Infection and allergic contact dermatitis may be encountered in postoperative and chronic wounds. Since symptoms overlap, differentiating these complications in real time could help guide management. We propose applying potentially allergenic wound care agents to an area of healthy skin while managing postoperative and chronic wounds. This method can help identify allergic contact dermatitis rapidly, thereby reducing misdiagnosis and improving patient care.
Rosacea is a chronic inflammatory skin condition of the central face driven by immune dysregulation, genetic predisposition, epidermal barrier dysfunction, and microbial dysbiosis. Recent evidence implicates both the gut and skin microbiomes-through direct immune interactions and the gut-skin axis-in driving cutaneous inflammation and disease severity, with an increase in proinflammatory species such as Demodex folliculorum, Staphylococcus epidermidis, and Bacillus oleronius alongside a decline in protective species such as Cutibacterium acnes. Therapeutic strategies now aim to restore microbial balance using narrow-spectrum antibiotics, anthelmintics, topical and oral probiotics, and microbiome-friendly skin care to reduce inflammation, reinforce skin barrier function, and improve clinical outcomes. Future research to refine precision treatments that target specific microbial and immune pathways would be beneficial to modulate dysbiosis and improve outcomes in rosacea.
Hidradenitis suppurativa (HS) is a chronic inflammatory skin condition of the follicular epithelium that impacts 1% to 4% of the general population. It manifests clinically as inflamed nodules that typically are located in intertriginous areas of the body and frequently recur. The nodules can become infected and lead to abscesses, pain, and scarring-all of which can have debilitating consequences for a patient's quality of life. This study aimed to improve HS outcomes by analyzing what pathogens most frequently grow in HS wound cultures. We conducted a retrospective medical chart review of 485 patients with a diagnosis of HS from January 2006 to December 2021 comprising 600 visits at the University of Texas Medical Branch at Galveston. We also provide recommendations for empiric antibiotics based on the anatomic location of HS lesions and culture sensitivity profiles. Utilizing tailored antibiotic therapy following initial clinical evaluation may increase early disease control and improve morbidity and disease outcomes, thereby improving patient quality of life.
Vitamin C deficiency can occur in industrialized nations in at-risk populations, such as those with a history of smoking, alcohol use, restrictive diet, poor oral intake, psychiatric disorders, dementia, bone marrow transplantation, gastroesophageal reflux disease, or end-stage renal disease. In this case series, we present 4 hospitalized patients with thrombocytopenia and a range of risk factors for micronutrient deficiency who were diagnosed with scurvy.
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