06611-3","url":null,"abstract":"This review explores the remarkable metabolic adaptations of species that thrive in extreme environments, providing insights into their resilience, flexibility and disease resistance. Species such as hibernating brown bears, migratory birds, cavefish, Greenland sharks and naked mole rats exhibit unique metabolic traits that challenge conventional paradigms of metabolic regulation. These adaptations, including resistance to hypoxia and metabolic ageing, offer potential solutions to human metabolic disorders, including obesity, type 2 diabetes and CVD. Insights from comparative physiology, particularly the mechanisms by which animals cope with food scarcity, extreme temperatures and hypoxia, could help identify novel therapeutic targets for advancing human health. For example, hibernation can serve as a model for understanding metabolic diseases, providing insights into reversible insulin resistance and energy homeostasis. This review also highlights the impact of environmental stressors, including climate change, on these species, which may jeopardise their survival despite their resilience. Accelerating anthropogenic environmental change threatens even the most resilient animal species. We call for a holistic approach to conservation and environmental protection to preserve these species and the valuable lessons they offer for managing our metabolic health. Graphical","PeriodicalId":11164,"journal":{"name":"Diabetologia","volume":"32 1","pages":""},"PeriodicalIF":8.2,"publicationDate":"2025-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145553309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-20DOI: 10.1007/s00125-025-06602-4
Martin Hein,Hassanain Qambari,Paula Yu,Andrew Mehnert,Dao-Yi Yu,Chandrakumar Balaratnasingam
AIMS/HYPOTHESISInterpericyte tunnelling nanotubes (IP-TNTs) regulate microvascular blood flow by coordinating pericyte-pericyte communication across distant capillaries in the retina. Perfusion abnormalities are observed in preclinical diabetic retinopathy, and the state of IP-TNTs in this condition is unknown.METHODSUsing high-resolution confocal microscopy with isolated perfusion labelling of human donor retina, we investigated changes to IP-TNTs, pericytes and capillaries in the macular vasculature of individuals with preclinical diabetic retinopathy (n=7) and control individuals (n=12).RESULTSWe observed diffuse loss of IP-TNTs in the superficial vascular plexus (SVP), the intermediate capillary plexus (ICP) and the deep capillary plexus (DCP) as well as in the four quadrants of the macula in preclinical diabetic retinopathy. The mean ± SD numbers of IP-TNTs per 500 × 500 µm area were 2.5 ± 0.79 (diabetic) and 3.93 ± 0.82 (control) (p<0.0001) in the SVP; 1.40 ± 0.83 (diabetic) and 1.98 ± 0.88 (control) (p=0.012) in the ICP; and 1.11 ± 0.87 (diabetic) and 1.75 ± 0.99 (control) (p=0.011) in the DCP. Within the ICP and DCP, IP-TNT losses were identified despite an absence of pericyte density changes. In the SVP, IP-TNT losses were present despite an absence of capillary density change.CONCLUSIONS/INTERPRETATIONThese observations suggest that IP-TNT loss is a very early feature of diabetic retinopathy that can selectively precede alterations to pericytes and retinal capillaries. Given that IP-TNTs are intimately associated with pericytes, there is the potential that IP-TNT loss contributes to perfusion abnormalities and may be one of the major pathogenic factors in diabetic retinopathy. Future studies should confirm this exploratory work; the development of therapeutic agents designed to maintain IP-TNT structure and function may be an important factor for the preservation of retinal health.
{"title":"Interpericyte tunnelling nanotube loss in very early diabetic retinal disease.","authors":"Martin Hein,Hassanain Qambari,Paula Yu,Andrew Mehnert,Dao-Yi Yu,Chandrakumar Balaratnasingam","doi":"10.1007/s00125-025-06602-4","DOIUrl":"https://doi.org/10.1007/s00125-025-06602-4","url":null,"abstract":"AIMS/HYPOTHESISInterpericyte tunnelling nanotubes (IP-TNTs) regulate microvascular blood flow by coordinating pericyte-pericyte communication across distant capillaries in the retina. Perfusion abnormalities are observed in preclinical diabetic retinopathy, and the state of IP-TNTs in this condition is unknown.METHODSUsing high-resolution confocal microscopy with isolated perfusion labelling of human donor retina, we investigated changes to IP-TNTs, pericytes and capillaries in the macular vasculature of individuals with preclinical diabetic retinopathy (n=7) and control individuals (n=12).RESULTSWe observed diffuse loss of IP-TNTs in the superficial vascular plexus (SVP), the intermediate capillary plexus (ICP) and the deep capillary plexus (DCP) as well as in the four quadrants of the macula in preclinical diabetic retinopathy. The mean ± SD numbers of IP-TNTs per 500 × 500 µm area were 2.5 ± 0.79 (diabetic) and 3.93 ± 0.82 (control) (p<0.0001) in the SVP; 1.40 ± 0.83 (diabetic) and 1.98 ± 0.88 (control) (p=0.012) in the ICP; and 1.11 ± 0.87 (diabetic) and 1.75 ± 0.99 (control) (p=0.011) in the DCP. Within the ICP and DCP, IP-TNT losses were identified despite an absence of pericyte density changes. In the SVP, IP-TNT losses were present despite an absence of capillary density change.CONCLUSIONS/INTERPRETATIONThese observations suggest that IP-TNT loss is a very early feature of diabetic retinopathy that can selectively precede alterations to pericytes and retinal capillaries. Given that IP-TNTs are intimately associated with pericytes, there is the potential that IP-TNT loss contributes to perfusion abnormalities and may be one of the major pathogenic factors in diabetic retinopathy. Future studies should confirm this exploratory work; the development of therapeutic agents designed to maintain IP-TNT structure and function may be an important factor for the preservation of retinal health.","PeriodicalId":11164,"journal":{"name":"Diabetologia","volume":"8 1","pages":""},"PeriodicalIF":8.2,"publicationDate":"2025-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145559046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-17DOI: 10.1007/s00125-025-06601-5
Mia Bajramagic, Tadej Battelino, Xavier Cos, Mark Cote, Nancy Cui, Angus Forbes, Alfonso Galderisi, Lutz Heinemann, Sufyan Hussain, Jessica Imbert, Christian Holm Jönsson, Michael Joubert, Nebojša M. Lalić, Moshe Phillip, Peter Schwarz, Bart Torbeyns, Deborah J. Wake, Katerina Zakrzewska, Stefano Del Prato
{"title":"Artificial intelligence-driven clinical decision support systems to assist healthcare professionals and people with diabetes in Europe at the point of care: a Delphi-based consensus roadmap","authors":"Mia Bajramagic, Tadej Battelino, Xavier Cos, Mark Cote, Nancy Cui, Angus Forbes, Alfonso Galderisi, Lutz Heinemann, Sufyan Hussain, Jessica Imbert, Christian Holm Jönsson, Michael Joubert, Nebojša M. Lalić, Moshe Phillip, Peter Schwarz, Bart Torbeyns, Deborah J. Wake, Katerina Zakrzewska, Stefano Del Prato","doi":"10.1007/s00125-025-06601-5","DOIUrl":"https://doi.org/10.1007/s00125-025-06601-5","url":null,"abstract":"","PeriodicalId":11164,"journal":{"name":"Diabetologia","volume":"95 1","pages":""},"PeriodicalIF":8.2,"publicationDate":"2025-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145532097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aims/hypothesis: Available methods for predicting the onset and progression of diabetic kidney disease (DKD) and end-stage kidney disease (ESKD) are not yet ready for clinical application. We used a Japanese diabetes cohort study (J-DREAMS) to examine whether the Ahlqvist et al diabetes clustering is useful for stratifying DKD or ESKD outcomes independent of known risk factors in real-world settings.
Methods: Data-driven cluster analysis using k-means was performed based on GAD antibody levels, age at diagnosis, BMI, HbA1c and HOMA2 estimates of beta cell function and insulin resistance in 12,093 individuals with type 1 or type 2 diabetes. The risk of developing DKD/ESKD was analysed using Kaplan-Meier analysis and the Cox proportional hazards model.
Results: Diabetes clustering classified individuals in the J-DREAMS cohort into five subtypes, the clinical characteristics of which were comparable to those of the previously reported five subtypes. Kaplan-Meier curve analysis showed that events for chronic kidney disease (CKD) stages 3b, 4 and 5 were highest in the severe insulin-resistant diabetes subtype. The Cox proportional hazards model showed that the severe insulin-resistant diabetes subtype had significant HRs after correction for multiple confounding factors. The Cox proportional hazards model showed that each subtype had a diverse combination of factors associated with CKD stage 3b and proteinuria events.
Conclusions/interpretation: Data-driven analysis provides diabetes subtyping, which can predict the probability of developing DKD/ESKD; each subtype has diverse combinations of factors predisposing to DKD development and progression. Data-driven diabetes subtyping to predict the likelihood of developing DKD/ESKD and mitigating predisposing factors may help personalise prevention strategies.
{"title":"Diverse combination of factors associated with the development of diabetic kidney disease among data-driven diabetes subtypes: analysis of the J-DREAMS registry.","authors":"Kiriko Watanabe-Shimoji, Hayato Tanabe, Mitsuru Ohsugi, Eiryo Kawakami, Kenichi Tanaka, Junichiro J Kazama, Kohjiro Ueki, Michio Shimabukuro","doi":"10.1007/s00125-025-06594-1","DOIUrl":"https://doi.org/10.1007/s00125-025-06594-1","url":null,"abstract":"<p><strong>Aims/hypothesis: </strong>Available methods for predicting the onset and progression of diabetic kidney disease (DKD) and end-stage kidney disease (ESKD) are not yet ready for clinical application. We used a Japanese diabetes cohort study (J-DREAMS) to examine whether the Ahlqvist et al diabetes clustering is useful for stratifying DKD or ESKD outcomes independent of known risk factors in real-world settings.</p><p><strong>Methods: </strong>Data-driven cluster analysis using k-means was performed based on GAD antibody levels, age at diagnosis, BMI, HbA<sub>1c</sub> and HOMA2 estimates of beta cell function and insulin resistance in 12,093 individuals with type 1 or type 2 diabetes. The risk of developing DKD/ESKD was analysed using Kaplan-Meier analysis and the Cox proportional hazards model.</p><p><strong>Results: </strong>Diabetes clustering classified individuals in the J-DREAMS cohort into five subtypes, the clinical characteristics of which were comparable to those of the previously reported five subtypes. Kaplan-Meier curve analysis showed that events for chronic kidney disease (CKD) stages 3b, 4 and 5 were highest in the severe insulin-resistant diabetes subtype. The Cox proportional hazards model showed that the severe insulin-resistant diabetes subtype had significant HRs after correction for multiple confounding factors. The Cox proportional hazards model showed that each subtype had a diverse combination of factors associated with CKD stage 3b and proteinuria events.</p><p><strong>Conclusions/interpretation: </strong>Data-driven analysis provides diabetes subtyping, which can predict the probability of developing DKD/ESKD; each subtype has diverse combinations of factors predisposing to DKD development and progression. Data-driven diabetes subtyping to predict the likelihood of developing DKD/ESKD and mitigating predisposing factors may help personalise prevention strategies.</p>","PeriodicalId":11164,"journal":{"name":"Diabetologia","volume":" ","pages":""},"PeriodicalIF":10.2,"publicationDate":"2025-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145539254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aims/hypothesis Neuropsychological assessments and neuroimaging techniques have indicated impaired spatial working memory in adolescents with type 1 diabetes. We investigated the influence of diabetes-related factors on their spatial navigation performance. Methods Spatial navigation performance on the virtual Morris water maze task (vMWMT) was evaluated in adolescents with type 1 diabetes and compared with that of healthy control adolescents of similar age and sex. Collected data on diabetes-related variables included disease duration, diabetic ketoacidosis (DKA) at diagnosis and continuous glucose monitoring (CGM) metrics during the 2 weeks preceding the assessment, with focus upon nocturnal values measured during the night before testing. Time to first move, time to platform and path length were measured in visible and hidden platform vMWMT stages. Results The 74 study participants (age 15.6 ± 3.1 years, 45 boys) with type 1 diabetes demonstrated sex-specific patterns of spatial navigation, comparable with those observed in the healthy control group. Both the boys and girls had longer time to first move than the control groups in the visible platform stage, which assessed motor control ( p =0.036 and p =0.002, respectively). Test outcomes did not differ between the participants with and without type 1 diabetes in the hidden platform stages, which assessed spatial learning and memory. However, linear regression models adjusted for sex, age and DKA at diagnosis found that diabetes duration (β=0.464, p <0.001) independently predicted longer time to platform ( R2 =0.396, p =0.003), while nocturnal time spent in marked hypoglycaemia (β=0.397, p =0.002) predicted longer path length ( R2 =0.206, p =0.017). Conclusions/interpretation Spatial navigation performance in adolescents with type 1 diabetes is influenced by both disease duration and recent glycaemic control. Glycaemic excursions, especially during the night, were shown to impair performance. Graphical
目的/假设神经心理学评估和神经影像学技术表明1型糖尿病青少年的空间工作记忆受损。我们研究了糖尿病相关因素对他们空间导航能力的影响。方法评价1型糖尿病青少年在虚拟Morris水迷宫任务（vMWMT）中的空间导航能力，并与相同年龄和性别的健康对照组进行比较。收集的糖尿病相关变量数据包括疾病持续时间、诊断时的糖尿病酮症酸中毒（DKA）和评估前2周的连续血糖监测（CGM）指标，重点是在测试前一晚测量的夜间值。在可见和隐藏平台vMWMT阶段测量首次移动时间、到平台时间和路径长度。结果74例1型糖尿病患者（年龄15.6±3.1岁，其中45例为男孩）表现出性别特异性的空间导航模式，与健康对照组相当。在评估运动控制的可见平台阶段，男孩和女孩的第一次移动时间都比对照组长（p =0.036和p =0.002）。在评估空间学习和记忆的隐藏平台阶段，有1型糖尿病和没有1型糖尿病的参与者之间的测试结果没有差异。然而，经性别、年龄和诊断时DKA校正的线性回归模型发现，糖尿病病程（β=0.464, p <0.001）独立预测更长的到达平台时间（r2 =0.396, p =0.003），而明显低血糖的夜间时间（β=0.397, p =0.002）预测更长的路径长度（r2 =0.206, p =0.017）。结论/解释青少年1型糖尿病患者的空间导航能力受病程和近期血糖控制的影响。血糖升高，尤其是夜间血糖升高，会损害运动表现。图形化的
{"title":"The virtual Morris water maze for cognitive function assessment in adolescents with type 1 diabetes","authors":"Hussein Zaitoon, Liat Perl, Eyal Cohen-Sela, Asaf Oren, Yael Lebenthal, Avivit Brener","doi":"10.1007/s00125-025-06598-x","DOIUrl":"https://doi.org/10.1007/s00125-025-06598-x","url":null,"abstract":"Aims/hypothesis Neuropsychological assessments and neuroimaging techniques have indicated impaired spatial working memory in adolescents with type 1 diabetes. We investigated the influence of diabetes-related factors on their spatial navigation performance. Methods Spatial navigation performance on the virtual Morris water maze task (vMWMT) was evaluated in adolescents with type 1 diabetes and compared with that of healthy control adolescents of similar age and sex. Collected data on diabetes-related variables included disease duration, diabetic ketoacidosis (DKA) at diagnosis and continuous glucose monitoring (CGM) metrics during the 2 weeks preceding the assessment, with focus upon nocturnal values measured during the night before testing. Time to first move, time to platform and path length were measured in visible and hidden platform vMWMT stages. Results The 74 study participants (age 15.6 ± 3.1 years, 45 boys) with type 1 diabetes demonstrated sex-specific patterns of spatial navigation, comparable with those observed in the healthy control group. Both the boys and girls had longer time to first move than the control groups in the visible platform stage, which assessed motor control ( <jats:italic>p</jats:italic> =0.036 and <jats:italic>p</jats:italic> =0.002, respectively). Test outcomes did not differ between the participants with and without type 1 diabetes in the hidden platform stages, which assessed spatial learning and memory. However, linear regression models adjusted for sex, age and DKA at diagnosis found that diabetes duration (β=0.464, <jats:italic>p</jats:italic> <0.001) independently predicted longer time to platform ( <jats:italic>R</jats:italic> <jats:sup>2</jats:sup> =0.396, <jats:italic>p</jats:italic> =0.003), while nocturnal time spent in marked hypoglycaemia (β=0.397, <jats:italic>p</jats:italic> =0.002) predicted longer path length ( <jats:italic>R</jats:italic> <jats:sup>2</jats:sup> =0.206, <jats:italic>p</jats:italic> =0.017). Conclusions/interpretation Spatial navigation performance in adolescents with type 1 diabetes is influenced by both disease duration and recent glycaemic control. Glycaemic excursions, especially during the night, were shown to impair performance. Graphical","PeriodicalId":11164,"journal":{"name":"Diabetologia","volume":"93 1","pages":""},"PeriodicalIF":8.2,"publicationDate":"2025-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145531662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-13DOI: 10.1007/s00125-025-06603-3
Camille Préfontaine, Jasmine Pipella, Nayara Rampazzo Morelli, Yi-Chun Chen, C. Bruce Verchere, Peter J. Thompson
{"title":"Insulin production is sustained during DNA damage-mediated senescence in adult human beta cells","authors":"Camille Préfontaine, Jasmine Pipella, Nayara Rampazzo Morelli, Yi-Chun Chen, C. Bruce Verchere, Peter J. Thompson","doi":"10.1007/s00125-025-06603-3","DOIUrl":"https://doi.org/10.1007/s00125-025-06603-3","url":null,"abstract":"","PeriodicalId":11164,"journal":{"name":"Diabetologia","volume":"174 1","pages":""},"PeriodicalIF":8.2,"publicationDate":"2025-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145498364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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