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Epidemiology and demographics of head and neck cancers: a hospital based retrospective study in Andhra Pradesh 头颈癌的流行病学和人口统计学:安得拉邦一项基于医院的回顾性研究
Pub Date : 2019-11-30 DOI: 10.17511/jooo.2019.i07.08
Dr. A. Kusumanjali, Dr. Niveditha Meenuga, Dr. Grace Vandana Jyothi R., Dr. V. Krishna Chaitanya
Background : Head and Neck cancers (HNC) in India make up 25-30 percent of all cancers and are the most common cancer in Indian men and the third most common cancer in women. The aim of this study was to study the demographic profile, sites involved and the histopathological patterns of HNC at a tertiary care hospital in Sri Potti Sriramulu Nellore district, Andhra Pradesh. Materials and Methods: This was a retrospective study conducted in Department of Otolaryngology, Narayana Medical College and Hospital, SPS Nellore, Andhra Pradesh. The data was collected from the years 2015 to 2018. Only histopathologically confirmed cases of malignancies of Head and Neck were included in the study. Results: A total of 75 cases were included in the study. There were 53 (70.66%) male and 22 (29.33%) female patients. The mean age of male and female patients was 56.45±11.46 and 51.68±9.20 years respectively. The most common sites HNC, in both male and female patients, were found to be larynx (36%) followed by oral cavity (33.33%). It was also observed that squamous cell carcinoma (SCC) was the most common histopathological variant amongst all the HNC. All the patients in this study had one or more associated risk factors for HNC. Conclusion: There is a spurt of HNC cases in SPS Nellore. It is important to focus on prevention and early detection of HNC and also have a dedicated cancer hospital to cater the needs of the patients.
背景:印度头颈癌(HNC)占所有癌症的25- 30%,是印度男性中最常见的癌症,也是女性中第三常见的癌症。本研究的目的是研究安得拉邦Sri Potti Sriramulu Nellore区的一家三级保健医院HNC的人口统计资料、涉及的地点和组织病理学模式。材料和方法:回顾性研究在安得拉邦SPS Nellore Narayana医学院耳鼻喉科进行。这些数据是从2015年到2018年收集的。只有组织病理学证实的头颈部恶性肿瘤病例被纳入研究。结果:共纳入75例。男性53例(70.66%),女性22例(29.33%)。男性平均年龄56.45±11.46岁,女性平均年龄51.68±9.20岁。HNC在男性和女性患者中最常见的部位是喉部(36%),其次是口腔(33.33%)。我们还观察到鳞状细胞癌(SCC)是所有HNC中最常见的组织病理学变异。本研究中的所有患者都有一个或多个与HNC相关的危险因素。结论:云南省SPS地区HNC病例呈井喷式增长。重点关注HNC的预防和早期发现,并建立专门的癌症医院以满足患者的需求,这一点很重要。
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引用次数: 2
Screening and management of retinopathy of prematurity at a tertiary health care centre 三级保健中心早产儿视网膜病变的筛查和管理
Pub Date : 2019-11-30 DOI: 10.17511/jooo.2019.i07.05
Chethana Warad, Prakash V Suranagi, B. Prasad
Background: Retinopathy of Prematurity is a serious vaso-proliferative disorder that affects premature babies. ROP is a significant cause of childhood blindness unless recognized and treated timely and adequately. Objectives : 1) To determine the magnitude of ROP among premature neonates of less than or equal to 36 weeks of gestational age at SSIMS & RC, NICU. 2) To determine its association with certain risk factors. 3) To assess the response to laser photocoagulation given to babies with prethreshold ROP type1 and threshold ROP and APROP cases. Materials: 1) All premature neonates of either sex less than or equal to 36 weeks of G.A. 2) Birth weight less than or equal to 2000gm. Methods of data Collection: 1) Place of study: SSIMS & RC HOSPITAL, LEVEL3 NICU. 2) Duration of study: 1 st DEC 2012 to 30 th NOV 2013. 3) Sample Size: 110. Results: Out of 110 babies screened for ROP 43 (39.1%) of them showed signs of ROP in one or both eyes. Statistical analysis showed that incidence of ROP increased as gestational age decreased and also as birth weight decreased. Oxygen therapy, apnoea, RDS, anaemia, blood transfusion, sepsis were found to be significant risk factors. Out of 43 cases with ROP, 13 cases were treated by diode laser. Signs of regression were noted in all 13 cases. Conclusion: The prevalence of ROP in this study was 39.1%, indicating that it is quite a significant cause for childhood blindness. Laser treatment has proved that timely intervention can eliminate blindness due to ROP. Laser photocoagulation is an established technique for the treatment of ROP. At present, the standard of care in ROP is the diode red laser indirect ophthalmoscope. Laser indeed has many advantages over cryotherapy like less post treatment pain, adnexal edema, exudative retinal detachment, vitreo retinal traction and vitreous hemorrhage due to reduced break down of the blood retinal barrier. The limitations of the present study were the number of patients included in the study population.
背景:早产儿视网膜病变是一种影响早产儿的严重血管增殖性疾病。除非得到及时和充分的认识和治疗,ROP是儿童失明的重要原因。目的:1)确定sims & RC NICU小于或等于36周胎龄的早产儿ROP的大小。2)确定其与某些危险因素的关联。3)评价阈前ROP 1型及阈前ROP合并APROP患儿激光光凝治疗的疗效。材料:1)所有出生月龄小于或等于36周的男女早产儿。2)出生体重小于或等于2000gm。资料收集方法:1)研究地点:上海市中西医结合医院三级NICU。2)学习时间:2012年12月1日至2013年11月30日。3)样本量:110。结果:筛查的110名婴儿中,有43名(39.1%)出现单眼或双眼ROP征象。统计分析表明,ROP的发生率随着胎龄的降低和出生体重的降低而增加。氧疗、呼吸暂停、RDS、贫血、输血、败血症是显著的危险因素。43例ROP中13例采用激光治疗。所有13例患者均有退化迹象。结论:本研究ROP患病率为39.1%,是儿童致盲的重要原因。激光治疗已证明及时干预可消除ROP致盲。激光光凝是一种成熟的治疗ROP的技术。目前,ROP的护理标准是二极管红色激光间接检眼镜。激光确实比冷冻疗法有许多优点,如治疗后疼痛少,附件水肿,渗出性视网膜脱离,玻璃体视网膜牵引和玻璃体出血,由于血液视网膜屏障的破坏减少。本研究的局限性在于纳入研究人群的患者数量。
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引用次数: 1
Sinonasal and nasopharyngeal pathology in chronic otitis media patients: a prospective study 慢性中耳炎患者的鼻咽病理:一项前瞻性研究
Pub Date : 2019-11-30 DOI: 10.17511/jooo.2019.i07.02
Dr. Kayedjohar K. Rathwala
Background and Aim: Chronic Suppurative Otitis Media (CSOM) is a persistent inflammation that causes irreversible changes of the mucosa in the middle ear and mastoid cavity. The present study was conducted at ENT department of Tertiary care institute of Gujarat, India involving 130 patients suffering from chronic otitis media. The study also aimed to compare the microbiological flora of the diseased ear and the nasopharynx. Material and Methods: Present prospective study conducted at department of Otorhinolaryngology Tertiary care institute of Gujarat. Total 130 patients having a clinical diagnosis of chronic suppurative otitis media were invited to participate in the study and an informed consent was sought. Clinical presentation including complaints related with ear and nose were noted. Bilateral ear examination was done using Valsalva maneuver. Pure tone audiometry was also performed on all the cases to assess the effect on hearing status. The nasopharyngeal swab was collected by a sterile technique to avoid commensal growth. Results: The most common presenting nasal complaint was nasal obstruction, followed by postnasal drip, nasal discharge, sneezing, snoring, headache, around 25% of patients had no nasal symptoms. The comparative study of ear and nasopharyngeal swab showed statistically significant correlation. 80 % of ear swabs and 92% of nasopharyngeal swabs were found to be sterile. Conclusion: Chronic otitis media is a disease with multiple factors and different possible aetiologies. The concept of a relationship between sinonasal and nasopharyngeal pathologies and chronic otitis media has been supported by the present study.
背景与目的:慢性化脓性中耳炎(CSOM)是一种引起中耳及乳突腔粘膜不可逆变化的持续性炎症。本研究在印度古吉拉特邦三级保健研究所耳鼻喉科进行,涉及130名患有慢性中耳炎的患者。该研究还旨在比较患病耳朵和鼻咽部的微生物菌群。材料和方法:本前瞻性研究在古吉拉特邦三级保健研究所耳鼻喉科进行。共有130名临床诊断为慢性化脓性中耳炎的患者被邀请参加研究,并获得知情同意。临床表现包括与耳鼻部有关的投诉。双耳检查采用Valsalva手法。对所有病例进行纯音测听,以评估对听力状况的影响。鼻咽拭子采集采用无菌技术,以避免共生生长。结果:最常见的鼻部主诉为鼻塞,其次为鼻后滴涕、流鼻涕、打喷嚏、打鼾、头痛,约25%的患者无鼻部症状。耳部和鼻咽拭子的比较研究显示有统计学意义。80%的耳拭子和92%的鼻咽拭子是无菌的。结论:慢性中耳炎是一种多因素、病因多样的疾病。鼻腔和鼻咽部病变与慢性中耳炎之间关系的概念已得到本研究的支持。
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引用次数: 0
Ocular manifestations of leprosy 麻风病的眼部表现
Pub Date : 2019-11-30 DOI: 10.17511/jooo.2019.i07.03
G. N. Reddy, G. Reddy
Introduction: Leprosy or Hansen’s disease is a chronic infectious disease caused by an intracellular rod-shaped acid-fast bacilli Mycobacterium leprae which affects the skin, nasal mucosa, peripheral nerves and the anterior segment of the eye. Mycobacterium leprae was discovered by a Norwegian physician G. Armauer Hansen in the year 1874. Materials and Methods: The present study was carried out in the outpatient Department of Ophthalmology and inpatient department of Dermatology at Mamatha Medical College and Hospital, Khammam from March 2015-March 2016. In this study a total of 78 patients were taken, 61 males and 17 females of the age group 20 years and above. All diagnosed cases of leprosy. Old and new cases, both genders and age group of 20 years and above. Noncompliant patients, Patients with preexisting ocular disorders due to other causes than leprosy. Results: In the group 'A' there are 21 patients of whom 7 patients (33.3%) showed evidence of ocular involvement. In group 'B' 8 out of 12 patients had eye lesions, thus a greater percentage (66.6%) showed ocular involvement. 39 out of 45 (86.6%) patients of group 'C' showed ocular involvement. Thus, it is found that the greater the duration of the disease, the more are the chance for ocular involvement. Most of the patients had eye lesions when the disease is more than 10 years in duration. Conclusion: Visual impairment is preventable in Leprosy if detected early. The risk of ocular complications increases with the duration of the disease, despite being treated with systemic anti-leprosy drugs.
简介:麻风或汉森病是一种由细胞内杆状抗酸杆菌麻风分枝杆菌引起的慢性传染病,可累及皮肤、鼻黏膜、周围神经和眼睛前段。麻风分枝杆菌是由挪威医生G. Armauer Hansen在1874年发现的。材料与方法:本研究于2015年3月- 2016年3月在Khammam Mamatha医学院医院眼科门诊和皮肤科住院部进行。本研究共纳入78例患者,其中男性61例,女性17例,年龄在20岁及以上。所有确诊的麻风病病例。新老病例,男女皆可,年龄在20岁及以上。非依从性患者,麻风病以外的其他原因导致的既往眼部疾病患者。结果:A组21例患者,其中7例(33.3%)表现为眼部受累。B组12例患者中有8例有眼部病变,可见眼部受累的比例更高(66.6%)。C组45例患者中有39例(86.6%)出现眼部受累。因此,发现病程越长,眼部受累的机会越大。病程在10年以上的患者多出现眼部病变。结论:麻风病早期发现视力损害是可以预防的。眼部并发症的风险随着病程的延长而增加,尽管接受了全身抗麻风病药物治疗。
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引用次数: 0
Tear Film Break up time (TBUT) in allergic papillary conjunctivitis and immediate effect of carboxy methylcellulose on TBUT 过敏性乳头状结膜炎的泪膜破裂时间及羧甲基纤维素对泪膜破裂时间的直接影响
Pub Date : 2019-11-30 DOI: 10.17511/jooo.2019.i07.01
Rathnamma Jarmale, Vidhya Mysore Jagadeeshwara
Purpose: To find out the effect of papillae due to allergic conjunctivitis on the tear film break up time (TBUT) and immediate effect of topical carboxymethyl cellulose (CMC) on TBUT in these patients. Methods: 62 eyes of the 31 patients in the age group of 20-40 years with papillae in the tarsal conjunctiva due to allergic conjunctivitis were subjected to measurement of TBUT. This was followed by application of one drop of 0.5% carboxy methylcellulose eye drop and TBUT was repeated after 5 minutes. Patients not in the 20-40-year age group, presence of any ocular surface disorder, mebomian gland dysfunction and lagophthalmos were excluded from the study. Results: 31 patients (62 eyes) were included in the study. TBUT was less than 15secs in 47 eyes (75.80%) and more than 15sec in 15eyes (24.19%). TBUT improved after application of topical CMC in 23 eyes (37.09%) and reduced in 21 eyes (33.87%) and remained the same in 18 eyes (29.56%). Percentage of patients who showed improvement in TBUT who had less than normal TBUT was 40.42%. Percentage of patients who showed reduction in TBUT with normal TBUT was 66.66%. Conclusion: TBUT is less than normal in around two third of the patients with allergic papillary conjunctivitis. Immediate effect of topical CMC showed no significant changes in the TBUT. Topical CMC drops showed better improvement in TBUT in patients with initial reduced TBUT rather than in patients with normal initial TBUT.
目的:探讨变应性结膜炎患者泪膜破裂时间(TBUT)的影响及外用羧甲基纤维素(CMC)对TBUT的直接影响。方法:对31例20 ~ 40岁变应性结膜炎致跗结膜乳头状病变患者62眼进行TBUT测定。随后滴0.5%羧甲基纤维素滴眼液1滴,5分钟后重复TBUT。非20-40岁年龄组、存在任何眼表疾病、膜腺功能障碍和眼lagophthalmmos的患者被排除在研究之外。结果:31例患者(62只眼)纳入研究。TBUT小于15秒的有47眼(75.80%),大于15秒的有15眼(24.19%)。局部应用CMC后TBUT改善23眼(37.09%),降低21眼(33.87%),保持不变18眼(29.56%)。TBUT低于正常TBUT的患者TBUT改善的比例为40.42%。TBUT正常的患者TBUT减少的比例为66.66%。结论:三分之二的变应性乳头状结膜炎患者TBUT低于正常水平。局部应用CMC后,TBUT未见明显变化。与初始TBUT正常的患者相比,初始TBUT减少的患者局部滴注CMC对TBUT的改善效果更好。
{"title":"Tear Film Break up time (TBUT) in allergic papillary conjunctivitis and immediate effect of carboxy methylcellulose on TBUT","authors":"Rathnamma Jarmale, Vidhya Mysore Jagadeeshwara","doi":"10.17511/jooo.2019.i07.01","DOIUrl":"https://doi.org/10.17511/jooo.2019.i07.01","url":null,"abstract":"Purpose: To find out the effect of papillae due to allergic conjunctivitis on the tear film break up time (TBUT) and immediate effect of topical carboxymethyl cellulose (CMC) on TBUT in these patients. Methods: 62 eyes of the 31 patients in the age group of 20-40 years with papillae in the tarsal conjunctiva due to allergic conjunctivitis were subjected to measurement of TBUT. This was followed by application of one drop of 0.5% carboxy methylcellulose eye drop and TBUT was repeated after 5 minutes. Patients not in the 20-40-year age group, presence of any ocular surface disorder, mebomian gland dysfunction and lagophthalmos were excluded from the study. Results: 31 patients (62 eyes) were included in the study. TBUT was less than 15secs in 47 eyes (75.80%) and more than 15sec in 15eyes (24.19%). TBUT improved after application of topical CMC in 23 eyes (37.09%) and reduced in 21 eyes (33.87%) and remained the same in 18 eyes (29.56%). Percentage of patients who showed improvement in TBUT who had less than normal TBUT was 40.42%. Percentage of patients who showed reduction in TBUT with normal TBUT was 66.66%. Conclusion: TBUT is less than normal in around two third of the patients with allergic papillary conjunctivitis. Immediate effect of topical CMC showed no significant changes in the TBUT. Topical CMC drops showed better improvement in TBUT in patients with initial reduced TBUT rather than in patients with normal initial TBUT.","PeriodicalId":112259,"journal":{"name":"Tropical Journal of Ophthalmology and Otolaryngology","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124533338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison of ranibizumab and bevacizumab for macular edema associated with retinal vein occlusion 雷尼单抗和贝伐单抗治疗视网膜静脉闭塞性黄斑水肿的比较
Pub Date : 2019-11-30 DOI: 10.17511/jooo.2019.i07.04
Nupur Sharma, N. Jat, Priti Singh, Kavita Kumar
Purpose: To assess the effectiveness of intravitreal ranibizumab compared with bevacizumab for the treatment of macular edema associated with retinal vein occlusion (RVO). Methods: This was a retrospective study of 64 eyes with macular edema associated with RVO. Patients received either 1.25 mg of intravitreal bevacizumab (n = 32) or 0.5 mg of intravitreal ranibizumab (n = 32). Visual acuity, clinical bio-microscopic examination and central macular thickness (CMT) by Optical Coherence Tomography (OCT) was assessed at 6 weeks post injection. The CMT before and six weeks after the injection as assessed by OCT were compared. Statistical analysis was performed using paired student t-test. The improvement in CMT was also compared between the two groups, statistical analysis was performed using un-paired student t-test. Results: The best-corrected visual acuity significantly improved from logarithm of the minimal angle of resolution (logMAR) 0.792 ±0.36 at baseline to 0.575 ± 0.34 at 6 weeks in the bevacizumab group (p =0.001) and from logMAR 0.851 ± 0.35 at baseline to 0.336 ± 0.20 at 6 weeks in the ranibizumab group (p = 0.001), which is statistically significant difference. The reduction in CMT was from 545.44 ± 176.43 μm at baseline to 378.34 ±95.13 at 6 weeks in the bevacizumab group (p = 0.001) and 524.25± 195.94 μm at baseline to 243±80.72 μm at 6 weeks in the ranibizumab group (p=0.001) which was also a statistically significant difference (p = 0.001). Conclusions: Both ranibizumab and bevacizumab were effective for the treatment of RVO. The visual outcome and reduction in macular thickness was better by ranibizumab at the earliest follow-up of 6 weeks.
目的:评价玻璃体内注射雷尼单抗与贝伐单抗治疗视网膜静脉闭塞(RVO)黄斑水肿的疗效。方法:对64只黄斑水肿伴RVO的眼进行回顾性研究。患者接受1.25 mg玻璃体内贝伐单抗(n = 32)或0.5 mg玻璃体内雷尼单抗(n = 32)。注射后6周评估视力、临床生物显微镜检查和光学相干断层扫描(OCT)中央黄斑厚度(CMT)。比较注射前和注射后6周OCT评估的CMT。采用配对学生t检验进行统计分析。比较两组CMT的改善情况,采用非配对学生t检验进行统计学分析。结果:贝伐单抗组最佳矫正视力由基线时的最小分辨角对数(logMAR) 0.792±0.36提高到6周时的0.575±0.34 (p =0.001),雷尼单抗组由基线时的logMAR 0.851±0.35提高到6周时的0.336±0.20 (p =0.001),差异均有统计学意义。贝伐单抗组CMT从基线值545.44±176.43 μm降低至6周时的378.34±95.13 μm (p=0.001),雷尼单抗组CMT从基线值524.25±195.94 μm降低至6周时的243±80.72 μm (p=0.001),差异均有统计学意义(p=0.001)。结论:雷尼单抗和贝伐单抗治疗RVO均有效。在最早随访6周时,雷尼单抗的视力和黄斑厚度的减少效果更好。
{"title":"Comparison of ranibizumab and bevacizumab for macular edema associated with retinal vein occlusion","authors":"Nupur Sharma, N. Jat, Priti Singh, Kavita Kumar","doi":"10.17511/jooo.2019.i07.04","DOIUrl":"https://doi.org/10.17511/jooo.2019.i07.04","url":null,"abstract":"Purpose: To assess the effectiveness of intravitreal ranibizumab compared with bevacizumab for the treatment of macular edema associated with retinal vein occlusion (RVO). Methods: This was a retrospective study of 64 eyes with macular edema associated with RVO. Patients received either 1.25 mg of intravitreal bevacizumab (n = 32) or 0.5 mg of intravitreal ranibizumab (n = 32). Visual acuity, clinical bio-microscopic examination and central macular thickness (CMT) by Optical Coherence Tomography (OCT) was assessed at 6 weeks post injection. The CMT before and six weeks after the injection as assessed by OCT were compared. Statistical analysis was performed using paired student t-test. The improvement in CMT was also compared between the two groups, statistical analysis was performed using un-paired student t-test. Results: The best-corrected visual acuity significantly improved from logarithm of the minimal angle of resolution (logMAR) 0.792 ±0.36 at baseline to 0.575 ± 0.34 at 6 weeks in the bevacizumab group (p =0.001) and from logMAR 0.851 ± 0.35 at baseline to 0.336 ± 0.20 at 6 weeks in the ranibizumab group (p = 0.001), which is statistically significant difference. The reduction in CMT was from 545.44 ± 176.43 μm at baseline to 378.34 ±95.13 at 6 weeks in the bevacizumab group (p = 0.001) and 524.25± 195.94 μm at baseline to 243±80.72 μm at 6 weeks in the ranibizumab group (p=0.001) which was also a statistically significant difference (p = 0.001). Conclusions: Both ranibizumab and bevacizumab were effective for the treatment of RVO. The visual outcome and reduction in macular thickness was better by ranibizumab at the earliest follow-up of 6 weeks.","PeriodicalId":112259,"journal":{"name":"Tropical Journal of Ophthalmology and Otolaryngology","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121648500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A case report: orbital myiasis 眼眶蝇蛆病1例
Pub Date : 2019-10-31 DOI: 10.17511/jooo.2019.i06.02
Priyanka Chandrakant Choudhari, Vishaka Naik, T. Raiturcar, U. Usgaonkar
The aim of the present study was to report a rare case of orbital myiasis. Myiasis is the invasion of living animal tissue by a fly larvae (maggots). Larvae lay eggs which develop into future larvae and increase the destruction of tissues. Orbital involvement occurs in 5% of all cases of myiasis. It is common in tropical countries with low standards of hygiene. The patient 70-year-old male was admitted to the hospital GMC, Bambolim, Goa on 6 th of February 2019 with pain and bleeding from his right eye for last 8 days with necrotized orbital tissue with several attached larvae. Patient underwent orbital wound tissue debridement and 82 larvae were removed and kept in turpentine solution; thorough saline wash was given. Systemic analgesics and antibiotics were given and as wound showed signs of healing on day 5 of admission patient was discharged. Infestations of orbital and ocular tissue by a fly larvae (Ophthalmo-myiasis) progresses rapidly and can completely destroy orbital tissue within days, most commonly seen in old debilitated patients with psychiatric illness and most commonly associated with eyelid tumors and should be treated promptly. ………………………………………………………………………………………………………………………………...
本文报告一例罕见的眼眶蝇蛆病。蝇蛆病是指蝇幼虫(蛆)侵入活体动物组织。幼虫产卵,这些卵发育成未来的幼虫,增加了对组织的破坏。在所有蝇蛆病病例中,眼眶受累占5%。这在卫生标准较低的热带国家很常见。患者为70岁男性,于2019年2月6日入住果阿邦班伯利姆GMC医院,右眼疼痛和出血持续8天,眼眶组织坏死,伴有数只幼虫附着。患者行眼眶创面组织清创,取出82只幼虫保存于松节油液中;给予彻底的生理盐水冲洗。给予全身镇痛和抗生素治疗,入院第5天伤口出现愈合迹象,患者出院。蝇幼虫(眼蝇病)对眼眶和眼部组织的侵袭进展迅速,可在几天内完全破坏眼眶组织,最常见于老年衰弱的精神疾病患者,最常见于眼睑肿瘤,应及时治疗。...................................................................................................................................................
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引用次数: 1
Visual outcomes following intravitreal bevacizumab and focal laser in diabetic macular edema 玻璃体内注射贝伐单抗和局灶激光治疗糖尿病黄斑水肿的视力结果
Pub Date : 2019-10-31 DOI: 10.17511/jooo.2019.i06.07
Nupur Sharma, Priti Singh, Neha Singh, Kavita Kumar
Purpose: The aim of this study was to evaluate the visual outcome and central macular thickness (CMT) after intravitreal injection of bevacizumab followed by focal laser for the treatment of Diabetic Macular Edema (DME). Patients and methods: This is a prospective, observational study. A total of 30 eyes of 30 patients with Diabetic macular edema were included in this study. The following data were recorded at baseline and during the follow-up periods (≤6 months): bestcorrected visual acuity (BCVA), slit-lamp biomicroscopy, CMT and intraocular pressure measurement by applanation tonometry. All eyes received intravitreal bevacizumab at a dose of 1.25 mg in 0.05 ml followed by focal laser after 2 weeks. Results: This study included 30 eyes of 30 patients, the mean age of the patient 59.4±8.5 years. There were 19 males and 11 females. The mean baseline BCVA in LogMAR was 0.78±0.23, and the final mean BCVA at 6 months had improved to 0.45±0.20. Significant improvement was seen in all the patients over the study period (p<0.001). Mean CMT at baseline was 485±122 μm, which decreased to a mean of 321±82μm at the end of the follow-up period (6 months). Conclusion: Primary treatment for DME with intravitreal bevacizumab followed by focal laser results in improvement of vision and reduces CMT. Combined therapy seems to be an effective modality for treatment of DME.
目的:本研究的目的是评估玻璃体内注射贝伐单抗后局灶激光治疗糖尿病性黄斑水肿(DME)的视力结果和中央黄斑厚度(CMT)。患者和方法:这是一项前瞻性观察性研究。本研究共纳入30例糖尿病性黄斑水肿患者的30只眼。在基线和随访期间(≤6个月)记录以下数据:最佳矫正视力(BCVA)、裂隙灯生物显微镜、CMT和压平眼压测量。所有眼均接受贝伐单抗玻璃体内注射,剂量为1.25 mg / 0.05 ml, 2周后进行病灶激光治疗。结果:本研究纳入30例患者30只眼,患者平均年龄59.4±8.5岁。其中男性19人,女性11人。LogMAR患者的平均基线BCVA为0.78±0.23,6个月时的最终平均BCVA改善至0.45±0.20。所有患者在研究期间均有显著改善(p<0.001)。基线时平均CMT为485±122 μm,随访6个月后下降至321±82μm。结论:玻璃体内注射贝伐单抗治疗DME后,局部激光治疗可改善视力,减少CMT。联合治疗似乎是治疗二甲醚的有效方式。
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引用次数: 0
Correlation between stereoacuity and induced astigmatism: a prospective study 立体视敏度与诱发性散光的相关性:一项前瞻性研究
Pub Date : 2019-10-31 DOI: 10.17511/jooo.2019.i06.03
B. Gagal, Kavita Parekh
Background and Aim: Stereopsis represents the highest grade of Binocular Single Vision wherein two dissimilar images of the same object are formed, simultaneously, at the maculae of the two eyes, and these images are then processed in the visual cortex to produce a single fused image, whose location in space can be perceived. Material and Methods: Present Randomized, Prospective, Comparative, study was performed at Department of Ophthalmology Bharati Hospital & Research Centre, Pune. Two thousand subjects were divided into two groups, they were divided into 2 groups using randomized table. Group 1 was subjected to binocular induced astigmatism. Group 2 was subjected to monocular induced astigmatism. Binocular Induced Astigmatism was induced in two groups, (500 participants in each group) either Myopic Astigmatism or Hypermetropic Astigmatism, similarly Monocular was further subdivided in to two groups (500 participants in each group): Myopic Astigmatism and Hypermetropic Astigmatism. Results: With both +1 Dcyl & +2 Dcyl binocular induced myopic astigmatism, stereoacuity was affected maximum at 45 and least affected at 180. With both -1 Dcyl & -2 Dcyl binocular induced hypermetropic astigmatism, stereoacuity was affected maximum at 45 and least affected at 180. Stereoacuity in binocular induced hypermetropic astigmatism was more affected than binocular induced myopic astigmatism. Stereoauity was grossly affected in both monocular myopic and hypermetropic astigmatism. With the rule astigmatism had remarkable difference in stereoacuity in both myopic and hypermetropic induced astigmatism of 1 and 2 diopters cylinders. Stereoacuity was more affected in hypermetropic group. Conclusion: Stereoacuity is most affected at oblique axis (450). There is gross reduction in stereoacuity in induced monocular astigmatism than binocular astigmatism. Both myopic and hypermetropic against the rule astigmatism has comparable deterioration of stereoacuity.
背景和目的:立体视是双眼单一视觉的最高等级,在双眼的黄斑处同时形成同一物体的两个不同图像,然后这些图像在视觉皮层中进行处理,产生一个单一的融合图像,其空间位置可以被感知。材料和方法:本研究是在浦那巴拉蒂医院眼科和研究中心进行的随机、前瞻性、比较研究。将2000名受试者分为两组,采用随机表法分为两组。第1组行双眼性散光。第二组行单眼诱导散光。双眼性散光分为两组,每组500人,分别为近视散光和远视散光。同样,单眼性散光又分为两组,每组500人,分别为近视散光和远视散光。结果:+1 Dcyl和+2 Dcyl双眼性近视散光,立体视敏度在45时受影响最大,180时受影响最小。对于-1 Dcyl和-2 Dcyl双眼性远视散光,立体视敏度在45度处受影响最大,在180度处受影响最小。双眼大屈光散光对立体视力的影响大于双眼近视散光。单眼近视和远视散光均严重影响立体感。根据该规律,1屈光度和2屈光度圆柱体散光在近视和远视散光中的立体视敏度均有显著差异。远视组立体视敏受影响较大。结论:斜轴(450)对立体视敏的影响最大。与双目散光相比,单眼散光的立体视敏度明显降低。近视和远视散光都有类似的立体视力退化。
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引用次数: 0
Study of intraocular pressure and glaucoma risk in myopes and hypermetropes in middle aged adults 中年人近视和远视患者眼压与青光眼风险的关系研究
Pub Date : 2019-10-31 DOI: 10.17511/jooo.2019.i06.06
Dr. J. Samuel Cornelius Gnanadurai, Dr. S. Vimala Karunanidhi, Dr. Balaji Ramraj, Dr. M. Sathish Kumar, Dr. S.V. Swamyraj
Aim: To study the relationship between Intra ocular pressure and refractive errors (myopia and hypermetropia) and assess glaucoma risk in middle aged adults and compare with a normal emmetropic population of same age group. Materials and Methods: This is a prospective observational study of 150 patients between the age of 30-50 years attending ophthalmology outpatient department of SRM Medical College Hospital & Research Centre for a period of 6months. They were categorized into five groups as Emmetropia (+0.5D to -0.5D), Hypermetropia(>+0.5D), Low Myopia (-0.75D to< -3D), Moderate Myopia (-3D to -6D) and High Myopia (>-6D). Intraocular pressure will be measured with Goldmann applanation tonometer three times at one weekly interval and the average value will be taken. Results: The intra ocular pressure in moderate and high myopia was found to be higher compared to emmetropic, hypermetropic and low myopic patients which was statistically significant (P value-0.0001). In all the refractive error groups, the intra ocular pressure was higher in the 40-50 years age group compared to the 30-39 years age group. There was no statistically significant difference between Intra ocular pressure in the right eye and left eye and between the sexes in all the refractive error groups. Conclusion: The intra ocular pressure was higher in moderate and high myopia and in the 40-50 years age group. This confirms that intra ocular pressure increases with advancing age. Patients with moderate and high myopia have increased risk of developing Glaucoma. Therefore, it would be advisable to routinely check intra ocular pressure for myopes.
目的:研究中年人眼压与屈光不正(近视和远视)的关系,评价青光眼的发病风险,并与同年龄组正常屈光不正人群进行比较。材料与方法:本研究是一项为期6个月的前瞻性观察研究,对象为在SRM医学院附属医院及研究中心眼科门诊就诊的150例年龄在30-50岁之间的患者。他们被分为五组:近视(+0.5D至-0.5D)、远视(>+0.5D)、低近视(-0.75D至< -3D)、中度近视(-3D至-6D)和高度近视(>-6D)。用Goldmann眼压计测眼压,每隔一周测3次,取平均值。结果:中、高度近视患者眼压高于远视、远视和低视患者,差异有统计学意义(P值0.0001)。在所有屈光不正组中,40-50岁年龄组的眼内压高于30-39岁年龄组。在所有屈光不正组中,右眼和左眼的眼压差异无统计学意义,性别差异无统计学意义。结论:40 ~ 50岁人群中、高度近视眼压较高。这证实眼压随年龄增长而升高。中度和高度近视患者发生青光眼的风险增加。因此,建议定期检查眼压是否近视。
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引用次数: 0
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Tropical Journal of Ophthalmology and Otolaryngology
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